Publications by authors named "M Angeles Jimenez"

2,227 Publications

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The robotic surgery learning curve of a surgeon experienced in video-assisted thoracoscopic surgery compared with his own video-assisted thoracoscopic surgery learning curve for anatomical lung resections.

Eur J Cardiothorac Surg 2021 Sep 18. Epub 2021 Sep 18.

Department of Thoracic Surgery, Salamanca University Hospital, Salamanca, Spain.

Objectives: Robotic surgery, although it shares some technical features with video-assisted thoracoscopic surgery (VATS), offers some advantages, such as ergonomic design and a 3-dimensional view. Thus, the learning curve for robotic lung resection could be expected to be shorter than that of VATS for surgeons who are proficient in VATS. The goal of this study was to analyse the robotic learning curve of a VATS experienced surgeon and to compare it to his own VATS learning curve for anatomical lung resections.

Methods: We conducted a retrospective observational study based on the prospectively recorded data of the first 150 anatomical lung resections performed with VATS (75 cases) and with the robotic (75 cases) approach by the same surgeon in our centre. Learning curves were analysed using the cumulative sum method to assess the trends for total operating time and surgical failure (intraoperative complications, conversion, technical postoperative complications and reintervention) across case sequences. Subsequently, using adequate statistical tests, we compared the postoperative outcomes in both groups.

Results: The median operating time was similar for both approaches (P = 0.401). Surgical failure rate was higher for the robotic cases (21.3% vs 12%; P = 0.125). Based on cumulative sum analyses, operating time decreased starting with case 34 in the VATS group and with case 32 in the robotic cohort. Surgical failure tended to decline starting with case 28 in the VATS group and with case 32 in the robotic group. Perioperative results were similar in both groups.

Conclusions: When we compared robotic and VATS learning curves for anatomical lung resection, we did not find any differences. Postoperative outcomes were also similar with both approaches.
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http://dx.doi.org/10.1093/ejcts/ezab385DOI Listing
September 2021

Digital Implementation of Oscillatory Neural Network for Image Recognition Applications.

Front Neurosci 2021 26;15:713054. Epub 2021 Aug 26.

Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier, University of Montpellier, CNRS, Montpellier, France.

Computing paradigm based on von Neuman architectures cannot keep up with the ever-increasing data growth (also called "data deluge gap"). This has resulted in investigating novel computing paradigms and design approaches at all levels from materials to system-level implementations and applications. An alternative computing approach based on artificial neural networks uses oscillators to compute or Oscillatory Neural Networks (ONNs). ONNs can perform computations efficiently and can be used to build a more extensive neuromorphic system. Here, we address a fundamental problem: can we efficiently perform artificial intelligence applications with ONNs? We present a digital ONN implementation to show a proof-of-concept of the ONN approach of "computing-in-phase" for pattern recognition applications. To the best of our knowledge, this is the first attempt to implement an FPGA-based fully-digital ONN. We report ONN accuracy, training, inference, memory capacity, operating frequency, hardware resources based on simulations and implementations of 5 × 3 and 10 × 6 ONNs. We present the digital ONN implementation on FPGA for pattern recognition applications such as performing digits recognition from a camera stream. We discuss practical challenges and future directions in implementing digital ONN.
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http://dx.doi.org/10.3389/fnins.2021.713054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427800PMC
August 2021

Mitochondrial bioenergetics boost macrophages activation promoting liver regeneration in metabolically compromised animals.

Hepatology 2021 Sep 12. Epub 2021 Sep 12.

Transplant Coordination Unit. Marqués de Valdecilla University Hospital-IDIVAL. Cantabria University, Santander, Spain.

Background And Aims: Hepatic ischemia-reperfusion injury (IRI) is the leading cause of early post-transplantation organ failure, as mitochondrial respiration and ATP production are affected. Shortage of donors has extended liver donor criteria, including aged or steatotic livers, which are more susceptible to IRI. Given the lack of an effective treatment and the extensive transplantation waitlist, we aimed at characterizing the effects of an accelerated mitochondrial activity by silencing Methylation-controlled J protein (MCJ) in three pre-clinical models of IRI and liver regeneration, focusing on metabolically compromised animal models.

