Lynn Raymond

Lynn Raymond

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Lynn Raymond

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Dysfunctional striatal dopamine signaling in Huntington's disease.

J Neurosci Res 2019 Dec 15;97(12):1636-1654. Epub 2019 Jul 15.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/jnr.24495DOI Listing
December 2019

Alterations in synaptic function and plasticity in Huntington disease.

J Neurochem 2019 Aug 6;150(4):346-365. Epub 2019 Jun 6.

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, the University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/jnc.14723DOI Listing
August 2019

Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease.

Front Cell Neurosci 2019 16;13:209. Epub 2019 May 16.

Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fncel.2019.00209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532531PMC
May 2019

Altered Regulation of Striatal Neuronal -Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model.

Front Synaptic Neurosci 2019 21;11. Epub 2019 Feb 21.

Department of Psychiatry, Brain Research Centre and Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fnsyn.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393405PMC
February 2019

Direct assessment of presynaptic modulation of cortico-striatal glutamate release in a Huntington's disease mouse model.

J Neurophysiol 2018 12 17;120(6):3077-3084. Epub 2018 Oct 17.

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia , Vancouver, British Columbia , Canada.

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http://dx.doi.org/10.1152/jn.00638.2018DOI Listing
December 2018

Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease.

BMC Biol 2018 06 27;16(1):58. Epub 2018 Jun 27.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, V5Z 4H4, Canada.

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http://dx.doi.org/10.1186/s12915-018-0526-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020351PMC
June 2018

An Automated Home-Cage System to Assess Learning and Performance of a Skilled Motor Task in a Mouse Model of Huntington's Disease.

eNeuro 2017 Sep-Oct;4(5). Epub 2017 Sep 18.

Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://dx.doi.org/10.1523/ENEURO.0141-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602104PMC
May 2018

Cause or compensation?-Altered neuronal Ca handling in Huntington's disease.

CNS Neurosci Ther 2018 04 9;24(4):301-310. Epub 2018 Feb 9.

Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/cns.12817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489756PMC
April 2018

Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model.

J Neurosci 2018 01 30;38(3):544-554. Epub 2017 Nov 30.

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health,

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http://dx.doi.org/10.1523/JNEUROSCI.1739-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777109PMC
January 2018

Characteristics and outcomes of Canadian MD/PhD program graduates: a cross-sectional survey.

CMAJ Open 2017 Apr;5(2):E308-E314

Affiliations: Faculty of Medicine (Skinnider, Squair, Twa, Ji, Raymond), University of British Columbia, Vancouver, BC; Clinician-Investigator Training Association of Canada(Kuzyk, Wang, Steadman, Zaslavsky, Dey); Faculty of Health Sciences (Kuzyk, HayGlass), University of Manitoba, Winnipeg, Man.; Faculty of Medicine (Wang, Steadman, Zaslavsky, Dey, Rosenblum), University of Toronto, Toronto, Ont.; Faculty of Medicine (Eisenberg), McGill University, Montréal, Que.; Faculty of Medicine (Gagné), Université de Sherbrooke, Sherbrooke, Que.; Faculty of Medicine (Lewis), Western University, London, Ont.; Faculty of Medicine (Margetts), McMaster University, Hamilton, Ont.; Faculty of Medicine (Underhill), University of Alberta, Edmonton, Alta.; Canadian Society for Clinical Investigation (Underhill), Ottawa, Ont.

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http://dx.doi.org/10.9778/cmajo.20160152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498176PMC
April 2017

Striatal synaptic dysfunction and altered calcium regulation in Huntington disease.

Authors:
Lynn A Raymond

Biochem Biophys Res Commun 2017 02 14;483(4):1051-1062. Epub 2016 Jul 14.

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 4834-2255 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.07.058DOI Listing
February 2017

A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.

Neurology 2017 Jan 2;88(2):152-159. Epub 2016 Dec 2.

