Publications by authors named "M Ashwin Reddy"

2,913 Publications

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Why do multiple arteries in left lobe liver grafts need special attention?

Langenbecks Arch Surg 2021 Jul 29. Epub 2021 Jul 29.

Institute of Liver Disease and Transplantation, Gleneagles Global Hospital and Health City, Cheran Nagar, Chennai, 600100, India.

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http://dx.doi.org/10.1007/s00423-021-02280-zDOI Listing
July 2021

Anti-Mullerian Hormone and Macrophage Migration Inhibitory Factor Determine the Reproductive Health of Ladakhi Women Residing at 3,500 m.

High Alt Med Biol 2021 Jul 26. Epub 2021 Jul 26.

High Altitude Physiology Group, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Delhi, India.

Shaw, Snigdha, Himashree Gidugu, Gopinath Bhaumik, Maramreddy Prasanna Kumar Reddy, Usha Panjwani, and Dishari Ghosh. Anti-Mullerian hormone and macrophage migration inhibitory factor determine the reproductive health of Ladakhi women residing at 3,500 m. 00:000-000, 2021. Reproductive health of Ladakhi high-altitude (HA) native females was investigated for the first time in this study. Available literature suggest that, female reproductive cycle and hormonal profile varies in different HA populations due to heterogeneity. Although these studies illustrate some progress on the role of HA hypoxia, it still leaves scope for evaluation of the remaining mechanisms involved in the maintenance of reproductive health in this contemporary population. Menstrual details, phasic variations in circulatory steroid hormones, and gonadotropins along with oxytocin in sea level (SL) and HA (∼3,500 m) native females of India were assessed. Moreover, ovarian reserve marker anti-Mullerian hormone (AMH) and proinflammatory cytokine macrophage migration inhibitory factor (MIF) were measured. A difference in Ladakhi women was registered compared to SL, regarding luteinizing hormone (LH) (2.6 mIU/ml vs. 4.4 mIU/ml,  < 0.05) and progesterone (P) (4.1 ng/ml vs. 9.4 ng/ml,  < 0.05) levels in their luteal phase. Reduced LH might contribute to poor development of the ovarian corpus luteum, subsequently diminish P level. Decreased AMH level in three age groups: 21-30 years (1.4 ng/ml vs. 3.2 ng/ml,  < 0.01), 31-40 years (0.6 ng/ml vs. 2.1 ng/ml,  < 0.01), and >40 years (0.4 ng/ml vs. 1.7 ng/ml,  < 0.01) of Ladakhi women were recorded than their SL counterpart. Elevated oxytocin (83.5 ng/ml vs. 76.3 ng/ml,  < 0.05) and MIF levels (70.2 ng/ml vs. 49.7 ng/ml,  < 0.01) along with low P and AMH levels delineated the reason for recorded early menopause (43.9 years), shorter reproductive span (∼29 years), and history of miscarriage in HA dwellers compared to SL. Therefore, the findings insinuated that the response of the reproductive system to hypoxia in Ladakhi women differs from SL women, and the adaptive response in these women might be in favor of their reproductive health.
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http://dx.doi.org/10.1089/ham.2021.0024DOI Listing
July 2021

Endoscopic Ultrasound Detection of Type B Aortic Dissection.

ACG Case Rep J 2021 Jul 21;8(7):e00639. Epub 2021 Jul 21.

Department of Gastroenterology and Hepatology, Elmhurst Hospital, Queens, New York, NY.

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http://dx.doi.org/10.14309/crj.0000000000000639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294883PMC
July 2021

Etiological Analysis of Reactive Gastropathy in an Urban Population.

Gastrointest Tumors 2021 Jun 14;8(3):115-120. Epub 2021 Apr 14.

Department of Gastroenterology, NYU Brooklyn Hospital, Brooklyn, New York, USA.

Background: Reactive gastropathy (RG) is an adaptive response to assaults of the gastric mucosa. Demographic information regarding RG as well as the coincidence of RG and gastrointestinal cancer are poorly characterized entities.

Objective: Herein, we aim to investigate relationships of RG to both modifiable and nonmodifiable risk factors, as well as conduct a stratified analysis by race in an ethnically diverse, urban population.

Methods: In this retrospective study, we queried an urban hospital inpatient pathology database searching for patients with surgical gastric biopsies positive for RG between March 25, 2015, and March 25, 2016. Of the 728 patients with a final diagnosis of RG, 292 were selected based on strict inclusion and exclusion criteria. We explored risk factors and conducted a stratified analysis for associations based on patient demographics.

Results: In this urban minority population, nonsteroidal anti-inflammatory drugs (NSAIDs) were the most common medication associated with RG (Fig. 1), as well as the most common cause of RG, followed by chronic bile reflux. In addition, significant differences in demographics and gastropathic characteristics associated with RG, stratified by ethnicity, were found (Fig. 2). Notably, Hispanics, African Americans, and Caucasians had the highest rate of concomitant RG and diabetes, hypertension, and tobacco/alcohol use, respectively.

Conclusion: Our study indicated that NSAID usage is the most common cause of RG, followed by bile reflux-mediated mucosal injury, in an ethnically diverse urban US-based population. Of note, few patients had intestinal metaplasia, suggesting it to be a slow or negligent sequela of RG.
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http://dx.doi.org/10.1159/000513610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280425PMC
June 2021

Development of a SYBR Green-based RT-qPCR assay for the detection of Indian citrus ringspot virus.

3 Biotech 2021 Jul 30;11(7):359. Epub 2021 Jun 30.

Indian Council of Agricultural Research, Central Citrus Research Institute, Amravati Road, Nagpur, Maharashtra 440033 India.

The Indian citrus ringspot virus (ICRSV) that causes ringspot disease, especially to 'Kinnow mandarin' hampers the sustainability of crop production. Presently, the disease is not amenable for control through host resistance or the introduction of chemicals, hence raising virus-free plants is one of the most effective approaches to manage the disease. Consequently, it is necessary to develop rapid, sensitive, specific, and early diagnostic methods for disease control. In the present study, newly designed primers targeting a 164 bp region of the ICRSV coat protein gene were used to develop and optimize a SYBR Green-based quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay, for the detection of ICRSV. The RT-qPCR assay was evaluated and confirmed using viral RNA extracted from ICRSV infected plants maintained in screen house as well as field samples. The standard curves displayed a dynamic linear range across eight log units of ICRSV-cRNA copy number ranging from 9.48.1 fmol (5.709 × 10) to 0.000948 amol (5.709 × 10), with detection limit of 5.709 × 10 copies per reaction using serial tenfold diluted in vitro transcribed viral cRNA. The developed RT-qPCR is very specific to ICRSV does not react to other citrus pathogens, and approximately 100-fold more sensitive than conventional RT-PCR. Thus, this assay will be useful in laboratories, KVKs, and nurseries for the citrus budwood certification program as well as in plant quarantine stations. To our knowledge, this is the first study of the successful detection of ICRSV by RT-qPCR.
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http://dx.doi.org/10.1007/s13205-021-02903-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245607PMC
July 2021
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