Lutz Birnbaumer

Lutz Birnbaumer

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Lutz Birnbaumer

Publications by authors named "Lutz Birnbaumer"

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TRPC3 determines osmosensitive [Ca2+]i signaling in the collecting duct and contributes to urinary concentration.

PLoS One 2019 18;14(12):e0226381. Epub 2019 Dec 18.

Department of Integrative Biology and Pharmacology, the University of Texas Health Science Center at Houston, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226381PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919627PMC
March 2020

TRPC1 participates in the HSV-1 infection process by facilitating viral entry.

Sci Adv 2020 03 18;6(12):eaaz3367. Epub 2020 Mar 18.

Wuxi School of Medicine and School of Food Science and Technology, Jiangnan University, Jiangsu, China.

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http://dx.doi.org/10.1126/sciadv.aaz3367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080438PMC
March 2020

Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus.

Sci Rep 2020 Jan 21;10(1):812. Epub 2020 Jan 21.

Department of Pharmacology and Toxicology, Little Rock, Arkansas, United States of America.

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http://dx.doi.org/10.1038/s41598-020-57733-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972937PMC
January 2020

Angiotensin-II-Evoked Ca Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels.

Cells 2020 Jan 29;9(2). Epub 2020 Jan 29.

Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, INF 366, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/cells9020322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072683PMC
January 2020

Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1 mice.

Channels (Austin) 2019 12 11;13(1):410-423. Epub 2019 Oct 11.

Vascular Biology Research Centre, Molecular & Clinical Sciences Research Institute, St. George's, University of London, London, UK.

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http://dx.doi.org/10.1080/19336950.2019.1673131DOI Listing
December 2019

TRPC channels are not required for graded persistent activity in entorhinal cortex neurons.

Hippocampus 2019 11 19;29(11):1038-1048. Epub 2019 Apr 19.

Institute of Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hipo.23094
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http://dx.doi.org/10.1002/hipo.23094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791731PMC
November 2019

Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis.

Antioxid Redox Signal 2019 06 29;30(16):1851-1879. Epub 2018 Nov 29.

1 Laboratoire de Recherche en Physiologie et Physiopathologie, Pôle Technologie Santé, Faculté de Médecine, Université Saint Joseph, Beirut, Lebanon.

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https://www.liebertpub.com/doi/10.1089/ars.2018.7545
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http://dx.doi.org/10.1089/ars.2018.7545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486676PMC
June 2019

Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice.

Mol Brain 2019 06 20;12(1):57. Epub 2019 Jun 20.

Departments of Anatomy, Ajou University School of Medicine, Woldcup-ro 164, Yeongtong-gu, Suwon, 16499, South Korea.

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http://dx.doi.org/10.1186/s13041-019-0477-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585000PMC
June 2019

Evidence for a regulated Ca entry in proximal tubular cells and its implication in calcium stone formation.

J Cell Sci 2019 04 30;132(9). Epub 2019 Apr 30.

Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington DC, DC 20422, USA

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http://jcs.biologists.org/lookup/doi/10.1242/jcs.225268
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http://dx.doi.org/10.1242/jcs.225268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526711PMC
April 2019

Central role of G protein Gαi2 and Gαi2 vomeronasal neurons in balancing territorial and infant-directed aggression of male mice.

Proc Natl Acad Sci U S A 2019 03 25;116(11):5135-5143. Epub 2019 Feb 25.

Laboratoire de Physiologie de la Reproduction et des Comportements, UMR Institut National de la Recherche Agronomique (INRA)-CNRS-Institut Français du Cheval et de l'Equitation (IFCE)-University of Tours, 37380 Nouzilly, France;

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http://dx.doi.org/10.1073/pnas.1821492116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421405PMC
March 2019

Lipid-independent control of endothelial and neuronal TRPC3 channels by light.

Chem Sci 2019 Mar 15;10(9):2837-2842. Epub 2019 Jan 15.

Gottfried Schatz Research Center - Biophysics , Medical University of Graz , Neue Stiftingtalstraße 6/D/04 , 8010 Graz , Austria . Email:

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http://dx.doi.org/10.1039/c8sc05536jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427946PMC
March 2019

M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry.

iScience 2018 Oct 20;8:85-102. Epub 2018 Sep 20.

Department of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S25890042183014
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http://dx.doi.org/10.1016/j.isci.2018.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174824PMC
October 2018

Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.

J Neurochem 2018 08 1;146(4):374-389. Epub 2018 Aug 1.

Institute of Integrative Neuroanatomy, Charité-Universitätsmedizin, Berlin, Germany.