From Cooper University Healthcare at Rowan University (A.M.), Camden, NJ; University of Rochester (M.M., K.K., E.A.d.B., K.B., P.C.); Weill Cornell Medical Center (F.B.); Columbia Presbyterian Medical Center (K.M.), New York, NY; Johns Hopkins Medical Center (C.R.), Baltimore, MD; Georgetown University (I.S.), Washington, DC; NINDS (P.G.), Bethesda, MD; Hereditary Neurological Disease Center (W.M.M.), Wichita, KS; The Centre for Movement Disorders (M.G.), Toronto, Canada; Indiana University School of Medicine (J.W.), Indianapolis; Colorado Neurological Institute (R.K.), Englewood; University of Tennessee Health Science Center (M.S.L.), Memphis; London Health Sciences Centre (M.J.), Canada; Massachusetts General Hospital (H.D.R.), Boston; Struthers Parkinson's Center (M.N.), Minneapolis, MN; University of Kansas Medical Center (R.M.D.), Kansas City; Rush University Medical Center (K.M.S.), Chicago, IL; University of Texas Southwestern Medical Center (P.O.), Dallas; University of Michigan (K.C.), Ann Arbor; Wake Forest University (F.W.), Winston-Salem, NC; University of Alberta (W.M.), Edmonton, Canada; University of California Davis (V.L.W.), Sacramento; Westmead Hospital (E. McCusker), Westmead, Australia; Baylor College of Medicine (J.J.), Houston, TX; University of Miami Miller School of Medicine (C.S.), FL; University of South Florida (J.S.-R.), Tampa; Duke University (B.S.), Durham, NC; University of Calgary (O.S.), Canada; Emory University School of Medicine (S.A.F.), Atlanta, GA; Albany Medical College (D.S.H., Eric Molho), NY; University of Cincinnati (F.R.), OH; Mayo Clinic Arizona (J.N.C.), Scottsdale; Butler Hospital (J.H.F.), Providence, RI; Washington University (J.S.P.), St. Louis, MO; Feinstein Institute for Medical Research (A.F.), Manhasset, NY; Georgetown University (K.A.), Washington, DC; University of Florida (R.R., N.R.M.), Gainesville; Johns Hopkins University (R.L.M.), Baltimore, MD; University of Nevada School of Medicine (E.S.F.), Reno; University of British Columbia (L.A.R.), Vancouver, Canada; University of Pittsburgh (V.S.), PA; Ohio State University (S.K.), Columbus; The Cooper University Health System (A.C.), Camden, NJ; Idaho Elks Rehabilitation Hospital (L.S.), Boise, ID; University of Iowa (E.E.), Iowa City; North York General Hospital 1 (S.E.), Toronto, Canada; St. Luke's Hospital (N.D.), Allentown, PA; North York General Hospital 2 (W.L.A.F.), University of Toronto, Canada; Washington Regional Medical Center (A.D.), Fayetteville, AR; Beth-Israel Deaconess Medical Center (S.F.), Boston, MA; NJ Neuroscience Institute (P.H.), Edison; University of California Irvine (N.H.); The University of Alabama at Birmingham (L.S.D.); and Massachusetts General Hospital (M.C.), Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000003478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224719PMC
January 2017

Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice.

BMC Biol 2016 12 7;14(1):108. Epub 2016 Dec 7.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia (UBC), Vancouver, BC, V5Z 4H4, Canada.

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http://dx.doi.org/10.1186/s12915-016-0333-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142322PMC
December 2016

Influence of cortical synaptic input on striatal neuronal dendritic arborization and sensitivity to excitotoxicity in corticostriatal coculture.

J Neurophysiol 2016 08 27;116(2):380-90. Epub 2016 Apr 27.

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada; and

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http://dx.doi.org/10.1152/jn.00933.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969384PMC
August 2016

Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons.

J Huntingtons Dis 2012 ;1(1):89-96

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada ; Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3233/JHD-2012-129000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864911PMC
May 2016

Treatment of Huntington Disease and Comorbid Trichotillomania With Aripiprazole.

