Publications by authors named "M I Kogan"

564 Publications

Do Medical Students Who Participate in a Research Gap Year Produce More Research During Residency?

J Am Acad Orthop Surg Glob Res Rev 2021 05 13;5(5). Epub 2021 May 13.

From the Hospital for Special Surgery, Orthopaedic Surgery, New York, NY (Dr. Wright-Chisem, and Dr. Osei), and the Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL (Dr. Cohn, Yang, and Dr. Kogan).

Background: The research gap year has become increasingly popular among medical students. It is also a well-known factor in consideration for orthopaedic surgery residency programs. Although medical students who participated in a research gap year typically enter residency with more research experience than their counterparts, it is unknown whether this translates to increased research productivity during residency compared with their peers. The purpose of this study was to investigate (1) whether residents who participated in a research gap year during medical school publish more peer-reviewed publications than their peers during residency, (2) whether residents who participated in a research gap year during medical school publish more first-author publications than their peers during residency, and (3) which applicant characteristics are associated with a greater number of peer-reviewed publications produced during residency.

Methods: The number of peer-reviewed journal publications before and during residency was determined by querying PubMed for 81 orthopaedic surgery residents at two academic institutions. Electronic residency application service applications and curriculum vitae were reviewed to evaluate the number of conference podiums and conference posters presented before residency and during residency. The research productivity of residents who participated in a research gap year during medical school was compared with that of residents who had not participated in a research gap year. Multivariate regression was done to determine predictors of publishing peer-reviewed journal publications during residency.

Results: Residents who participated in a research gap year during medical school produced more peer-reviewed journal publications during residency than those who did not (22.0 ± 20 versus 16.5 ± 20, P = 0.025). However, residents who participated in a research gap year did not produce more first-author publications compared with their peers (7.6 ± 10.0 versus 7.9 ± 7.0, P = 0.12). Residents who produced more publications before residency produced more publications while in residency (R = 0.363, P < 0.001). The United States Medical Licensing Examination step 1 score, medical school ranking, and sex were not associated with any difference in the number of journal publications produced during residency.

Conclusion: A dedicated research year during medical school is associated with an increase in the number of peer-reviewed publications produced during residency. However, students who completed a research year did not publish more first-author publications than their peers. The number of publications before residency was a strong predictor of research output as a resident.
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http://dx.doi.org/10.5435/JAAOSGlobal-D-21-00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126556PMC
May 2021

In vivo micro computed tomography detection and decrease in amyloid load by using multifunctionalized gold nanorods: a neurotheranostic platform for Alzheimer's disease.

Biomater Sci 2021 Jun 13;9(11):4178-4190. Epub 2021 May 13.

Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.

The development and use of nanosystems is an emerging strategy for the diagnosis and treatment of a broad number of diseases, such as Alzheimer's disease (AD). Here, we developed a neurotheranostic nanosystem based on gold nanorods (GNRs) that works as a therapeutic peptide delivery system and can be detected in vivo for microcomputed tomography (micro-CT), being a diagnostic tool. GNRs functionalized with the peptides Ang2 (a shuttle to the Central Nervous System) and D1 (that binds to the Aβ peptide, also inhibiting its aggregation) allowed detecting differences in vivo between wild type and AD mice (APPswe/PSEN1dE9) 15 minutes after a single dose by micro-CT. Moreover, after a recurrent treatment for one month with GNRs-D1/Ang2, we observed a diminution of amyloid load and inflammatory markers in the brain. Thus, this new designed nanosystem exhibits promising properties for neurotheranostics of AD.
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http://dx.doi.org/10.1039/d0bm01825bDOI Listing
June 2021

An integrative active surveillance of prostate cancer.

Explore (NY) 2021 Apr 18. Epub 2021 Apr 18.

George Washington University Medical Faculty Associates, Washington DC, United States; George Washington University Center for Integrative Medicine, Washington DC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.explore.2021.04.005DOI Listing
April 2021

[Current issues of epidemiology, etiology, risk factors and predisposing conditions of acute pyelonephritis (review part I)].

Urologiia 2021 May(2):109-115

Dept. of Urology and Human Reproductive Health Rostov State Medical University, Rostov-on-Don, Russia.

A growing body of research indicates an upward trend in the incidence of urinary tract infections (UTIs) around the world. Acute pyelonephritis (AP), which is dangerous by the development of complex, life-threatening conditions, is no exception. Today the demographic portrait, as well as the characteristics of the causative agents and predisposing conditions of this disease are a global issue for the entire scientific community. In order to assess the data available in the global literature on the issues of epidemiology, etiology and predisposing factors for the development of AP, the search for publications was performed in the medical literature databases The Cochrane Database, MEDLINE/PubMed Database, eLIBRARY, ClinicalKey. The presented material includes, among others, 43 sources over the past 10 years, of which 31 publications over the past 5 years: the largest and most representative studies reflecting the current situation with AP in the population among patients in certain areas and under various exogenous and endogenous conditions. This study opens a series of three reviews on the problem of AP, involving discussion of key aspects of pathogenesis AP. Analysis of the literature indicates fragmentation and limited data when comparing the incidence of AP in different countries and different periods of time. The complexity of the intranosological structure of the varieties of acute pyelonephritis today dictates the advisability of updating approaches to research in this area, and the disease itself dynamically evolves along with its etiological agents, the nature of social behavior of people and environmental conditions in general.
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May 2021

The Use of Personality Assessment in Mentoring and to Aid in Self-reflection in Orthopaedic Surgery Residency Programs.

J Am Acad Orthop Surg 2021 Apr 13. Epub 2021 Apr 13.

From the Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, MA (Tornetta), Boston University School of Medicine, Boston, MA (Resad), and Pediatric Orthopaedics, Rush University Medical Center, Chicago, IL (Kogan).

Personality plays an important role in performance in medical education and mentorship. Personality assessment can aid in the ability to identify strengths and areas for development by understanding how one's personality influences their learning and interpersonal relationships. We sought to evaluate personality assessment as an effective tool in mentoring during orthopaedic residency in this prospective, cross-sectional study from two orthopaedic surgery residency programs using the Hogan Personality Inventory (HPI). Participants completed a survey regarding their experience with the assessment. Descriptive statistics were calculated, and two-sample t-tests were used to examine differences between groups. In total, thirty-four individuals completed the survey. Our results showed 82.4% reported that the HPI very accurately represented them and 58.8% reported better understanding potentially perceived strengths and weaknesses. In total, 75.7% and 72.7% were satisfied with their mentorship about development as a clinician and researcher, respectively. Significant differences were seen between participants who did and did not re-review their results, and participants who did and did-not believe their results profile was accurate. We conclude that personality assessments can be valuable in promoting introspection and strengthening relationships within orthopaedic surgery, particularly when they are valued and emphasized by the user. Our results suggest that use of the HPI provided participants with a better understanding of their perceived strengths and weaknesses as they progress through their orthopaedic residency training.
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http://dx.doi.org/10.5435/JAAOS-D-20-01345DOI Listing
April 2021