Dr. Lukasz P Kozlowski, PhD - International Institute of Molecular and Cell Biology

Dr. Lukasz P Kozlowski

PhD

International Institute of Molecular and Cell Biology

Warsaw, Mazovian | Poland

ORCID logohttps://orcid.org/0000-0001-8187-1980


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Dr. Lukasz P Kozlowski, PhD - International Institute of Molecular and Cell Biology

Dr. Lukasz P Kozlowski

PhD

Introduction

Primary Affiliation: International Institute of Molecular and Cell Biology - Warsaw, Mazovian , Poland

Research Interests:


View Dr. Lukasz P Kozlowski’s Resume / CV

Education

Jan 2008 - May 2013
Institute of Biochemistry and Biophysics of the Polish Academy of Science
Doctor of Philosophy (Ph.D.) (biochemistry, bioinformatics, cum laude)
Jan 2005 - Jan 2007
Uniwersytet Jana Kochanowskiego w Kielcach
Bechelor (Computer Science)
Division of Computer Science
Jan 2004 - Jan 2006
Uniwersytet Jana Kochanowskiego w Kielcach
Master (genetics)
Department of Biochemistry and Genetics
Jan 2001 - Jan 2004
Uniwersytet Jana Kochanowskiego w Kielcach
Bechelor (biology)
Department of Biochemistry and Genetics

Experience

Jun 2015 - Jun 2017
Max Planck Institute for Biophysical Chemistry
Postdoctoral researcher
Quantitative and Computational Biology Group
Oct 2018
University of Warsaw
Assistant Professor
Institute of Informatics

Publications

11Publications

248Reads

3Profile Views

153PubMed Central Citations

Proteome-pI: proteome isoelectric point database.

Nucleic Acids Res 2017 01 26;45(D1):D1112-D1116. Epub 2016 Oct 26.

Quantitative and Computational Biology Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Lower Saxony, 37077, Germany

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http://dx.doi.org/10.1093/nar/gkw978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210655PMC
January 2017
15 Reads
7 Citations
9.112 Impact Factor

IPC - Isoelectric Point Calculator.

Biol Direct 2016 10 21;11(1):55. Epub 2016 Oct 21.

, Kielce, 25-430, Poland.

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http://dx.doi.org/10.1186/s13062-016-0159-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075173PMC
October 2016
10 Reads
16 Citations
4.660 Impact Factor

GDFuzz3D: a method for protein 3D structure reconstruction from contact maps, based on a non-Euclidean distance function.

Bioinformatics 2015 Nov 30;31(21):3499-505. Epub 2015 Jun 30.

Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland.

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http://dx.doi.org/10.1093/bioinformatics/btv390DOI Listing
November 2015
13 Reads
6 Citations
4.981 Impact Factor

Sequence-specific cleavage of dsRNA by Mini-III RNase.

Nucleic Acids Res 2015 Mar 29;43(5):2864-73. Epub 2015 Jan 29.

Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, ul. Ks. Trojdena 4, 02-109 Warsaw, Poland

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http://dx.doi.org/10.1093/nar/gkv009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357697PMC
March 2015
25 Reads
7 Citations
9.112 Impact Factor

Female-specific gene expression in dioecious liverwort Pellia endiviifolia is developmentally regulated and connected to archegonia production.

BMC Plant Biol 2014 Jun 17;14:168. Epub 2014 Jun 17.

Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, 89 Umultowska Street, 61-614 Poznan, Poland.

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http://dx.doi.org/10.1186/1471-2229-14-168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074843PMC
June 2014
14 Reads
1 Citation
3.813 Impact Factor

Computational modeling of protein-RNA complex structures.

Methods 2014 Feb 29;65(3):310-9. Epub 2013 Sep 29.

Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, ul. Ks. Trojdena 4, PL-02-109 Warsaw, Poland; Bioinformatics Laboratory, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, ul. Umultowska 89, PL-61-614 Poznan, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2013.09.014DOI Listing
February 2014
32 Reads
6 Citations
3.645 Impact Factor

CompaRNA: a server for continuous benchmarking of automated methods for RNA secondary structure prediction.

Nucleic Acids Res 2013 Apr 21;41(7):4307-23. Epub 2013 Feb 21.

Bioinformatics Laboratory, Institute for Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, ul. Umultowska 89, 61-614 Poznan, Poland.

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http://dx.doi.org/10.1093/nar/gkt101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627593PMC
April 2013
30 Reads
27 Citations
9.112 Impact Factor

MetaDisorder: a meta-server for the prediction of intrinsic disorder in proteins.

BMC Bioinformatics 2012 May 24;13:111. Epub 2012 May 24.

Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, ul, Trojdena 4, 02-109, Warsaw, Poland.

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http://dx.doi.org/10.1186/1471-2105-13-111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465245PMC
May 2012
7 Reads
72 Citations
2.580 Impact Factor

A novel homozygous p. Arg527Leu LMNA mutation in two unrelated Egyptian families causes overlapping mandibuloacral dysplasia and progeria syndrome

20 (11), 1134-1140

European Journal of Human Genetics

Mandibuloacral dysplasia (MAD) is a rare disease resulting from a mutation of LMNA gene encoding lamins A and C. The most common mutation associated with this disease is a homozygous arginine 527 replacement by histidine. Three female patients originating from two unrelated families from Northeast Egypt were examined. Their growth was retarded; they had microcephaly, widened cranial sutures, prominent eyes and cheeks, micrognathia, dental crowding, hypoplastic mandible, acro-osteolysis of distal phalanges, and joint contractures. In addition, they presented some progeroid features, such as pinched nose, premature loss of teeth, loss of hair, scleroderma-like skin atrophy, spine rigidity, and waddling gait. The clinical presentation of the disease varied between the patient originating from Family 1 and patients from Family 2, suggesting that unknown, possibly epigenetic factors, modify the course of the disease. The first symptoms of the disease appeared at the age of 2.5 (a girl from Family 1), 5, and 3 years (girls from Family 2). All patients had the same, novel homozygous c.1580G>T LMNA mutation, resulting in the replacement of arginine 527 by leucine. Computational predictions of such substitution effects suggested that it might alter protein stability and increase the tendency for protein aggregation, and as a result, might influence its interaction with other proteins. In addition, restriction fragment-length polymorphism analysis performed in 178 unrelated individuals showed that up to 1.12% of inhabitants of Northeast Egypt might be heterozygous carriers of this mutation, suggesting the presence of a founder effect in this area.

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May 2012
8 Reads