Publications by authors named "M Daniela D"

34 Publications

Experimental measurements of the bacterial oxidation of HT in soils: Impact over a zone influenced by an industrial release of tritium in HT form.

J Environ Radioact 2022 Feb 27;242:106779. Epub 2021 Nov 27.

Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-ENV/SRTE/LRC, BP 10, rue Max Pol Fouchet, 50130, Cherbourg-En-Cotentin, France.

Tritium is a radionuclide released to the atmosphere by nuclear industries in various forms, mainly HTO and to a lesser extent HT. However, some nuclear sites may emit predominantly HT in the atmosphere. The HT is oxidized to HTO essentially in the top cm of soils, and that the formed HTO is then possibly released into the atmosphere. HTO is an assimilable form by plants. Therefore, it is important to understand the environmental behaviour of HT. In this work, we adapt the bacterial oxidation model of HT in soils of Ota et al. (2007) by laboratory experiments on soils typical of western France, and we have in particular adapted the frequency factor A and the Michaelis-Menten enzymatic reaction parameter (Km) on the basis of an Arrhenius equation in function of the porosity of the soil. We then applied this model to the environment near the reprocessing plant of Orano la Hague (France), which emits a significant amount of HT. Based on the adapted model, and knowing the atmospheric variations of HTO and HT over the period 2013-2016, we estimated that the mean HTO activity in soil due to atmospheric HT reached 0.6 Bq.L (with a peak value of 5 Bq.L) while the mean value with all sources taken into account is 6.2 Bq.L. Then, in an environment such as that surrounding the Orano La Hague plant, where near-field atmospheric HT activity is very high, the bacterial oxydation contribution to produce HTO in the soil can be considered as approximately 10%. The flux to the atmosphere from these source representing approximately. 1.5 Bq.m.d. If we consider an area of 2 km around the plant (i.e. 13 km), we estimate 218 Bq.s of HTO was released by the soil, representing less than 0.1% of the direct atmospheric release of HTO around the site. From this work, it appears clear that this secondary source term from the soil is insignificant at this specific site.
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http://dx.doi.org/10.1016/j.jenvrad.2021.106779DOI Listing
February 2022

3D printed customised external cranial plate in a patient with syndrome of trephined: 'a case report'.

3D Print Med 2021 Nov 12;7(1):35. Epub 2021 Nov 12.

Department of Clinical Neurosciences, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Background: Syndrome of the trephined is a well-recognised phenomenon that occurs in patients following a craniectomy. It is associated with several symptoms, including headaches, motor impairments, cognitive disorders and reduced consciousness. Treatment for the syndrome usually involves replacing the skull defect.

Case Study: A 71-year-old male underwent a left-sided craniectomy after being diagnosed with biopsy-confirmed invasive squamous cell carcinoma with associated skull erosion. Subsequently, he developed a severe case of syndrome of the trephined (SoT,) resulting in having to lie flat to prevent the motor component of the Glasgow Coma Score (GCS) falling from M5/6 (E3/4 Vt M5/6) to M1 (E3/4 Vt M1) on sitting to 30 degrees. Unfortunately, due to ongoing chest sepsis and physical frailty, he was unable to undergo a cranioplasty. Therefore, to aid in clinical stabilisation, the treating physicians and clinical engineering teams designed and manufactured a prosthesis on-site, allowing rapid patient treatment. The prosthesis led to the patient being able to sit up to 30 degrees without the motor component of the GCS falling from M6 to M1 (E4 VT M6).

Conclusion: Clinical improvements were demonstrated with definitive neurological improvement after applying the external cranial plate in clinical outcome measures and radiographically. Furthermore, we have shown that rapid prototyping technology provides a flexible solution to synthesise bespoke medical prostheses with the correct expertise and regulatory framework.
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http://dx.doi.org/10.1186/s41205-021-00123-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588646PMC
November 2021

A new cerebral ischemic injury model in rats, preventive effect of gallic acid and approaches.

Saudi J Biol Sci 2021 Sep 24;28(9):5204-5213. Epub 2021 May 24.

Creative Educational Societys College of Pharmacy, Kurnool, Andhra Pradesh, India.

