Publications by authors named "Lyle Armstrong"

84Publications

Room temperature shipment does not affect the biological activity of pluripotent stem cell-derived retinal organoids.

PLoS One 2020 1;15(6):e0233860. Epub 2020 Jun 1.

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, England, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233860PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263587PMC
August 2020

Differentiation of Retinal Organoids from Human Pluripotent Stem Cells.

Curr Protoc Stem Cell Biol 2019 09;50(1):e95

Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle upon Tyne, United Kingdom.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cpsc.95
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http://dx.doi.org/10.1002/cpsc.95DOI Listing
September 2019

Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations.

Mol Pharmacol 2019 10 9;96(4):475-484. Epub 2019 Aug 9.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom (M.A., R.L.S., C.R., K.C.L., I.G.C., C.A.A.) and Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom (D.C.L., L.A.)

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http://dx.doi.org/10.1124/mol.119.117259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744389PMC
October 2019

Endothelial Differentiation G Protein-Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency.

Stem Cells 2019 03 7;37(3):318-331. Epub 2019 Feb 7.

International Centre for Life, Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom.

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http://doi.wiley.com/10.1002/stem.2954
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http://dx.doi.org/10.1002/stem.2954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446721PMC
March 2019

Hepatic differentiation of human iPSCs in different 3D models: A comparative study.

Int J Mol Med 2017 Dec 16;40(6):1759-1771. Epub 2017 Oct 16.

Bioreactor Group, Berlin Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, D-13353 Berlin, Germany.

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http://dx.doi.org/10.3892/ijmm.2017.3190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716452PMC
December 2017

Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion.

Toxicol In Vitro 2017 Dec 15;45(Pt 3):445-454. Epub 2017 Aug 15.

Division of Molecular and Computational toxicology, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2017.07.023DOI Listing
December 2017

A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs.

Sci Rep 2017 02 3;7:41693. Epub 2017 Feb 3.

Institute of Genetic Medicine, Newcastle University, International Centre for Life, NE1 3BZ, UK.

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http://dx.doi.org/10.1038/srep41693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290526PMC
February 2017

Concise Review: Getting to the Core of Inherited Bone Marrow Failures.

Stem Cells 2017 02 4;35(2):284-298. Epub 2016 Dec 4.

Institute of Genetic Medicine, Newcastle University, United Kingdom.

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http://dx.doi.org/10.1002/stem.2543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299470PMC
February 2017

JNK/SAPK Signaling Is Essential for Efficient Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells.

Stem Cells 2016 05 4;34(5):1198-212. Epub 2016 Mar 4.

Institute of Genetic Medicine, International Centre for Life and Centre for Integrated Systems Biology of Ageing and Nutrition.

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http://dx.doi.org/10.1002/stem.2327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982072PMC
May 2016

Primordial Germ Cells: Current Knowledge and Perspectives.

Stem Cells Int 2016 9;2016:1741072. Epub 2015 Nov 9.

Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000 Kragujevac, Serbia ; Spebo Medical, Norvezanska 16, 16 000 Leskovac, Serbia.

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http://dx.doi.org/10.1155/2016/1741072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655300PMC
December 2015

Brief Report: Inhibition of miR-145 Enhances Reprogramming of Human Dermal Fibroblasts to Induced Pluripotent Stem Cells.

Stem Cells 2016 Jan 9;34(1):246-51. Epub 2015 Oct 9.

Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/stem.2220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982107PMC
January 2016

Aging of Stem and Progenitor Cells: Mechanisms, Impact on Therapeutic Potential, and Rejuvenation.

Rejuvenation Res 2016 Feb;19(1):3-12

2 Centre for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac , Kragujevac, Serbia .

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http://dx.doi.org/10.1089/rej.2015.1676DOI Listing
February 2016

Concise Review: Cardiac Disease Modeling Using Induced Pluripotent Stem Cells.

Stem Cells 2015 Sep 23;33(9):2643-51. Epub 2015 Jun 23.

Institute of Genetic Medicine, Newcastle University, The International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/stem.2070DOI Listing
September 2015

Generation of Human Induced Pluripotent Stem Cells Using RNA-Based Sendai Virus System and Pluripotency Validation of the Resulting Cell Population.

