Publications by authors named "M H Gouda"

147 Publications

Clinical Efficacy of Combined Probiotics and Immunotherapy in Childhood Allergic Rhinitis.

Egypt J Immunol 2020 Jun;27(2):73-79

Medical Microbiology & Immunology,Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Sublingual immunotherapy (SLIT) is considered a safe and beneficial treatment for allergic rhinitis (AR). Probiotics are unusual treatment options for AR and have lately created great concern in the scientific community. The aim of this study was to investigate the efficacy of combined probiotics plus SLIT on nasal symptoms in AR children. In this study, the SLIT only group (n = 15) received SLIT for 6 months, combined treatment group (n =15) received probiotics plus SLIT for 2 months and then SLIT for another 4 months. After 6 months of therapy, all symptoms of AR were significantly improved in both groups. The nasal obstruction was significantly resolved in both groups, p < 0.001. Total nasal symptom score (TNSS) was significantly decreased after treatment in both groups (p< 0.001). However, a significant difference was observed between the percent change in TNSS between both groups (P= 0.031). Also statistically significant difference was found between the studied groups regarding decrease use of anti-allergic medications (P= 0.034). In Conclusion: combined probiotics plus SLIT showed efficacy in improving symptoms of AR in children.
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June 2020

Pomegranate, its Components and Modern Deliverable Formulations as Potential Botanicals in the Prevention and Treatment of Various Cancers.

Curr Drug Deliv 2021 Feb 3. Epub 2021 Feb 3.

Department of Pathology & Laboratory Medicine, University of Ottawa, Faculty of Medicine, Ottawa, Ontario, . Canada.

Cancer is a global multifactorial disease consisting of over 200 types of cancers. It is well recognized that primary prevention is an effective way to fight cancers by using natural polyphenolic anticancer foods, vegetables and fruits, avoiding exposure to carcinogenic environment, smoking cessation, and through lifestyle modifications. The present review provides up to date information on the effects and functions of pomegranate juice and its bioactive components on the most widespread six cancer types. Pomegranate contains important polyphenolic compounds such as ellagitannins and punicalagin, with strong antioxidant ability for scavenging free radicals and producing metal-chelates in the biological tissues. The in vitro and in vivo studies suggests that antioxidant and anti-inflammation properties of pomegranate constitute have major antimutagenic and antiproliferative activities for regulating gene expression, modulating cellular mechanisms, and limiting the ability of cancers to metastasize. A limited number of clinical studies have suggested that pomegranate ingredients have the potential for the prevention and treatment of cancer, especially colorectal and prostate cancer. In cancer therapy, it remains a clinical dilemma to hit the right target without inducing side effects. The costly anticancer chemotherapies are often associated with drug resistance and serious side effects in vital organs, and noncancerous neighboring cells. It appears that the pomegranate based phytotherapies would be affordable and cost-effective for next generation non-pharmacologic anticancer remedies with lesser side effects. However, well-designed, randomized, double-blind, and multi-center studies are needed to establish the long-term safety, efficacy and dose schedules for orally deliverable pomegranate formulations.
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http://dx.doi.org/10.2174/1567201818666210203180853DOI Listing
February 2021

Pernicious pregnancy: Type B aortic dissection in pregnant women.

J Card Surg 2021 Feb 2. Epub 2021 Feb 2.

Vascular Surgery Department, Royal Blackburn Teaching Hospital, Blackburn, UK.

Background: Type B aortic dissection (TBAD) occurs seldomly, particularly in pregnancy, but has disastrous consequences for both mother and fetus. The focus of immediate surgical repair of type A aortic dissection due to higher mortality of patients is less clear in its counterpart, TBAD, in which management is controversial and debated. This article collates knowledge so far on this rare event during pregnancy.

Methods: A comprehensive literature search was performed in PubMed, Scopus, Google Scholar, Embase, and Medline. Key search terms included "type B aortic dissection," "pregnancy," and corresponding synonyms. Non-English papers were excluded.

Results: Risk factors for TBAD include aortic wall stress due to hypertension, previous cardiac surgery, structural abnormalities (bicuspid aortic valve, aortic coarctation), and connective tissue disorders. In pregnancy, pre-eclampsia is a cause of increased aortic wall stress. Management of this condition is often conservative, but this is dependent on a number of factors, including gestation, cardiovascular stability of the patient, and symptomology. In most cases, a cesarean section before intervention is carried out unless certain indications are present.

Conclusions: Due to a scarce number of cases across the decades, it is difficult to determine which management is optimal. The gold-standard management of TBAD has traditionally been the medical treatment for uncomplicated cases and open surgery for those needing urgent intervention, but with the advent of techniques, such as thoracic endovascular aortic repair, the management of these group of patients continues to develop.
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http://dx.doi.org/10.1111/jocs.15354DOI Listing
February 2021

Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA.

Clin Cancer Res 2021 Jan 22;27(1):226-236. Epub 2020 Oct 22.

Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, Michigan.

Purpose: A subset of pancreatic ductal adenocarcinomas (PDACs) is highly resistant to systemic chemotherapy, but no markers are available in clinical settings to identify this subset. We hypothesized that a glycan biomarker for PDACs called sialylated tumor-related antigen (sTRA) could be used for this purpose.

Experimental Design: We tested for differences between PDACs classified by glycan expression in multiple systems: sets of cell lines, organoids, and isogenic cell lines; primary tumors; and blood plasma from human subjects.

Results: The sTRA-expressing models tended to have stem-like gene expression and the capacity for mesenchymal differentiation, in contrast to the nonexpressing models. The sTRA cell lines also had significantly increased resistance to seven different chemotherapeutics commonly used against pancreatic cancer. Patients with primary tumors that were positive for a gene expression classifier for sTRA received no statistically significant benefit from adjuvant chemotherapy, in contrast to those negative for the signature. In another cohort, based on direct measurements of sTRA in tissue microarrays, the patients who were high in sTRA again had no statistically significant benefit from adjuvant chemotherapy. Furthermore, a blood plasma test for the sTRA glycan identified the PDACs that showed rapid relapse following neoadjuvant chemotherapy.

Conclusions: This research demonstrates that a glycan biomarker could have value to detect chemotherapy-resistant PDAC in clinical settings. This capability could aid in the development of stratified treatment plans and facilitate biomarker-guided trials targeting resistant PDAC.
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http://dx.doi.org/10.1158/1078-0432.CCR-20-2475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785673PMC
January 2021

Decoding of voluntary and involuntary upper-limb motor imagery based on graph fourier transform and cross-frequency coupling coefficients.