Current study was designed multiple occlusions and reperfusion of bilateral carotid arteries induced cerebral injury model and evaluated the protective effect of gallic acid on it. study was involved to study gallic acid binding affinity on cerebrotonic proteins compared with standard drugs using . Cerebral ischemia was induced by occlusion of bilateral common carotid arteries for 10 mins followed by 10 reperfusions (1 cycle), cycle was continued to 3 cycles (MO/RCA), then pathological changes were observed by estimation of brain antioxidants as superoxide dismutase, glutathione, catalase, oxidants like malonaldehyde, cerebral infarction area, histopathology, and study gallic acid treatment against cerebral injury. Gallic acid exhibited a strong binding affinity on targeted cerebrotoxic proteins. MO/RCA rat brain antioxidant levels were significantly decreased and increased MDA levels (p < 0.0001), Infarction size compared to sham rats. Gallic acid treatment rat brain MDA levels significantly decreased (p < 0.4476) and increased SOD (p < 0.0001), CAT (p < 0.0001), GSH (p < 0.0001), cerebral infarction area when compared to MO/RCA group. Developed model showed significant cerebral ischemic injury in rats, injury was ameliorated by Gallic acid treatment and in silico approaches also inhibit the cerebrotoxic protein function by targeting on active sites.
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http://dx.doi.org/10.1016/j.sjbs.2021.05.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381014PMC
September 2021

Doctors and Nurses Social Media Ads Reduced Holiday Travel and COVID-19 infections: A cluster randomized controlled trial in 13 States.

ArXiv 2021 Jun 21. Epub 2021 Jun 21.

During the COVID-19 epidemic, many health professionals started using mass communication on social media to relay critical information and persuade individuals to adopt preventative health behaviors. Our group of clinicians and nurses developed and recorded short video messages to encourage viewers to stay home for the Thanksgiving and Christmas Holidays. We then conducted a two-stage clustered randomized controlled trial in 820 counties (covering 13 States) in the United States of a large-scale Facebook ad campaign disseminating these messages. In the first level of randomization, we randomly divided the counties into two groups: high intensity and low intensity. In the second level, we randomly assigned zip codes to either treatment or control such that 75% of zip codes in high intensity counties received the treatment, while 25% of zip codes in low intensity counties received the treatment. In each treated zip code, we sent the ad to as many Facebook subscribers as possible (11,954,109 users received at least one ad at Thanksgiving and 23,302,290 users received at least one ad at Christmas). The first primary outcome was aggregate holiday travel, measured using mobile phone location data, available at the county level: we find that average distance travelled in high-intensity counties decreased by -0.993 percentage points (95% CI -1.616, -0.371, p-value 0.002) the three days before each holiday. The second primary outcome was COVID-19 infection at the zip-code level: COVID-19 infections recorded in the two-week period starting five days post-holiday declined by 3.5 percent (adjusted 95% CI [-6.2 percent, -0.7 percent], p-value 0.013) in intervention zip codes compared to control zip codes.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219102PMC
June 2021

A critical look into different salt removal treatments for the production of high value pigments and fatty acids from marine microalgae (NIOT-74).

Biotechnol Rep (Amst) 2021 Jun 7;30:e00627. Epub 2021 May 7.

Marine Biotechnology Division, National Institute of Ocean Technology, (Ministry of Earth Sciences, Government of India), Velachery - Tambaram Main Road, Pallikaranai, Chennai, 600 100, India.

The prime challenge in seawater culture of microalgae for high value biomolecules production is presence of salt. Hence, twelve different salt removal treatments were evaluated for their impact on the lutein, total carotenoid, chlorophyll yields and fatty acid profile of marine microalgae (NIOT-74). The effectiveness of different treatments on salt removal was also visualized with the aid of Scanning Electron Microscope (SEM). Among the tested treatments, washing the algal biomass with 0.5 % HCl augmented the lutein (11.56 mg/g) and total carotenoid yield (60.88 mg/g) 1.82 and 1.86 fold respectively, in comparison to untreated control. Highest chlorophyll content (30.64 mg/g) was noticed in the distilled water wash treatment. Different salt removal treatments also impacted the fatty acid profile and degree of unsaturation of the fatty acids significantly. This study thus, signified the importance of salt removal treatments for the commercial production of biomolecules from marine microalgae cultured in natural seawater.
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http://dx.doi.org/10.1016/j.btre.2021.e00627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138460PMC
June 2021
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