Publications by authors named "Lusha Cen"

3 Publications

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Therapeutic effects of auricular point acupressure on the recovery of patients after pterygium surgery: A pilot study.

Authors:
Lusha Cen Cao Yi

Complement Ther Clin Pract 2021 Feb 20;43:101339. Epub 2021 Feb 20.

Department of Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, China. Electronic address:

Background: and purpose: Postoperative pain in the pterygium of the eye seriously affects patient recovery. This study was conducted to assess the efficacy of auricular point acupressure treatment on post-operative recovery in patients after pterygium surgery.

Materials And Methods: This was a pilot, randomized controlled study. A total of 60 patients (60 eyes) were randomly assigned to two groups. After pterygium surgery, the auricular group was treated using ear acupressure (acupressure points with Cowherb seeds) and the control group was treated using sham auricular therapy (acupressure points without Cowherb seeds). Both groups were treated for one week. Outcome measures included pain score, corneal epithelial score, best-corrected visual acuity, and recurrence rate.

Results: Fifty-three patients completed the study. The mean pain scores and corneal epithelial scores were significantly reduced over time in the auricular group compared with those in the control group (p < 0.05). The time-group interaction for both pain scores and corneal epithelial scores was significant between the two groups (p < 0.05). Simple main effect analysis showed the mean pain scores in the auricular group were significantly lower at each time point (the first 2-h, the first day, the third day and the first week, p < 0.05) than the control group. Mean corneal epithelial scores of the auricular group were significantly lower on the first day and third day respectively than the control group (p < 0.05). There was no significant difference in the best-corrected visual acuity or recurrence rate between the two groups (p > 0.05).

Conclusion: Auricular point acupressure accelerates corneal epithelium reconstruction and suppresses postoperative pain, making it an ideal adjunct treatment for postoperative pterygium recovery.

Clinical Trial Registration Number: ChiCTR2000032490 on http://www.chictr.org.cn/.
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http://dx.doi.org/10.1016/j.ctcp.2021.101339DOI Listing
February 2021

COVID-19 and Perioperative Management Strategies for Gastrointestinal Surgery: An Experience From Jiaxing, China.

Authors:
Yuan Zhou Lusha Cen

Am Surg 2021 Feb 19:3134821995087. Epub 2021 Feb 19.

Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hang Zhou, China.

Background: The coronavirus disease (COVID-19) was leading to a worldwide pandemic, which affected surgical operation. This study assessed the efficacy of perioperative management of patients scheduled for gastrointestinal surgery during COVID-19 pandemic of 2020.

Methods: We retrospectively analyzed 188 patients who underwent gastrointestinal surgery during the COVID-19 outbreak in Jiaxing, China. Perioperative data were collected, including data on pre-, intra-, and postoperative management strategies. The same data over the same period in 2019 were also collected for comparison.

Results: A total of 117, 63, and 8 patients underwent emergency, semi-elective, and elective surgeries, respectively. The locals: nonlocals ratio was significantly higher during this investigation period in 2020 than during the same period in 2019 ( < .05). After screening, 12 patients were identified as unqualified. The number of gastrointestinal surgeries was reduced in 2020. There were no differences in the ratio of emergency surgery or semi-elective surgery between in 2020 and in 2019. The elective surgery ratio between January 27 and February 28 was found to be lower in 2020 than in 2019 ( < .05). The disease spectra of emergency surgery and semi-elective surgery were similar. A total of 31 elective surgeries were postponed. There were five cases of short-term complications for emergency surgeries and two cases of short-term complications for semi-elective surgeries. No long-term complications or COVID-19 infection occurred in any of the cases, and no medical staff member was infected.

Conclusion: Perioperative management strategies minimize the risk of nosocomial infection and reduce the influence of epidemics on gastrointestinal surgery.
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http://dx.doi.org/10.1177/0003134821995087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900525PMC
February 2021

Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus.

J Diabetes Res 2020 15;2020:6927429. Epub 2020 Sep 15.

Department of Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Youdian Rd. 54th, Hangzhou 310006, China.

Nuclear factor of activated T cells 5 (NFAT5), a Rel/nuclear factor- (NF-) B family member, is the only known gene regulator of the mammalian adaptive response to osmotic stress. Exposure to elevated glucose increases the expression and nuclear translocation of NFAT5, as well as NFAT5-driven transcriptional activity in vivo and in vitro. Increased expression of NFAT5 is closely correlated with the progression of diabetes in patients. The distinct structure of NFAT5 governs its physiological and pathogenic roles, indicating its opposing functions. The ability of NFAT5 to maintain cell homeostasis and proliferation is impaired in patients with diabetes. NFAT5 promotes the formation of aldose reductase, pathogenesis of diabetic vascular complications, and insulin resistance. Additionally, NFAT5 activates inflammation at a very early stage of diabetes and induces persistent inflammation. Recent studies revealed that NFAT5 is an effective therapeutic target for diabetes. Here, we describe the current knowledge about NFAT5 and its relationship with diabetes, focusing on its diverse regulatory functions, and highlight the importance of this protein as a potential therapeutic target in patients with diabetes.
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http://dx.doi.org/10.1155/2020/6927429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512074PMC
September 2020