Publications by authors named "Lukas Bunse"

18Publications

A Set of Cell Lines Derived from a Genetic Murine Glioblastoma Model Recapitulates Molecular and Morphological Characteristics of Human Tumors.

Authors:
Barbara Costa Michael N C Fletcher Pavle Boskovic Ekaterina L Ivanova Tanja Eisemann Sabrina Lohr Lukas Bunse Martin Löwer Stefanie Burchard Andrey Korshunov Nadia Coltella Melania Cusimano Luigi Naldini Hai-Kun Liu Michael Platten Bernhard Radlwimmer Peter Angel Heike Peterziel

Cancers (Basel) 2021 Jan 10;13(2). Epub 2021 Jan 10.

Division of Signal Transduction and Growth Control, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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January 2021

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas.

Authors:
Katrin Aslan Verena Turco Jens Blobner Jana K Sonner Anna Rita Liuzzi Nicolás Gonzalo Núñez Donatella De Feo Philipp Kickingereder Manuel Fischer Ed Green Ahmed Sadik Mirco Friedrich Khwab Sanghvi Michael Kilian Frederik Cichon Lara Wolf Kristine Jähne Anna von Landenberg Lukas Bunse Felix Sahm Daniel Schrimpf Jochen Meyer Allen Alexander Gianluca Brugnara Ralph Röth Kira Pfleiderer Beate Niesler Andreas von Deimling Christiane Opitz Michael O Breckwoldt Sabine Heiland Martin Bendszus Wolfgang Wick Burkhard Becher Michael Platten

Nat Commun 2020 02 18;11(1):931. Epub 2020 Feb 18.

DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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February 2020

TCR validation toward gene therapy for cancer.

Authors:
Edward W Green Lukas Bunse Matthias Bozza Khwab Sanghvi Michael Platten

Methods Enzymol 2019 6;629:419-441. Epub 2019 Nov 6.

German Cancer Research Center, DKFZ, Heidelberg, Germany; University Hospital Mannheim, Mannheim, Germany; University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

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June 2020

High-throughput discovery of cancer-targeting TCRs.

Authors:
Lukas Bunse Edward W Green Michael Platten

Methods Enzymol 2019 6;629:401-417. Epub 2019 Nov 6.

German Cancer Research Center, DKFZ, Heidelberg, Germany; University Hospital Mannheim, Mannheim, Germany; University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

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June 2020

Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma.

Authors:
Norbert Hilf Sabrina Kuttruff-Coqui Katrin Frenzel Valesca Bukur Stefan Stevanović Cecile Gouttefangeas Michael Platten Ghazaleh Tabatabai Valerie Dutoit Sjoerd H van der Burg Per Thor Straten Francisco Martinez-Ricarte Berta Ponsati Hideho Okada Ulrik Lassen Arie Admon Christian H Ottensmeier Alexander Ulges Sebastian Kreiter Andreas von Deimling Marco Skardelly Denis Migliorini Judith R Kroep Manja Idorn Jordi Rodon Jordi Piro Hans S Poulsen Bracha Shraibman Katy McCann Regina Mendrzyk Martin Lower Monika Stieglbauer Cedrik M Britten David Capper Marij J P Welters Juan Sahuquillo Katharina Kiesel Evelyna Derhovanessian Elisa Rusch Lukas Bunse Colette Song Sandra Heesch Claudia Wagner Alexandra Kemmer-Bruck Jorg Ludwig John C Castle Oliver Schoor Arbel D Tadmor Edward Green Jens Fritsche Miriam Meyer Nina Pawlowski Sonja Dorner Franziska Hoffgaard Bernhard Rossler Dominik Maurer Toni Weinschenk Carsten Reinhardt Christoph Huber Hans-Georg Rammensee Harpreet Singh-Jasuja Ugur Sahin Pierre-Yves Dietrich Wolfgang Wick

Nature 2019 02;566(7745):E13

University Hospital Heidelberg, Heidelberg, Germany.

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February 2019

Actively personalized vaccination trial for newly diagnosed glioblastoma.

