Publications by authors named "M G Balta"

17 Publications

  • Page 1 of 1

Specialized Pro-Resolving Mediators as Potential Regulators of Inflammatory Macrophage Responses in COVID-19.

Front Immunol 2021 24;12:632238. Epub 2021 Feb 24.

Department of Pathology, Oslo University Hospital, Oslo, Norway.

The recent outbreak of SARS-CoV2 has emerged as one of the biggest pandemics of our century, with outrageous health, social and economic consequences globally. Macrophages may lay in the center of COVID-19 pathogenesis and lethality and treatment of the macrophage-induced cytokine storm has emerged as essential. Specialized pro-resolving mediators (SPMs) hold strong therapeutic potentials in the management of COVID-19 as they can regulate macrophage infiltration and cytokine production but also promote a pro-resolving macrophage phenotype. In this review, we discuss the homeostatic functions of SPMs acting directly on macrophages on various levels, towards the resolution of inflammation. Moreover, we address the molecular events that link the lipid mediators with COVID-19 severity and discuss the clinical potentials of SPMs in COVID-19 immunotherapeutics.
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http://dx.doi.org/10.3389/fimmu.2021.632238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943727PMC
March 2021

Host Modulation and Treatment of Periodontal Disease.

J Dent Res 2021 Mar 3:22034521995157. Epub 2021 Mar 3.

Center for Clinical and Translational Research, Forsyth Institute, Cambridge, MA, USA.

Periodontitis is the sixth-most prevalent disease in the world and the first cause for tooth loss in adults. With focus shifted to the inflammatory/immune response in the pathogenesis of periodontitis, there is a critical need to evaluate host modulatory agents. Synthetic and biological disease-modifying antirheumatic drugs are a cornerstone for the treatment of inflammatory diseases. Recent prospective cohort studies showed that synthetic disease-modifying antirheumatic drugs improved periodontal clinical parameters following nonsurgical periodontal treatment in patients with rheumatoid arthritis. Treatment with recombinant humanized monoclonal antibodies against CD20 (rituximab) and IL-6 receptor (tocilizumab), the latter also in clinical trials for the treatment of COVID-19 pneumonia, resulted in decreased periodontal inflammation and improved periodontal status. Studies on the effect of TNF-α inhibitors in patients with periodontitis yielded inconsistent results. Recent data suggest that probiotics provide anti-inflammatory clinical benefit, as do nutritional supplements, such as n-3 fatty acids, when combined with periodontal therapy. Probiotics reduce the production of proinflammatory cytokines/chemokines by suppressing NF-κB pathways and promote the accumulation of T regulatory cells. Statins, like aspirin, have been shown to exhibit anti-inflammatory and bone-preserving actions by upregulating production of Specialized Proresolving Mediators (SPMs). Currently, there is insufficient scientific support for the topical delivery of statins or bisphosphonates as adjuncts to periodontal therapy. Here, we present a critical review of the most recent host modulatory agents applied in humans and the key immune pathways that they target. Emerging evidence from novel drug candidates, including SPMs and complement inhibitors as previously studied in animal models and currently in human clinical trials, suggests future availability of adjunctive therapeutic strategies for the management of periodontitis.
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http://dx.doi.org/10.1177/0022034521995157DOI Listing
March 2021

Composition of hemidesmosomes in basal keratinocytes of normal buccal mucosa and oral lichen planus.

Eur J Oral Sci 2020 10 1;128(5):369-378. Epub 2020 Sep 1.

Institute of Oral Biology, University of Oslo, Oslo, Norway.

Oral lichen planus (OLP) is a chronic inflammatory disease displaying ultrastructural disturbances in epithelial hemidesmosomes. The expression of several key hemidesmosomal components in OLP as well as in normal buccal mucosa is, however, unknown. The aim of the study was therefore to examine intracellular and extracellular components involved in hemidesmosomal attachment, in OLP (n = 20) and in normal buccal mucosa (n = 10), by immunofluorescence. In normal buccal mucosa, laminin-α3γ2, integrin-α6β4, CD151, collagen α-1(XVII) chain, and dystonin showed linear expression along the basal membrane, indicating the presence of type I hemidesmosomes. Plectin stained most epithelial cell membranes and remained unphosphorylated at S4642. In OLP, most hemidesmosomal molecules examined showed disturbed expression consisting of discontinuous increases, apicolateral location, and/or intracellular accumulation. Plectin showed S4642-phosphorylation at the basement membrane, and deposits of laminin-α3 and laminin-γ2 were found within the connective tissue. The disturbed expression of hemidesmosomal proteins in OLP indicates deficient attachment of the basal cell layer, which can contribute to detachment and cell death of basal keratinocytes seen in the disease.
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http://dx.doi.org/10.1111/eos.12732DOI Listing
October 2020

Tumors of the labial mucosa: a retrospective study of 1045 biopsies.

