Publications by authors named "M Tamura"

2,689 Publications

  • Page 1 of 1

Sapropterin For Phenylketonuria: A Japanese Post-Marketing Surveillance Study.

Pediatr Int 2021 Jul 31. Epub 2021 Jul 31.

Daiichi Sankyo Company Limited, 3-5-1, Nihonbashi Honcho, Chuo-ku, Tokyo, 103-8426, Japan.

Background: To assess the long-term safety and efficacy of sapropterin in a real-world setting in Japanese patients with tetrahydrobiopterin (BH4)-responsive phenylketonuria (PKU).

Methods: This post-marketing surveillance study enrolled all patients in Japan with confirmed BH4-responsive PKU who were administrated sapropterin between July 2008 and October 2017. Patients were observed at least every 3 months during follow-up, with key data collected on treatment exposure/duration, effectiveness according to physician judgement, serum phenylalanine levels, and adverse events.

Results: Of 87 enrolled patients, 85 patients (male, 42.4%; outpatients, 96.5%) were included in the safety and efficacy analysis sets. Treatment started at age <4 years in 43 (50.6%) patients and the most common starting daily dose was 5-10 mg/kg (n=41 [48.2%]) with the overall duration of treatment between 0.2 and 17.2 years. Serum phenylalanine levels according to loading tests reduced from a baseline level of 9.66 mg/dL (range 0.48-36.80 mg/dL) by >30% in 84 patients. Treatment was deemed effective in 79 of 85 patients (92.9%, 95% CI 85.3-97.4). One (1.2%) patient experienced an adverse drug reaction (alanine aminotransferase increased) 50 days after the start of administration, which resolved without complications with continued treatment.

Conclusions: Sapropterin appears well tolerated and highly effective in Japanese patients treated in a real-world setting, including those who start treatment at age <4 years and pregnant women.
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http://dx.doi.org/10.1111/ped.14939DOI Listing
July 2021

Adsorption of Keggin-Type Polyoxometalates on Rh Metal Particles under Reductive Conditions.

Inorg Chem 2021 Jul 29. Epub 2021 Jul 29.

Department of Applied Chemistry, School of Engineering, Tohoku University, 6-6-07 Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan.

The adsorption of POMs on Rh/SiO in water solvent under strongly reductive conditions was investigated. Aqueous solutions of α-Keggin type silicotungstate and silicovanadotungstates were mixed with Rh/SiO at 393-473 K under 1 MPa of H. Monovanadium-substituted silicotungstate, α-SiVWO (SiVW), was more readily adsorbed than nonsubstituted silicotungstate, α-SiWO (SiW). After adsorption at 433 K, SiVW was desorbed from Rh/SiO by oxidation with Br water without change of the Keggin structure, as evidenced by V NMR. Trivanadium-substituted silicotungstate, α-1,2,3-SiVWO, was not stable, and the desorbed species from Rh/SiO by oxidation with Br did not maintain the Keggin structure. The very high temperature for adsorption (473 K) also led to the decomposition of the Keggin structure of SiVW. An increase in the concentration of SiVW in the liquid phase gave a saturation of the amount of desorbable SiVW, up to five SiVW anions per one Rh particle with a 3 nm size. The elemental analysis and W L-edge extended X-ray absorption fine structure of Rh/SiO after the adsorption of SiVW showed that a part of SiVW was decomposed and irreversibly adsorbed as metallic W species incorporated into the surface of Rh metal particles. The amount of decomposed SiVW was almost the same as that of SiVW adsorbed as the original Keggin structure. The desorbable SiVW was probably bonded on the W atom incorporated on the Rh metal particles as the two-electron-reduced form (α-SiVWO).
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http://dx.doi.org/10.1021/acs.inorgchem.1c01644DOI Listing
July 2021

Community-Level Participation in Volunteer Groups and Individual Depressive Symptoms in Japanese Older People: A Three-Year Longitudinal Multilevel Analysis Using JAGES Data.

Int J Environ Res Public Health 2021 Jul 14;18(14). Epub 2021 Jul 14.

School of Health Innovation, Kanagawa University of Human Services, Kawasaki 210-0821, Japan.

Background: The current study aimed to investigate the contextual effect of volunteer group participation on subsequent depressive symptoms in older people.

Methods: We analyzed the longitudinal data of 37,552 people aged 65 years and older in 24 municipalities surveyed in the Japan Gerontological Evaluation Study. Volunteer group participation of older people was assessed in 2013 by one question and depressive symptoms were assessed by the Geriatric Depression Scale 15 in 2016. To investigate a contextual effect, we aggregated individual-level volunteer group participation by each residence area as a community-level independent variable. We conducted a two-level multilevel Poisson regression analysis using the Random Intercepts and Fixed Slopes Model.