J Neural Eng 2020 11 4;17(5):056043. Epub 2020 Nov 4.

Department of Mechanical Engineering and Automation, Northeastern University, Shenyang City, Liaoning, People's Republic of China.

Objective: Brain-computer interface (BCI) technology based on motor imagery (MI) control has become a research hotspot but continues to encounter numerous challenges. BCI can assist in the recovery of stroke patients and serve as a key technology in robot control. Current research on MI almost exclusively focuses on the hands, feet, and tongue. Therefore, the purpose of this paper is to establish a four-class MI BCI system, in which the four types are the four articulations within the right upper limbs, involving the shoulder, elbow, wrist, and hand.

Approach: Ten subjects were chosen to perform nine upper-limb analytic movements, after which the differences were compared in P300, movement-related potentials(MRPS), and event-related desynchronization/event-related synchronization under voluntary MI (V-MI) and involuntary MI (INV-MI). Next, the cross-frequency coupling (CFC) coefficient based on mutual information was extracted from the electrodes and frequency bands with interest. Combined with the image Fourier transform and twin bounded support vector machine classifier, four kinds of electroencephalography data were classified, and the classifier's parameters were optimized using a genetic algorithm.

Main Results: The results were shown to be encouraging, with an average accuracy of 93.2% and 92.2% for V-MI and INV-MI, respectively, and over 95% for any three classes and any two classes. In most cases, the accuracy of feature extraction using the proximal articulations as the basis was found to be relatively high and had better performance.

Significance: This paper discussed four types of MI according to three aspects under two modes and classed them by combining graph Fourier transform and CFC. Accordingly, the theoretical discussion and classification methods may provide a fundamental theoretical basis for BCI interface applications.
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http://dx.doi.org/10.1088/1741-2552/abc024DOI Listing
November 2020

Acute aortic dissection during pregnancy: Trials and tribulations.

J Card Surg 2020 Sep 29. Epub 2020 Sep 29.

Vascular Surgery Department, Blackburn Hospital, East Lancashire Hospitals NHS Trust, Blackburn, UK.

Background: Type A acute aortic dissection (TAAD) during pregnancy is a life-threatening event for both the mother and the unborn baby. Pregnancy has been recognized as an independent risk factor for TAAD, postulated to be due to physiological changes that cause hyperdynamic circulation. This review seeks to outline the current controversies around this unique group.

Methods: A comprehensive literature search was carried out across large databases to assimilate relevant papers regarding acute aortic dissection in pregnant women.

Results: The presentation can be atypical in many cases and further concern from clinicians of fetal radiation exposure can result in missed or delayed diagnoses. Investigation via the quickest form of imaging, whether computed tomography, magnetic resonance imaging, or transesophageal echocardiography, should be carried out promptly due to the high risk of mortality. Surgical management of TAAD in pregnancy revolves primarily around the decision to deliver the fetus concomitantly or to perform the aortic repair with the fetus in utero.

Conclusions: Management of this group includes rapid and dynamic assessment without delay. From conception to postpartum, there are multiple stages in which to manage these women. Challenges in carrying out management in the form of operative techniques and cardiopulmonary bypass place the fetus at risk and must be approached with caution, particularly as there is little evidence-base for many of these decisions. Further research into reducing maternal and fetal mortality is necessary.
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http://dx.doi.org/10.1111/jocs.15068DOI Listing
September 2020

Trends in corticosteroid prescriptions for ulcerative colitis and factors associated with long-term corticosteroid use: analysis using Japanese claims data from 2006 to 2016.

J Crohns Colitis 2020 Aug 26. Epub 2020 Aug 26.

Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Tokyo, Japan.

Background And Aims: Recent treatment guidelines for ulcerative colitis (UC) do not recommend long-term corticosteroid (CS) use. This study aimed to capture the changes in CS use from 2006 to 2016 and to identify factors associated with long-term CS use after 2014, when the first two anti-tumor necrosis factor antibodies (infliximab and adalimumab) became available.

Methods: A retrospective study using the JMDC Claims Database included UC patients who initiated UC medications in any year from January 2006 to December 2016, or after January 2014, who were under continuous observation from 6 months before to 12 months after initiation. Patients with Crohn's disease before initiation and those prescribed <8 days of CSs were excluded.

Results: Among 7,907 UC patients who initiated UC medications within the study period, 1,555 were prescribed CSs. The proportion of patients using CSs in each year decreased from 2011 as use of thiopurines and biologics increased. The proportion of patients with a starting dose ≥30 mg/day of CSs and patients continuing CSs for <90 days increased from 2011, reaching 49.1% and 41.0%, respectively, in 2016. However, even in 2016, 34.3% continued to use CSs for ≥180 days. Among 1,230 patients with CS use after January 2014, low initial CS dose (<10 mg/day) was most strongly associated with long-term CS use (≥180 days).

Conclusions: CS use became more appropriate as thiopurine and biologics use increased, although there were still many cases of inappropriate use. Long-term CS use was most strongly associated with low initial doses of CSs.
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http://dx.doi.org/10.1093/ecco-jcc/jjaa172DOI Listing
August 2020

In-Situ Deposition of Metal Oxides Nanoparticles in Cellulose Derivative and Its Utilization for Wastewater Disinfection.

Polymers (Basel) 2020 Aug 16;12(8). Epub 2020 Aug 16.

Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

The target of this work is to investigate and assess the utilization of the synthesized in-situ deposition of metal oxide nanoparticles such as nano-nickel oxide (nNiO), nanocopper oxides (nCuO) and nanoiron oxides (nFeO) in aminated cellulose (Acell), as a protected and compelling antibacterial channel of contamination from domestic wastewater. The prepared Acell and nNiO/Acell, nCuO/Acell and nFeO/Acell nanocomposites were characterized by field emission-scanning electron microscopy (FE-SEM), Fourier transform-infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy, transmission electron microscopy (TEM), selected area diffraction pattern (SAED) and X-ray diffraction techniques (XRD). TEM declared the synthesis of nNiO, nCuO and nFeO with regular size of 10, 23 and 43 nm, correspondingly. The antibacterial impact of both nNiO/Acell, nCuO/Acell and nFeO/Acell nanocomposites was inspected against Gram-positive microorganisms (, ) and Gram-negative microbes (, ) utilizing agar disk diffusion routes. Furthermore, the ability of the synthesized nanocomposites as sterilizers for optional domestic wastewater was studied. The data for the disk diffusion obtained revealed that nFeO/Acell had a greater antibacterial impact than nCuO/Acell and nNiO/Acell. In addition, the purification of domestic wastewater utilizing 1.0 mg of nFeO, nCuO and nNiO in 1 gm of Acell was accomplished by killing 99.6%, 94.5% and 92.0% of total and fecal coliforms inside 10 mins, respectively.
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http://dx.doi.org/10.3390/polym12081834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464245PMC
August 2020

Relation between left atrial strain and exercise tolerance in patients with mild mitral stenosis: An insight from 2D speckle-tracking echocardiography.