Methods Mol Biol 2016 ;1353:285-307

Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1007/7651_2015_205DOI Listing
August 2016

Engraftment's Holy Grail: is one signal enough?

Blood 2014 Nov;124(20):3035-6

NEWCASTLE UNIVERSITY.

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http://dx.doi.org/10.1182/blood-2014-09-600452DOI Listing
November 2014

Concise review: the epigenetic contribution to stem cell ageing: can we rejuvenate our older cells?

Stem Cells 2014 Sep;32(9):2291-8

Institute of Genetic Medicine, Newcastle University, The International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/stem.1720DOI Listing
September 2014

An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes.

Stem Cells Transl Med 2014 Apr 3;3(4):416-23. Epub 2014 Mar 3.

Institute of Genetic Medicine and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom; Soochow University, Su Zhou, China; Princess Al Jawhara Center of Excellence in Research, King Abdulaziz University, Jeddah, Saudi Arabia; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic; Institute of Cardiovascular Science, Manchester Academic Health Science Centre, CoreTechnology Facility, Manchester, United Kingdom; School of Biomedical Sciences, University of Durham, Durham, United Kingdom; Department of Human Genetics, University of Kragujevac, Kragujevac, Serbia.

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http://dx.doi.org/10.5966/sctm.2013-0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973710PMC
April 2014

A putative role for the immunoproteasome in the maintenance of pluripotency in human embryonic stem cells.

Stem Cells 2012 Jul;30(7):1373-84

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://doi.wiley.com/10.1002/stem.1113
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http://dx.doi.org/10.1002/stem.1113DOI Listing
July 2012

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.

Authors:
Katherine Amps Peter W Andrews George Anyfantis Lyle Armstrong Stuart Avery Hossein Baharvand Julie Baker Duncan Baker Maria B Munoz Stephen Beil Nissim Benvenisty Dalit Ben-Yosef Juan-Carlos Biancotti Alexis Bosman Romulo Martin Brena Daniel Brison Gunilla Caisander María V Camarasa Jieming Chen Eric Chiao Young Min Choi Andre B H Choo Daniel Collins Alan Colman Jeremy M Crook George Q Daley Anne Dalton Paul A De Sousa Chris Denning Janet Downie Petr Dvorak Karen D Montgomery Anis Feki Angela Ford Victoria Fox Ana M Fraga Tzvia Frumkin Lin Ge Paul J Gokhale Tamar Golan-Lev Hamid Gourabi Michal Gropp Guangxiu Lu Ales Hampl Katie Harron Lyn Healy Wishva Herath Frida Holm Outi Hovatta Johan Hyllner Maneesha S Inamdar Astrid Kresentia Irwanto Tetsuya Ishii Marisa Jaconi Ying Jin Susan Kimber Sergey Kiselev Barbara B Knowles Oded Kopper Valeri Kukharenko Anver Kuliev Maria A Lagarkova Peter W Laird Majlinda Lako Andrew L Laslett Neta Lavon Dong Ryul Lee Jeoung Eun Lee Chunliang Li Linda S Lim Tenneille E Ludwig Yu Ma Edna Maltby Ileana Mateizel Yoav Mayshar Maria Mileikovsky Stephen L Minger Takamichi Miyazaki Shin Yong Moon Harry Moore Christine Mummery Andras Nagy Norio Nakatsuji Kavita Narwani Steve K W Oh Sun Kyung Oh Cia Olson Timo Otonkoski Fei Pan In-Hyun Park Steve Pells Martin F Pera Lygia V Pereira Ouyang Qi Grace Selva Raj Benjamin Reubinoff Alan Robins Paul Robson Janet Rossant Ghasem H Salekdeh Thomas C Schulz Karen Sermon Jameelah Sheik Mohamed Hui Shen Eric Sherrer Kuldip Sidhu Shirani Sivarajah Heli Skottman Claudia Spits Glyn N Stacey Raimund Strehl Nick Strelchenko Hirofumi Suemori Bowen Sun Riitta Suuronen Kazutoshi Takahashi Timo Tuuri Parvathy Venu Yuri Verlinsky Dorien Ward-van Oostwaard Daniel J Weisenberger Yue Wu Shinya Yamanaka Lorraine Young Qi Zhou

Nat Biotechnol 2011 Nov 27;29(12):1132-44. Epub 2011 Nov 27.

