Lynell W Klassen

Lynell W Klassen

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Lynell W Klassen

Publications by authors named "Lynell W Klassen"

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Review: Precision Cut Liver Slices for the Evaluation of Fatty Liver and Fibrosis.

Curr Mol Pharmacol 2017 ;10(3):249-254

Experimental Immunology Laboratory at the Omaha Veterans Administration Medical Center, Research Services 151, 4101 Woolworth Avenue, Omaha, NE 68105. United States.

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http://dx.doi.org/10.2174/1874467208666150817112345DOI Listing
February 2019

Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival.

Clin Exp Metastasis 2018 12 16;35(8):797-818. Epub 2018 Oct 16.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-6495, USA.

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http://link.springer.com/10.1007/s10585-018-9941-7
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http://dx.doi.org/10.1007/s10585-018-9941-7DOI Listing
December 2018

Immune regulation and anti-cancer activity by lipid inflammatory mediators.

Int Immunopharmacol 2018 Dec 14;65:580-592. Epub 2018 Nov 14.

University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198-6495, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183092
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http://dx.doi.org/10.1016/j.intimp.2018.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322683PMC
December 2018

Novel Antioxidant Properties of Doxycycline.

Int J Mol Sci 2018 Dec 17;19(12). Epub 2018 Dec 17.

Department of Internal Medicine, University of Nebraska Medical Center, 982650 Nebraska Medical Center, Omaha, NE 68198-2265, USA.

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http://www.mdpi.com/1422-0067/19/12/4078
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http://dx.doi.org/10.3390/ijms19124078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321135PMC
December 2018

Long-Chain Omega-3 Polyunsaturated Fatty Acids Modulate Mammary Gland Composition and Inflammation.

J Mammary Gland Biol Neoplasia 2018 06 25;23(1-2):43-58. Epub 2018 Mar 25.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1007/s10911-018-9391-5DOI Listing
June 2018

Liver tissue metabolically transformed by alcohol induces immune recognition of liver self-proteins but not in vivo inflammation.

Am J Physiol Gastrointest Liver Physiol 2018 03 28;314(3):G418-G430. Epub 2017 Dec 28.

Experimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.

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http://dx.doi.org/10.1152/ajpgi.00183.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899239PMC
March 2018

Malondialdehyde-acetaldehyde antibody concentrations in rheumatoid arthritis and other rheumatic conditions.

Int Immunopharmacol 2018 Mar 2;56:113-118. Epub 2018 Feb 2.

Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, United States; Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, United States.

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http://dx.doi.org/10.1016/j.intimp.2018.01.022DOI Listing
March 2018

Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology.

J Nutr Biochem 2018 02 4;52:92-102. Epub 2017 Oct 4.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2017.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996979PMC
February 2018

Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging.

Redox Biol 2017 10 2;13:588-593. Epub 2017 Aug 2.

Department of Internal Medicine, University of Nebraska Medical Center, 982650 Nebraska Medical Center, Omaha, NE 68198-2265, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552384PMC
October 2017

Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss.

PLoS One 2016 1;11(8):e0158735. Epub 2016 Aug 1.

Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158735PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968800PMC
August 2017

Systemic IL-6 Effector Response in Mediating Systemic Bone Loss Following Inhalation of Organic Dust.

J Interferon Cytokine Res 2017 01 22;37(1):9-19. Epub 2016 Nov 22.

1 Pulmonary, Critical Care, Sleep & Allergy Division, University of Nebraska Medical Center , The Nebraska Medical Center, Omaha, Nebraska.

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http://dx.doi.org/10.1089/jir.2016.0048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240004PMC
January 2017

Age Impacts Pulmonary Inflammation and Systemic Bone Response to Inhaled Organic Dust Exposure.

J Toxicol Environ Health A 2015 5;78(19):1201-16. Epub 2015 Oct 5.

a Pulmonary, Critical Care, Sleep & Allergy Division , University of Nebraska Medical Center , Omaha , Nebraska , USA.

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http://dx.doi.org/10.1080/15287394.2015.1075165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706168PMC
April 2016

Unique antibody responses to malondialdehyde-acetaldehyde (MAA)-protein adducts predict coronary artery disease.

PLoS One 2014 11;9(9):e107440. Epub 2014 Sep 11.

Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, Omaha, NE, United States of America; Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, United States of America; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107440PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161424PMC
October 2015

Precision-cut liver slices from diet-induced obese rats exposed to ethanol are susceptible to oxidative stress and increased fatty acid synthesis.