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http://doi.wiley.com/10.1111/jnc.14460
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http://dx.doi.org/10.1111/jnc.14460DOI Listing
August 2018

Gαi Proteins are Indispensable for Hearing.

Cell Physiol Biochem 2018 21;47(4):1509-1532. Epub 2018 Jun 21.

Molecular Physiology of Hearing, Tübingen Hearing Research Centre, Department of Otolaryngology, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1159/000490867DOI Listing
August 2018

Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits.

Neuron 2018 08 12;99(4):754-767.e4. Epub 2018 Jul 12.

Department of Neurobiology, Northwestern University, Evanston, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.06.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107377PMC
August 2018

Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K currents in adult murine atria.

Am J Physiol Cell Physiol 2018 05 17;314(5):C616-C626. Epub 2018 Jan 17.

The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry , London , United Kingdom.

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http://dx.doi.org/10.1152/ajpcell.00271.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008071PMC
May 2018

Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway.

Oncogene 2018 05 8;37(22):2953-2966. Epub 2018 Mar 8.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, 211198, China.

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http://dx.doi.org/10.1038/s41388-018-0177-4DOI Listing
May 2018

Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.

Neuron 2018 05 12;98(3):575-587.e4. Epub 2018 Apr 12.

Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.03.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048973PMC
May 2018

Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus.

Proc Natl Acad Sci U S A 2018 04 5;115(15):E3549-E3558. Epub 2018 Mar 5.

Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow University, Suzhou 215000, China;

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http://dx.doi.org/10.1073/pnas.1722493115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899481PMC
April 2018

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca concentration in mouse cardiomyocytes.

J Physiol Sci 2018 Mar 19;68(2):153-164. Epub 2017 Jan 19.

Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, 700-8558, Japan.

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http://dx.doi.org/10.1007/s12576-016-0519-3DOI Listing
March 2018

Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3.

Atherosclerosis 2018 03 22;270:199-204. Epub 2017 Dec 22.

Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Health Science Campus, 3000 Transverse Dr., Toledo, OH 43614, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835414PMC
March 2018

Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response.

Proc Natl Acad Sci U S A 2018 03 12;115(13):E2960-E2969. Epub 2018 Mar 12.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, 211198 Nanjing, China;

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http://dx.doi.org/10.1073/pnas.1720696115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879702PMC
March 2018

TRPC3/6/7 Knockdown Protects the Brain from Cerebral Ischemia Injury via Astrocyte Apoptosis Inhibition and Effects on NF-кB Translocation.

Mol Neurobiol 2017 12 8;54(10):7555-7566. Epub 2016 Nov 8.

Department of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

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http://dx.doi.org/10.1007/s12035-016-0227-2DOI Listing
December 2017

Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway.

Am J Transl Res 2017 15;9(12):5619-5630. Epub 2017 Dec 15.

Department of Anatomy, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, Hubei, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752912PMC
December 2017

Integration of TRPC6 and NADPH oxidase activation in lysophosphatidylcholine-induced TRPC5 externalization.

Am J Physiol Cell Physiol 2017 Nov 23;313(5):C541-C555. Epub 2017 Aug 23.

Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio;

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http://www.physiology.org/doi/10.1152/ajpcell.00028.2017
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http://dx.doi.org/10.1152/ajpcell.00028.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792165PMC
November 2017

Evidence for constitutive bone morphogenetic protein-2 secretion by M1 macrophages: Constitutive auto/paracrine osteogenic signaling by BMP-2 in M1 macrophages.

Biochem Biophys Res Commun 2017 09 12;491(1):154-158. Epub 2017 Jul 12.

Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, University of Toledo Health Science Campus, 3000 Transverse Dr., Toledo, OH 43614, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.07.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572828PMC
September 2017

Corrigendum to "TRPC3 channels critically regulate hippocampal excitability and contextual fear memory" Behav. Brain Res. 281(March) 2015, 69-77.

Behav Brain Res 2017 08 30;332:379. Epub 2017 May 30.

Dept. of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2017.05.038DOI Listing
August 2017

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.

Sci Rep 2017 08 8;7(1):7511. Epub 2017 Aug 8.

Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences (Okazaki Institute for Integrative Bioscience), National Institutes of Natural Sciences, Aichi, 444-8787, Japan.

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http://dx.doi.org/10.1038/s41598-017-07903-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548754PMC
August 2017

Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells.

Channels (Austin) 2017 Jul 16;11(4):329-339. Epub 2017 Mar 16.

b Vascular Biology Research Centre, Institute of Molecular & Clinical Sciences Research Institute , St. George's, University of London , Cranmer Terrace, London , UK.

