Publications by authors named "M Alagawany"

107 Publications

Propolis: properties and composition, health benefits and applications in fish nutrition.

Fish Shellfish Immunol 2021 Jun 18. Epub 2021 Jun 18.

Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt. Electronic address:

Propolis is a viscous, waxy, resinous substance that is produced from the exudates of flowers and buds by the action of salivary enzymes of honey bees. Propolis may differ in color (brown, red or green), with color being influenced by the chemical composition and age of the product. Propolis has a special distinctive odor owing to the high concentration of volatile essential oils. It is composed of 5% pollen grains, 10% essential and aromatic oils, 30% wax, 50% resin and balsams, and other minor trace substances. Natural propolis products may be useful for a range of applications in aquaculture systems instead of relying on the application of synthetic compounds to manage many ailments that affect business profitability. It has been reported in several studies that propolis enhances performance, economics, immunity response and disease resistance in different fish species. This present review discusses the functional actions of propolis and the prospects of its use as an antimicrobial, antioxidant, immune-modulatory, antiseptic, antiparasitic, anti-inflammatory and food additive in aquaculture production. In summary, propolis could be a natural supplement that has the potential to improve fish health status and immunity thereby enhancing growth and productivity of the fish industry as well as economic efficiency.
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http://dx.doi.org/10.1016/j.fsi.2021.06.010DOI Listing
June 2021

Effects of injection of polysaccharide on early growth, carcass weights and blood metabolites in broiler chickens.

Anim Biotechnol 2021 Jun 7:1-7. Epub 2021 Jun 7.

Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.

This study aimed to determine the impact of polysaccharide (AKP) injections on performance, carcass weights, and blood constituents in Cobb chicks. Un-sexed 1 day broiler chicks (250) were divided into five treatment groups with five replicates of 10 chicks per group. The groups were as follows: (1) negative control (without additive), (2) positive control (saline injection), (3) 1.5 mg AKP, (4) 3.0 mg AKP, and (5) 4.5 mg AKP injections. Apart from the control groups, no significant changes in body weight at 3 and 5 weeks of age, and daily weight gains during 0-3 weeks of age were detected among the treatment groups. Daily feed consumption was decreased in AKP groups, while feed conversion ratio was improved with AKP when compared to the PC. AKP injections significantly altered the lipid profile parameters, including total cholesterol, triglycerides, low-density lipoproteins, and very low-density lipoproteins in the plasma ( < 0.05); but there were no statistical differences in HDL ( > 0.001). AKP injections significantly impacted biochemical blood parameters, including total protein, albumin, and globulin, in broiler chicken plasma ( < 0.05). Liver and kidney functions were influenced by AKP injections in broilers. Antioxidant enzymes also changed significantly after injection with AKP. Moreover, injection of AKP significantly altered immunity (IgG and IgM) in broilers. In conclusion, injection of AKP significantly improved liver and kidney functions, antioxidant activity, and immune function in broilers.
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http://dx.doi.org/10.1080/10495398.2021.1924763DOI Listing
June 2021

The potential mechanistic insights and future implications for the effect of prebiotics on poultry performance, gut microbiome, and intestinal morphology.

Poult Sci 2021 Mar 23;100(7):101143. Epub 2021 Mar 23.

College of Animal Science, Zhejiang University, Hangzhou 310058, PR China. Electronic address:

Prebiotics may modify the biological processes in the chickens' gastrointestinal tract to improve poultry performance and health. Prebiotics are natural feed additives that offer many economic advantages by decreasing mortality rates, increasing growth rates, and improving birds' feed efficiency. Prebiotic action potentially affects the degradation of indigestible dietary compounds, the synthesis of nitrogen components and vitamins, and simplifies the removal of undesirable elements in the diet. Prebiotics could also induce desirable gut microbiome modifications and affect host metabolism and immune health. It is worth mentioning that gut bacteria metabolize the prebiotic compounds into organic compounds that the host can subsequently use. It is important to limit the concept of prebiotics to compounds that influence the metabolism of resident microorganisms. Any medicinal component or feed ingredient beneficial to the intestinal microecosystem can be considered a prebiotic. In this review, the impacts of prebiotics on the gut microbiome and physiological structure are discussed, emphasizing the poultry's growth performance. The current review will highlight the knowledge gaps in this area and future research directions.
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http://dx.doi.org/10.1016/j.psj.2021.101143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170421PMC
March 2021

Chloroquine and Hydroxychloroquine for the Prevention and Treatment of COVID-19: A Fiction, Hope or Hype? An Updated Review.

