Luisa Ugedo

Luisa Ugedo

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Luisa Ugedo

Luisa Ugedo

Publications by authors named "Luisa Ugedo"

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Dysfunction of serotonergic neurons in Parkinson's disease and dyskinesia.

Int Rev Neurobiol 2019 18;146:259-279. Epub 2019 Jul 18.

Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain; Neurodegenerative Diseases, Biocruces Health Research Institute, Barakaldo, Spain. Electronic address:

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http://dx.doi.org/10.1016/bs.irn.2019.06.013DOI Listing
February 2020

Opioid Activity in the Locus Coeruleus Is Modulated by Chronic Neuropathic Pain.

Mol Neurobiol 2019 Jun 3;56(6):4135-4150. Epub 2018 Oct 3.

Instituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz, INiBICA, Hospital Universitario Puerta del Mar, Avda. Ana de Viya, 21, 11009, Cádiz, Spain.

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http://dx.doi.org/10.1007/s12035-018-1361-9DOI Listing
June 2019

Nanodelivery of therapeutic agents in Parkinson's disease.

Prog Brain Res 2019 2;245:263-279. Epub 2019 Apr 2.

Neuropharmacology Group, University of the Basque Country (UPV-EHU), Leioa, Spain.

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http://dx.doi.org/10.1016/bs.pbr.2019.03.004DOI Listing
June 2019

Effects of adult enriched environment on cognition, hippocampal-prefrontal plasticity and NMDAR subunit expression in MK-801-induced schizophrenia model.

Eur Neuropsychopharmacol 2019 May 26;29(5):590-600. Epub 2019 Mar 26.

Deparment of Neuroscience, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n, Leioa 48940, Bizkaia, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S0924977X193019
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http://dx.doi.org/10.1016/j.euroneuro.2019.03.009DOI Listing
May 2019

Cannabinoids differentially modulate cortical information transmission through the sensorimotor or medial prefrontal basal ganglia circuits.

Br J Pharmacol 2019 04 18;176(8):1156-1169. Epub 2019 Mar 18.

Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.

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http://dx.doi.org/10.1111/bph.14613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451076PMC
April 2019

Ketamine promotes rapid and transient activation of AMPA receptor-mediated synaptic transmission in the dorsal raphe nucleus.

Prog Neuropsychopharmacol Biol Psychiatry 2019 01 31;88:243-252. Epub 2018 Jul 31.

Department of Pharmacology, School of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2018.07.022DOI Listing
January 2019

Beneficial effects of n-3 polyunsaturated fatty acids administration in a partial lesion model of Parkinson's disease: The role of glia and NRf2 regulation.

Neurobiol Dis 2019 01 6;121:252-262. Epub 2018 Oct 6.

NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz 01006, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.10.001DOI Listing
January 2019

The Neuroprotective Effect of Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells is Impaired by N-acetyl Cysteine Supplementation.

Mol Neurobiol 2018 01;55(1):13-25

Departments of Cell Biology and Histology, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.

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http://dx.doi.org/10.1007/s12035-017-0714-0DOI Listing
January 2018

Impairment of Serotonergic Transmission by the Antiparkinsonian Drug L-DOPA: Mechanisms and Clinical Implications.

Front Cell Neurosci 2017 12;11:274. Epub 2017 Sep 12.

Institut des Maladies Neurodégénératives, Université de Bordeaux, UMR 5293Bordeaux, France.

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http://dx.doi.org/10.3389/fncel.2017.00274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600927PMC
September 2017

Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats.

Int J Neuropsychopharmacol 2017 06;20(6):463

Neuropsychopharmacology and Psychobiology Research Group, Department of Neuroscience, University of Cádiz, Cádiz, Spain (Drs Borges and Mico); Departamento de Biomedicina-Unidade de Biologia Experimental, da Faculdade de Medicina da Universidade do Porto (FMUP), Porto, Portugal (Drs Borges and Neto); Instituto de Biologia Molecular e Celular (IBMC) e Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Porto, Portugal (Drs Borges and Neto); Department of Pharmacology, Faculty of Medicine and Dentistry, University of the Basque Country UPV/EHU, Leioa, Spain (Drs Miguelez and Ugedo); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain (Drs Mico and Berrocoso); Neuropsychopharmacology and Psychobiology Research Group, Department of Psychology, University of Cádiz, Cádiz, Spain (Dr Berrocoso); Instituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz, INiBICA, Hospital Universitario Puerta del Mar, Cádiz, Spain (Drs Mico and Berrocoso).