Echocardiography 2020 09 10;37(9):1406-1412. Epub 2020 Aug 10.

Cardiology Department, Zagazig University Hospitals, Zagazig, Egypt.

Background: Mild mitral stenosis (MS) is a progressive disease but unfortunately, its clinical course is still unclearly studied. We aimed to study the left atrial (LA) deformation in such patients and how it is related to exercise intolerance.

Methods: Seventy-five patients with mitral valve area of 1.81 ± 0.13 cm and 40 healthy control subjects were enrolled. All participants had sinus rhythm, and they underwent conventional echocardiography and LA strain analysis with speckle-tracking study. The following parameters were obtained: left atrial reservoir strain (LAS-s), LA conduit strain (LAS-e), and LA contraction strain (LAS-a). All participants underwent symptoms limited stress ECG using modified Bruce protocol.

Results: Comparing with control subjects, patients with mild MS had significant lower LAS-s value (P < .01) and LAS-e (<0.03). Patients with exercise intolerance (METs < 8) had lower LAS-s (P < .001), LAS-e (P < .01), and LAS-a (P < .05) values compared to those with METs ≥ 8. We found that METs was significantly related to LAS-s (P < .001), brain natriuretic peptide (P < .001), and Δ TAPSE (P < .03). Multivariate analysis showed that LAS-s was an independent predictor of reduced exercise capacity. With ROC analysis, LAS-s ≤ 26.5% was the optimal value for prediction of exercise intolerance in patients with mild MS.

Conclusion: A significant percentage of patients with mild mitral stenosis had exercise intolerance. We found that LAS-s was significantly associated with exercise capacity in patients with mild MS. Hence, we thought that LA deformation could be of great value in the follow-up of patients with mild MS.
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http://dx.doi.org/10.1111/echo.14818DOI Listing
September 2020

Relation of microvascular dysfunction and exercise tolerance in patients with heart failure with preserved ejection fraction.

Echocardiography 2020 08 26;37(8):1192-1198. Epub 2020 Jul 26.

Department of Cardiology, Zagazig Faculty of Medicine, Zagazig, Egypt.

Purpose: We aimed to investigate the association of coronary flow reserve (CFR) with exercise tolerance (ET) in subjects with heart failure with preserved ejection fraction (HFpEF).

Materials And Methods: Seventy-seven patients with HFpEF were recruited for the study and compared with 30 healthy matched age and sex controls. All subjects underwent comprehensive echocardiographic evaluation. Exercise tolerance was assessed using 6-minute walking test (6 MWT). CFR was calculated with adenosine stress transthoracic Doppler echocardiography.

Results: Out of 77 patients with HFpEF, 51 (66%) had CFR < 2.0. Patients with CFR < 2.0 had lower 6 MWT distance (P < .001), increased E/e' ratio (P < .001), when compared to HFpEF patients with CFR ≥ 2.0 and controls. In subjects with HFpEF, CFR was significantly correlated with 6 MWTD (P < .001) and inversely correlated with E/e" (P < .01). With univariate analysis, the results showed that left ventricular mass index, left atrial volume index, E/e', and CFR were independent predictors for reduced exercise tolerance, whereas at multivariate analysis, reduced CFR was the only independent predictor (P < .001) for both reduced exercise tolerance in patients with HFpEF.

Conclusion: The current study demonstrated that reduced CFR was an independent predictor for reduced exercise tolerance in patients with HFpEF. We supposed that microvascular dysfunction has an important role in pathogenesis and clinical course in subjects with HFpEF.
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http://dx.doi.org/10.1111/echo.14799DOI Listing
August 2020

Proteomics Analysis Revealed the Importance of Inflammation-Mediated Downstream Pathways and the Protective Role of Curcumin in Bleomycin-Induced Pulmonary Fibrosis in C57BL/6 Mice.

J Proteome Res 2020 08 22;19(8):2950-2963. Epub 2020 Jul 22.

Yenepoya Research Centre, Yenepoya University (Deemed to be University), Deralakatte, Mangalore 575018, Karnataka, India.

Bleomycin (BLM)-induced pulmonary fibrosis is characterized by inflammation in the alveoli, subsequent deposition of extracellular matrix (ECM) and myofibroblasts, and an impaired fibrinolytic system. Here, we describe major hematological changes, the IL-17A-mediated p53-fibrinolytic pathway, and the high throughput hits of liquid chromatography-mass spectrometry (LC-MS) analysis during the progression of pulmonary fibrosis and the therapeutic potential of curcumin against disease progression. C57BL/6 mice were exposed to BLM, followed by curcumin intervention after 24 and 48 h. Mice were sacrificed after 7 days to validate the hematological parameters, molecular pathways, and proteomics. Various techniques such as western blotting, immunofluorescence, reverse transcriptase polymerase chain reaction (RT-PCR), hematoxylin and eosin staining, Masson's trichrome staining, and immunohistochemistry were used to validate the proposed theory. LC-MS analysis was performed using a Q-Orbitrap mass spectrometer. The Schrödinger approach was used to perform the molecular docking studies. BLM-exposed mice exhibited gradual weight loss and altered lung morphology; however, these were reversed by curcumin treatment. Significant changes in the hematological parameters confirmed the severity of BLM exposure in the mice, and expression of IL-17A-mediated p53-fibrinolytic system components and alveolar epithelial cell (AEC) apoptosis further confirmed the pathophysiology of pulmonary fibrosis. Differentially expressed proteins were characterized and mapped using the proteomics approach. A strong interaction of curcumin is observed with p53, uPA, and PAI-I proteins. The key role of IL-17A-mediated inflammation in the impairment of the p53-fibrinolytic system and AEC apoptosis was confirmed during BLM-induced pulmonary fibrosis. Therapeutic efficacy of curcumin exhibited a protective role against the progression of pulmonary fibrosis, which promises potent therapeutic modality to target the IL-17A-mediated p53-fibrinolytic system during pulmonary fibrosis.
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http://dx.doi.org/10.1021/acs.jproteome.9b00838DOI Listing
August 2020

Efficiency of a cubic NaI(Tl) detector with rectangular cavity using standard radioactive point sources placed at non-axial position.

