Lyn-Marie Birkholtz

Lyn-Marie Birkholtz

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Lyn-Marie Birkholtz

Lyn-Marie Birkholtz

Publications by authors named "Lyn-Marie Birkholtz"

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50Publications

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Molecular Imaging of a Zirconium-89 Labeled Antibody Targeting Plasmodium falciparum-Infected Human Erythrocytes.

Mol Imaging Biol 2019 Apr 19. Epub 2019 Apr 19.

Preclinical Imaging Facility, The South African Nuclear Energy Corporation SOC Ltd (Necsa), Pelindaba, South Africa.

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http://link.springer.com/10.1007/s11307-019-01360-3
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http://dx.doi.org/10.1007/s11307-019-01360-3DOI Listing
April 2019

Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae).

Malar J 2019 Mar 8;18(1):65. Epub 2019 Mar 8.

Malaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag x20, Hatfield, 0028, South Africa.

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http://dx.doi.org/10.1186/s12936-019-2694-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408838PMC
March 2019

Ultra-low-density Plasmodium falciparum infections in African settings.

Clin Infect Dis 2019 Feb 15. Epub 2019 Feb 15.

Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control & MRC Collaborating Centre for Malaria Research, University of Pretoria, Private Bag x20, Hatfield, Pretoria, South Africa.

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http://dx.doi.org/10.1093/cid/ciz147DOI Listing
February 2019

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites.

Sci Rep 2018 Nov 8;8(1):16581. Epub 2018 Nov 8.

Department of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag x20, Hatfield, 0028, South Africa.

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http://dx.doi.org/10.1038/s41598-018-34964-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224408PMC
November 2018

Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids.

Bioorg Med Chem Lett 2018 10 28;28(19):3161-3163. Epub 2018 Aug 28.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.08.037DOI Listing
October 2018

Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa.

Malar J 2018 Mar 20;17(1):120. Epub 2018 Mar 20.

Malaria Parasite Molecular Laboratory, Department of Biochemistry, Institute for Sustainable Malaria Control & MRC Collaborating Centre for Malaria Research, University of Pretoria, Private Bag x20, Hatfield, Pretoria, 0028, South Africa.

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http://dx.doi.org/10.1186/s12936-018-2271-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859786PMC
March 2018

Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives.

Bioorg Med Chem Lett 2018 02 26;28(3):289-292. Epub 2017 Dec 26.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.12.057DOI Listing
February 2018

Preliminary Evaluation of Artemisinin-Cholesterol Conjugates as Potential Drugs for the Treatment of Intractable Forms of Malaria and Tuberculosis.

ChemMedChem 2018 01 15;13(1):67-77. Epub 2017 Dec 15.

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, 2520, South Africa.

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http://dx.doi.org/10.1002/cmdc.201700579DOI Listing
January 2018

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites.

ChemMedChem 2017 12 8;12(24):2086-2093. Epub 2017 Dec 8.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa.

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http://dx.doi.org/10.1002/cmdc.201700599DOI Listing
December 2017

Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites.

Sci Rep 2017 04 4;7(1):607. Epub 2017 Apr 4.

Department of Biochemistry, Institute for Sustainable Malaria Control, University of Pretoria, Private bag x20, Hatfield, Pretoria, South Africa.

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http://dx.doi.org/10.1038/s41598-017-00687-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428830PMC
April 2017

Resisting resistance: is there a solution for malaria?

Expert Opin Drug Discov 2016 29;11(4):395-406. Epub 2016 Feb 29.

a Department of Biochemistry, Centre for Sustainable Malaria Control, Faculty of Natural and Agricultural Sciences , University of Pretoria , Pretoria , South Africa.

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http://dx.doi.org/10.1517/17460441.2016.1154037DOI Listing
December 2016

Discovering New Transmission-Blocking Antimalarial Compounds: Challenges and Opportunities.

Trends Parasitol 2016 09 18;32(9):669-681. Epub 2016 May 18.

Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2016.04.017DOI Listing
September 2016

Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities.

Bioorg Med Chem Lett 2016 07 9;26(13):3006-3009. Epub 2016 May 9.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.05.024DOI Listing
July 2016

Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.

Bioorg Med Chem 2015 Aug 28;23(16):5131-43. Epub 2015 Jan 28.

Department of Biochemistry, Faculty of Natural and Agricultural Sciences, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag x20, Pretoria 0028, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.01.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517987PMC
August 2015

Morphological and Molecular Descriptors of the Developmental Cycle of Babesia divergens Parasites in Human Erythrocytes.

PLoS Negl Trop Dis 2015 May 8;9(5):e0003711. Epub 2015 May 8.

Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.

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http://dx.plos.org/10.1371/journal.pntd.0003711
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http://dx.doi.org/10.1371/journal.pntd.0003711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425553PMC
May 2015

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.

Malar J 2015 May 22;14:213. Epub 2015 May 22.

Malaria Parasite Molecular Laboratory, Centre for Sustainable Malaria Control, Department of Biochemistry, University of Pretoria, Private Bag x20, Hatfield, Pretoria, 0028, South Africa.

