Publications by authors named "M Teixeira"

3,245 Publications

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Histopathological differential diagnosis of frontal fibrosing alopecia and fibrosing alopecia in a pattern distribution.

Br J Dermatol 2021 Jun 22. Epub 2021 Jun 22.

Department of Pathology of the Fluminense Federal University, Pedro University Hospital, Antonio, Niteroi, Brazil.

Frontal Fibrosing Alopecia (FFA) and Fibrosing Alopecia in a Pattern Distribution (FAPD) are forms of primary cicatricial alopecia, classified as subtypes of lichen planopilaris (LPP). FAPD and FFA may present with clinical overlap and similar histopathology and dermoscopy features. Parietal scalp involvement with frontal hair line recession can obscure the clincial deliniation between FAPD and FFA. The aim of this study is to establish whether FAPD can be differentiated from FFA by histopathological analysis.
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http://dx.doi.org/10.1111/bjd.20592DOI Listing
June 2021

Depression, anxiety, and drug usage history indicators among institutionalized juvenile offenders of Brasilia.

Psicol Reflex Crit 2021 Jun 22;34(1):17. Epub 2021 Jun 22.

Faculty of Psychology, University of Lisbon, 1649-013, Lisbon, Portugal.

Introduction: One of the most serious socio-educational measures for children and adolescents in conflict with the law in Brazil is their internment. This measure may represent an additional source of stress to this population and present significant impacts in the mental health context. This study aims to describe anxiety levels, depression, and addictive consumption, as well as to estimate the causalities and interactions of these variables.

Methods: Herein, we report a study in which 175 male juveniles from youth detention institutions of the Federal District voluntarily completed the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), and a short self-rating questionnaire asking whether and how often they had experienced cannabis, alcohol, and other "hard" psychotropic drugs (e.g., crack, cocaine, amphetamine) 1 year prior to institutionalization.

Results: Of the total participants, 28.00% showed moderate to severe depression scores and 34.28% showed moderate to severe anxiety scores. In addition, the vast majority of participants also reported some antecedent drug abuse, including cannabis, alcohol, and other "hard drugs." The BDI scores moderately correlated with BAI, but none of these parameters considerably correlated with the antecedent drug abuse.

Conclusions: The data indicate potentially concerning levels of emotional distress in these institutionalized juveniles which seem to be independent of addictive behaviors. These data deserve attention and further investigation. Thus, a need for preventative mental health for the general population and socio-educational intervention aimed at interned youth which can decrease levels of emotional stress is emphasized.
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http://dx.doi.org/10.1186/s41155-021-00184-xDOI Listing
June 2021

Associations between fetal testosterone and pro-social tendencies, anxiety and autistic symptoms in Williams syndrome: a preliminary study.

Int J Dev Disabil 2017 Sep 27;65(2):82-88. Epub 2017 Sep 27.

Developmental Disorders Program, Mackenzie Presbyterian University, São Paulo, Brazil.

Fetal testosterone (fT) has organizational effects on the developing human nervous system and can be reliably estimated by the ratio between the length of the second and fourth digits - 2D:4D. Previous studies reported altered patterns of fT in some developmental disabilities (e.g. ASD) relative to typically developing individuals (TD). Williams syndrome (WS) is a rare genetic disorder characterized by exacerbated empathy and social approach and heightened anxiety. Recent reports also highlight the co-occurrence of significant levels of autistic symptoms. Despite constituting an interesting model to study androgenic contributions to social behavior, no studies have sought to explore fT in WS. The main aims of this preliminary study were two-fold: (a) to compare 2D:4D in WS and TD; (b) to analyze the pattern of associations between 2D:4D and hypersociability, affective and cognitive empathy, anxiety and autistic symptoms in WS. 2D:4D were measured from digital scans of the ventral surface of the right hand. Hypersociability, empathy, anxiety and autistic symptoms were obtained from parental reports. There were no significant differences in 2D:4D between WS than TD. In WS lower fT (higher 2D:4D) was significantly associated with hypersociability and affective empathy, as well as marginally associated with anxiety/depression scores. In contrast, cognitive empathy was marginally and negatively associated with 2D:4D, while levels of autistic symptoms were unrelated with this measure. Our results suggest that fT may be implicated in the emergence of several cardinal features of WS, namely hypersociability, affective empathy and anxiety, but not in ASD symptoms.
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http://dx.doi.org/10.1080/20473869.2017.1376163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115471PMC
September 2017

Molecular diversity within the genus (Annelida, Nereididae) along the west Atlantic coast: paving the way for integrative taxonomy.