J Neuropsychiatry Clin Neurosci 2015 ;27(3):e211-2

University of British Columbia Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1176/appi.neuropsych.14090232DOI Listing
May 2016

Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models.

Nat Commun 2016 Apr 7;7:11251. Epub 2016 Apr 7.

Brain Research Centre and Djavad Mowafaghian Centre for Brain Health, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1Z3.

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http://dx.doi.org/10.1038/ncomms11251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829692PMC
April 2016

Impaired development of cortico-striatal synaptic connectivity in a cell culture model of Huntington's disease.

Neurobiol Dis 2016 Mar 19;87:80-90. Epub 2015 Dec 19.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.12.009DOI Listing
March 2016

Differential changes in thalamic and cortical excitatory synapses onto striatal spiny projection neurons in a Huntington disease mouse model.

Neurobiol Dis 2016 Feb 24;86:62-74. Epub 2015 Nov 24.

Department of Psychiatry, Brain Research Centre and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.11.020DOI Listing
February 2016

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.

Authors:
Kevin Michael Biglan Ira Shoulson Karl Kieburtz David Oakes Elise Kayson M Aileen Shinaman Hongwei Zhao Megan Romer Anne Young Steven Hersch Jack Penney Karen Marder Jane Paulsen Kimberly Quaid Eric Siemers Caroline Tanner William Mallonee Greg Suter Richard Dubinsky Carolyn Gray Martha Nance Scott Bundlie Dawn Radtke Sandra Kostyk Corrine Baic James Caress Francis Walker Victoria Hunt Christine O'Neill Sylvain Chouinard Stewart Factor Timothy Greenamyre Cathy Wood-Siverio Jody Corey-Bloom David Song Guerry Peavy Carol Moskowitz Melissa Wesson Ali Samii Thomas Bird Hillary Lipe Karen Blindauer Frederick Marshall Carol Zimmerman Jody Goldstein Diana Rosas Peter Novak John Caviness Charles Adler Amy Duffy Vicki Wheelock Teresa Tempkin David Richman Lauren Seeberger Roger Albin Kelvin L Chou Brad Racette Joel S Perlmutter Susan Perlman Yvette Bordelon Wayne Martin Marguerite Wieler Blair Leavitt Lynn Raymond Joji Decolongon Lorne Clarke Joseph Jankovic Christine Hunter Robert A Hauser Juan Sanchez-Ramos Sarah Furtado Oksana Suchowersky Mary Lou Klimek Mark Guttman Rustom Sethna Andrew Feigin Marie Cox Barbara Shannon Alan Percy Leon Dure Madaline Harrison William Johnson Donald Higgins Eric Molho Constance Nickerson Sharon Evans Douglas Hobson Carlos Singer Nestor Galvez-Jimenez Kathleen Shannon Cynthia Comella Christopher Ross Marie H Saint-Hilaire Claudia Testa Adam Rosenblatt Penelope Hogarth William Weiner Peter Como Rajeev Kumar Candace Cotto Julie Stout Alicia Brocht Arthur Watts Shirley Eberly Christine Weaver Tatiana Foroud James Gusella Marcy MacDonald Richard Myers Stanley Fahn Clifford Shults

JAMA Neurol 2016 Jan;73(1):102-10

Department of Neuroscience, University of California, San Diego, La Jolla.

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http://dx.doi.org/10.1001/jamaneurol.2015.2736DOI Listing
January 2016

Motor onset and diagnosis in Huntington disease using the diagnostic confidence level.

J Neurol 2015 Dec 26;262(12):2691-8. Epub 2015 Sep 26.

Department of Psychiatry, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.

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http://dx.doi.org/10.1007/s00415-015-7900-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666501PMC
December 2015

Region-specific pro-survival signaling and global neuronal protection by wild-type Huntingtin.

J Huntingtons Dis 2014 ;3(4):365-76

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.3233/JHD-140122DOI Listing
April 2015

Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of Huntington disease.

PLoS One 2014 11;9(4):e94562. Epub 2014 Apr 11.

Department of Psychiatry, Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094562PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984157PMC
January 2015

Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice.

