Luisa-Maria Botella

Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa.

Authors:

Tania Aguado Marta García Adela García Gemma Ferrer-Mayorga Lucía Martínez-Santamaría Marcela Del Río Luisa-María Botella José-María Sánchez-Puelles

Cells 2020 09 16;9(9). Epub 2020 Sep 16.

Department of Molecular Biomedicine, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, U-707 CIBERER, 28040 Madrid, Spain.

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September 2020

Targeting β2-Adrenergic Receptors Shows Therapeutical Benefits in Clear Cell Renal Cell Carcinoma from Von Hippel-Lindau Disease.

Authors:

Virginia Albiñana Eunate Gallardo-Vara Isabel de Rojas-P Lucia Recio-Poveda Tania Aguado Ana Canto-Cano Daniel T Aguirre Marcelo M Serra Pilar González-Peramato Luis Martínez-Piñeiro Angel M Cuesta Luisa Maria Botella

J Clin Med 2020 Aug 25;9(9). Epub 2020 Aug 25.

Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), 9 Ramiro de Maeztu Street, 28050 Madrid, Spain.

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August 2020

Review of Pharmacological Strategies with Repurposed Drugs for Hereditary Hemorrhagic Telangiectasia Related Bleeding.

Authors:

Virginia Albiñana Angel M Cuesta Isabel de Rojas-P Eunate Gallardo-Vara Lucía Recio-Poveda Carmelo Bernabéu Luisa María Botella

J Clin Med 2020 Jun 6;9(6). Epub 2020 Jun 6.

Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), 9 Ramiro de Maeztu Street, 28040 Madrid, Spain.

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June 2020

CLN5 in heterozygosis may protect against the development of tumors in a VHL patient.

Authors:

Isabel de Rojas-P Virginia Albiñana Lucía Recio-Poveda Amanda Rodriguez-Rufián Ángel M Cuesta Luisa-María Botella

Orphanet J Rare Dis 2020 06 2;15(1):132. Epub 2020 Jun 2.

Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

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June 2020

11PS04 is a new chemical entity identified by microRNA-based biosensing with promising therapeutic potential against cancer stem cells.

Authors:

Tania Aguado José A Romero-Revilla Rosario Granados Susana Campuzano Rebeca M Torrente-Rodríguez Ángel M Cuesta Virginia Albiñana Luisa María Botella Silvia Santamaría Jose A Garcia-Sanz José Manuel Pingarrón Francisco Sánchez-Sancho José-María Sánchez-Puelles

Sci Rep 2019 08 15;9(1):11916. Epub 2019 Aug 15.

Departamento de Biomedicina Molecular, Centro de Investigaciones Biológicas, CSIC, c/Ramiro de Maeztu 9, 28040, Madrid, Spain.

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August 2019

Topically Applied Etamsylate: A New Orphan Drug for HHT-Derived Epistaxis (Antiangiogenesis through FGF Pathway Inhibition).

Authors:

Virginia Albiñana Guillermo Giménez-Gallego Angela García-Mato Patricia Palacios Lucia Recio-Poveda Angel-M Cuesta José-Luis Patier Luisa-María Botella

TH Open 2019 Jul 26;3(3):e230-e243. Epub 2019 Jul 26.

Molecular Biomedicine Department, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.

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July 2019

Safety of thalidomide and bevacizumab in patients with hereditary hemorrhagic telangiectasia.

Authors:

Elisabetta Buscarini Luisa Maria Botella Urban Geisthoff Anette D Kjeldsen Hans Jurgen Mager Fabio Pagella Patrizia Suppressa Roberto Zarrabeitia Sophie Dupuis-Girod Claire L Shovlin

Orphanet J Rare Dis 2019 02 4;14(1):28. Epub 2019 Feb 4.

VASCERN HHT Reference Center, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, and Vascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK.

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February 2019

Case Report: Propranolol increases the therapeutic response to temozolomide in a patient with metastatic paraganglioma.

Authors:

Miguel-Angel Díaz-Castellanos Karina Villar Gómez de Las Heras Tamara Díaz-Redondo Encarnación González-Flores Virginia Albiñana Luisa-María Botella

F1000Res 2017 4;6:2087. Epub 2017 Dec 4.

Centro de Investigaciones Biológicas, U-707 CIBERER, Madrid, Spain.

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December 2017

Repurposing propranolol as a drug for the treatment of retinal haemangioblastomas in von Hippel-Lindau disease.

Authors:

Virginia Albiñana Rosa María Jiménez Escribano Isabel Soler Luis Rodríguez Padial Lucia Recio-Poveda Karina Villar Gómez de Las Heras Luisa María Botella

Orphanet J Rare Dis 2017 06 29;12(1):122. Epub 2017 Jun 29.

Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.

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June 2017

Quality of life in patients with hereditary haemorrhagic telangiectasia (HHT).

Authors:

Roberto Zarrabeitia Concepción Fariñas-Álvarez Miguel Santibáñez Blanca Señaris Ana Fontalba Luisa María Botella José Antonio Parra

Health Qual Life Outcomes 2017 Jan 23;15(1):19. Epub 2017 Jan 23.

Department of Radiology, Hospital Universitario Marqués de Valdecilla and Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain.

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January 2017

Propranolol reduces viability and induces apoptosis in hemangioblastoma cells from von Hippel-Lindau patients.

Authors:

Virginia Albiñana Karina Villar Gómez de Las Heras Gemma Serrano-Heras Tomás Segura Ana Belén Perona-Moratalla Mercedes Mota-Pérez José María de Campos Luisa María Botella

Orphanet J Rare Dis 2015 Sep 22;10:118. Epub 2015 Sep 22.

Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.

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September 2015

Research on potential biomarkers in hereditary hemorrhagic telangiectasia.

Authors:

Luisa-María Botella Virginia Albiñana Luisa Ojeda-Fernandez Lucia Recio-Poveda Carmelo Bernabéu

Front Genet 2015 31;6:115. Epub 2015 Mar 31.

Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientificas , Madrid, Spain ; Centro de Investigación Biomédica en Red de Enfermedades Raras , Madrid, Spain.

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April 2015

MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells.

Authors:

Sebastien P Tabruyn Sylvain Hansen Maria-Luisa Ojeda-Fernández Nicolas Bovy Roberto Zarrabeitia Lucia Recio-Poveda Carmelo Bernabéu Joseph A Martial Luisa-Maria Botella Ingrid Struman

Angiogenesis 2013 Oct 26;16(4):877-87. Epub 2013 Jun 26.

Unit of Molecular Biology and Genetic Engineering, GIGA, University of Liège, Sart-Tilman, 4000, Liège, Belgium.

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October 2013

Propranolol as antiangiogenic candidate for the therapy of hereditary haemorrhagic telangiectasia.

Authors:

Virginia Albiñana Lucía Recio-Poveda Roberto Zarrabeitia Carmelo Bernabéu Luisa María Botella

Thromb Haemost 2012 Jul 3;108(1):41-53. Epub 2012 May 3.

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas and Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.

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July 2012