Publications by authors named "M K Frank"

3,054 Publications

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Advancing Transparency and Openness in Child Development Research: Opportunities.

Child Dev Perspect 2020 Mar 24;14(1):3-8. Epub 2020 Feb 24.

Stanford University.

Transparency and openness are basic scientific values. They lie at the heart of practices that accelerate discovery and broaden access to scientific knowledge. In this article, we argue that these values are essential to ensure the enduring influence of research on child development. They are also critical for the Society for Research in Child Development (SRCD) to accomplish its mission to benefit diverse global stakeholders and constituents. A companion article in this issue (Gilmore, Cole, Verma, van Aken, Worthman) discusses the challenges in realizing SRCD's vision for a science of child development that is open, transparent, robust, impactful, and conducted with the highest integrity. Here, we discuss opportunities for the society to set standards that ensure the full integration of transparency and openness into developmental science.
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http://dx.doi.org/10.1111/cdep.12356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112604PMC
March 2020

Glioma with Leptomeningeal Spread Mimics Chronic Meningoencephalitis in a Young Adult.

Case Rep Neurol 2021 Jan-Apr;13(1):179-183. Epub 2021 Mar 18.

Department of Neurology, Asklepios Klinik Altona, Hamburg, Germany.

The most malignant type of intrinsic brain tumor is glioblastoma (WHO grade IV). Primary leptomeningeal spread is rare and leads to a variety of differential considerations, as there is no typical clinical or imaging pattern. Here we present a rare and uncommon case of a primary leptomeningeal glioblastoma in combination with a low-grade glioma in a 21-year-old male, initially presenting with only headache and lower back pain. The presented case illustrates the challenging differential considerations and the severe course of leptomeningeal glioblastomas.
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http://dx.doi.org/10.1159/000513562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077407PMC
March 2021

Computational phenotyping of brain-behavior dynamics underlying approach-avoidance conflict in major depressive disorder.

PLoS Comput Biol 2021 May 10;17(5):e1008955. Epub 2021 May 10.

Department of Cognitive, Linguistic & Psychological Sciences, Brown University, Providence, Rhode Island, United States of America.

Adaptive behavior requires balancing approach and avoidance based on the rewarding and aversive consequences of actions. Imbalances in this evaluation are thought to characterize mood disorders such as major depressive disorder (MDD). We present a novel application of the drift diffusion model (DDM) suited to quantify how offers of reward and aversiveness, and neural correlates thereof, are dynamically integrated to form decisions, and how such processes are altered in MDD. Hierarchical parameter estimation from the DDM demonstrated that the MDD group differed in three distinct reward-related parameters driving approach-based decision making. First, MDD was associated with reduced reward sensitivity, measured as the impact of offered reward on evidence accumulation. Notably, this effect was replicated in a follow-up study. Second, the MDD group showed lower starting point bias towards approaching offers. Third, this starting point was influenced in opposite directions by Pavlovian effects and by nucleus accumbens activity across the groups: greater accumbens activity was related to approach bias in controls but avoid bias in MDD. Cross-validation revealed that the combination of these computational biomarkers were diagnostic of patient status, with accumbens influences being particularly diagnostic. Finally, within the MDD group, reward sensitivity and nucleus accumbens parameters were differentially related to symptoms of perceived stress and depression. Collectively, these findings establish the promise of computational psychiatry approaches to dissecting approach-avoidance decision dynamics relevant for affective disorders.
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http://dx.doi.org/10.1371/journal.pcbi.1008955DOI Listing
May 2021

Angular Analysis of the B^{+}→K^{*+}μ^{+}μ^{-} Decay.

Phys Rev Lett 2021 Apr;126(16):161802

Laboratoire Leprince-ringuet (llr), Palaiseau, France.

We present an angular analysis of the B^{+}→K^{*+}(→K_{S}^{0}π^{+})μ^{+}μ^{-} decay using 9  fb^{-1} of pp collision data collected with the LHCb experiment. For the first time, the full set of CP-averaged angular observables is measured in intervals of the dimuon invariant mass squared. Local deviations from standard model predictions are observed, similar to those in previous LHCb analyses of the isospin-partner B^{0}→K^{*0}μ^{+}μ^{-} decay. The global tension is dependent on which effective couplings are considered and on the choice of theory nuisance parameters.
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http://dx.doi.org/10.1103/PhysRevLett.126.161802DOI Listing
April 2021

Vincetoxicum arnottianum modulates motility features and metastatic marker expression in pediatric rhabdomyosarcoma by stabilizing the actin cytoskeleton.

BMC Complement Med Ther 2021 May 4;21(1):136. Epub 2021 May 4.

Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, Rostock University Medical Center, Rostock, Germany.

Background: Prevention of metastatic invasion is one of the main challenges in the treatment of alveolar rhabdomyosarcoma. Still the therapeutic options are limited. Therefore, an anti-tumor screening was initiated focusing on the anti-metastatic and anti-invasion properties of selected medicinal plant extracts and phytoestrogens, already known to be effective in the prevention and treatment of different cancer entities.

Methods: Treatment effects were first evaluated by cell viability, migration, invasion, and colony forming assays on the alveolar rhabdomyosarcoma cell line RH-30 in comparison with healthy primary cells.

Results: Initial anti-tumor screenings of all substances analyzed in this study, identified the plant extract of Vincetoxicum arnottianum (VSM) as the most promising candidate, harboring the highest anti-metastatic potential. Those significant anti-motility properties were proven by a reduced ability for migration (60%), invasion (99%) and colony formation (61%) under 48 h exposure to 25 μg/ml VSM. The restricted motility features were due to an induction of the stabilization of the cytoskeleton - actin fibers were 2.5-fold longer and were spanning the entire cell. Decreased proliferation (PCNA, AMT, GCSH) and altered metastasis (e. g. SGPL1, CXCR4, stathmin) marker expression on transcript and protein level confirmed the significant lowered tumorigenicity under VSM treatment. Finally, significant alterations in the cell metabolism were detected for 25 metabolites, with levels of uracil, N-acetyl serine and propanoyl phosphate harboring the greatest alterations. Compared to the conventional therapy with cisplatin, VSM treated cells demonstrated a similar metabolic shutdown of the primary cell metabolism. Primary control cells were not affected by the VSM treatment.

Conclusions: This study revealed the VSM root extract as a potential, new migrastatic drug candidate for the putative treatment of pediatric alveolar rhabdomyosarcoma with actin filament stabilizing properties and accompanied by a marginal effect on the vitality of primary cells.
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http://dx.doi.org/10.1186/s12906-021-03299-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097906PMC
May 2021