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http://dx.doi.org/10.1080/19336950.2017.1303025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555289PMC
July 2017

Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.

Proc Natl Acad Sci U S A 2017 06 19;114(23):E4582-E4591. Epub 2017 May 19.

Department of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;

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http://dx.doi.org/10.1073/pnas.1621384114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468654PMC
June 2017

Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice.

Sci Rep 2017 06 23;7(1):4145. Epub 2017 Jun 23.

Institute for Cardiovascular and Metabolic Disease, University of North Texas Health Science Center, Fort Worth, Texas, 76107, USA.

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http://dx.doi.org/10.1038/s41598-017-04067-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482875PMC
June 2017

Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho.

Kidney Int 2017 04 12;91(4):830-841. Epub 2016 Dec 12.

Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357448PMC
April 2017

Inhibition of L-Type Ca Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons.

J Neurosci 2017 03 3;37(12):3364-3377. Epub 2017 Mar 3.

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58201, and

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.3010-1
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http://dx.doi.org/10.1523/JNEUROSCI.3010-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373123PMC
March 2017

TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice.

Epilepsia 2017 02 24;58(2):247-254. Epub 2016 Dec 24.

Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, U.S.A.

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http://dx.doi.org/10.1111/epi.13648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291823PMC
February 2017

Reduced Necrosis and Content of Apoptotic M1 Macrophages in Advanced Atherosclerotic Plaques of Mice With Macrophage-Specific Loss of Trpc3.

Sci Rep 2017 02 10;7:42526. Epub 2017 Feb 10.

Department of Physiology and Pharmacology, and Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, University of Toledo Health Science Campus, 3000 Transverse Dr., Toledo, Ohio 43614, USA.

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http://dx.doi.org/10.1038/srep42526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301208PMC
February 2017

Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3.

Sci Rep 2017 01 4;7:39867. Epub 2017 Jan 4.

Department of Physiology and Pharmacology, and Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, University of Toledo Health Science Campus, 3000 Transverse Dr., Toledo, Ohio 43614 USA.

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http://dx.doi.org/10.1038/srep39867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209678PMC
January 2017

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.

Sci Rep 2016 12 19;6:39383. Epub 2016 Dec 19.

Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Aichi 444-8787, Japan.

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http://dx.doi.org/10.1038/srep39383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171702PMC
December 2016

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.

Sci Rep 2016 11 11;6:37001. Epub 2016 Nov 11.

Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan.

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http://dx.doi.org/10.1038/srep37001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105134PMC
November 2016

Resistance to pathologic cardiac hypertrophy and reduced expression of CaV1.2 in Trpc3-depleted mice.

Mol Cell Biochem 2016 Oct 13;421(1-2):55-65. Epub 2016 Aug 13.

Department of Pharmacology and Brain Korea, 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.

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http://dx.doi.org/10.1007/s11010-016-2784-0DOI Listing
October 2016

Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice.

Proc Natl Acad Sci U S A 2016 09 13;113(39):10974-9. Epub 2016 Sep 13.

Department of Anatomy, Ajou University School of Medicine, Suwon 16499, South Korea; Department of Biomedical Sciences, The Graduate School, Ajou University School of Medicine, Suwon 16499, South Korea;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047177PMC
http://dx.doi.org/10.1073/pnas.1613026113DOI Listing
September 2016

Store depletion induces Gαq-mediated PLCβ1 activity to stimulate TRPC1 channels in vascular smooth muscle cells.

FASEB J 2016 Feb 14;30(2):702-15. Epub 2015 Oct 14.

*Vascular Biology Research Centre, Institute of Cardiovascular and Cell Sciences, and Institute of Medical and Biomedical Education, St. George's, University of London, London, United Kingdom; and Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1096/fj.15-280271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714548PMC
February 2016

Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation.

Proc Natl Acad Sci U S A 2016 Feb 8;113(8):2110-5. Epub 2016 Feb 8.

Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195; Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH 44195

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http://dx.doi.org/10.1073/pnas.1600371113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776520PMC
February 2016

The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.

Neurosci Lett 2016 Jan 28;610:36-42. Epub 2015 Oct 28.

Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.neulet.2015.10.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683096PMC
January 2016

Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries.

PLoS One 2014 13;9(10):e110413. Epub 2014 Oct 13.

Department of Physiology and BK21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110413PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195735PMC
December 2015

TRPC1 regulates calcium-activated chloride channels in salivary gland cells.

