Publications by authors named "Lynn Heasley"

67Publications

Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines.

Mol Pharmacol 2019 12 25;96(6):862-870. Epub 2019 Sep 25.

Departments of Craniofacial Biology (T.K.H., E.K.K., K.R.S., J.C., L.A.M., L.E.H.) and Medicine (J.K., A.C.T.), University of Colorado Anschutz Medical Campus, Aurora, Colorado

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December 2019

Translating mesothelioma molecular genomics and dependencies into precision oncology-based therapies.

Semin Cancer Biol 2020 04 20;61:11-22. Epub 2019 Sep 20.

Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States. Electronic address:

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April 2020

Therapeutic opportunity in innate immune response induction by oncogene-targeted drugs.

Future Med Chem 2019 05 14;11(10):1083-1086. Epub 2019 May 14.

Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

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May 2019

Linking tyrosine kinase inhibitor-mediated inflammation with normal epithelial cell homeostasis and tumor therapeutic responses.

Cancer Drug Resist 2018 19;1:118-125. Epub 2018 Sep 19.

Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.

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September 2018

Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) Isoform are Regulated through Binding to the Phosphatase Calcineurin.

Mol Pharmacol 2019 01 7;95(1):20-32. Epub 2018 Nov 7.

Department of Pharmacology (E.S.G., K.M.W., M.L.D.) and Department of Medicine, Division of Renal Diseases and Hypertension (R.A.N.), University of Colorado School of Medicine, Aurora, Colorado; Department of Craniofacial Biology, University of Colorado School of Dental Medicine, Aurora, Colorado (L.E.H.); Immune Disease Institute, Harvard Medical School, Boston, Massachusetts (H.L.); and La Jolla Institute for Allergy and Immunology, La Jolla, California (P.G.H.)

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January 2019

A miRNA Panel Predicts Sensitivity of FGFR Inhibitor in Lung Cancer Cell Lines.

Clin Lung Cancer 2018 09 28;19(5):450-456. Epub 2018 Jun 28.

Department of Medicine, Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address:

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September 2018

Mechanisms of rapid cancer cell reprogramming initiated by targeted receptor tyrosine kinase inhibitors and inherent therapeutic vulnerabilities.

Mol Cancer 2018 02 19;17(1):60. Epub 2018 Feb 19.

Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

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February 2018

Analysis of Drug Resistance Using Kinome-Wide Functional Screens.

Methods Mol Biol 2017 ;1636:163-177

Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., MS-8120, Aurora, CO, 80045, USA.

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April 2018

Therapy-induced E-cadherin downregulation alters expression of programmed death ligand-1 in lung cancer cells.

Lung Cancer 2017 07 19;109:1-8. Epub 2017 Apr 19.

Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave, RC-1 South, Aurora, CO 80045, USA.

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July 2017

Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC.

Cancer Res 2015 Oct 10;75(20):4398-406. Epub 2015 Sep 10.

Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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October 2015

Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data.

Bioinformatics 2015 Dec 23;31(23):3799-806. Epub 2015 Jul 23.

Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, Department of Medicine, Department of Computer Science and Engineering, Korea University, Seoul, Korea and Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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December 2015

Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer.

J Thorac Oncol 2015 Jul;10(7):1083-90

*Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Tongji University Institute, Shanghai, People's Republic of China; †Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado; ‡Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; §Institute of Pathology, University Hospital Cologne, Medical Centre, Cologne, Germany; ‖Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado; ¶Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado; and #Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Tongji University Institute, Shanghai, People's Republic of China.

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July 2015

FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers.

Clin Cancer Res 2015 Oct 26;21(19):4356-64. Epub 2015 May 26.

Section of Prostate Cancer Research, University Hospital of Bonn, Center for Integrated Oncology Cologne-Bonn, Bonn, Germany. Institute of Pathology, University Hospital of Bonn, Center for Integrated Oncology Cologne-Bonn, Bonn, Germany.

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October 2015

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.

PLoS One 2015 6;10(5):e0123600. Epub 2015 May 6.

Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America; Veterans Affairs Eastern Colorado Healthcare System, Denver, Colorado, United States of America.

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February 2016

FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area.

Ann Transl Med 2013 Oct;1(3):23

1 Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Germany ; 2 Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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October 2013

Hypoxia regulates alternative splicing of HIF and non-HIF target genes.

Mol Cancer Res 2014 Sep 21;12(9):1233-43. Epub 2014 May 21.

Molecular Biology Graduate Program and Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

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September 2014

Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy.

