Luna Musib

Luna Musib

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Luna Musib

Luna Musib

Publications by authors named "Luna Musib"

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34Publications

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Pediatric Dose Selection and Utility of PBPK in Determining Dose.

AAPS J 2018 02 13;20(2):31. Epub 2018 Feb 13.

Department of Clinical Pharmacology, Genentech Inc., 1 DNA Way, SSF, South San Francisco, California, 94180, USA.

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http://dx.doi.org/10.1208/s12248-018-0187-8DOI Listing
February 2018

A survey of new oncology drug approvals in the USA from 2010 to 2015: a focus on optimal dose and related postmarketing activities.

Cancer Chemother Pharmacol 2016 Mar 25;77(3):459-76. Epub 2016 Jan 25.

Department of Clinical Pharmacology, Genentech, Inc., 1 DNA Way, MS 463A, South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.1007/s00280-015-2931-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767861PMC
March 2016

Effects of enzastaurin and its metabolites on the QT interval in cancer patients.

J Clin Pharmacol 2016 Jan 17;56(1):101-8. Epub 2015 Aug 17.

Comprehensive Cancer Center and Biotrial, Rennes, France.

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http://dx.doi.org/10.1002/jcph.573DOI Listing
January 2016

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.

Drug Metab Dispos 2016 Jan 8;44(1):28-39. Epub 2015 Oct 8.

Departments of Drug Metabolism and Pharmacokinetics (R.H.T., E.F.C., S.M., S.W., J.H., Y.D., C.E.C.A.H., S.C.K.,), Product Development Oncology (I.R.), Early Clinical Development (M.G.), and Clinical Pharmacology (M.J.D, L.M.), Genentech, South San Francisco, California.

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http://dx.doi.org/10.1124/dmd.115.066282DOI Listing
January 2016

Population pharmacokinetics and dosing implications for cobimetinib in patients with solid tumors.

Cancer Chemother Pharmacol 2015 Nov 13;76(5):917-24. Epub 2015 Sep 13.

Clinical Pharmacology, Genentech Inc, South San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s00280-015-2862-0DOI Listing
November 2015

MEK inhibitors beyond monotherapy: current and future development.

Curr Opin Pharmacol 2015 Aug 7;23:61-7. Epub 2015 Jun 7.

Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080 USA. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2015.05.012DOI Listing
August 2015

Determination of cobimetinib in human plasma using protein precipitation extraction and high-performance liquid chromatography coupled to mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Dec 7;972:117-23. Epub 2014 Oct 7.

Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S15700232140060
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http://dx.doi.org/10.1016/j.jchromb.2014.09.034DOI Listing
December 2014

Absolute bioavailability and effect of formulation change, food, or elevated pH with rabeprazole on cobimetinib absorption in healthy subjects.

Mol Pharm 2013 Nov 30;10(11):4046-54. Epub 2013 Sep 30.

Genentech, Inc. , 1 DNA Way, South San Francisco, California, 94080, United States.

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http://pubs.acs.org/doi/10.1021/mp400383x
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http://dx.doi.org/10.1021/mp400383xDOI Listing
November 2013

Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: a phase I study.

Neuro Oncol 2010 Jun 15;12(6):608-13. Epub 2010 Feb 15.

Department of Neurological Surgery, University of California San Francisco, 400 Parnassus Avenue, A808, San Francisco, CA 94143-0350, USA.

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http://dx.doi.org/10.1093/neuonc/nop070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940647PMC
June 2010

A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas.

Neuro Oncol 2010 Feb 22;12(2):181-9. Epub 2010 Jan 22.

Neuro-Oncology Branch, National Cancer Institute, NIH, 9030 Old Georgetown Road, Bloch Bldg. 82, room 225, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/neuonc/nop042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940576PMC
February 2010

Carboplatin and paclitaxel in combination with oral enzastaurin in advanced ovarian or primary peritoneal cancer: results from a safety lead-in study.

Int J Gynecol Cancer 2009 Dec;19(9):1505-10

Department of Gynaecological Oncology, Division Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/IGC.0b013e3181bda1a7DOI Listing
December 2009

Pharmacokinetic evaluation of platinum derived from cisplatin administered alone and with pemetrexed in head and neck cancer patients.

Cancer Chemother Pharmacol 2009 Jul 15;64(2):233-41. Epub 2008 Nov 15.

Department of Medical Oncology, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.

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http://dx.doi.org/10.1007/s00280-008-0853-0DOI Listing
July 2009

A phase I trial of enzastaurin in patients with recurrent gliomas.

Clin Cancer Res 2009 May 5;15(10):3617-23. Epub 2009 May 5.

Neuro-Oncology Branch and Biometric Research Branch, National Cancer Institute, National Institute of Neurological Disorder and Stroke, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-3071DOI Listing
May 2009

Safety of an IV formulation of carbamazepine.

Epilepsy Res 2009 Apr 18;84(2-3):242-4. Epub 2009 Mar 18.

Experimental and Clinical Pharmacology, University of Minnesota, 5-130 WDH, 308 Harvard St. S.E., Minneapolis, MN 55455, United States.

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http://dx.doi.org/10.1016/j.eplepsyres.2009.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973440PMC
April 2009