Appl Radiat Isot 2020 Sep 24;163:109139. Epub 2020 Mar 24.

Physics Department, Faculty of Science, Alexandria University, 21511, Alexandria, Egypt. Electronic address:

Low cost scintillation detectors as compared with HPGe detectors are considered to be one of most important radiation detection tools. Therefore, these detectors can be manufactured in different shapes and work at room temperature without any cooling systems, which added an extra advantage to it. This work presents a study of a cubic detector with a rectangular cavity in different experimental setup geometries, using standard point-like gamma-ray sources, where the efficiency of the detector in these geometries was the target to be studied. According to this aim, the data from the experimental measurements was used to determine the detector efficiency. An analytical calculation of the detector efficiency was done by using a new mathematical expression, this mathematical expression depends on the efficiency transfer technique and effective solid angle calculations. To support the mathematical model, the source-to-detector arrangement was simulated by Geant4 Monte Carlo code. All the compared efficiency results were found to be promising and trusted based on the calculated deviation percentages.
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http://dx.doi.org/10.1016/j.apradiso.2020.109139DOI Listing
September 2020

Micellization and Solvation Properties of Newly Synthesized Imidazolium- and Aminium-Based Surfactants.

ACS Omega 2020 Apr 13;5(16):9429-9441. Epub 2020 Apr 13.

Chemistry Department, Faculty of Science, Port Said University, Port Said 42522, Egypt.

This work aimed to study the solvation properties of newly synthesized cationic surfactants: 1-hexyl-1-methyl-1-imidazol-1-ium bromide (RIm), 1-dodecyl-1-methyl-1-imidazol-1-ium bromide (RIm), ,,-tributylhexan-1-aminium bromide (RN), and ,,-tributyldodecan-1-aminium bromide (RN) in water and ethanol-water solvents with a 0.237 mole fraction of ethanol at 298.15 K using conductivity, refractive index, surface tension, and density measurements. Critical micelle concentration (CMC) for the synthesized surfactants was determined and discussed. Thermodynamic parameters including association constant, molal volume, and polarizability were calculated and discussed. Some surface properties of surfactants including excess surface concentration and minimum area per molecule were also calculated and discussed. A good agreement was found between the CMC values obtained from different techniques, such as conductivity, refractive index, and surface tension. Imidazolium surfactants had been proved to decrease the CMC and increase the association constant with the increase of ethanol mole fraction, while tributylamine had been proved to increase the CMC and decrease the association constant with the increase of ethanol mole fraction. Also, imidazolium surfactants had been proved to have higher CMC than tributylamine, which may be related to higher solvation of imidazolium surfactants than that of tributylamine. Both surfactants (RIm) and (RN) were proved to have lesser CMC.
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http://dx.doi.org/10.1021/acsomega.0c00603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191861PMC
April 2020

Effect of the Morphology of Tungsten Oxide Embedded in Sodium Alginate/Polyvinylpyrrolidone Composite Beads on the Photocatalytic Degradation of Methylene Blue Dye Solution.

Materials (Basel) 2020 Apr 17;13(8). Epub 2020 Apr 17.

Center of Physics and Engineering of Advanced Materials (CeFEMA), Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal.

Tungsten oxide nanostructures were modified by oxygen vacancies through hydrothermal treatment. Both the crystalline structure and morphological appearance were completely changed. Spherical WO·HO was prepared from tungstic acid solution by aging at room temperature, while rod-like WO·0.33HO was prepared by hydrothermal treatment of tungstic acid solution at 120 °C. These structures embedded in sodium alginate (SA)/polyvinylpyrrolidone (PVP) were synthesized as novel porous beads by gelation method into calcium chloride solution. The performance of the prepared materials as photocatalysts is examined for methylene blue (MB) degradation in aqueous solutions. Different operation parameters affecting the dye degradation process, such as light intensity, illumination time, and photocatalyst dosage are investigated. Results revealed that the photocatalytic activity of novel nanocomposite changed with the change in WO morphology. Namely, the beads with rod nanostructure of WO have shown better effectiveness in MB removal than the beads containing WO in spherical form. The maximum degradation efficiency was found to be 98% for WO nanorods structure embedded beads, while the maximum removal of WO nanospheres structure embedded beads was 91%. The cycling-ability and reuse results recommend both prepared structures to be used as effective tools for treating MB dye-contaminated wastewaters. The results show that the novel SA/PVP/WO nanocomposite beads are eco-friendly nanocomposite materials that can be applied as photocatalysts for the degradation of cationic dyes in contaminated water.
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http://dx.doi.org/10.3390/ma13081905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216279PMC
April 2020

Effective Elimination of Contaminant Antibiotics Using High-Surface-Area Magnetic-Functionalized Graphene Nanocomposites Developed from Plastic Waste.

Materials (Basel) 2020 Mar 26;13(7). Epub 2020 Mar 26.

Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, Alexandria 21934, Egypt.

The presence of pharmaceutical residues in aquatic environments represents a risk for the equilibrium of the ecosystem and may seriously affect human safety itself in the long term. To address this issue, we have synthesized functional materials based on highly-reduced graphene oxide (HRGO), sulfonated graphene (SG), and magnetic sulfonated graphene (MSG). The method of synthesis adopted is simple and inexpensive and makes use of plastic bottle waste as the raw material. We have tested the fabricated materials for their adsorption efficiency against two model antibiotics in aqueous solutions, namely Garamycin and Ampicillin. Our tests involved the optimization of different experimental parameters of the adsorption process, such as starting antibiotic concentration, amount of adsorbent, and time. Finally, we characterized the effect of the antibiotic adsorption process on common living organisms, namely DH5α ( DH5α) bacteria. The results obtained demonstrate the efficiency of the method in addressing the issue of the emergence of antibiotic-resistant bacteria, which will help in preventing changes in the ecosystem.
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http://dx.doi.org/10.3390/ma13071517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177265PMC
March 2020

Right ventricular mechanics and exercise capacity in patients with microvascular angina: The impact of microvascular function.