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http://dx.doi.org/10.1186/s12936-015-0718-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449569PMC
May 2015

A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail.

Malar J 2015 Feb 5;14:54. Epub 2015 Feb 5.

Department of Biochemistry, UP Centre for Sustainable Malaria Control, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag X20, Hatfield, 0028, South Africa.

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http://dx.doi.org/10.1186/s12936-015-0572-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342090PMC
February 2015

Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters.

Eur J Med Chem 2015 Jan 7;90:33-44. Epub 2014 Nov 7.

Center of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.11.016DOI Listing
January 2015

Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs.

Antimicrob Agents Chemother 2014 May 18;58(5):2586-97. Epub 2014 Feb 18.

Commissariat à l'Energie Atomique, Centre National de la Recherche Scientifique, Université Grenoble Alpes, Institut National de la Recherche Agronomique, Unité Mixte de Recherche 5168, Institut de Recherches en Technologies et Sciences pour le Vivant, Grenoble, France.

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http://dx.doi.org/10.1128/AAC.01445-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993238PMC
May 2014

Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites.

Int J Parasitol Drugs Drug Resist 2014 Apr 5;4(1):28-36. Epub 2013 Dec 5.

Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.

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http://dx.doi.org/10.1016/j.ijpddr.2013.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940083PMC
April 2014

Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum.

Biochem J 2013 Jan;449(1):175-87

Bernhard Nocht Institute for Tropical Medicine, Department of Biochemistry, Bernhard Nocht-Strasse 74, D-20359 Hamburg, Germany.

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http://dx.doi.org/10.1042/BJ20120925DOI Listing
January 2013

Sustainable malaria control: transdisciplinary approaches for translational applications.

Malar J 2012 Dec 26;11:431. Epub 2012 Dec 26.

Department of Biochemistry, University of Pretoria, Private Bag x20, Pretoria, Gauteng, South Africa 0028.

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http://dx.doi.org/10.1186/1475-2875-11-431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548719PMC
December 2012

Thermo-responsive non-woven scaffolds for "smart" 3D cell culture.

Biotechnol Bioeng 2012 Aug 24;109(8):2147-58. Epub 2012 Feb 24.

Biosciences, CSIR, PO Box 395, Pretoria 0002, South Africa.

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http://dx.doi.org/10.1002/bit.24469DOI Listing
August 2012

Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by natural product rubreserine.

J Biol Chem 2012 Jun 10;287(26):22367-76. Epub 2012 May 10.

Laboratoire de Physiologie Cellulaire Végétale, Commissariat à l'Energie Atomique/CNRS UMR5168/INRA USC1200/Université Joseph Fourier Grenoble I, Institut de Recherches en Technologies et Sciences pour le Vivant, F-38054 Grenoble, France.

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http://dx.doi.org/10.1074/jbc.M112.365833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381196PMC
June 2012

Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum.

Mol Biochem Parasitol 2011 Nov 22;180(1):17-26. Epub 2011 Jul 22.

Department of Biochemistry, University of Pretoria, Hatfield, South Africa.

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http://dx.doi.org/10.1016/j.molbiopara.2011.07.004DOI Listing
November 2011

Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities.

J Med Chem 2011 Oct 14;54(19):6624-33. Epub 2011 Sep 14.

Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, PO Box x20, Pretoria, 0028, South Africa.

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http://pubs.acs.org/doi/abs/10.1021/jm200463z
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http://dx.doi.org/10.1021/jm200463zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191323PMC
October 2011

Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities.

Biochem J 2011 Sep;438(2):229-44

Department of Biochemistry, University of Pretoria, Hatfield, South Africa.

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http://dx.doi.org/10.1042/BJ20110362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253432PMC
September 2011

Proteomic profiling of Plasmodium falciparum through improved, semiquantitative two-dimensional gel electrophoresis.

J Proteome Res 2010 May;9(5):2170-81

Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, 0002, South Africa.

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http://dx.doi.org/10.1021/pr9009244DOI Listing
May 2010

Transcriptional responses of Plasmodium falciparum to alpha-difluoromethylornithine-induced polyamine depletion.

Biol Chem 2008 Feb;389(2):111-25

Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa.

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http://dx.doi.org/10.1515/BC.2008.014DOI Listing
February 2008

Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study.

Malar J 2007 May 22;6:64. Epub 2007 May 22.

Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa.

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http://dx.doi.org/10.1186/1475-2875-6-64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890295PMC
May 2007

Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase.

Bioorg Med Chem 2007 Feb 13;15(4):1628-37. Epub 2006 Dec 13.

Bioinformatics and Computational Biology Unit, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa.

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http://dx.doi.org/10.1016/j.bmc.2006.12.017DOI Listing
February 2007

Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling.

J Mol Graph Model 2006 Jan 27;24(4):307-18. Epub 2005 Oct 27.

Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa.

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http://dx.doi.org/10.1016/j.jmgm.2005.09.011DOI Listing
January 2006

Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.

Biochem J 2004 Jan;377(Pt 2):439-48

Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, 0002, South Africa.

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http://dx.doi.org/10.1042/BJ20030614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223860PMC
January 2004