Am J Physiol Gastrointest Liver Physiol 2014 Feb 27;306(3):G208-17. Epub 2013 Nov 27.

Experimental Immunology Laboratory, Veterans Affairs Nebraska-Western Iowa Health Care System (VA NWIHCS), Omaha, Nebraska;

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http://dx.doi.org/10.1152/ajpgi.00124.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920111PMC
February 2014

IL-6 and its receptors in coronary artery disease and acute myocardial infarction.

Cytokine 2013 Jun 10;62(3):395-400. Epub 2013 Apr 10.

Experimental Immunology, Research in Cardiovascular Disease Laboratory, The University of Nebraska Medical Center, Wittson Hall Room 3004, 986350 Nebraska Medical Center, Omaha, NE 68198-6350, United States.

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http://dx.doi.org/10.1016/j.cyto.2013.03.020DOI Listing
June 2013

Polyclonal antibody to soman-tyrosine.

Chem Res Toxicol 2013 Apr 21;26(4):584-92. Epub 2013 Mar 21.

Eppley Institute, University of Nebraska Medical Center , Omaha, Nebraska 68198-5950, United States.

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http://dx.doi.org/10.1021/tx400027nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732541PMC
April 2013

Ultrasound imaging in an animal model of vascular inflammation following balloon injury.

Ultrasound Med Biol 2012 Sep 3;38(9):1552-8. Epub 2012 Jul 3.

Department of Internal Medicine, Division of Cardiology, Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2012.05.011DOI Listing
September 2012

A method for the making and utility of gadolinium-labeled albumin microbubbles.

Magn Reson Imaging 2012 Jan 6;30(1):96-103. Epub 2011 Nov 6.

Experimental Immunology, Research in Cardiovascular Disease Laboratory at the University of Nebraska Medical Center, Division of Cardiology, Department of Internal Medicine, 982265 Nebraska Medical Center, Omaha, NE 68198-2265, USA.

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http://dx.doi.org/10.1016/j.mri.2011.07.023DOI Listing
January 2012

Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites.

Alcohol Clin Exp Res 2010 Dec 22;34(12):2126-36. Epub 2010 Sep 22.

Experimental Immunology Laboratory, Department of Internal Medicine, Section of Rheumatology, University of Nebraska Medical Center, 983025 Nebraska Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2010.01309.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014581PMC
December 2010

Albumin-based microbubbles bind up-regulated scavenger receptors following vascular injury.

J Biol Chem 2010 Dec 21;285(52):40645-53. Epub 2010 Oct 21.

Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-6350, USA.

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http://dx.doi.org/10.1074/jbc.M110.134809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003363PMC
December 2010

Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis.

Free Radic Biol Med 2010 Nov 6;49(10):1480-6. Epub 2010 Aug 6.

Experimental Immunology Laboratory, Section of Rheumatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952714PMC
November 2010

Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis.

Am J Physiol Gastrointest Liver Physiol 2010 Sep 1;299(3):G661-8. Epub 2010 Jul 1.

Veterans Affairs Medical Center and the Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA.

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http://dx.doi.org/10.1152/ajpgi.00287.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950678PMC
September 2010

Alcohol metabolites and lipopolysaccharide: roles in the development and/or progression of alcoholic liver disease.

World J Gastroenterol 2009 Mar;15(10):1209-18

Department of Internal Medicine, University of Nebraska Medical Center, 986350 Nebraska Medical Center, Omaha, NE 68198-6350, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658861PMC
http://dx.doi.org/10.3748/wjg.15.1209DOI Listing
March 2009

Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde.

Int Immunopharmacol 2008 Aug 28;8(8):1112-8. Epub 2008 Apr 28.

University of Nebraska Medical Center, Department of Internal Medicine, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, United States.

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http://dx.doi.org/10.1016/j.intimp.2008.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518647PMC
August 2008

An in vitro method of alcoholic liver injury using precision-cut liver slices from rats.

Biochem Pharmacol 2008 Aug 21;76(3):426-36. Epub 2008 May 21.

Experimental Immunology Laboratory, University of Nebraska Medical Center, Department of Internal Medicine, Section of Rheumatology, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA.

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http://dx.doi.org/10.1016/j.bcp.2008.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845461PMC
August 2008

Formation and immunological properties of aldehyde-derived protein adducts following alcohol consumption.

Methods Mol Biol 2008 ;447:235-57

Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, OH, USA.