Echocardiography 2020 01 16;37(1):71-76. Epub 2019 Dec 16.

Cardiology Department, Zagazig University Hospitals, Zagazig University, Zagazig, Egypt.

Objectives: We planned to assess the right ventricular mechanics in subjects with typical chest pain and angiographically normal coronary arteries (microvascular angina [MVA]) and to search for an association between right ventricular mechanics, coronary flow reserve, and exercise tolerance.

Methods: Seventy-one patients with MVA (mean age of 48.5 ± 7.9 years, 63% female) and 30 healthy control subjects were recruited. Right ventricular mechanics were calculated utilizing speckle tracking imaging. The exercise capacity was assessed by metabolic equivalents (METs). Coronary flow reserve (CFR) was calculated as the ratio between hyperemic (in response to intravenous adenosine) diastolic peak flow velocity and the basal diastolic peak velocity.

Results: Coronary flow reserve (a surrogate marker of microvascular dysfunction) was diminished in MVA patients compared with the control group (2.41 ± 0.35 vs 3.35 ± 0.5; P < .03). Patients with lower right ventricular global longitudinal strain (RVGLS) and right ventricular global longitudinal strain rate (RVGLSr) had a considerably lower CFR (P < .001) and a significantly lower MET (P < .001) than patients with normal RV mechanics. Right ventricular global longitudinal strain and RVGLSr were significantly correlated with both CFR and METs in subjects with MVA. Receiver operating characteristic (ROC) curve analysis demonstrated that RVGLS ≤ -14.5 was the best cutoff value for the prediction of impaired exercise tolerance in patients with MVA.

Conclusion: We suggested that impaired right ventricular mechanics in subjects with microvascular angina was associated with reduced exercise capacity. Moreover, right ventricular mechanics is significantly correlated with coronary flow reserve. Henceforth, right ventricular mechanics might be of value for both risk stratification and follow-up in cases with microvascular dysfunction.
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http://dx.doi.org/10.1111/echo.14563DOI Listing
January 2020

Evaluation of the therapeutic efficacy of albendazole-loaded silver nanoparticles against infection in experimental mice.

J Parasit Dis 2019 Dec 15;43(4):658-671. Epub 2019 Jul 15.

3Pathology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.

The drug of choice for treatment of hydatid disease, albendazole (ABZ) is a poorly water-soluble drug; thus, enhancing its solubility is required. Among metal nanoparticles (NPs), silver (Ag) NPs showed antimicrobial efficacies. Therefore, this study was conducted to evaluate nanosilver particles (Ag NPs) free or combined with albendazole against infection in vivo. In this study, besides the normal control group (GI) (n = 5), 80 mice were infected with 2000 viable protoscoleces intraperitoneally then divided equally (n = 20) into the infected control (GII), ABZ-treated (GIII), nanosilver-treated (GIV) and ABZ-loaded-Ag NPs-treated (GV) groups. On the 90th post-infection day, treatment was started and continued for 8 weeks then the experiment was terminated. Each mouse was subjected to measurement of hydatid cysts' sizes and weights, serum IFN-γ, liver enzymes; histopathological and transmission electron microscopy studies. In all treated groups, there were significant reductions of hydatid cysts' sizes and weights; however, the highest efficacy rate (63.9%) was detected in group V associated with obvious ultrastructure alterations of the cysts. The liver tissues of group II showed intense granulomatous reactions, congestion, fibrosis, necrosis and steatosis associated with significant increases in serum IFN-γ and liver enzymes. Interestingly, the best antiparasitic effect and the most significant reduction of IFN-γ towards the normal values were found in GV. Moreover, Ag NPs had reduced the toxic effects of ABZ such as necrosis, steatosis and the elevated serum liver enzymes. Therefore, loading ABZ on Ag NPs could be a potential method to improve ABZ efficacy against hydatid disease.
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http://dx.doi.org/10.1007/s12639-019-01145-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841915PMC
December 2019

SPME-GC-MS & metal oxide E-Nose 18 sensors to validate the possible interactions between bio-active terpenes and egg yolk volatiles.

Food Res Int 2019 11 20;125:108611. Epub 2019 Aug 20.

National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, PR China.

This study was focused on the differences between three concentrations of four safe bio-active volatile terpenes and natural compounds (trans-cinnamaldehyde, thymol, menthol, and vanillin) on the egg yolk volatile components. In which, Headspace Solid phase Micro Extraction (HS-SPME) followed by GC/MS were used for volatiles analysis, and electronic nose (E-Nose) with 18 sensors was used for the aroma pattern. In the results, a total of 111 different volatile compounds were identified by using GC/MS. Some ketones, amines, nitro and organic acid compounds such as hexanone were significantly reduced after using these compounds. On the other hand, first principal components (PC1) of trans-cinnamaldehyde (0.1%) was decreased significantly (p < .05) to -4.8 ± 0.8, compared to the control with 4.3 ± 2.1. And, it increased benzaldehyde and nonanal peaks area significantly to 46.56 ± 14.46 and 9.22 ± 4.81 MPA. In menthol (0.1%), the content of d-limonene was decreased to 4.65 ± 0.49 MPA, compared to the control with 14.16 ± 4.95 MPA. On the other hand, by E-Nose, vanillin (0.1%) PC1 was decreased significantly to -4.48 ± 0.43. Moreover, thymol (0.1%) decreased hydrocarbon sensation to 0.448 ± 0.005. And, vanillin (0.1%) decreased hydrogen sulfide and ketones sensation to 0.169 ± 0.01 and 0.344 ± 0.01, respectively. In conclusion, this study is providing novel information to understand the effects of bio-active molecules on the biological fatty media volatility. Also, it explains how terpenes can protect egg yolk media from the unacceptable odor formation which results from the degradation of its lipids and proteins.
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http://dx.doi.org/10.1016/j.foodres.2019.108611DOI Listing
November 2019

Ciprofloxacin removal using magnetic fullerene nanocomposite obtained from sustainable PET bottle wastes: Adsorption process optimization, kinetics, isotherm, regeneration and recycling studies.

Chemosphere 2020 Jan 31;239:124728. Epub 2019 Aug 31.

Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, 21934, Alexandria, Egypt.