PeerJ 2021 27;9:e11364. Epub 2021 May 27.

Centro de Biologia Molecular e Ambiental, Universidade do Minho, Braga, Portugal.

The polychaete genus (Annelida, Nereididae) occurs over a broad geographic range and extends nearly across the entire Atlantic coast of America, from the USA to Uruguay. Despite the research efforts to clarify its diversity and systematics, mostly by morphological and ecological evidence, there is still uncertainty, mainly concerning the species , which constitutes an old and notorious case of taxonomic ambiguity. Here, we revised the molecular diversity and distribution of species based on a multi-locus approach, including DNA sequence analyses of partial segments of the cytochrome c oxidase subunit I (COI), 16S rRNA, and 28S rRNA genes. We examined specimens collected from 26 sites along the American Atlantic coast from Massachusetts (USA) to Mar del Plata (Argentina). Although no comprehensive morphological examination was performed between different populations, the COI barcodes revealed seven highly divergent MOTUs, with a mean K2P genetic distance of 16.9% (from 6.8% to 21.9%), which was confirmed through four clustering algorithms. All MOTUs were geographically segregated, except for MOTUs 6 and 7 from southeastern Brazil, which presented partially overlapping ranges between Rio de Janeiro and São Paulo coast. Sequence data obtained from 16S rRNA and 28S rRNA markers supported the same MOTU delimitation and geographic segregation as those of COI, providing further evidence for the existence of seven deeply divergent lineages within the genus. The extent of genetic divergence between MOTUs observed in our study fits comfortably within the range reported for species of polychaetes, including Nereididae, thus providing a strong indication that they might constitute separate species. These results may therefore pave the way for integrative taxonomic studies, aiming to clarify the taxonomic status of the MOTUs herein reported.
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http://dx.doi.org/10.7717/peerj.11364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164838PMC
May 2021

The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant.

Genet Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Purpose: To evaluate the association between a previously published 313 variant-based breast cancer (BC) polygenic risk score (PRS) and contralateral breast cancer (CBC) risk, in BRCA1 and BRCA2 pathogenic variant heterozygotes.

Methods: We included women of European ancestry with a prevalent first primary invasive BC (BRCA1 = 6,591 with 1,402 prevalent CBC cases; BRCA2 = 4,208 with 647 prevalent CBC cases) from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), a large international retrospective series. Cox regression analysis was performed to assess the association between overall and ER-specific PRS and CBC risk.

Results: For BRCA1 heterozygotes the estrogen receptor (ER)-negative PRS showed the largest association with CBC risk, hazard ratio (HR) per SD = 1.12, 95% confidence interval (CI) (1.06-1.18), C-index = 0.53; for BRCA2 heterozygotes, this was the ER-positive PRS, HR = 1.15, 95% CI (1.07-1.25), C-index = 0.57. Adjusting for family history, age at diagnosis, treatment, or pathological characteristics for the first BC did not change association effect sizes. For women developing first BC < age 40 years, the cumulative PRS 5th and 95th percentile 10-year CBC risks were 22% and 32% for BRCA1 and 13% and 23% for BRCA2 heterozygotes, respectively.

Conclusion: The PRS can be used to refine individual CBC risks for BRCA1/2 heterozygotes of European ancestry, however the PRS needs to be considered in the context of a multifactorial risk model to evaluate whether it might influence clinical decision-making.
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http://dx.doi.org/10.1038/s41436-021-01198-7DOI Listing
June 2021