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http://dx.doi.org/10.1007/978-1-59745-242-7_17DOI Listing
May 2008

Immunological response in alcoholic liver disease.

World J Gastroenterol 2007 Oct;13(37):4938-46

Omaha VA Medical Center, Research Service 151, Rm 325, 4101 Woolworth Avenue, Omaha, NE 68105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434616PMC
http://dx.doi.org/10.3748/wjg.v13.i37.4938DOI Listing
October 2007

Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins.

Mol Pharmacol 2005 Nov 16;68(5):1423-30. Epub 2005 Aug 16.

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, Omaha, NE 68105, USA.

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http://dx.doi.org/10.1124/mol.105.016121DOI Listing
November 2005

Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol.

Biochem Pharmacol 2005 Nov 3;70(11):1593-600. Epub 2005 Oct 3.

University of Nebraska Medical Center, Department of Internal Medicine, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA.

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http://dx.doi.org/10.1016/j.bcp.2005.08.014DOI Listing
November 2005

Recent advances in alcohol-induced adduct formation.

Alcohol Clin Exp Res 2005 Jul;29(7):1310-6

University of Nebraska Medical Center and the Veterans Administration Medical Center, Omaha, Nebraska, USA.

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July 2005

Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines.

Chem Res Toxicol 2005 May;18(5):817-24

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.

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http://dx.doi.org/10.1021/tx0500676DOI Listing
May 2005

Halothane potentiates the alcohol-adduct induced TNF-alpha release in heart endothelial cells.

BMC Anesthesiol 2005 Apr 12;5(1). Epub 2005 Apr 12.

University of Nebraska Medical Center, Department of Internal Medicine, 988090 Nebraska Medical Center, Omaha, NE, 68198-3025, USA.

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http://dx.doi.org/10.1186/1471-2253-5-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1090549PMC
April 2005

Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells.

Alcohol Clin Exp Res 2004 Dec;28(12):1931-8

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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December 2004

Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity.

Front Biosci 2004 Sep 1;9:3145-55. Epub 2004 Sep 1.

University of Nebraska Medical Center, Department of Internal Medicine, 988090 Nebraska Medical Center, Omaha, NE 68198-8090, USA.

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September 2004

Immunologic mechanisms of alcoholic liver injury.

Semin Liver Dis 2004 Aug;24(3):273-87

University of Nebraska Medical Center, Department of Internal Medicine, Section of Rheumatology and Immunology, Nebraska Medical Center, Omaha, Nebraska 68198-3205, USA.

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http://dx.doi.org/10.1055/s-2004-832940DOI Listing
August 2004

Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage.

Int Immunopharmacol 2004 Jul;4(7):885-99

Department of Internal Medicine, University of Nebraska Medical Center, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA.

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http://dx.doi.org/10.1016/j.intimp.2004.04.004DOI Listing
July 2004

Malondialdehyde-acetaldehyde (MAA) modified proteins induce pro-inflammatory and pro-fibrotic responses by liver endothelial cells.

Comp Hepatol 2004 Jan 14;3 Suppl 1:S25. Epub 2004 Jan 14.

University of Nebraska Medical Center, Department of Internal Medicine, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA.

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http://dx.doi.org/10.1186/1476-5926-2-S1-S25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410244PMC
January 2004

T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated.

Int Immunopharmacol 2003 Oct;3(10-11):1381-99

Veterans Affairs Alcohol Research Center, Omaha Veterans Affairs Medical Center, 4101 Woolworth Ave., Omaha, NE 68105.

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http://dx.doi.org/10.1016/S1567-5769(03)00136-XDOI Listing
October 2003

Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells.

Biochem Pharmacol 2003 Sep;66(6):1045-54

Department of Internal Medicine, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE 68198-3025, USA.

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http://dx.doi.org/10.1016/s0006-2952(03)00416-7DOI Listing
September 2003

Malondialdehyde-acetaldehyde-haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells.

Int Immunopharmacol 2002 Mar;2(4):519-35

Department of Pathology, University of Texas Southwestern, Dallas 75390-9072, USA.

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March 2002

In vitro exposure to malondialdehyde-acetaldehyde adducted protein inhibits cell proliferation and viability.

Alcohol Clin Exp Res 2002 Feb;26(2):158-64

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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February 2002

Adduction of soluble proteins with malondialdehyde-acetaldehyde (MAA) induces antibody production and enhances T-cell proliferation.

Alcohol Clin Exp Res 2002 Jan;26(1):94-106

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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January 2002