Numerous of pollutants threaten our planet, for instance plastic wastes causes a huge potential risk on the environment in addition to many of emergened pollutants as pharmaceutical residue in aquatic environments which affecting ecological balance and in-turn affecting human health. Accordingly, this research proposed an innovative facile, one-step synthesis of functionalized magnetic fullerene nanocomposite (FMFN) via catalytic thermal decomposition of sustainable poly (ethylene terephthalate) bottle wastes as feedstock and ferrocene as a catalyst and precursor of magnetite. Growth mechanism of FMFN was discussed and batch experiments were achieved to examine its adsorption efficiency in relation to Ciprofloxacin antibiotic. Different adsorption parameters including time, initial Ciprofloxacin concentration, and solution temperature were investigated and optimized using Response Surface Methodology (RSM) model. In addition, a study on the antibiotic adsorption process impact on the organisms of an ecosystem was conducted using E. coli DH5α, and results validated method's efficiency in overcoming problem of appearance of antibiotic-resistant microbes.
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http://dx.doi.org/10.1016/j.chemosphere.2019.124728DOI Listing
January 2020

Radiotherapy for metastatic prostate cancer.

Lancet 2019 09;394(10201):829

Department of Clinical Oncology, Faculty of Medicine, Menoufia University, Shebin Al-Kom, 32511, Egypt. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(19)31782-9DOI Listing
September 2019

Fabrication of a novel low-cost superoleophilic nonanyl chitosan-poly (butyl acrylate) grafted copolymer for the adsorptive removal of crude oil spills.

Int J Biol Macromol 2019 Nov 20;140:588-599. Epub 2019 Aug 20.

Polymer Materials Research Department, Advanced Technologies and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O. Box: 21934, Alexandria, Egypt. Electronic address:

A novel superoleophilic-hydrophobic nonanyl chitosan-poly (butyl acrylate) grafted copolymer was fabricated as a low-cost oil-adsorbent. Chitosan (CS) was coupled with a hydrophobic nonanal (N) to form nonanyl chitosan (NCS) schiff base, and followed by grafting with butyl acrylate monomers (ButA). The grafted copolymer was characterized by FTIR, TGA and SEM tools. The grafting percent was augmented and reached 88.5% with increasing ButA concentration up to 156 mM. Moreover, measurements of contact angle proved the superoleophilic character of NCS-g-poly (ButA) copolymer with an oil-contact angle 31°. Factors affecting the removal process such as contact time, oil type, oil dose, adsorbent dose, temperature and agitation speed were optimized. An increment in the oil removal (%) was observed with increasing the oil viscosity in the order of gasoil < mobil-1 oil < light crude oil < heavy crude oil. Besides, the adsorption process followed the pseudo-second order model and the equilibrium data were sufficiently fitted with the Langmuir model with a maximum adsorption capacity 108.79 g/g at 25 °C. Thermodynamic parameters computed from Van't Hoff plot confirmed the process to be exothermic, favorable and spontaneous. The results nominate the superoleophilic adsorbent as a potential oil- adsorbent for petroleum oil spills removal.
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http://dx.doi.org/10.1016/j.ijbiomac.2019.08.169DOI Listing
November 2019

Mean platelet volume as a predictor of pulmonary hypertension in patients with stable COPD.

Int J Chron Obstruct Pulmon Dis 2019 23;14:1099-1108. Epub 2019 May 23.

Clinical and Chemical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Pulmonary hypertension (PH) is one of the most common complications developed during the course of chronic obstructive pulmonary disease (COPD). Platelet activation plays an important role in its pathophysiology, and mean platelet volume (MPV) is considered a respectable index of platelet activation. The aim of this work is to assess the ability of MPV in predicting PH secondary to COPD as well as its severity. A cross-sectional study was conducted on 228 stable COPD patients. CBC, echocardiography, and pulmonary function tests were performed. The prevalence of PH in stable COPD patients was high (63%), and the majority of patients had a mild degree (33%). There was no significant association between PH presence with different COPD grade, but, in very severe COPD, severe PH was significantly presented. MPV in COPD patients with PH was significantly higher than those without (9.02±1.14 vs 7.11±0.98, <0.001). Moreover, a significant statistical rising of MPV with increased severity of PH. Multivariate regression analysis of predictors of PH demonstrated that; MPV is a real predictor of PH in such patients. The likelihood probability of PH increased up to 7-times with increasing one unit of MPV; (OR=6.7). A cut-off value of MPV >7.25 had 96% sensitivity and 76% specificity in predicting PH. MPV was higher in COPD patients with PH and positively correlated with PH severity. If the data are to be confirmed, MPV may be taken into consideration in decision-making and management of COPD patients.
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http://dx.doi.org/10.2147/COPD.S176413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536816PMC
January 2020

Acute Lung Injury: IL-17A-Mediated Inflammatory Pathway and Its Regulation by Curcumin.

Inflammation 2019 Aug;42(4):1160-1169

Yenepoya Research Centre, Yenepoya University, Deralakatte, Mangalore, Karnataka, 575018, India.

Acute lung injury (ALI) is characterized by acute inflammation and tissue injury results in dysfunction of the alveolar epithelial membrane. If the epithelial injury is severe, a fibroproliferative phase of ALI can develop. During this phase, the activated fibroblast and myofibroblasts synthesize excessive collagenous extracellular matrix that leads to a condition called pulmonary fibrosis. Lung injury can be caused by several ways; however, the present review focus on bleomycin (BLM)-mediated changes in the pathology of lungs. BLM is a chemotherapeutic agent and has toxic effects on lungs, which leads to oxidative damage and elaboration of inflammatory cytokines. In response to the injury, the inflammatory cytokines will be activated to defend the system from injury. These cytokines along with growth factors stimulate the proliferation of myofibroblasts and secretion of pathologic extracellular matrix. During BLM injury, the pro-inflammatory cytokine such as IL-17A will be up-regulated and mediates the inflammation in the alveolar epithelial cell and also brings about recruitment of certain inflammatory cells in the alveolar surface. These cytokines probably help in up-regulating the expression of p53 and fibrinolytic system molecules during the alveolar epithelial cells apoptosis. Here, our key concern is to provide the adequate knowledge about IL-17A-mediated p53 fibrinolytic system and their pathogenic progression to pulmonary fibrosis. The present review focuses mainly on IL-17A-mediated p53-fibrinolytic aspects and how curcumin is involved in the regulation of pathogenic progression of ALI and pulmonary fibrosis.
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http://dx.doi.org/10.1007/s10753-019-01010-4DOI Listing
August 2019

The Unique Pharmacological and Pharmacokinetic Profile of Teneligliptin: Implications for Clinical Practice.

