Luke B Hesson

Luke B Hesson

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Luke B Hesson

Luke B Hesson

Publications by authors named "Luke B Hesson"

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42Publications

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Non-CpG methylation biases bisulphite PCR towards low or unmethylated mitochondrial DNA: recommendations for the field.

Environ Epigenet 2020 Jan 4;6(1):dvaa001. Epub 2020 Feb 4.

School of Medical Sciences, UNSW Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1093/eep/dvaa001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055202PMC
January 2020

Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing.

JNCI Cancer Spectr 2019 Jun 16;3(2):pkz012. Epub 2019 Apr 16.

Prince of Wales Clinical School and Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1093/jncics/pkz012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649856PMC
June 2019

Disruption of a -35 kb Enhancer Impairs CTCF Binding and Expression in Colorectal Cells.

Clin Cancer Res 2018 09 13;24(18):4602-4611. Epub 2018 Jun 13.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3678DOI Listing
September 2018

The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System.

Front Immunol 2017 10;8:417. Epub 2017 Apr 10.

The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fimmu.2017.00417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385369PMC
April 2017

Validation of specificity of antibodies for immunohistochemistry: the case of ROR2.

Virchows Arch 2017 Jan 8;470(1):99-108. Epub 2016 Sep 8.

Adult Cancer Program, Level 2, Metastasis Research Group, Lowy Cancer Research Centre and School of Women's and Children's Health, University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/s00428-016-2019-5DOI Listing
January 2017

Defining the criteria for identifying constitutional epimutations.

Clin Epigenetics 2016 18;8:39. Epub 2016 Apr 18.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia, Kensington, Sydney, New South Wales 2052 Australia.

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http://dx.doi.org/10.1186/s13148-016-0207-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835913PMC
December 2016

Erratum to: Validation of specificity of antibodies for immunohistochemistry: the case of ROR2.

Virchows Arch 2016 Dec 29;469(6):717. Epub 2016 Oct 29.

Adult Cancer Program, Level 2, Metastasis Research Group, Lowy Cancer Research Centre and School of Women's and Children's Health, University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/s00428-016-2036-4DOI Listing
December 2016

Pathogenic germline MCM9 variants are rare in Australian Lynch-like syndrome patients.

Cancer Genet 2016 Nov 11;209(11):497-500. Epub 2016 Oct 11.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia, Sydney, New South Wales 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2016.10.001DOI Listing
November 2016

An investigation of the potential for epigenetic inactivation by transcription read-through in a sporadic colorectal cancer.

Gene 2016 Jul 22;585(1):154-158. Epub 2016 Mar 22.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.gene.2016.03.031DOI Listing
July 2016

ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration.

BMC Cancer 2016 07 20;16:508. Epub 2016 Jul 20.

Metastasis Research Group, Adult Cancer Program, School of Women's and Children's Health, Lowy Cancer Research Centre, UNSW Australia, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1186/s12885-016-2576-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955198PMC
July 2016

Understanding the Pathogenicity of Noncoding Mismatch Repair Gene Promoter Variants in Lynch Syndrome.

Hum Mutat 2016 May 18;37(5):417-26. Epub 2016 Mar 18.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/humu.22971DOI Listing
May 2016

Establishing the clinical utility of epigenetic markers in cancer: many challenges ahead.

Epigenomics 2013 ;5(5):513-23

Adult Cancer Program, Lowy Cancer Research Centre & Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.2217/epi.13.53DOI Listing
April 2016

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

Proc Natl Acad Sci U S A 2016 Apr 4;113(16):E2306-15. Epub 2016 Apr 4.

Lowy Cancer Research Centre, University of New South Wales (UNSW) Australia, Sydney, NSW 2052, Australia; The Prince of Wales Clinical School, UNSW Australia, Sydney, NSW 2052, Australia; Department of Haematology, The Prince of Wales Hospital, Sydney, NSW 2032, Australia

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http://dx.doi.org/10.1073/pnas.1518244113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843430PMC
April 2016

A cryptic paracentric inversion of MSH2 exons 2-6 causes Lynch syndrome.

Carcinogenesis 2016 Jan 24;37(1):10-17. Epub 2015 Oct 24.

Adult Cancer Program , Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia , Sydney New South Wales 2052 , Australia.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgv154DOI Listing
January 2016

Mosaic Epigenetic Inheritance as a Cause of Early-Onset Colorectal Cancer.

JAMA Oncol 2015 Oct;1(7):953-7

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia4Brian Wilson Chancellery, University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1001/jamaoncol.2015.1484DOI Listing
October 2015

The search for cis-regulatory driver mutations in cancer genomes.

Oncotarget 2015 Oct;6(32):32509-25

Prince of Wales Clinical School and Lowy Cancer Research Centre, UNSW Australia, Sydney, Australia.

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http://dx.doi.org/10.18632/oncotarget.5085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741709PMC
October 2015

Lynch syndrome associated with two MLH1 promoter variants and allelic imbalance of MLH1 expression.

Hum Mutat 2015 Jun 17;36(6):622-30. Epub 2015 Apr 17.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia, Sydney, New South Wales, Australia.

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http://doi.wiley.com/10.1002/humu.22785
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http://dx.doi.org/10.1002/humu.22785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682451PMC
June 2015

Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas.