J Cell Physiol 2015 Nov;230(11):2848-56

Department of Basic Sciences, School of Medicine Health Sciences, University of North Dakota, Grand Forks, North Dakota.

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http://dx.doi.org/10.1002/jcp.25017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872598PMC
November 2015

Murine cardiac growth, TRPC channels, and cGMP kinase I.

Pflugers Arch 2015 Oct 30;467(10):2229-34. Epub 2014 Dec 30.

FOR923, Institut für Pharmakologie und Toxikologie, Technische Universität München, Biedersteiner Str. 29, 80802, Munich, Germany.

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http://dx.doi.org/10.1007/s00424-014-1682-0DOI Listing
October 2015

TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response.

J Exp Med 2015 Oct 21;212(11):1883-99. Epub 2015 Sep 21.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611

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http://dx.doi.org/10.1084/jem.20150353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612081PMC
October 2015

An essential role for Gα(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.

Sci Signal 2015 Sep 15;8(394):ra92. Epub 2015 Sep 15.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA. Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aaa7
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http://dx.doi.org/10.1126/scisignal.aaa7355DOI Listing
September 2015

From GTP and G proteins to TRPC channels: a personal account.

Authors:
Lutz Birnbaumer

J Mol Med (Berl) 2015 Sep 16;93(9):941-53. Epub 2015 Sep 16.

Neurobiology Laboratory, National Institute of Environmental Research, Research Triangle Park, NC, 27009, USA.

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http://dx.doi.org/10.1007/s00109-015-1328-5DOI Listing
September 2015

Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis.

J Am Soc Nephrol 2015 Aug 5;26(8):1855-76. Epub 2014 Dec 5.

Physiology and Pathophysiology Research Laboratory, Pole of Technology and Health, Faculty of Medicine and

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http://dx.doi.org/10.1681/ASN.2014010065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520158PMC
August 2015

Gαi2- and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury.

PLoS One 2014 23;9(5):e98325. Epub 2014 May 23.

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Center of Pharmacogenomics and Drug Research, Tuebingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098325PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032280PMC
June 2015

Innate Predator Odor Aversion Driven by Parallel Olfactory Subsystems that Converge in the Ventromedial Hypothalamus.

Curr Biol 2015 May 30;25(10):1340-6. Epub 2015 Apr 30.

Department of Physiology and Center for Integrative Physiology and Molecular Medicine, University of Saarland School of Medicine, 66421 Homburg, Germany.

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http://dx.doi.org/10.1016/j.cub.2015.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439360PMC
May 2015

Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice.

Proc Natl Acad Sci U S A 2015 May 5;112(20):6491-6. Epub 2015 May 5.

Department of Pharmacology and Experimental Therapy and Interfaculty Center of Pharmacogenomics and Drug Research, University of Tübingen, 72074 Tubingen, Germany;

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http://dx.doi.org/10.1073/pnas.1505887112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443332PMC
May 2015

Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1.

Proc Natl Acad Sci U S A 2015 04 30;112(15):4731-6. Epub 2015 Mar 30.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing 211198, China;

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http://dx.doi.org/10.1073/pnas.1503779112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403188PMC
April 2015

Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel.

Proc Natl Acad Sci U S A 2015 Apr 13;112(17):E2201-6. Epub 2015 Apr 13.

Department of Physiology and Pharmacology, Center for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, OH 43614; and

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http://dx.doi.org/10.1073/pnas.1505410112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418920PMC
April 2015

The loss of Gnai2 and Gnai3 in B cells eliminates B lymphocyte compartments and leads to a hyper-IgM like syndrome.

PLoS One 2013 19;8(8):e72596. Epub 2013 Aug 19.

B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072596PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747273PMC
January 2015

The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation.

PLoS One 2014 15;9(5):e97324. Epub 2014 May 15.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097324PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022657PMC
January 2015

The TRPC family of TRP channels: roles inferred (mostly) from knockout mice and relationship to ORAI proteins.

Handb Exp Pharmacol 2014 ;223:1055-75

Department of Anatomy, College of Medicine, Huazhong University of Science and Technology, Wuhan, 430074, China,

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http://dx.doi.org/10.1007/978-3-319-05161-1_14DOI Listing
November 2014

TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel.

FASEB J 2014 Nov 11;28(11):4677-85. Epub 2014 Aug 11.

School of Biomedical Sciences and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China;

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http://dx.doi.org/10.1096/fj.14-251652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200325PMC
November 2014

Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2).

Am J Physiol Endocrinol Metab 2014 Nov 9;307(9):E800-12. Epub 2014 Sep 9.

