Lukas C Heukamp

Lukas C Heukamp

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Lukas C Heukamp

Lukas C Heukamp

Publications by authors named "Lukas C Heukamp"

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Detection of Discrepant Driver Mutations in a Patient with Two Synchronous Primary Non-Small Cell Lung Cancers (NSCLCs) with Liquid Biopsy.

J Thorac Oncol 2017 11;12(11):e186-e188

Lung Cancer Network NOWEL, Oldenburg, Germany; Pius Hospital, Medical Campus, University of Oldenburg, Oldenburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2017.07.018DOI Listing
November 2017

Targeted next-generation sequencing for TP53, RAS, BRAF, ALK and NF1 mutations in anaplastic thyroid cancer.

Endocrine 2016 Dec 1;54(3):733-741. Epub 2016 Oct 1.

Department of Endocrinology and Metabolism, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45122, Germany.

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http://dx.doi.org/10.1007/s12020-016-1080-9DOI Listing
December 2016

The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.

Cancer Res 2016 05 15;76(9):2587-99. Epub 2016 Mar 15.

Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, Liège, Belgium. Laboratory of Medical Chemistry, GIGA Molecular Biology of Diseases, University of Liege, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), University of Liege, Liège, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1473DOI Listing
May 2016

Implementing amplicon-based next generation sequencing in the diagnosis of small cell lung carcinoma metastases.

Exp Mol Pathol 2015 Dec 10;99(3):682-6. Epub 2015 Nov 10.

Institute of Pathology, University Hospital Cologne, Kerpener Straße 62, 50937 Cologne, Germany; Center for Integrated Oncology Cologne/Bonn, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany; Lung Cancer Group Cologne, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yexmp.2015.11.002DOI Listing
December 2015

Successful AZD9291 Therapy Based on Circulating T790M.

J Thorac Oncol 2015 Dec;10(12):e122-3

Tumorzentrum, Luzerner Kantonsspital, Luzern, SwitzerlandNEO New Oncology AG, Cologne, Germany.

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http://dx.doi.org/10.1097/JTO.0000000000000676DOI Listing
December 2015

Endogenous Il10 alleviates the systemic antiviral cellular immune response and T cell-mediated immunopathology in select organs of acutely LCMV-infected mice.

Am J Pathol 2015 Nov;185(11):3025-38

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.07.019DOI Listing
November 2015

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.

J Exp Med 2015 Nov 2;212(12):2057-75. Epub 2015 Nov 2.

Interdisciplinary Cluster for Applied Genoproteomics, University of Liège, 4000 Liège, Belgium Laboratory of Medical Chemistry, University of Liège, 4000 Liège, Belgium GIGA-Signal Transduction, University of Liège, 4000 Liège, Belgium Walloon Excellence in Life Sciences and Biotechnology, 1300 Wavre, Belgium

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http://dx.doi.org/10.1084/jem.20142288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647259PMC
November 2015

Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients.

J Thorac Oncol 2015 Jul;10(7):1049-57

*Institute of Pathology, University Hospital of Cologne, Cologne, Germany; †Center for Integrated Oncology Cologne/Bonn, University Hospital of Cologne, Cologne, Germany; ‡Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; §Labor Dr. Quade und Kollegen GmbH, Cologne, Germany; ‖Institute of Human Genetics, University of Cologne, Cologne, Germany; ¶Targos Molecular Pathology GmbH, Kassel, Germany; #Department of Translational Genomics, University of Cologne, Cologne, Germany; **Cologne Center for Genomics, Cologne, Germany; ††GENterprise GENOMICS GmbH, Mainz, Germany; ‡‡Bristol-Myers Squibb R&D, Princeton, New Jersey; §§Evangelische Kliniken Johanniter, Bonn, Germany; ‖‖Malteser Krankenhaus, Lung Cancer Center, Bonn, Germany; ¶¶Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; ##Institute for Hematopathology Hamburg, Hamburg, Germany; and ***New Oncology, Cologne, Germany.

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http://dx.doi.org/10.1097/JTO.0000000000000570DOI Listing
July 2015

Spatial Tumor Heterogeneity in Lung Cancer with Acquired Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance: Targeting High-Level MET-Amplification and EGFR T790M Mutation Occurring at Different Sites in the Same Patient.

J Thorac Oncol 2015 Jun;10(6):e40-3

*Lung Cancer Group Cologne, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; †Center for Integrated Oncology Köln Bonn, Institute of Pathology, University Hospital of Cologne, Cologne, Germany; ‡Department of Translational Genomics, Center for Integrated Oncology Köln Bonn, University of Cologne, Cologne, Germany; §Lung Cancer Group Cologne, Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany; ‖Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany; ¶Center for Integrated Oncology Köln Bonn, Institute of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany; and #Institute of Hematopathology Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1097/JTO.0000000000000503DOI Listing
June 2015

Alterations of global histone H3K9 and H3K27 methylation levels in bladder cancer.

Urol Int 2014 18;93(1):113-8. Epub 2014 Feb 18.

Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany.

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http://dx.doi.org/10.1159/000355467DOI Listing
April 2015

A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC.

Cancer Discov 2014 May 20;4(5):592-605. Epub 2014 Feb 20.

1Department of Translational Genomics; 2Institute of Pathology; 3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne; 4Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany; and 5Michael F. Price Center, Albert Einstein College of Medicine, Bronx, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0907DOI Listing
May 2014

Transient antiangiogenic treatment improves delivery of cytotoxic compounds and therapeutic outcome in lung cancer.

Cancer Res 2014 May 27;74(10):2816-24. Epub 2014 Mar 27.

Authors' Affiliations: Clinic I of Internal Medicine and Center for Integrated Oncology, University Hospital Cologne; Max Planck Institute for Neurological Research; Center for Molecular Medicine; Max Planck Institute for Biology of Aging; and Institute of Pathology, University Hospital Medical School, Cologne, GermanyAuthors' Affiliations: Clinic I of Internal Medicine and Center for Integrated Oncology, University Hospital Cologne; Max Planck Institute for Neurological Research; Center for Molecular Medicine; Max Planck Institute for Biology of Aging; and Institute of Pathology, University Hospital Medical School, Cologne, GermanyAuthors' Affiliations: Clinic I of Internal Medicine and Center for Integrated Oncology, University Hospital Cologne; Max Planck Institute for Neurological Research; Center for Molecular Medicine; Max Planck Institute for Biology of Aging; and Institute of Pathology, University Hospital Medical School, Cologne, Germany

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2986DOI Listing
May 2014

CD74-NRG1 fusions in lung adenocarcinoma.

Cancer Discov 2014 Apr 27;4(4):415-22. Epub 2014 Jan 27.

1Department of Translational Genomics; 2Department I of Internal Medicine; 3Laboratory of Translational Cancer Genomics; 4Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn; 5Center for Molecular Medicine Cologne (CMMC); 6Cologne Center for Genomics (CCG); 7Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD); 8Department of Pathology, University Hospital Medical Center, University of Cologne; 9Blackfield AG; 10Max Planck Institute for Neurological Research; 11Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH; 12Institute of Human Genetics, Cologne; 13Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Berlin; 14Department of Prostate Cancer Research, Institute of Pathology; 15Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn; 16Institute of Pathology; 17Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University, Jena; 18Institute for Pathology Bad Berka, Bad Berka, Germany;19Division of Molecular Oncology, Aichi Cancer Center Research Institute; 20Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan; Departments of 21Surgery and22Pathology, St. Vincent's Hospital; 23Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;24Department of Pathology, 25CHU Grenoble Institut National de la Santé et de la Recherche Medicale (INSERM) U823, Institute Albert Bonniot, Grenoble-Alpes University, Grenoble, France; 26Laboratory of Oncology IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; 27Laboratory for Molecular Medicine and Biotechnology, University Campus Bio-Medico, Rome, Italy; 28Center for the Biology of Disease, VIB, Leuven; and 29Oncology Discovery, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0633DOI Listing
April 2014

Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer.

Diagn Pathol 2014 Mar 4;9:48. Epub 2014 Mar 4.

Department of Cardiology, Angiology and Pneumology, University of Bonn Medical School, Sigmund-Freud-Strasse 25, Bonn 53127, Germany.

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http://dx.doi.org/10.1186/1746-1596-9-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975884PMC
March 2014

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.

Cancer Discov 2014 Feb 3;4(2):246-57. Epub 2013 Dec 3.

1Department of Translational Genomics, University of Cologne; 2Max-Planck-Institute for Neurological Research; Institutes of 3Pathology and 4Virology, University of Cologne;5Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne; 6Blackfield AG, Cologne; 7Technical University Dortmund, Dortmund, Germany; 8Medical Oncology and 9Institute of Pathology, Cantonal Hospital, Luzern; 10Novartis Pharma AG, Basel, Switzerland; and 11Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-13-0323DOI Listing
February 2014

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer.

J Clin Invest 2013 Apr;123(4):1732-40

Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1172/JCI65385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613914PMC
April 2013

Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.

PLoS One 2012 18;7(7):e41179. Epub 2012 Jul 18.

Chemical Biology and Medicinal Chemistry Unit, Life and Medical Sciences (LIMES) Institute, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041179PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399819PMC
January 2013

Circulating mitochondrial DNA in serum: a universal diagnostic biomarker for patients with urological malignancies.

Urol Oncol 2012 Jul-Aug;30(4):509-15. Epub 2010 Sep 26.

Klinik und Poliklinik für Urologie, Universitätsklinikum Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.urolonc.2010.03.004DOI Listing
November 2012

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Nat Genet 2012 Oct 2;44(10):1104-10. Epub 2012 Sep 2.

Department of Translational Genomics, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/ng.2396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915822PMC
October 2012

Mast cells play a protumorigenic role in primary cutaneous lymphoma.

Blood 2012 Sep 26;120(10):2042-54. Epub 2012 Jul 26.