Med Oral Patol Oral Cir Bucal 2021 Jan 1;26(1):e36-e42. Epub 2021 Jan 1.

Department of Oral Medicine and Pathology Faculty of Dentistry, National and Kapodistrian University of Athens 2 Thivon Street, 11527 Athens, Greece

Background: To investigate the relative frequency of localized mucosal swellings of the upper and lower labial mucosa, the clinical-pathological diagnosis agreement and whether patient's age and gender and tumor's site and size may raise the suspicion of neoplasm.

Material And Methods: Retrospective analysis was performed on upper or lower labial mucosal tumors, histopathologically diagnosed between 2009-2018. The diagnostic categories developmental/reactive tumors, benign and malignant neoplasms were associated with patient's age and gender and tumor's site and size; clinical-pathological diagnosis agreement was, also, evaluated.

Results: Overall, 1000 (95.7%) developmental/reactive tumors, 35 (3.3%) benign and 10 (1%) malignant neoplasms were found. Upper/lower lip tumor ratio was 0.14:1. The diagnostic category was significantly associated with age (p<0.0001), site (p<0.0001) and diameter (p<0.0001). Age ≥60 years, tumor's location on the upper lip and diameter >1cm were independent predictors for neoplasms. Patients presenting 2 or 3 of these variables were 20.2 times (p < 0.0001) or 33.6 times (p < 0.0001), respectively, more likely to have a neoplasm. Complete/partial agreement between clinical and pathological diagnosis was seen in 96.3% of the cases.

Conclusions: Most lip tumors involve the lower lip and are reactive, but upper lip tumors measuring >1cm in patients≥60 years have significantly higher probability to be neoplasms.
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http://dx.doi.org/10.4317/medoral.23933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806354PMC
January 2021

The use of digital technologies by small and medium enterprises during COVID-19: Implications for theory and practice.

Int J Inf Manage 2020 Dec 1;55:102192. Epub 2020 Jul 1.

Technology, Innovation Management and Enterprise (TIME) Research Centre, Kent Business School, The University of Kent, Canterbury CT2 7FS United Kingdom.

Scholars have highlighted the role of Digital Technologies (DT) in enhancing productivity and performance in Small and Medium Enterprises (SMEs). However, there is limited evidence on the use of DT for dealing with the consequences of extreme events, such as COVID-19. We discuss this gap by (i) outlining potential research avenues and (ii) reflecting on the managerial implications of using DT within SMEs to deal with the repercussions of COVID-19 and securing business continuity.
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http://dx.doi.org/10.1016/j.ijinfomgt.2020.102192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327446PMC
December 2020

Expression of keratins 8, 18, and 19 in epithelia of atrophic oral lichen planus.

Eur J Oral Sci 2020 02 28;128(1):7-17. Epub 2020 Jan 28.

The CrossTalk Group, Institute of Oral Biology, University of Oslo, Oslo, Norway.

Keratins form intermediate filaments of the cytoskeleton in keratinocytes and have roles in cell structure, signaling, intracellular transport, and cell death. Oral lichen planus (OLP) is an oral inflammatory disease with derangements in basal keratinocytes and disruption of the basal membrane. Here, we focused on epithelial expression of keratins 8, 18, and 19 because these proteins are known to modulate cell death. Biopsies were taken from buccal oral mucosa of persons with normal oral mucosa (n = 10) or atrophic OLP (n = 10). Cultured normal oral keratinocytes (n = 4) showed expression of mRNA and protein for keratins 8, 18, and 19. Immunohistochemistry showed consistent staining for keratins 8 and 18 in basal keratinocytes of normal oral mucosa. In OLP, staining for keratin (K)8 was mostly negative and staining for K18 was weak. Keratin 19 was expressed irregularly in most biopsies of normal oral mucosa and not at all in OLP. Several mononuclear leukocytes in the cellular infiltrate showed membrane staining for K8 and K18. Positive staining for K16 confirmed partial collapse of the basal cell layer in OLP. The basal cell niche in OLP therefore appeared to be partly populated with keratinocytes demonstrating a higher degree of differentiation (K8 K18 K19 K16 ); consequently, such areas may be more susceptible to the action of cell death factors released from the cell infiltrate as a result of lacking the protective, normal keratin present in the basal epithelial cell layer of normal oral mucosa.
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http://dx.doi.org/10.1111/eos.12666DOI Listing
February 2020

Periodontal therapy increases neutrophil extracellular trap degradation.