Centre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, UK.

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http://www.nature.com/articles/nbt.2051
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http://dx.doi.org/10.1038/nbt.2051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454460PMC
November 2011

Epigenetic control of embryonic stem cell differentiation.

Authors:
Lyle Armstrong

Stem Cell Rev Rep 2012 Mar;8(1):67-77

Institute of Genetic Medicine, Newcastle University, The International Centre for Life, Central Parkway, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s12015-011-9300-4DOI Listing
March 2012

An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.

Stem Cells 2011 Apr;29(4):651-9

Institute of Human Genetics, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/stem.620DOI Listing
April 2011

Opposing putative roles for canonical and noncanonical NFκB signaling on the survival, proliferation, and differentiation potential of human embryonic stem cells.

Stem Cells 2010 Nov;28(11):1970-80

Institute of Human Genetics, International Centre for Life, Newcastle University, Newcastle Upon Tyne, United Kingdom.

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http://doi.wiley.com/10.1002/stem.528
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http://dx.doi.org/10.1002/stem.528DOI Listing
November 2010

Nanog regulates primordial germ cell migration through Cxcr4b.

Stem Cells 2010 Sep;28(9):1457-64

Instituto de Investigación Sanitaria, Fundación para la Investigación Hospital La Fe, Valencia, Spain.

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http://dx.doi.org/10.1002/stem.469DOI Listing
September 2010

Expression of GFP under the control of the RNA helicase VASA permits fluorescence-activated cell sorting isolation of human primordial germ cells.

Stem Cells 2010 Jan;28(1):84-92

North East Stem Cell Institute, Newcastle University, International Centre for Life, NE1 3BZ, United Kingdom.

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http://doi.wiley.com/10.1002/stem.263
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http://dx.doi.org/10.1002/stem.263DOI Listing
January 2010

Epigenetic landscaping during hESC differentiation to neural cells.

Stem Cells 2009 Jun;27(6):1298-308

Institute of Human Genetics, University of Newcastle Upon Tyne, International Centre for Life, United Kingdom.

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http://dx.doi.org/10.1002/stem.59DOI Listing
June 2009

G1 to S transition and pluripotency: two sides of the same coin?

Cell Cycle 2009 Apr 26;8(8):1108-9. Epub 2009 Apr 26.

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April 2009

Isolation of primordial germ cells from differentiating human embryonic stem cells.

Stem Cells 2008 Dec 18;26(12):3075-85. Epub 2008 Sep 18.

North East Institute for Stem Cell Research, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

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http://doi.wiley.com/10.1634/stemcells.2008-0289
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http://dx.doi.org/10.1634/stemcells.2008-0289DOI Listing
December 2008

Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells.

Regen Med 2008 Jul;3(4):505-22

North East Institute for Stem Cell Research, Newcastle University International Centre for Life, Newcastle NE13BZ, UK.

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http://dx.doi.org/10.2217/17460751.3.4.505DOI Listing
July 2008

A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells.

Stem Cells 2008 Jun 20;26(6):1609-19. Epub 2008 Mar 20.

North East Stem Cell Institute and, Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1634/stemcells.2007-0782DOI Listing
June 2008

Epigenetic marking prepares the human HOXA cluster for activation during differentiation of pluripotent cells.

Stem Cells 2008 May 21;26(5):1174-85. Epub 2008 Feb 21.

North East Institute for Stem Cell Research, University of Newcastle upon Tyne, International Centre for Life, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1634/stemcells.2007-0497DOI Listing
May 2008

Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.

Stem Cells 2008 Feb 29;26(2):455-64. Epub 2007 Nov 29.

Crucible Lab, Institute of Human Genetics, Central Parkway, Newcastle upon Tyne NE1 3BZ, United Kingdom.

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http://dx.doi.org/10.1634/stemcells.2007-0628DOI Listing
February 2008

Epigenetics in embryonic stem cells: regulation of pluripotency and differentiation.