Approach And Results: Wt, MCJ KO and Mcj silenced Wt mice were subjected to 70% Partial hepatectomy (Phx), prolonged IRI and 70% Phx with IRI. Old and mice with metabolic syndrome were also subjected to these procedures. Expression of MCJ, an endogenous negative regulator of mitochondrial respiration, increases in pre-clinical models of Phx with or without vascular occlusion, and in donors' livers. Mice lacking MCJ initiate liver regeneration 12h faster than WT, show reduced ischemic injury and increased survival. MCJ knockdown enables a mitochondrial adaptation that restores the bioenergetic supply for enhanced regeneration and prevents cell death after IRI. Mechanistically, increased ATP secretion facilitates the early activation of kupffer cells and production of TNF, IL-6 and HB-EGF accelerating the priming phase and the progression through G1/S transition during liver regeneration. Therapeutic silencing of MCJ in 15-month-old mice and in mice fed with a high fat-high fructose diet for 12 weeks improves mitochondrial respiration, reduces steatosis and overcomes regenerative limitations.

Conclusions: Boosting mitochondrial activity by silencing MCJ could pave the way for a novel protective approach after major liver resection or IRI, specially in metabolically compromised, IRI susceptible organs.
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http://dx.doi.org/10.1002/hep.32149DOI Listing
September 2021

Inter-hairpin linker sequences determine the structure of the ββ-solenoid fold: a "bottom-up" study of pneumococcal LytA choline-binding module.

Int J Biol Macromol 2021 Sep 8;190:679-692. Epub 2021 Sep 8.

Centro de Investigaciones Biológicas Margarita Salas, Spanish National Research Council (CSIC), Madrid, Spain; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández, Elche, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Electronic address:

The ββ-solenoid structures are part of many proteins involved in the recognition of bacterial cell wall. They are elongated polypeptides consisting of repeated β-hairpins connected by linker sequences and disposed around a superhelical axis stabilised by short-range interactions. Among the most studied ββ-solenoids are those belonging to the family of choline-binding modules (CBMs) from the respiratory pathogen Streptococcus pneumoniae (pneumococcus) and its bacteriophages, and their properties have been employed to develop several biotechnological and biomedical tools. We have carried out a theoretical, spectroscopic and thermodynamic study of the ββ-solenoid structure of the CBM from the pneumococcal LytA autolysin using peptides of increasing length containing 1-3 repeats of this structure. Our results show that hints of native-like tertiary structure are only observed with a minimum of three β-hairpins, corresponding to one turn of the solenoid superhelix, and identify the linker sequences between hairpins as the major directors of the solenoid folding. This study paves the way for the rational structural engineering of ββ-solenoids aimed to find novel applications.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.08.223DOI Listing
September 2021

The Level of Processing Modulates Visual Awareness: Evidence from Behavioral and Electrophysiological Measures.

J Cogn Neurosci 2021 Jun;33(7):1295-1310

University of Turku.

The level of processing hypothesis (LoP) proposes that the transition from unaware to aware visual perception is graded for low-level (i.e., energy, features) stimulus whereas dichotomous for high-level (i.e., letters, words, meaning) stimulus. In this study, we explore the behavioral patterns and neural correlates associated with different depths (i.e., low vs. high) of stimulus processing. The low-level stimulus condition consisted of identifying the color (i.e., blue/blueish vs. red/reddish) of the target, and the high-level stimulus condition consisted of identifying stimulus category (animal vs. object). Behavioral results showed that the levels of processing manipulation produced significant differences in both the awareness rating distributions and accuracy performances between tasks, the low-level task producing more intermediate subjective ratings and linearly increasing accuracy performances and the high-level task producing less intermediate ratings and a more nonlinear pattern for accuracies. The electrophysiological recordings revealed two correlates of visual awareness, an enhanced posterior negativity in the N200 time window (visual awareness negativity [VAN]), and an enhanced positivity in the P3 time window (late positivity [LP]). The analyses showed a double dissociation between awareness and the level of processing hypothesis manipulation: Awareness modulated VAN amplitudes only in the low-level color task, whereas LP amplitude modulations were observed only in the higher level category task. These findings are compatible with a two-stage microgenesis model of conscious perception, where an early elementary phenomenal sensation of the stimulus (i.e., the subjective perception of color) would be indexed by VAN, whereas stimulus' higher level properties (i.e., the category of the target) would be reflected in the LP in a later latency range.
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http://dx.doi.org/10.1162/jocn_a_01712DOI Listing
June 2021
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