Innate Immun 2020 07 22;26(5):331-340. Epub 2019 Nov 22.

Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, The Netherlands.

In periodontitis, polymorphonuclear leucocytes (PMNs) are activated. They entrap and eliminate pathogens by releasing neutrophil extracellular traps (NETs). Abnormal NET degradation is part of a pro-inflammatory status, affecting co-morbidities such as cardiovascular disease. We aimed to investigate the NET degradation capacity of plasma from periodontitis patients compared to controls (part 1) and to quantify NET degradation before and after periodontal therapy (part 2). Fresh NETs were obtained by stimulating blood-derived PMNs with phorbol 12-myristate 13-acetate. Plasma samples from untreated periodontitis patients and controls were incubated for 3 h onto freshly generated NETs (part 1). Similarly, for part 2, NET degradation was studied for 91 patients before and 3, 6 and 12 mo after non-surgical periodontal therapy with and without adjunctive systemic antibiotics. Finally, NET degradation was fluorospectrometrically quantified. NET degradation levels did not differ between periodontitis patients and controls, irrespective of subject-related background characteristics. NET degradation significantly increased from 65.6 ± 1.7% before periodontal treatment to 75.7 ± 1.2% at 3 mo post periodontal therapy, and this improvement was maintained at 6 and 12 mo, irrespective of systemic usage of antibiotics. Improved NET degradation after periodontitis treatment is another systemic biomarker reflecting a decreased pro-inflammatory status, which also contributes to an improved cardiovascular condition.
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http://dx.doi.org/10.1177/1753425919889392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903525PMC
July 2020

Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1.

Front Immunol 2017 14;8:1682. Epub 2017 Dec 14.

Department of Periodontology, Academic Centre for Dentistry Amsterdam, Amsterdam, Netherlands.

Inflammatory response is a protective biological process intended to eliminate the harmful effect of the insulting influx. Resolution of inflammation constitutes an active sequence of overlapping events mediated by specialized proresolving mediators, such as lipoxins, resolvins, protectins, and maresins, which originate from the enzymatic conversion of polyunsaturated fatty acids (PUFAs). An unresolved acute inflammatory response results in chronic inflammation, which is a leading cause of several common pathological conditions. Periodontitis is a biofilm-induced chronic inflammatory disease, which results in loss of periodontal connective tissue and alveolar bone support around the teeth, leading to tooth exfoliation. An inadequate proresolving host response may constitute a mechanism explaining the pathogenesis of periodontal disease. An emerging body of clinical and experimental evidence has focused on the underlying molecular mechanisms of resolvins and particularly Resolvin E1 (RvE1) in periodontitis. Recently, RvE1 has been directly correlated with the resolution of inflammation in periodontal disease. Herein, we provide a comprehensive overview of the literature regarding the role and possible mechanisms of action of RvE1 on different cell populations recruited in periodontal inflammation as well as its potential therapeutic implications. Along with recent data on the benefits of PUFAs supplementation in periodontal clinical parameters, we touch upon suggested future directions for research.
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http://dx.doi.org/10.3389/fimmu.2017.01682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735081PMC
December 2017

PlasmaBlade vs. cold dissection tonsillectomy: A prospective, randomized, double-blind, controlled study in adults.

Ear Nose Throat J 2017 Jul;96(7):250-256

Department of Otolaryngology, Yeditepe University Hospital, Kulak Burun Bogaz Hastaliklari Anabilim Dali, Icerenkoy Mah. Hastane Sok. No:4 D:1 Atasehir, Istanbul, Turkiye.

We conducted a prospective, randomized, double-blind, controlled clinical study to compare the efficacy and safety of the PlasmaBlade device and cold dissection for adult tonsillectomy. Our study group was made up of 20 patients-12 men and 8 women, aged 18 to 50 years (mean: 27.1)-who were undergoing a bilateral tonsillectomy. Each patient had one randomly chosen tonsil removed by the PlasmaBlade and the other by cold instrumentation. We compared the duration of surgery, the amount of intraoperative blood loss, the number of sutures required, the status of tonsillar fossa wound healing at 7 and 14 days postoperatively, the amount of postoperative pain, and postoperative complications. We found statistically significant differences in the amount of blood loss and the number of sutures in favor of the PlasmaBlade technique. No significant differences were observed in any of the other outcomes.
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http://dx.doi.org/10.1177/014556131709600718DOI Listing
July 2017

Oleander Poisoning as an Example of Self-Medication Attempt.

