Publications by authors named "M Dolores Castro"

4,006 Publications

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A computational method for learning disease trajectories from partially observable EHR data.

IEEE J Biomed Health Inform 2021 Jun 15;PP. Epub 2021 Jun 15.

Diseases can show different courses of progression even when patients share the same risk factors. Recent studies have revealed that the use of trajectories, the order in which diseases manifest throughout life, can be predictive of the course of progression. In this study, we propose a novel computational method for learning disease trajectories from EHR data. The proposed method consists of three parts: first, we propose an algorithm for extracting trajectories from EHR data; second, three criteria for filtering trajectories; and third, a likelihood function for assessing the risk of developing a set of outcomes given a trajectory set. We applied our methods to extract a set of disease trajectories from Mayo Clinic EHR data and evaluated it internally based on log-likelihood, which can be interpreted as the trajectories' ability to explain the observed (partial) disease progressions. We then externally evaluated the trajectories on EHR data from an independent health system, M Health Fairview. The proposed algorithm extracted a comprehensive set of disease trajectories that can explain the observed outcomes substantially better than competing methods and the proposed filtering criteria selected a small subset of disease trajectories that are highly interpretable and suffered only a minimal (relative 5%) loss of the ability to explain disease progression in both the internal and external validation.
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http://dx.doi.org/10.1109/JBHI.2021.3089441DOI Listing
June 2021

COVID-19 poses alarming pregnancy and postpartum mortality risk in Brazil.

EClinicalMedicine 2021 Jun 30;36:100917. Epub 2021 May 30.

Harvard T.H. Chan School of Public Health, Department of Global Health and Population, 665 Huntington Avenue, Building 1, 11th floor, Boston, MA 02115, United States.

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http://dx.doi.org/10.1016/j.eclinm.2021.100917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173266PMC
June 2021

SARS-CoV-2 infection in a pediatrics STAT1 GOF patient under Ruxolitinib therapy-a matter of balance?

J Clin Immunol 2021 Jun 9. Epub 2021 Jun 9.

Pediatric Infectious Diseases, Rheumatology and Immunology Unit, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, IBiS/ Universidad de Sevilla/CSIC, Red de Investigación Traslacional en Infectología Pediátrica RITIP, Seville, Spain.

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http://dx.doi.org/10.1007/s10875-021-01081-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189704PMC
June 2021

Genetic diversity and population structure of Cynara cardunculus L. in southern Portugal.

PLoS One 2021 9;16(6):e0252792. Epub 2021 Jun 9.

Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo (CEBAL)/Instituto Politécnico de Beja (IPBeja), Beja, Portugal.

Cynara cardunculus L. is a cardoon species native to the Mediterranean region, which is composed of three botanical taxa, each having distinct biological characteristics. The aim of this study was to examine wild populations of C. cardunculus established in Portugal, in order to determine their genetic diversity, geographic distribution, and population structure. Based on SSR markers, 121 individuals of C. cardunculus from 17 wild populations of the Portuguese Alentejo region were identified and analysed. Ten SSRs were found to be efficient markers in the genetic diversity analysis. The total number of alleles ranged from 9 to 17 per locus. The expected and observed means in heterozygosity, by population analysed, were 0.591 and 0.577, respectively. The wild population exhibited a high level of genetic diversity at the species level. The highest proportion of genetic variation was identified within a geographic group, while variation was lower among groups. Geographic areas having highest genetic diversity were identified in Alvito, Herdade da Abóboda, Herdade da Revilheira and Herdade de São Romão populations. Moreover, significant genetic differentiation existed between wild populations from North-Alentejo geographic locations (Arraiolos, Évora, Monte da Chaminé) and Centro Hortofrutícola, compared with other populations. This study reports genetic diversity among a representative number of wild populations and genotypes of C. cardunculus from Portugal. These results will provide valuable information towards future management of C. cardunculus germplasm.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252792PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189484PMC
June 2021