Authors:
Norbert Hilf Sabrina Kuttruff-Coqui Katrin Frenzel Valesca Bukur Stefan Stevanović Cécile Gouttefangeas Michael Platten Ghazaleh Tabatabai Valerie Dutoit Sjoerd H van der Burg Per Thor Straten Francisco Martínez-Ricarte Berta Ponsati Hideho Okada Ulrik Lassen Arie Admon Christian H Ottensmeier Alexander Ulges Sebastian Kreiter Andreas von Deimling Marco Skardelly Denis Migliorini Judith R Kroep Manja Idorn Jordi Rodon Jordi Piró Hans S Poulsen Bracha Shraibman Katy McCann Regina Mendrzyk Martin Löwer Monika Stieglbauer Cedrik M Britten David Capper Marij J P Welters Juan Sahuquillo Katharina Kiesel Evelyna Derhovanessian Elisa Rusch Lukas Bunse Colette Song Sandra Heesch Claudia Wagner Alexandra Kemmer-Brück Jörg Ludwig John C Castle Oliver Schoor Arbel D Tadmor Edward Green Jens Fritsche Miriam Meyer Nina Pawlowski Sonja Dorner Franziska Hoffgaard Bernhard Rössler Dominik Maurer Toni Weinschenk Carsten Reinhardt Christoph Huber Hans-Georg Rammensee Harpreet Singh-Jasuja Ugur Sahin Pierre-Yves Dietrich Wolfgang Wick

Nature 2019 01 19;565(7738):240-245. Epub 2018 Dec 19.

University Hospital Heidelberg, Heidelberg, Germany.

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January 2019

Perspectives of immunotherapy in isocitrate dehydrogenase-mutant gliomas.

Authors:
Mirco Friedrich Lukas Bunse Wolfgang Wick Michael Platten

Curr Opin Oncol 2018 11;30(6):368-374

German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ).

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November 2018

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.

Authors:
Lukas Bunse Stefan Pusch Theresa Bunse Felix Sahm Khwab Sanghvi Mirco Friedrich Dalia Alansary Jana K Sonner Edward Green Katrin Deumelandt Michael Kilian Cyril Neftel Stefanie Uhlig Tobias Kessler Anna von Landenberg Anna S Berghoff Kelly Marsh Mya Steadman Dongwei Zhu Brandon Nicolay Benedikt Wiestler Michael O Breckwoldt Ruslan Al-Ali Simone Karcher-Bausch Matthias Bozza Iris Oezen Magdalena Kramer Jochen Meyer Antje Habel Jessica Eisel Gernot Poschet Michael Weller Matthias Preusser Minou Nadji-Ohl Niklas Thon Michael C Burger Patrick N Harter Miriam Ratliff Richard Harbottle Axel Benner Daniel Schrimpf Jürgen Okun Christel Herold-Mende Sevin Turcan Stefan Kaulfuss Holger Hess-Stumpp Karen Bieback Daniel P Cahill Karl H Plate Daniel Hänggi Marion Dorsch Mario L Suvà Barbara A Niemeyer Andreas von Deimling Wolfgang Wick Michael Platten

Nat Med 2018 08 9;24(8):1192-1203. Epub 2018 Jul 9.

German Cancer Consortium (DKTK) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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August 2018

Vaccine Strategies in Gliomas.

Authors:
Michael Platten Lukas Bunse Dennis Riehl Theresa Bunse Katharina Ochs Wolfgang Wick

Curr Treat Options Neurol 2018 Mar 28;20(5):11. Epub 2018 Mar 28.

Department of Neurology, Heidelberg Medical Center, University of Heidelberg, INF 400, 69120, Heidelberg, Germany.

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March 2018

The promises of immunotherapy in gliomas.

Authors:
Iris Mildenberger Lukas Bunse Katharina Ochs Michael Platten

Curr Opin Neurol 2017 Dec;30(6):650-658

aDepartment of Neurology, University Hospital Mannheim, Heidelberg University bCCU Neuroimmunology and Brain Tumor Immunology, First Division, German Cancer Research Center (DKFZ) cDepartment of Neurology and National Center for Tumor Diseases, Heidelberg University, Heidelberg, Germany.

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December 2017

K27M-mutant histone-3 as a novel target for glioma immunotherapy.