Results: The average proportion of community-level volunteer group participation was 10.6%. The results of the Poisson regression analysis showed that community-level volunteer group participation reduced the risk for the onset of depressive symptoms by 13% with a 10 percentage point increase in participation, after adjusting for sex, age, population density, total annual sunshine hours and annual rainfall (incident rate ratio, 0.87; 95% confidence interval, 0.78-0.98).

Conclusions: Older people living in areas with higher volunteer group participation had a lower risk of developing depressive symptoms regardless of whether or not they participated in a volunteer group.
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http://dx.doi.org/10.3390/ijerph18147502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306052PMC
July 2021

Differential Effects of a Left Frontal Glioma on the Cortical Thickness and Complexity of Both Hemispheres.

Cereb Cortex Commun 2020 27;1(1):tgaa027. Epub 2020 Jun 27.

Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, 153-8902, Japan.

Glioma is a type of brain tumor that infiltrates and compresses the brain as it grows. Focal gliomas affect functional connectivity both in the local region of the lesion and the global network of the brain. Any anatomical changes associated with a glioma should thus be clarified. We examined the cortical structures of 15 patients with a glioma in the left lateral frontal cortex and compared them with those of 15 healthy controls by surface-based morphometry. Two regional parameters were measured with 3D-MRI: the cortical thickness (CT) and cortical fractal dimension (FD). The FD serves as an index of the topological complexity of a local cortical surface. Our comparative analyses of these parameters revealed that the left frontal gliomas had global effects on the cortical structures of both hemispheres. The structural changes in the hemisphere were mainly characterized by a decrease in CT and mild concomitant decrease in FD, whereas those in the peripheral regions of the glioma ( hemisphere) were mainly characterized by a decrease in FD with relative preservation of CT. These differences were found irrespective of tumor volume, location, or grade. These results elucidate the structural effects of gliomas, which extend to the distant contralateral regions.
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http://dx.doi.org/10.1093/texcom/tgaa027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152868PMC
June 2020

Combinations of Peptides Synergistically Activate the Regenerative Capacity of Skin Cells In Vitro.

Int J Cosmet Sci 2021 Jul 17. Epub 2021 Jul 17.

The Procter & Gamble Company, Cincinnati, OH, USA.

Objective: To explore synergistic effects related to skin regeneration, peptides with distinct biological mechanisms of action were evaluated in combination in different skin cell lines in the presence or absence of niacinamide (Nam). Furthermore, the synergistic responses of peptide combinations on global gene expression were compared to the changes that occur with fractional laser resurfacing treatment, a gold standard approach for skin rejuvenation, to further define optimal peptide combinations.

Methods: Microarray profiling was used to characterize the biological responses of peptide combinations (+/- Nam) relative to the individual components in epidermal keratinocyte and dermal fibroblast cell lines. Cellular functional assays were utilized to confirm the synergistic effects of peptide combinations. Bioinformatics approaches were used to link the synergistic effects of peptide combinations on gene expression to the transcriptomics of the skin rejuvenation response from fractional laser treatment.

Results: Microarray analysis of skin cells treated with peptide combinations revealed synergistic changes in gene expression compared to individual peptide controls. Bioinformatic analysis of synergy genes in keratinocytes revealed activation of NRF2-mediated oxidative stress responses by a combination of Ac-PPYL, Pal-KTTKS, and Nam. Additional analysis revealed direct downstream transcriptional targets of NRF2/ARE exhibiting synergistic regulation by this combination of materials, which was corroborated by a cellular reporter assay. NRF2-mediated oxidative stress response pathways were also found to be activated in the transcriptomics of the early skin rejuvenation response to fractional laser treatment, suggesting the importance of this biology in the early stages of tissue repair. Additionally, a second combination of peptides (pal-KT and Ac-PPYL) was found to synergistically restore cellular ATP levels that had been depleted due to the presence of ROS, indicating an additional mechanism whereby peptide synergies may accelerate skin repair.

Conclusion: Through combinatorial synergy studies, we have identified additional in vitro skin repair mechanisms beyond the previously described functions of individual peptides and correlated these to the transcriptomics of the skin rejuvenation response of fractional laser treatment. These findings suggest that specific peptides can act together, via complementary and synergistic mechanisms, to holistically enhance the regenerative capacity of in vitro skin cells.
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http://dx.doi.org/10.1111/ics.12725DOI Listing
July 2021
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