Cell Tissue Res 2008 Jan 15;331(1):23-9. Epub 2007 Nov 15.

Institute of Human Genetics, Newcastle University, Newcastle, UK.

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http://dx.doi.org/10.1007/s00441-007-0536-xDOI Listing
January 2008

The future of human nuclear transfer?

Stem Cell Rev 2006 ;2(4):351-8

Centre For Stem Cell Biology and Developmental Genetics, University of Newcastle, International Centre for Life, Central Parkway, UK.

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http://dx.doi.org/10.1007/BF02698062DOI Listing
October 2007

Differentiation of human embryonic stem cells into corneal epithelial-like cells by in vitro replication of the corneal epithelial stem cell niche.

Stem Cells 2007 May 25;25(5):1145-55. Epub 2007 Jan 25.

Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1634/stemcells.2006-0516DOI Listing
May 2007

Derivation of human embryonic stem cells from developing and arrested embryos.

Stem Cells 2006 Dec 21;24(12):2669-76. Epub 2006 Sep 21.

Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, Newcastle upon Tyne, United Kingdom.

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http://doi.wiley.com/10.1634/stemcells.2006-0377
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http://dx.doi.org/10.1634/stemcells.2006-0377DOI Listing
December 2006

The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.

Hum Mol Genet 2006 Jun 27;15(11):1894-913. Epub 2006 Apr 27.

Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, University of Newcastle, Central Parkways, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/hmg/ddl112DOI Listing
June 2006

Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer.

Stem Cells 2006 Apr 10;24(4):805-14. Epub 2005 Nov 10.

Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, International Centre for Life, Newcastle upon Tyne NE1 3BZ, UK.

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http://dx.doi.org/10.1634/stemcells.2005-0350DOI Listing
April 2006

Human embryonic stem cells: biology and clinical implications.

Expert Rev Mol Med 2005 Sep 19;7(19):1-21. Epub 2005 Sep 19.

Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, ICFL, Central Parkway, Newcastle, NE1 3BZ, UK.

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http://dx.doi.org/10.1017/S1462399405009804DOI Listing
September 2005

Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes.

Reprod Biomed Online 2005 Aug;11(2):226-31

Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, UK.

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http://dx.doi.org/10.1016/s1472-6483(10)60962-5DOI Listing
August 2005

Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages.

Stem Cells 2005 Sep 27;23(8):1035-43. Epub 2005 Jun 27.

Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle International Centre for Life, Newcastle NE1 3BZ, United Kingdom.

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http://doi.wiley.com/10.1634/stemcells.2005-0080
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http://dx.doi.org/10.1634/stemcells.2005-0080DOI Listing
September 2005

Human-serum matrix supports undifferentiated growth of human embryonic stem cells.

Stem Cells 2005 Aug 11;23(7):895-902. Epub 2005 May 11.

Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1634/stemcells.2004-0326DOI Listing
August 2005

An autogeneic feeder cell system that efficiently supports growth of undifferentiated human embryonic stem cells.

Stem Cells 2005 Mar;23(3):306-14

Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK.

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http://dx.doi.org/10.1634/stemcells.2004-0137DOI Listing
March 2005

Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity.

Stem Cells 2004 ;22(7):1142-51

Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1634/stemcells.2004-0170DOI Listing
May 2005

Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells.

Stem Cells 2004 ;22(6):962-71

Henry Wellcome Laboratory for Biogerontology, Newcastle General Hospital, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK.

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http://dx.doi.org/10.1634/stemcells.22-6-962DOI Listing
April 2005

A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation.

Mech Dev 2004 Dec;121(12):1509-22

School of Biological and Biomedical Sciences, University of Durham, South Road, Durham DH1 3LE, UK.

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http://dx.doi.org/10.1016/j.mod.2004.07.005DOI Listing
December 2004

Hair follicle dermal cells repopulate the mouse haematopoietic system.

J Cell Sci 2002 Oct;115(Pt 20):3967-74

Department of Biological Sciences, South Road, University of Durham, Durham DH1 3LE, UK.

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http://dx.doi.org/10.1242/jcs.00060DOI Listing
October 2002