Balkan Med J 2016 Sep 1;33(5):559-562. Epub 2016 Sep 1.

Institute of Forensic Sciences, İstanbul University, Istanbul, Turkey.

Background: There is an increasing interest in herbal products as a self-medication method in recent years. Some plant extracts either turn into drugs over time or are consumed directly without treatment. One of these plants is L., which is a potentially lethal plant, since it has cardiac glycosides. However, numerous researches of its extracts have been performed against cancer cell lines in recent literature. This contradiction leads to misinterpretation and induces the prevalence of intoxication or fatal cases.

Case Report: This case is associated with an oleander-poisoned patient, who was admitted to the Emergency unit 20 hours after the first dose, and 8 hours after the second dose. Although she lives in a metropolis and has a higher level of education and numerous hospital facilities available, she had decided to take self-medication for her Hashimoto's thyroiditis and malignant thyroid disease which was caused by her apprehensive thoughts. Oleandrin was detected in the urine at a concentration of 3.2 ng/mL and in the serum at a concentration of 8.4 ng/mL by chromatographic analysis at the time of admission.

Conclusion: This case represents the misunderstanding of herbal treatments by the community. Promoting awareness of the potential toxicity of this plant among the public may help to reduce the incidence of poisoning due to Nerium species.
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http://dx.doi.org/10.5152/balkanmedj.2016.150307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056662PMC
September 2016

The role of pain catastrophizing score in the prediction of venipuncture pain severity.

Pain Pract 2014 Mar 16;14(3):245-51. Epub 2013 Apr 16.

Department of Anesthesiology and Reanimation, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey.

Background: In addition to the influence of tissue damage, the intensity of pain is also related to individual cognitive factors. The Pain Catastrophizing Scale (PCS) is used to measure individual tendency toward pain by inquiring about a subject's cognitive characteristics. Building on the knowledge that the venipuncture process causes severe pain and anxiety in some patients, the objective of this study was to investigate the relationship between the PCS score and venipuncture pain.

Methods: Patients were asked to complete the PCS questionnaire. Patients' demographic features, presence of chronic pain and American Society of Anesthesiologists (ASA) scores were recorded. Clinical and demographic characteristics of the patients were used for correlation with the PCS scores. Using an 11-point numeric rating scale (NRS), the patients then scored the amount of pain on cannulation.

Results: This prospective study was conducted with 196 patients; 31 patients were excluded for various reasons. One hundred sixty-five patients, 74 women and 91 men, were included in the evaluation. The study found that the venipuncture pain score had a significant positive correlation with the PCS score (r = 0.197, P < 0.05). With respect to age, no statistically significant differences in the PCS scores were found (P > 0.05). Female patients had a significantly higher PCS score than the males (P < 0.05). The PCS score of patients with chronic pain was found to be significantly higher in comparison with those without pain complaints (P < 0.05).

Conclusion: There was a positive correlation between venipuncture pain and PCS score. Consequently, the venipuncture pain score could be useful in informing practitioners about a patient's pain considerations.
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http://dx.doi.org/10.1111/papr.12060DOI Listing
March 2014

Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Oct 31;110(4):492-7. Epub 2010 Jul 31.

Department of Oral Pathology and Surgery, Dental School, National and Kapodistrian University of Athens, Greece.

Angiomyolipoma (AML) is the most common benign mesenchymal neoplasm of the kidneys with well-established clinical and morphological features. The oral and maxillofacial pathology literature contains several examples that identify angiomyomatous proliferations of the oral mucosa that contain an adipocytic component as analogous to classic renal AMLs although they differ significantly in their immunohistochemical phenotype. Herein, through review of the pertinent oral pathology literature and the detailed description of 2 lesions, one an oral angiomyoma with an adipocytic component and the other an apparently hamartomatous angioleiomyomatous proliferation with adipocytes, we provide, in our opinion, a solid argument against the use of the term AML for non-PEComatous oral tumors.
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http://dx.doi.org/10.1016/j.tripleo.2010.04.045DOI Listing
October 2010

"Mints", smells and traditional uses in Thessaloniki (Greece) and other Mediterranean countries.