Ther Clin Risk Manag 2021 28;17:371-387. Epub 2021 Apr 28.

Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt.

In December 2019, the novel coronavirus disease pandemic (COVID-19) that began in China had infected so far more than 109,217,366 million individuals worldwide and accounted for more than 2,413,912 fatalities. With the dawn of this novel coronavirus (SARS-CoV-2), there was a requirement to select potential therapies that might effectively kill the virus, accelerate the recovery, or decrease the case fatality rate. Besides the currently available antiviral medications for human immunodeficiency virus (HIV) and hepatitis C virus (HCV), the chloroquine/hydroxychloroquine (CQ/HCQ) regimen with or without azithromycin has been repurposed in China and was recommended by the National Health Commission, China in mid-February 2020. By this time, the selection of this regimen was based on its efficacy against the previous SARS-CoV-1 virus and its potential to inhibit viral replication of the SARS-CoV-2 in vitro. There was a shortage of robust clinical proof about the effectiveness of this regimen against the novel SARS-CoV-2. Therefore, extensive research effort has been made by several researchers worldwide to investigate whether this regimen is safe and effective for the management of COVID-19. In this review, we provided a comprehensive overview of the CQ/HCQ regimen, summarizing data from in vitro studies and clinical trials for the protection against or the treatment of SARS-CoV-2. Despite the initial promising results from the in vitro studies and the widespread use of CQ/HCQ in clinical settings during the 1st wave of COVID-19, current data from well-designed randomized controlled trials showed no evidence of benefit from CQ/HCQ supplementation for the treatment or prophylaxis against SARS-CoV-2 infection. Particularly, the two largest randomized controlled trials to date (RECOVERY and WHO SOLIDARITY trials), both confirmed that CQ/HCQ regimen does not provide any clinical benefit for COVID-19 patients. Therefore, we do not recommend the use of this regimen in COVID-19 patients outside the context of clinical trials.
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http://dx.doi.org/10.2147/TCRM.S301817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092643PMC
April 2021

Use of lemongrass essential oil as a feed additive in quail's nutrition: its effect on growth, carcass, blood biochemistry, antioxidant and immunological indices, digestive enzymes and intestinal microbiota.

Poult Sci 2021 Jun 26;100(6):101172. Epub 2021 Mar 26.

Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

The present study was designed to assess the impact of dietary supplementation of lemongrass essential oil (LGEO) on growth performance, carcass traits, liver and kidney function, immunity, antioxidant indices and caecal microbiota of growing quail. A total of 200 Japanese quails at 1-week-old were haphazardly allotted to 5 groups of 40 chicks in five replicates (8 per replicate). The first group was the control group, while LGEO was added at levels of 150, 300, 450, and 600 mg/kg diet in the 2nd, 3rd, 4th and 5th groups, respectively. Dietary supplementation of LGEO (150, 300 and 450 mg/ kg diet) increased body weight at 3 and 5 wk of age, and increased body weight gain during all periods compared with the control group (P < 0.05). All levels of LGEO improved feed conversion ratio during the periods from 1 to 3 and 1 to 5 wk of age. During 3 to 5 wk, feed conversion ratio was improved in quails fed LGEO (300 and 450 mg/kg diet) compared with the control and other treatments. Carcass traits, plasma globulin, alanine aminotransferase, and urea values did not differ among the treatments (P > 0.05), but the activity of aspartate aminotransferase in the plasma was significantly decreased (P < 0.05) in LGEO-treated groups. The total protein and albumin values were significantly increased (P < 0.05) in quails fed levels of LGEO (except 600 mg/kg diet) compared with the control. The inclusion of LGEO in quail diets improved (P < 0.05) plasma lipid profile. The dietary supplementation of LGEO increased (linear and quadratic, P < 0.05) plasma immunoglobulins (IgM, IgG, and IgA) levels, lysozyme values and activities of superoxide dismutase, total antioxidant capacity, reduced glutathione and catalase compared with the control group. The caecal Coliform, E. coli and Salmonella were lowered (P < 0.0001) in the quails treated with all LGEO levels, but the total bacterial count and Lactobacillus count were increased with dietary supplementation of LGEO levels (300 and 450 mg/kg) compared with those in the control group. The activities of digestive enzymes were significantly higher in birds fed the diet supplemented with LGEO levels than those fed the control diet. In conclusion, dietary supplementation of LGEO can improve the performance, lipid profile, immunity and antioxidant indices and decline intestinal pathogens and thus boost the health status of growing quail.
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http://dx.doi.org/10.1016/j.psj.2021.101172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111249PMC
June 2021