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Center of Pharmacogenomics and Drug Research, University of Tübingen, Tübingen, Germany;

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http://dx.doi.org/10.1152/ajpendo.00337.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216945PMC
November 2014

Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli.

Kidney Int 2014 Sep 19;86(3):506-14. Epub 2014 Mar 19.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

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http://dx.doi.org/10.1038/ki.2014.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149864PMC
September 2014

Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages.

Am J Physiol Cell Physiol 2014 Sep 16;307(6):C521-31. Epub 2014 Jul 16.

Department of Physiology and Pharmacology and Center for Diabetes and Endocrine Research, University of Toledo Health Science Campus, Toledo, Ohio; and

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http://dx.doi.org/10.1152/ajpcell.00369.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166736PMC
September 2014

Critical role of canonical transient receptor potential channel 7 in initiation of seizures.

Proc Natl Acad Sci U S A 2014 Aug 21;111(31):11533-8. Epub 2014 Jul 21.

Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205; and

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http://dx.doi.org/10.1073/pnas.1411442111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128138PMC
August 2014

Activation of endothelial transient receptor potential C3 channel is required for small conductance calcium-activated potassium channel activation and sustained endothelial hyperpolarization and vasodilation of cerebral artery.

J Am Heart Assoc 2014 Aug 20;3(4). Epub 2014 Aug 20.

Department of Anesthesiology, Baylor College of Medicine, Houston, TX (M.Y.K., A.B., S.P.M.) Department of Physiology and Biophysics and Graduate Program in Physiology, Cardiovascular Sciences Track, Baylor College of Medicine, Houston, TX (S.P.M.).

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http://dx.doi.org/10.1161/JAHA.114.000913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310376PMC
August 2014

Simultaneous deletion of floxed genes mediated by CaMKIIα-Cre in the brain and in male germ cells: application to conditional and conventional disruption of Goα.

Exp Mol Med 2014 May 2;46:e93. Epub 2014 May 2.

1] Departments of Anatomy, Ajou University, School of Medicine, Suwon, South Korea [2] Neuroscience Graduate Program, Ajou University, School of Medicine, Suwon, South Korea [3] BK21-Division of Cell Transformation and Restoration, Ajou University, School of Medicine, Suwon, South Korea.

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http://dx.doi.org/10.1038/emm.2014.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972788PMC
May 2014

Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation.

Circ Res 2014 Feb 21;114(5):823-32. Epub 2014 Jan 21.

From the Division of Cardiology, Department of Medicine (K.S., P.P.R., D.-i.L., S.H., D.B., O.H.C., D.A.K.) and Department of Biomedical Engineering (D.A.K.), The Johns Hopkins Medical Institutions, Baltimore, MD; Division of Cardiology, Medical University of Graz, Graz, Austria (P.P.R.); and National Institute of Environmental Health Science, Research Triangle Park, NC (L.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.302614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963144PMC
February 2014

Myristoylated alanine-rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4,5-bisphosphate and protein kinase C in vascular smooth muscle.

FASEB J 2014 Jan 10;28(1):244-55. Epub 2013 Sep 10.

1Pharmacology and Cell Physiology, Division of Biomedical Sciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK.

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http://dx.doi.org/10.1096/fj.13-238022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868830PMC
January 2014

Bone marrow deficiency of TRPC3 channel reduces early lesion burden and necrotic core of advanced plaques in a mouse model of atherosclerosis.

Cardiovasc Res 2014 Jan 6;101(1):138-44. Epub 2013 Oct 6.

Department of Physiology and Pharmacology and Center for Diabetes and Endocrine Research, University of Toledo Health Science Campus, 3000 Transverse Dr, Toledo, OH 43614, USA;

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http://dx.doi.org/10.1093/cvr/cvt231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868349PMC
January 2014

Classical transient receptor potential 1 and 6 contribute to hypoxic pulmonary hypertension through differential regulation of pulmonary vascular functions.

Hypertension 2014 Jan 21;63(1):173-80. Epub 2013 Oct 21.

Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102175PMC
January 2014

Early onset of ataxia in moonwalker mice is accompanied by complete ablation of type II unipolar brush cells and Purkinje cell dysfunction.

J Neurosci 2013 Dec;33(50):19689-94

Departments of Physiology and Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, Department of Physiology, Anatomy, and Genetics, MRC Functional Genomics Unit, Oxford OX1 3PT, United Kingdom, Institute of Neuroscience, Technical University Munich, 80802 Munich, Germany, and Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina 27709.

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http://dx.doi.org/10.1523/JNEUROSCI.2294-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858636PMC
December 2013