Drugs 2019 May;79(7):733-750

Ikuyaku. Integrated Value Development Division, Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan.

Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that was approved for the treatment of type 2 diabetes mellitus (T2DM) in Japan and Korea and is being researched in several countries. Teneligliptin is a potent, selective, and long-lasting DPP-4 inhibitor with a t of approximately 24 h and unique pharmacokinetic properties: it is metabolized by cytochrome P450 (CYP) 3A4 and flavin-containing monooxygenase 3 (FMO3), or excreted from the kidney in an unchanged form. Because of its multiple elimination pathways, dose adjustment is not needed in patients with hepatic or renal impairment, and it is considered to have a low potential for drug-drug interactions. Clinical studies and postmarketing surveillance show that teneligliptin, administered as monotherapy and/or in combination with antihyperglycemic agents, is effective and well tolerated in T2DM patients, including in elderly patients and those with renal impairment. Furthermore, teneligliptin has antioxidative properties, which induce the antioxidant cascade, as well as ·OH scavenging properties. In addition, it has shown endothelial protective effects in several non-clinical and clinical studies. From its unique profile and clinical data, teneligliptin represents a potential therapeutic option in a wide variety of patients, including elderly diabetic patients and those with renal impairment. The fixed-dose combination (FDC) tablet of teneligliptin and canagliflozin has been approved in Japan; this is the first FDC tablet of a DPP-4 inhibitor and sodium glucose co-transporter 2 inhibitor in Japan, and the third globally. The FDC tablet may also provide additional prescribing and adherence benefits.
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http://dx.doi.org/10.1007/s40265-019-01086-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520312PMC
May 2019

Characterization and classification of volatiles from different breeds of eggs by SPME-GC-MS and chemometrics.

Food Res Int 2019 02 10;116:767-777. Epub 2018 Sep 10.

National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, PR China. Electronic address:

Volatiles of shell eggs were identified by SPME-GC-MS to characterize and discriminate white Leghorn (W), Hy-line brown (H) and Jing fen (J) hatching eggs with comparison, principal components (PC), partial least squares (PLS), random forest classification (RFC) and canonical discriminant (CD) analyses. DVB/CAR/PDMS fiber and extraction 60 min were suited to analyze the volatiles emitted from eggs. A total of 17 or 18 volatile compounds were identified in raw shell hatching eggs, namely, nonanal, decanal and 6-methly-5-hepten-2-one were the main volatile components with contributions that over 70%. The composition and/or profile of volatile compounds from W and H eggs were much more similar than J eggs. Hexanal, decanal, 6-methly-5-hepten-2-one, heptanal, etc. have greatly contributed to the distinction of W, H and J eggs in sparse (S)-PLS and orthogonal (O)-PLS models. The accuracy of RFC and CD model were 100%, 100% (initial) and 83.3% (cross-validation), respectively. Heptanal, 6-methly-5-hepten-2-one, octanal, etc. were contributed positively to the classification of W, H, J eggs in RFC, especially for heptanal.
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http://dx.doi.org/10.1016/j.foodres.2018.09.010DOI Listing
February 2019

Association between fragmented QRS and exercise intolerance in hypertensive patients: the relation with coronary flow.

Blood Press 2019 04 22;28(2):124-130. Epub 2019 Jan 22.

a Cardiology Department , Zagazig University Hospital , Zagazig , Egypt.

Objective: We aimed to investigate the relation between the presence of fragmented QRS (FQRS) and exercise intolerance as assessed by 6 minute walking test (6MWT) and its association with coronary flow reserve (CFR).

Methods: One hundred and twenty patients with hypertension (age: 47.3 + 6.9) who were never treated and without left ventricular hypertrophy underwent 6MWT. Echocardiographic examination was obtained for all patients. CFR was calculated as the hyperemic to baseline mean velocity ratio (hyperemia was induced by intravenous adenosine 0.14 mg/kg/min). Patients were stratified into one group with FQRS and another group without FQRS. Forty-eight normotensive subjects with a mean age of 45.7 + 5.3 were recruited and served as a control group.

Results: The frequency of FQRS was 49% in hypertensive patients versus 2% in control subjects. Patients with FQRS had higher systolic blood pressure (p < .05; <.01), a significant lower 6MWTD (p < .001), increased LAVI (p <.05), increased E/e' ratio (p < .01) and lower CFR (p < .001) compared with those without FQRS and controls. FQRS was inversely correlated with CFR (-0.531; p < .001) and 6 MWTD (-0.415; p < .001) and positively correlated with E/e' (0.352, p < .02) and LAVI (0.296; p < .05). By a multivariate regression analysis, FQRS (OR = 6.13; p < .001) and CFR (OR = 3.28; p < .001) were the only two independent predictors for decreased 6 MWTD in hypertensive patients. Importantly the ≥3 cutoff number of leads was found to be the best predictor of CFR < 2.0 in hypertensive patients.

Conclusion: FQRS is frequent and an independent predictor of reduced exercise tolerance in hypertensive patients. More so, it is significantly associated with decreased CFR and left ventricular diastolic dysfunction. In light of these findings, fragmented QRS might be considered a simple marker for risk stratification of hypertensive patients.
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http://dx.doi.org/10.1080/08037051.2019.1569462DOI Listing
April 2019

Right ventricular dyssynchrony and functional capacity before and after percutaneous balloon mitral valvuloplasty in patients with mitral stenosis: Determinants and clinical impact.

Echocardiography 2019 02 19;36(2):297-305. Epub 2018 Dec 19.

Cardiology Department, Zagazig University Hospital, Zagazig, Egypt.

Objective: We aimed to investigate the utility of right ventricular (RV) dyssynchrony to assess functional capacity utilizing 6-minute walking test distance (6MWTD) and to measure brain natriuretic peptide levels (BNP) in patients with mitral stenosis (MS) and to study its value to predict adverse outcome following percutaneous balloon mitral valvuloplasty (PBMV).

Methods: A total of 108 patients with moderate to severe MS (26.5 ± 7.5 years) were included in this study. All were candidates for PBMV. RV strain curves were obtained using two-dimensional speckle-tracking echocardiography, and standard deviation (SD) of 4 segments without RV apex (-SD4) was also assessed. 6MWT and BNP were before and after 12 months following PBMV.