Neurobiol Dis 2014 Nov 15;71:140-50. Epub 2014 Aug 15.

Department of Pharmacology, University of Washington, Seattle, WA USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180675PMC
November 2014

Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model.

J Neurochem 2014 Jul 2;130(1):145-59. Epub 2014 Apr 2.

Department of Psychiatry, Division of Neuroscience, Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/jnc.12700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065618PMC
July 2014

Mechanisms of synaptic dysfunction and excitotoxicity in Huntington's disease.

Drug Discov Today 2014 Jul 3;19(7):990-6. Epub 2014 Mar 3.

Department of Psychiatry and Brain Research Centre, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2014.02.006DOI Listing
July 2014

It's not necessarily all about the delivery in Huntington's disease.

Neuron 2014 Jul;83(1):6-8

Department of Psychiatry, Brain Research Centre and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Medicine, Brain Research Centre and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.06.009DOI Listing
July 2014

Extrasynaptic NMDA receptor involvement in central nervous system disorders.

Neuron 2014 Apr;82(2):279-93

Department of Psychiatry and Brain Research Centre, 2255 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.03.030DOI Listing
April 2014

Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice.

Neurobiol Dis 2014 Feb 19;62:533-42. Epub 2013 Nov 19.

Department of Psychiatry, Division of Neuroscience, Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.11.013DOI Listing
February 2014

Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin.

J Biol Chem 2014 Feb 17;289(6):3518-28. Epub 2013 Dec 17.

From the Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3 and.

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http://dx.doi.org/10.1074/jbc.M113.513945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916553PMC
February 2014

Memory and synaptic deficits in Hip14/DHHC17 knockout mice.

Proc Natl Acad Sci U S A 2013 Dec 25;110(50):20296-301. Epub 2013 Nov 25.

Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.

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http://dx.doi.org/10.1073/pnas.1222384110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864353PMC
December 2013

P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease.

Neurobiol Dis 2012 Mar 14;45(3):999-1009. Epub 2011 Dec 14.

Graduate Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.nbd.2011.12.019DOI Listing
March 2012

Synaptic dysfunction in progranulin-deficient mice.

Neurobiol Dis 2012 Feb 25;45(2):711-22. Epub 2011 Oct 25.

Centre for Molecular Medicine & Therapeutics, Department of Medical Genetics, University of British Columbia, and Children's and Women's Hospital, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1016/j.nbd.2011.10.016DOI Listing
February 2012

Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function.

Mol Cell Neurosci 2011 Dec 7;48(4):308-20. Epub 2011 May 7.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.mcn.2011.05.001DOI Listing
December 2011

N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95.

J Neurochem 2010 Nov 28;115(4):1045-56. Epub 2010 Sep 28.

Graduate Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06994.xDOI Listing
November 2010

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease.

Trends Neurosci 2010 Nov 17;33(11):513-23. Epub 2010 Sep 17.

Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1016/j.tins.2010.08.002DOI Listing
November 2010

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

J Neurosci 2010 Nov;30(45):15019-29

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics , Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4.

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http://dx.doi.org/10.1523/JNEUROSCI.2071-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074336PMC
November 2010

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.

J Neurosci 2009 Feb;29(7):2193-204

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4.

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http://dx.doi.org/10.1523/JNEUROSCI.5473-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729178PMC
February 2009

NMDA receptor desensitization regulated by direct binding to PDZ1-2 domains of PSD-95.

J Neurophysiol 2008 Jun 9;99(6):3052-62. Epub 2008 Apr 9.

Graduate Program in Neuroscience, University of British Columbia, 4N3-2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

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http://www.physiology.org/doi/10.1152/jn.90301.2008
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013345PMC
http://dx.doi.org/10.1152/jn.90301.2008DOI Listing
June 2008

Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors.

J Neurochem 2008 Feb 30;104(3):790-805. Epub 2007 Oct 30.

Graduate Program in Neuroscience, University of British Columbia, British Columbia, Canada.

