Lyra Griffiths

Lyra Griffiths

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Lyra Griffiths

Lyra Griffiths

Publications by authors named "Lyra Griffiths"

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Nucleome Dynamics during Retinal Development.

Neuron 2019 Aug 21. Epub 2019 Aug 21.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.08.002DOI Listing
August 2019

Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses.

Cancer Cell 2018 09 23;34(3):411-426.e19. Epub 2018 Aug 23.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158019PMC
September 2018

Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures.

Cell Rep 2018 03;22(10):2601-2614

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872828PMC
March 2018

The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis.

Neuron 2017 May;94(3):550-568.e10

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508517PMC
May 2017

Reprogramming of mouse retinal neurons and standardized quantification of their differentiation in 3D retinal cultures.

Nat Protoc 2016 Oct 15;11(10):1955-1976. Epub 2016 Sep 15.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nprot.2016.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530375PMC
October 2016

Monitoring Ligand-Induced Protein Ordering in Drug Discovery.

J Mol Biol 2016 Mar 23;428(6):1290-1303. Epub 2016 Jan 23.

Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826315PMC
March 2016

Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors.

Cell Stem Cell 2015 Jul;17(1):101-15

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547539PMC
July 2015

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.

EMBO J 2014 Oct 6;33(19):2201-15. Epub 2014 Aug 6.

Massachusetts General Hospital Cancer Center and Harvard Medical School Laboratory of Molecular Oncology, Charlestown, MA, USA

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http://dx.doi.org/10.15252/embj.201488057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282507PMC
October 2014

The ATRX cDNA is prone to bacterial IS10 element insertions that alter its structure.

Springerplus 2014 2;3:222. Epub 2014 May 2.

Instituto de Fisiología Celular, Departamento de Genética Molecular, Universidad Nacional Autónoma de México, Ciudad Universitaria, México DF, México.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021028/
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https://www.researchgate.net/publication/312141402_ATRX_and_
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http://springerplus.springeropen.com/articles/10.1186/2193-1
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http://dx.doi.org/10.1186/2193-1801-3-222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021028PMC
May 2014

Regulation of base excision repair: Ntg1 nuclear and mitochondrial dynamic localization in response to genotoxic stress.

Nucleic Acids Res 2010 Jul 1;38(12):3963-74. Epub 2010 Mar 1.

Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1093/nar/gkq108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896512PMC
July 2010

Mitochondrial DNA oxidative damage and mutagenesis in Saccharomyces cerevisiae.

Methods Mol Biol 2009 ;554:267-86

Emory University School of Medicine, Atlanta, GA, USA.

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http://link.springer.com/10.1007/978-1-59745-521-3_17
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http://dx.doi.org/10.1007/978-1-59745-521-3_17DOI Listing
October 2009

Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress.

Mol Cell Biol 2009 Feb 24;29(3):794-807. Epub 2008 Nov 24.

Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1128/MCB.01357-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630693PMC
February 2009