Results: RV-SD4 was significantly prolonged in patients with MS compared with controls (P < 0.001). Patients with 6MWTD ≤300 m had a significantly increased RV-SD4 (P < 0.001) and had higher BNP values (P < 0.03) compared with those with 6MWTD >300 m. RV-SD4 showed a strong correlation with 6MWT and BNP level. RV-SD4 was the strongest independent predictor of adverse outcome following PBMV (P < 0.0001). Receiver operating characteristic analysis showed that RV-SD4 ≥24 ms was the cutoff value which predicts the adverse outcome following PBMV. A considerable improvement of mean 6MWT with significant reduction of BNP levels after 12 months of follow-up (P < 0.001) in subjects with RV dyssynchrony <24 ms.

Conclusion: Right ventricular dyssynchrony is a useful predictor of functional status, as assessed with 6MWTD and BNP level in patients with MS. Furthermore, it might be considered as an independent predictor of adverse outcome following PMBV.
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http://dx.doi.org/10.1111/echo.14227DOI Listing
February 2019

Determinants and impact of masked hypertension in offspring of patients with diabetes: relation with coronary flow and cardiac function.

Blood Press 2019 02 18;28(1):57-63. Epub 2018 Dec 18.

a Cardiology Department , Zagazig University Hospital , Zagazig , Egypt.

Objective: We aimed to evaluate the prevalence, determinants and clinical impact of masked hypertension in offspring of patients with diabetes. Masked hypertension was defined according to guidelines as daytime ambulatory blood pressure monitoring "ABPM" ≥135/85 mmHg and clinic BP <140/90 mmHg.

Methods: 100 nondiabetic offspring of patients with diabetes and 60 offspring of healthy people were enrolled; 24-h ABPM was applied to evaluate mean 24-h systolic/diastolic blood pressure "BP", daytime, nighttime and night dipping readings. Left ventricular parameters and coronary flow reserve of the left anterior descending artery (induced by adenosine 0.14 mg/kg/min) was calculated in all offspring.

Results: 29% of offspring of patients with diabetes had masked hypertension compared to only 3.3% offspring in healthy people (p < 0.001). Compared with those without masked hypertension, offspring with masked hypertension had a significantly reduced coronary flow reserve (p < 0.001), significantly higher E/e' (p < 0.01), [a surrogate marker of left ventricular filling pressure], more microalbuminuria (p < 0.01), and higher values of high-sensitive C-reactive protein "CRP" (p < 0.001). Multivariate regression analysis showed that, fasting blood glucose, and high-sensitive CRP, were independently associated with masked hypertension, whilst daytime systolic BP and non-dipping systolic BP were the strongest predictors for masked hypertension. Logistic regression analysis revealed that masked hypertension was independently associated with reduced coronary flow reserve (p < 0.0001) and diastolic dysfunction (p < 0.001).

Conclusion: Masked hypertension is prevalent in offspring of patients with diabetes and significantly associated with reduced coronary flow reserve and left ventricular diastolic dysfunction. These findings suggest that offspring of patients with diabetes constitute a high risk group and deserve close follow up, mainly with the use of ABPM.
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http://dx.doi.org/10.1080/08037051.2018.1524261DOI Listing
February 2019

Interatrial septal fat thickness and left atrial stiffness are mechanistic links between nonalcoholic fatty liver disease and incident atrial fibrillation.

Echocardiography 2019 02 12;36(2):249-256. Epub 2018 Dec 12.

Cardiology Department, Zagazig University Hospital-Egypt, Zagazig, Egypt.

Background And Aim: Recently, a clear evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of incident atrial fibrillation (AF). Yet, the underlying pathogenesis is speculative. Thereby, we aimed to investigate the hypothesis that, interatrial thickness (IAST) and left atrial stiffness (LASt) might have mechanistic links between NAFLD and AF.

Methods: Echocardiography and speckle-tracking assessment of left atrial function, transient elastography (TE) of the liver, basal ECG, and Holter monitoring were performed in 180 patients with (NAFLD) and 80 subjects without NAFLD.

Results: Patients with NAFLD had higher values of IAST (P < 0.001), LASt (<0.001), and E/e' ratio (<0.003) compared with controls. IAST was correlated with LASt (r = 0.413; P < 0.001). 15.6% of patients with NAFLD had AF. More so, patients with increased IAST/LASt had a higher incidence of AF (25%) vs 3.8% in those with normal IAST/LASt. The LASt and IAST increased significantly in those with AF compared with those without (P < 0.001). Patients who experienced AF had higher values (P < 0.01) of TE (kPa). The degree of liver stiffness TE (kPa) was correlated with both IAST and LASt (r = 461, r = 0.535; P < 0.001). Furthermore, multivariate regression analysis showed that LASt and IAST were independent predictors of incident AF in subjects with NAFLD.

Conclusions: Our data suggest that increased IAST and LASt index are independently associated with incident atrial fibrillation in patients with NAFLD. Increased IAST and LASt index might provide mechanistic links between NAFLD and incident atrial fibrillation.
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http://dx.doi.org/10.1111/echo.14229DOI Listing
February 2019

Effect of clove extract on lipid oxidation, antioxidant activity, volatile compounds and fatty acid composition of salted duck eggs.

J Food Sci Technol 2018 Dec 1;55(12):4719-4734. Epub 2018 Oct 1.

1National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070 Hubei People's Republic of China.

Antioxidant activity, lipid oxidation, fatty acid composition and volatile compounds of duck eggs supplemented with clove extract were monitored over the salting period. The results indicated that application of clove extracts significantly reduced 2-thiobarbituric acid reactive substances and anisidine values as well as the conjugated dienes levels during curing. Clove extracts along with salting time had significant effects on the fatty acid composition. The predominant fatty acid in salted duck eggs supplemented with clove extracts for 14 day of the salting process was oleic acid, followed by palmitic acid and arachidonic acid. Additionally, treated eggs exhibited a higher docosahexaenoic acid content than that of control. The results of SPME GC-MS showed the presence of 46 and 37 volatiles in the treated eggs. Eugenol, as the primary bioactive component of clove, was detected in salted eggs supplemented with clove extracts. In addition, analyzing the results obtained through electronic nose showed that clove extract brought significant changes in salted eggs flavor components.
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http://dx.doi.org/10.1007/s13197-018-3367-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233453PMC
December 2018