J Ethnopharmacol 2007 Jan 25;109(2):248-57. Epub 2006 Jul 25.

Laboratory of Systematic Botany & Phytogeography, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

The herbs of the "mint" group traded in the herbal market of Thessaloniki include eight taxa, members of two genera, Acinos (two species) and Mentha (four species and two hybrids). The essential oil content of 72 samples examined ranged from traces up to 1.69ml/100g of dry weight. Besides three almost scentless samples, the different "mints" are distinguished according to their prominent smell differences, i.e. samples with a pungent, musty and sweet type of smell. As a result, the commercial names attributed to them correspond to a particular type of smell and not to a particular taxon. A number of 29 medicinal uses were recorded in total. In most cases uses were not associated with particular taxa but were rather determined by plant smells. A literature survey has shown that the "mints" traded in Thessaloniki are also used as herbal medicines all over the Mediterranean area, with 67 different therapeutic uses. Among them the 22 uses, already mentioned by Dioscurides, show that the utilization of "mints" as herbal medicines in the Mediterranean countries has a long tradition.
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http://dx.doi.org/10.1016/j.jep.2006.07.022DOI Listing
January 2007

Duodenal ulcer and infection with Helicobacter pylori.

Rom J Intern Med 1995 Jul-Dec;33(3-4):151-4

N. Gh. Lupu Institute of Internal Medicine, Bucharest, Romania.

The incidence of gastritis with Helicobacter pylori (HP) was studied in 225 patients with active duodenal ulcer diagnosed endoscopically. The infection was diagnosed by the urease test and in some cases by histopathological examination. Infection with Helicobacter pylori was detected in 55% of the patients, a proportion much smaller than the one generally reported in the literature, a rather surprising fact for our sanitary conditions. This might mean that in our country unlike the west-European countries other pathogenetic factors could be more important than HP.
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July 1996

New data in the management of digestive steroses.

Authors:
M Baltă R Voiosu

Rom J Intern Med 1992 Jul-Sep;30(3):157-67

N. Gh. Lupu Institute of Internal Medicine, Bucharest, Romania.

The report is a review of the perendoscopic methods of treatment of stenoses at the level of the digestive tract and of the excretion canals of the annex glands. After a short description of the methods as well as of the necessary equipment, the authors discuss the indications according to the etiology of stenoses. The indications and contraindications are enumerated and an estimation is made of the therapeutic efficiency of the endoscopic methods as compared with the classical surgical methods. Emphasis is laid on the therapeutic advantages of the endoscopic palliative methods as an alternative to the surgical methods.
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February 1993

Pulmonary involvement in systemic lupus erythematosus.

Med Interne 1987 Oct-Dec;25(4):227-32

N. Gh. Lupu Institute of Internal Medicine, Bucharest, Romania.

In the course of an ample study of collagen diseases carried out in the "N. Gh. Lupu" Institute of Internal Medicine--Bucharest over a long period, a group of 608 patients with systemic lupus erythematosus (SLE) hospitalized between 1974 and 1986 formed the object of the present study. Of these patients 18% presented pulmonary alterations due to SLE and 3.9% lung diseases of other etiology. The types of pulmonary involvement due to SLE were: pleurisy, interstitial pneumonia, diaphragmatic myopathy. Latent pulmonary damage could also be diagnosed in 8 patients. Most of the patients (94.1%) were females and had been hospitalized several times. Concomitantly with pulmonary damage other organ involvements have also been observed. Complex investigation of respiratory function performed in a selected group of patients revealed: restrictive syndrome, decrease of the gas transfer factor, increase of elastic recoil, hypoxemia on exercise. In most of the cases (92%) the pulmonary diseases had a chronic evolution. The treatment used was corticosteroids in 60% of the cases investigated.
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February 1988

The value of endoscopy in the diagnosis of gastric ulcer.

Authors:
R Voiosu M Baltă

Med Interne 1986 Oct-Dec;24(4):273-6

The ever increasing application of digestive endoscopy has provided a new argument for diagnosis in gastroenterology. Based on a personal experience of 300 cases, the authors are revising the diagnosis of gastric ulcer, comparing the data obtained by X-ray, endoscopic, histologic and bioptic investigations. In about two per cent of the cases, the endoscopic diagnosis of benign ulcer was infirmed by examination of the histologic fragments.
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March 1987