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http://doi.wiley.com/10.1111/j.1471-4159.2007.05016.x
Publisher Site
http://dx.doi.org/10.1111/j.1471-4159.2007.05016.xDOI Listing
February 2008

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load.

J Physiol 2007 Dec 18;585(Pt 3):817-31. Epub 2007 Oct 18.

Deptartment of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada.

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http://dx.doi.org/10.1113/jphysiol.2007.142448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375504PMC
December 2007

Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.

J Neurosci 2007 Dec;27(50):13614-23

Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.

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http://dx.doi.org/10.1523/JNEUROSCI.3455-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673605PMC
December 2007

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease.

Prog Neurobiol 2007 Apr 22;81(5-6):272-93. Epub 2006 Dec 22.

Department of Psychiatry/Kinsmen Laboratories of Neurological Research, Brain Research Centre, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.pneurobio.2006.11.003DOI Listing
April 2007

Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease.

J Neurosci 2007 Apr;27(14):3768-79

Graduate Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.

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http://dx.doi.org/10.1523/JNEUROSCI.4356-06.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672397PMC
April 2007

Selective neuronal degeneration in Huntington's disease.

Curr Top Dev Biol 2006 ;75:25-71

Department of Psychiatry, Division of Neuroscience, Brain Research Centre University of British Columbia, Vancouver, British Columbia V6T 1Z3.

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http://dx.doi.org/10.1016/S0070-2153(06)75002-5DOI Listing
October 2006

Canadian Association of Neurosciences Review: polyglutamine expansion neurodegenerative diseases.

Can J Neurol Sci 2006 Aug;33(3):278-91

Department of Biochemistry and Biomedical Sciences McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1017/s031716710000514xDOI Listing
August 2006

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease.

Neurobiol Dis 2006 Feb 13;21(2):392-403. Epub 2005 Sep 13.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.nbd.2005.08.001DOI Listing
February 2006

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.

Neurobiol Dis 2006 Feb 17;21(2):444-55. Epub 2005 Oct 17.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1016/j.nbd.2005.08.007DOI Listing
February 2006

Wild-type huntingtin protects neurons from excitotoxicity.

J Neurochem 2006 Feb 17;96(4):1121-9. Epub 2006 Jan 17.

Centre for Molecular Medicine and Therapeutics, British Colombia Research Institute for Children's and Women's Health, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03605.xDOI Listing
February 2006

Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease.

J Neurophysiol 2004 Nov 7;92(5):2738-46. Epub 2004 Jul 7.

Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, 4N3-2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1152/jn.00308.2004DOI Listing
November 2004

Targeting energy metabolism in Huntington's disease.

Lancet 2004 Jul 24-30;364(9431):312-3

Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/S0140-6736(04)16739-1DOI Listing
August 2004

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease.

Mol Cell Neurosci 2004 Mar;25(3):469-79

Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.

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http://dx.doi.org/10.1016/j.mcn.2003.11.014DOI Listing
March 2004

Site within N-Methyl-D-aspartate receptor pore modulates channel gating.

Mol Pharmacol 2004 Jan;65(1):157-64

Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1124/mol.65.1.157DOI Listing
January 2004

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.

Neurobiol Aging 2003 Dec;24(8):1113-21

Kinsmen Laboratories, Department of Psychiatry, University of British Columbia, 4N3-2255 Westbrook Mall, BC, Vancouver, Canada V6T 1Z3.

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http://dx.doi.org/10.1016/j.neurobiolaging.2003.04.003DOI Listing
December 2003

Developmental decrease in NMDA receptor desensitization associated with shift to synapse and interaction with postsynaptic density-95.

J Neurosci 2003 Dec;23(35):11244-54

Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741033PMC
December 2003

Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro.

J Neurosci 2003 Apr;23(8):3364-72

Department of Physiology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742326PMC
April 2003

Differential regulation of synaptic and extra-synaptic NMDA receptors.

Nat Neurosci 2002 Sep;5(9):833-4

Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://dx.doi.org/10.1038/nn912DOI Listing
September 2002