Bioinformatics 2014 Sep 7;30(17):2393-8. Epub 2014 May 7.

Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, Department of Medicine, National Jewish Health, 80206 Denver, Department of Craniofacial Biology, School of Dental Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, Department of Medicine, National Jewish Health, 80206 Denver, Department of Craniofacial Biology, School of Dental Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea.

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September 2014

FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies.

Clin Cancer Res 2014 Jun 25;20(12):3299-309. Epub 2014 Apr 25.

Authors' Affiliations: Departments of Medicine, Pathology, Craniofacial Biology, and Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado; ARIAD Pharmaceuticals, Inc., Cambridge, Massachusetts; Medical University of Gdańsk, Poland; and Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Bonn, Germany

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June 2014

Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.

PLoS One 2013 13;8(12):e82236. Epub 2013 Dec 13.

Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America.

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October 2014

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

Clin Cancer Res 2012 Mar 10;18(5):1472-82. Epub 2012 Jan 10.

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80209, USA.

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March 2012

Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells.

Clin Cancer Res 2011 Aug 14;17(15):5016-25. Epub 2011 Jun 14.

Departments of Craniofacial Biology and Radiation Oncology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO80045, USA.

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August 2011

Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors.

Cancer Res 2011 Mar 18;71(6):2087-97. Epub 2011 Feb 18.

Program in Cancer Biology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, USA.

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March 2011

Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.

PLoS One 2010 May 3;5(5):e10443. Epub 2010 May 3.

Division of Pharmacology and Toxicology, Center for Molecular and Cellular Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, United States of America.

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May 2010

The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer.

Drug Resist Updat 2009 Aug-Oct;12(4-5):95-102. Epub 2009 Jun 4.

Department of Medicine, University of Colorado at Denver Anschutz Medical Campus, Aurora, CO 80045, USA.

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March 2010

Analysis of Wnt7a-stimulated JNK activity and cJun phosphorylation in non-small cell lung cancer cells.

Methods Mol Biol 2008 ;468:187-96

Department of Medicine, University of Colorado Health Sciences Centre, Denver, USA.

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January 2009

Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB.

Mol Pharmacol 2008 Mar 30;73(3):709-17. Epub 2007 Nov 30.

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Box C-281, 4200 East 9th Avenue, Denver, CO 80262, USA.

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March 2008

Concise review: regulation of embryonic stem cell lineage commitment by mitogen-activated protein kinases.

Stem Cells 2007 May 11;25(5):1090-5. Epub 2007 Jan 11.

INSERM, U626, Faculté de Médecine, 27 Bd J Moulin, 13385 Marseille, France.

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May 2007

Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma.

J Biol Chem 2006 Sep 11;281(37):26943-50. Epub 2006 Jul 11.

Veterans Administration Medical Center, Denver, and Department of Medicine, University of Colorado Health Sciences Center, 80220, USA.

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September 2006

JNK regulation of oncogenesis.

Mol Cells 2006 Apr;21(2):167-73

Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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April 2006

Inhibited neurogenesis in JNK1-deficient embryonic stem cells.

Mol Cell Biol 2005 Dec;25(24):10791-802

Department of Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA.

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December 2005

Interferon-beta-induced activation of c-Jun NH2-terminal kinase mediates apoptosis through up-regulation of CD95 in CH31 B lymphoma cells.

Exp Cell Res 2005 Apr 19;304(2):518-30. Epub 2004 Dec 19.

Department of Immunology and Intractable Disease Research Center, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, 160-8402, Tokyo, Japan.

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April 2005

Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells.

J Cell Physiol 2004 Dec;201(3):459-69

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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December 2004

Signalling in stem cells: meeting on signal transduction determining the fate of stem cells.

EMBO Rep 2004 Mar 20;5(3):241-4. Epub 2004 Feb 20.

Department of Renal Medicine, C-281, University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Denver, Colorado 80262, USA.

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March 2004

Differential gene regulation by specific gain-of-function JNK1 proteins expressed in Swiss 3T3 fibroblasts.

J Biol Chem 2002 Dec 26;277(49):47167-74. Epub 2002 Sep 26.

Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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December 2002

Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells.

Mol Pharmacol 2002 Sep;62(3):689-97

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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September 2002

Collaboration of JNKs and ERKs in nerve growth factor regulation of the neurofilament light chain promoter in PC12 cells.

J Biol Chem 2002 Feb 3;277(6):4110-8. Epub 2001 Dec 3.

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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February 2002