Department of Dermatology, University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2012-03-415638DOI Listing
September 2012

Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.

Clin Cancer Res 2012 Sep 21;18(17):4682-90. Epub 2012 Aug 21.

Department of Translational Genomics, University of Cologne, c/o MPI for Neurological Research, Gleueler Str. 50, 50931 Cologne, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3260DOI Listing
September 2012

The role of molecular diagnostics in cancer diagnosis and treatment.

Onkologie 2012 20;35 Suppl 1:8-12. Epub 2012 Jan 20.

Institute of Pathology, University Hospital of Cologne, Germany.

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http://dx.doi.org/10.1159/000334823DOI Listing
May 2012

Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer.

Cancer Invest 2012 Feb 7;30(2):92-7. Epub 2011 Dec 7.

Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany.

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http://dx.doi.org/10.3109/07357907.2011.636117DOI Listing
February 2012

Global histone H4K20 trimethylation predicts cancer-specific survival in patients with muscle-invasive bladder cancer.

BJU Int 2011 Oct 31;108(8 Pt 2):E290-6. Epub 2011 May 31.

Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany.

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http://dx.doi.org/10.1111/j.1464-410X.2011.10203.xDOI Listing
October 2011

Circulating microRNAs (miRNA) in serum of patients with prostate cancer.

Urology 2011 May;77(5):1265.e9-16

Klinik und Poliklinik für Urologie, Universitätsklinikum Bonn, Germany.

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http://dx.doi.org/10.1016/j.urology.2011.01.020DOI Listing
May 2011

Cytohesins are cytoplasmic ErbB receptor activators.

Cell 2010 Oct;143(2):201-11

LIMES Institute, Program Unit Chemical Biology & Medicinal Chemistry, Laboratory of Chemical Biology, Rheinische Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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http://hss.ulb.uni-bonn.de/2011/2583/2583a.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741001059
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http://dx.doi.org/10.1016/j.cell.2010.09.011DOI Listing
October 2010

Cell-free circulating DNA: Diagnostic value in patients with renal cell cancer.

Anticancer Res 2010 Jul;30(7):2785-9

Department of Urology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

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July 2010

Epidermal growth factor receptor mutations in non-small cell lung cancer influence downstream Akt, MAPK and Stat3 signaling.

J Cancer Res Clin Oncol 2009 May 11;135(5):723-30. Epub 2008 Nov 11.

Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.

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http://link.springer.com/10.1007/s00432-008-0509-9
Publisher Site
http://dx.doi.org/10.1007/s00432-008-0509-9DOI Listing
May 2009

MicroRNAs in the pathogenesis of neuroblastoma.

Cancer Lett 2009 Feb 17;274(1):10-5. Epub 2008 Jul 17.

Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany.

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http://dx.doi.org/10.1016/j.canlet.2008.06.010DOI Listing
February 2009

Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators.

Int J Cancer 2008 Jan;122(1):138-43

Klinik und Poliklinik für Urologie, Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Germany.

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http://dx.doi.org/10.1002/ijc.23057DOI Listing
January 2008

CpG island hypermethylation in cell-free serum DNA identifies patients with localized prostate cancer.

Prostate 2008 Jan;68(1):42-9

Klinik und Poliklinik für Urologie,Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

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http://download.bioon.com.cn/upload/month_0807/20080721_de39
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http://doi.wiley.com/10.1002/pros.20651
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http://dx.doi.org/10.1002/pros.20651DOI Listing
January 2008

Hypermethylation of cell-free serum DNA indicates worse outcome in patients with bladder cancer.

J Urol 2008 Jan 19;179(1):346-52. Epub 2007 Nov 19.

Klinik und Poliklinik für Urologie, Universitätsklinikum Bonn, Rheinische-Friedrich-Wilhelms-Universität Bonn, Germany.

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http://dx.doi.org/10.1016/j.juro.2007.08.091DOI Listing
January 2008

CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer.

Urology 2008 Jan;71(1):161-7

Klinik und Poliklinik für Urologie, Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.urology.2007.09.056DOI Listing
January 2008

Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy.

Eur Urol 2007 Mar 23;51(3):665-74; discussion 674. Epub 2006 Aug 23.

Klinik und Poliklinik für Urologie, Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms Universität Bonn, Germany.

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http://dx.doi.org/10.1016/j.eururo.2006.08.008DOI Listing
March 2007

DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer.

Histochem Cell Biol 2007 Feb 8;127(2):175-81. Epub 2006 Sep 8.

Department of Urology and Pediatric Urology, Giessen, Germany.

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http://dx.doi.org/10.1007/s00418-006-0234-xDOI Listing
February 2007

Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci.

Clin Cancer Res 2005 Jun;11(11):4097-106

Klinik und Poliklinik für Urologie and Institut für Pathologie, Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms Universität Bonn, Bonn, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1832DOI Listing
June 2005

Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope.

J Immunother 2002 Jan-Feb;25(1):46-56

Imperial Cancer Research Fund, Breast Cancer Biology Group, Guy's Hospital, London, United Kingdom.

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June 2002