Authors:
Katharina Ochs Martina Ott Theresa Bunse Felix Sahm Lukas Bunse Katrin Deumelandt Jana K Sonner Melanie Keil Andreas von Deimling Wolfgang Wick Michael Platten

Oncoimmunology 2017;6(7):e1328340. Epub 2017 May 12.

Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany.

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May 2017

Concepts in glioma immunotherapy.

Authors:
Michael Platten Lukas Bunse Wolfgang Wick Theresa Bunse

Cancer Immunol Immunother 2016 10 26;65(10):1269-75. Epub 2016 Jul 26.

DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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October 2016

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.

Authors:
Veit Rothhammer Ivan D Mascanfroni Lukas Bunse Maisa C Takenaka Jessica E Kenison Lior Mayo Chun-Cheih Chao Bonny Patel Raymond Yan Manon Blain Jorge I Alvarez Hania Kébir Niroshana Anandasabapathy Guillermo Izquierdo Steffen Jung Nikolaus Obholzer Nathalie Pochet Clary B Clish Marco Prinz Alexandre Prat Jack Antel Francisco J Quintana

Nat Med 2016 06 9;22(6):586-97. Epub 2016 May 9.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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June 2016

Mutant IDH1: An immunotherapeutic target in tumors.

Authors:
Theresa Schumacher Lukas Bunse Wolfgang Wick Michael Platten

Oncoimmunology 2014 Dec 7;3(12):e974392. Epub 2015 Jan 7.

DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology; German Cancer Research Center ; Heidelberg, Germany ; Department of Neurooncology; University Hospital Heidelberg ; Heidelberg, Germany.

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December 2014

Proximity ligation assay evaluates IDH1R132H presentation in gliomas.

Authors:
Lukas Bunse Theresa Schumacher Felix Sahm Stefan Pusch Iris Oezen Katharina Rauschenbach Marina Gonzalez Gergely Solecki Matthias Osswald David Capper Benedikt Wiestler Frank Winkler Christel Herold-Mende Andreas von Deimling Wolfgang Wick Michael Platten

J Clin Invest 2015 Feb 2;125(2):593-606. Epub 2015 Jan 2.

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February 2015

Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway.

Authors:
Martina Ott Ulrike M Litzenburger Katharina J Rauschenbach Lukas Bunse Katharina Ochs Felix Sahm Stefan Pusch Christiane A Opitz Jonas Blaes Andreas von Deimling Wolfgang Wick Michael Platten

Glia 2015 Jan 5;63(1):78-90. Epub 2014 Aug 5.

German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany.

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January 2015

A vaccine targeting mutant IDH1 induces antitumour immunity.

Authors:
Theresa Schumacher Lukas Bunse Stefan Pusch Felix Sahm Benedikt Wiestler Jasmin Quandt Oliver Menn Matthias Osswald Iris Oezen Martina Ott Melanie Keil Jörg Balß Katharina Rauschenbach Agnieszka K Grabowska Isabel Vogler Jan Diekmann Nico Trautwein Stefan B Eichmüller Jürgen Okun Stefan Stevanović Angelika B Riemer Ugur Sahin Manuel A Friese Philipp Beckhove Andreas von Deimling Wolfgang Wick Michael Platten

Nature 2014 Aug 25;512(7514):324-7. Epub 2014 Jun 25.

1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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August 2014

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy.

Authors:
Markus Weiler Jonas Blaes Stefan Pusch Felix Sahm Marcus Czabanka Sebastian Luger Lukas Bunse Gergely Solecki Viktoria Eichwald Manfred Jugold Sibylle Hodecker Matthias Osswald Christoph Meisner Thomas Hielscher Petra Rübmann Philipp-Niklas Pfenning Michael Ronellenfitsch Tore Kempf Martina Schnölzer Amir Abdollahi Florian Lang Martin Bendszus Andreas von Deimling Frank Winkler Michael Weller Peter Vajkoczy Michael Platten Wolfgang Wick

Proc Natl Acad Sci U S A 2014 Jan 23;111(1):409-14. Epub 2013 Dec 23.

German Cancer Consortium, Clinical Cooperation Units Neurooncology and Neuropathology, Helmholtz Group Experimental Neuroimmunology, Small Animal Imaging Facility, Biostatistics, and Functional Proteome Analysis, German Cancer Research Center, D-69120 Heidelberg, Germany.

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January 2014