Publications by authors named "Lydie Humbert"

37Publications

Distinct Postprandial Bile Acids Responses to a High-Calorie Diet in Men Volunteers Underscore Metabolically Healthy and Unhealthy Phenotypes.

Nutrients 2020 Nov 19;12(11). Epub 2020 Nov 19.

Institut National de la Santé et de la Recherche Médicale (INSERM, UMR_S 1166-ICAN), Research Institute of Cardiovascular Disease, Metabolism and Nutrition, Faculté de Médecine-Hôpital Pitié-Salpêtrière, Sorbonne Université, F-75013 Paris, France.

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November 2020

Variations in gastrointestinal lipases, pH and bile acid levels with food intake, age and diseases: Possible impact on oral lipid-based drug delivery systems.

Adv Drug Deliv Rev 2019 03 26;142:3-15. Epub 2019 Mar 26.

Aix-Marseille Université, CNRS, UMR7281 Bioénergétique et Ingénierie des Protéines, 31 chemin Joseph Aiguier, 13402 Marseille cedex 09, France. Electronic address:

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March 2019

Inhibitory Effect of Ursodeoxycholic Acid on Germination Is Insufficient to Prevent Colitis: A Study in Hamsters and Humans.

Front Microbiol 2018 22;9:2849. Epub 2018 Nov 22.

INSERM U1149, Centre de Recherche sur l'Inflammation, Faculté de Médecine Paris Diderot, Université Paris Diderot, Paris, France.

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November 2018

Antipruritic effect of bezafibrate and serum autotaxin measures in patients with primary biliary cholangitis.

Gut 2019 10 18;68(10):1902-1903. Epub 2018 Sep 18.

Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, Saint-Antoine Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.

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October 2019

Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients.

J Lipid Res 2018 11 11;59(11):2202-2213. Epub 2018 Sep 11.

CNRS, Aix-Marseille Université, UMR 7281 Bioénergétique et Ingénerie des Protéines, Marseille, France

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November 2018

Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis.

Aliment Pharmacol Ther 2018 11 24;48(9):961-974. Epub 2018 Aug 24.

Inflammation Chimiokines et Immunopathologie, DHU Hepatinov, Faculté de Médecine-Université Paris-Sud/Université Paris-Saclay, INSERM, UMR-S 996, Clamart, France.

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November 2018

A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis.

N Engl J Med 2018 Jun;378(23):2171-2181

From the Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, Hepatology and Gastroenterology Department, Saint-Antoine University Hospital, Assistance Publique-Hôpitaux de Paris (APHP) (C.C., O.C., S.L., F.G., R.P.), INSERM Unité Mixte de Recherche (UMR) S938 (C.C., O.C., S.L., R.P.) and the Biochemistry Laboratory (L.H., D.R.), Saint-Antoine University Hospital, APHP, INSERM Unité 1157/UMR 7203, Sorbonne University, the Biochemistry Laboratory, Tenon University Hospital, APHP (G.L.), and the Immunology Laboratory, INSERM UMR S996, Bichat University Hospital, APHP (L.C., S.C.-M.), Paris-Sud University, the Department of Clinical Pharmacology and Clinical Research Platform of the East of Paris, APHP (A.R., F.-H.A., T.S.), and Sorbonne University (T.S.), Paris, the Hepatology and Gastroenterology Department, Rouen University Hospital, Rouen (O.G.), the Hepatology and Gastroenterology Department, Pontchaillou University Hospital, Rennes (A.L.G.), the Hepatology and Gastroenterology Department, University Hospitals of Strasbourg, Institute of Viral and Liver Diseases, INSERM Unité 1110, Laboratory of Excellence HepSYS, University of Strasbourg, Strasbourg (F.H.), the Hepatology and Gastroenterology Department, Claude Huriez University Hospital, Lille (P.M.), the Hepatology and Gastroenterology Department, Orleans Hospital, Orleans (P.P.), the Hepatology and Gastroenterology Department, Dijon Bourgogne University Hospital, Dijon (A.M.), the Hepatology and Gastroenterology Department, University Hospital of Poitiers, Poitiers (C.S.), the Hepatology and Gastroenterology Department, Estaing University Hospital, Clermont-Ferrand (A.A.), the Hepatology and Gastroenterology Department, University Hospital of Limoges, Limoges (M.D.-G.), the Hepatology and Gastroenterology Department, Saint-Eloi University Hospital, Montpellier (D.L.), the Hepatology Department, Beaujon University Hospital, Clichy (O.R.), the Hepatology and Gastroenterology Department, Brabois University Hospital, Nancy (J.-P.B.), the Hepatology and Gastroenterology Department, University Hospital of Angers, Hemodynamics, Interaction, Fibrosis, and Tumor Invasiveness in Hepatic and Digestive Organs Laboratory, Unité Propre de Recherche de l'Enseignement Supérieur 3859, Structures Fédératives de Recherche 4208, Bretagne Loire University, Angers (J.B.), the Hepatology and Gastroenterology Department, Haut-Lévêque University Hospital, Pessac (V.L.), the Hepatology and Gastroenterology Department, Robert Debré University Hospital, Reims (A.H.-B.), the Hepatology and Gastroenterology Department, University Hospital of Amiens, Amiens (E.N.-K.), the Hepatology and Gastroenterology Department, Croix-Rousse University Hospital, Lyon (F.Z.), the Hepatology and Gastroenterology Department, University Hospital of Caen, Caen (I.O.-H.), the Hepatology and Gastroenterology Department, Michallon University Hospital, Grenoble (J.-P.Z.), and the Hepatology and Gastroenterology Department, Jean Verdier University Hospital, Bondy (G.N.) - all in France.

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June 2018

Roux-en-Y Gastric-Bypass and sleeve gastrectomy induces specific shifts of the gut microbiota without altering the metabolism of bile acids in the intestinal lumen.

Int J Obes (Lond) 2019 02 30;43(2):428-431. Epub 2018 Jan 30.

Sorbonne Universités, UPMC Univ. Paris 06, École normale supérieure, PSL Research University, CNRS, INSERM, APHP, Laboratoire des Biomolécules (LBM), 27 rue de Chaligny, Paris, 75005, France.

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February 2019

Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation.

Drug Metab Dispos 2017 12 19;45(12):1292-1303. Epub 2017 Sep 19.

INSERM UMR991/1241, Liver Metabolism and Cancer/Numecan, Rennes, France (A.S., A.B., C.G.-G., A.G.); Université de Rennes 1, Rennes, France (A.S., A.B., C.G.-G., A.G.); and ERL INSERM U1157/UMR7203, Faculté de Médecine Pierre et Marie Curie, Site Saint Antoine, Paris, France (L.H., D.R.)

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December 2017

Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice.

J Hepatol 2017 04 25;66(4):806-815. Epub 2016 Nov 25.

INSERM U996, DHU Hepatinov, Univ Paris-Sud, Université Paris-Saclay, 92140 Clamart, France; Institut Paris-Sud d'Innovation Thérapeutique (IPSIT), IFR141, Faculté de Pharmacie, Univ Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France. Electronic address:

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April 2017