Genes Chromosomes Cancer 2015 May 27;54(5):303-14. Epub 2015 Feb 27.

Adult Cancer Program, Prince of Wales Clinical School, Lowy Cancer Research Centre, UNSW, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1002/gcc.22243DOI Listing
May 2015

Discrimination of pseudogene and parental gene DNA methylation using allelic bisulfite sequencing.

Methods Mol Biol 2014 ;1167:265-74

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Kensington, Sydney, NSW, 2227, Australia,

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http://dx.doi.org/10.1007/978-1-4939-0835-6_18DOI Listing
January 2015

The importance of distinguishing pseudogenes from parental genes.

Clin Epigenetics 2014 31;6(1):90. Epub 2014 Dec 31.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW, Sydney, Australia.

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http://dx.doi.org/10.1186/s13148-014-0033-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280768PMC
January 2015

Nucleosome positioning is unaltered at MLH1 splice site mutations in cells derived from Lynch syndrome patients.

Clin Epigenetics 2014 13;6(1):32. Epub 2014 Dec 13.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW Australia.

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http://dx.doi.org/10.1186/s13148-014-0032-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272815PMC
December 2014

Altered promoter nucleosome positioning is an early event in gene silencing.

Epigenetics 2014 Oct;9(10):1422-30

a Adult Cancer Program; Lowy Cancer Research Center and Prince of Wales Clinical School; UNSW ; Sydney , Australia.

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http://dx.doi.org/10.4161/15592294.2014.970077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622968PMC
October 2014

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.

Epigenetics 2014 Aug 16;9(8):1092-100. Epub 2014 May 16.

Adult Cancer Program; Lowy Cancer Research Centre and Prince of Wales Clinical School; Sydney, NSW Australia.

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http://dx.doi.org/10.4161/epi.29222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164494PMC
August 2014

The evidence for functional non-CpG methylation in mammalian cells.

Epigenetics 2014 Jun 9;9(6):823-8. Epub 2014 Apr 9.

Adult Cancer Program; Lowy Cancer Research Centre and Prince of Wales Clinical School; University of New South Wales; Sydney, NSW Australia.

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http://dx.doi.org/10.4161/epi.28741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065179PMC
June 2014

Reassembly of nucleosomes at the MLH1 promoter initiates resilencing following decitabine exposure.

PLoS Genet 2013 25;9(7):e1003636. Epub 2013 Jul 25.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1003636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723495PMC
January 2014

Prognostic significance of promoter DNA methylation in patients with childhood neuroblastoma.

Clin Cancer Res 2012 Oct 28;18(20):5690-700. Epub 2012 Aug 28.

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0294DOI Listing
October 2012

A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines.

Biol Proced Online 2012 Apr 10;14(1). Epub 2012 Apr 10.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia.

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http://biologicalproceduresonline.biomedcentral.com/articles
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http://dx.doi.org/10.1186/1480-9222-14-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342897PMC
April 2012

Epimutations and cancer predisposition: importance and mechanisms.

Curr Opin Genet Dev 2010 Jun 31;20(3):290-8. Epub 2010 Mar 31.

Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Kensington, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.gde.2010.02.005DOI Listing
June 2010

RAN GTPase is a RASSF1A effector involved in controlling microtubule organization.

Curr Biol 2009 Jul 25;19(14):1227-32. Epub 2009 Jun 25.

Section of Medical and Molecular Genetics, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1016/j.cub.2009.05.064DOI Listing
July 2009

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias.

Mol Cancer 2009 Jul 1;8:42. Epub 2009 Jul 1.

Department of Medical and Molecular Genetics, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, B15 2TT, UK.

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http://dx.doi.org/10.1186/1476-4598-8-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711046PMC
July 2009

Epigenetic analysis of childhood acute lymphoblastic leukemia.

Epigenetics 2009 Apr 12;4(3):185-93. Epub 2009 Apr 12.

Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.4161/epi.4.3.8752DOI Listing
April 2009

Epigenetic markers in human gliomas: prospects for therapeutic intervention.

Expert Rev Neurother 2008 Oct;8(10):1475-96

Department of Reproductive and Child Health, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, B15 2TT, UK.

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http://dx.doi.org/10.1586/14737175.8.10.1475DOI Listing
October 2008

The role of RASSF1A methylation in cancer.

Dis Markers 2007 ;23(1-2):73-87

Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850810PMC
http://dx.doi.org/10.1155/2007/291538DOI Listing
May 2007

The RASSF1A tumor suppressor activates Bax via MOAP-1.

J Biol Chem 2006 Feb 12;281(8):4557-63. Epub 2005 Dec 12.

Department of Cell and Cancer Biology, NCI, National Institutes of Health, Rockville, Maryland 20850-3300, USA.

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http://dx.doi.org/10.1074/jbc.M512128200DOI Listing
February 2006

CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations.

Oncogene 2005 Jun;24(24):3987-94

Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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http://www.nature.com/articles/1208566
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http://dx.doi.org/10.1038/sj.onc.1208566DOI Listing
June 2005

Multigene methylation analysis of Wilms' tumour and adult renal cell carcinoma.

Oncogene 2003 Oct;22(43):6794-801

Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1038/sj.onc.1206914DOI Listing
October 2003