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http://dx.doi.org/10.1093/ijnp/pyx005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458337PMC
June 2017

Chronic citalopram administration desensitizes prefrontal cortex but not somatodendritic α-adrenoceptors in rat brain.

Neuropharmacology 2017 03 28;114:114-122. Epub 2016 Nov 28.

Department of Pharmacology, University of the Basque Country UPV/EHU, Leioa, Bizkaia, Spain; Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Spain; BioCruces Health Research Institute, Bizkaia, Spain.

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http://dx.doi.org/10.1016/j.neuropharm.2016.11.025DOI Listing
March 2017

Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons.

Physiol Rep 2017 Feb;5(3)

Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain

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http://dx.doi.org/10.14814/phy2.13141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309581PMC
February 2017

L-DOPA elicits non-vesicular releases of serotonin and dopamine in hemiparkinsonian rats in vivo.

Eur Neuropsychopharmacol 2016 08 24;26(8):1297-309. Epub 2016 May 24.

Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2016.05.004DOI Listing
August 2016

Cystine/glutamate antiporter blockage induces myelin degeneration.

Glia 2016 08 1;64(8):1381-95. Epub 2016 Jun 1.

Achucarro Basque Center for Neurosciences, CIBERNED and Departamento de Neurociencias, Universidad Del País Vasco, Leioa, Spain.

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http://dx.doi.org/10.1002/glia.23011DOI Listing
August 2016

Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine.

Neuropharmacology 2016 Feb 8;101:76-86. Epub 2015 Sep 8.

Mental Illness Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782767PMC
February 2016

Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT1A Receptor-Mediated Signaling and Results in a Depression-Resistant Behavior.

Int J Neuropsychopharmacol 2015 May 8;18(11):pyv051. Epub 2015 May 8.

Department of Pharmacology, Faculty of Medicine and Dentistry, University of the Basque Country UPV/EHU, Leioa, Spain (Drs Llamosas, Bruzos-Cidón, Ugedo, and Torrecilla); Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain (Dr Rodríguez); Department of Neuroscience, University of the Basque Country UPV/EHU and CIBERNED, Leioa, Spain (Dr Rodríguez).

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https://academic.oup.com/ijnp/article-lookup/doi/10.1093/ijn
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http://dx.doi.org/10.1093/ijnp/pyv051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756724PMC
May 2015

Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease.

Int J Nanomedicine 2014 27;9:2677-87. Epub 2014 May 27.

NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country (UPV/EHU), School of Pharmacy, Vitoria, Spain ; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain.

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http://dx.doi.org/10.2147/IJN.S61940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043720PMC
December 2014

Interaction between the 5-HT system and the basal ganglia: functional implication and therapeutic perspective in Parkinson's disease.

Front Neural Circuits 2014 17;8:21. Epub 2014 Mar 17.

Department of Pharmacology, Faculty of Medicine and Dentistry, University of the Basque Country UPV/EHU Leioa, Spain.

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http://dx.doi.org/10.3389/fncir.2014.00021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955837PMC
September 2014

Buspirone anti-dyskinetic effect is correlated with temporal normalization of dysregulated striatal DRD1 signalling in L-DOPA-treated rats.

Neuropharmacology 2014 Apr 10;79:726-37. Epub 2013 Dec 10.

Laboratory of Stem Cells and Neural Repair, Inbiomed, P. Mikeletegi, 81, 20009 San Sebastian, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2013.11.024DOI Listing
April 2014

In vivo administration of VEGF- and GDNF-releasing biodegradable polymeric microspheres in a severe lesion model of Parkinson's disease.

Eur J Pharm Biopharm 2013 Nov 30;85(3 Pt B):1183-90. Epub 2013 Apr 30.

NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain.

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http://dx.doi.org/10.1016/j.ejpb.2013.03.034DOI Listing
November 2013

Role of GIRK channels on the noradrenergic transmission in vivo: an electrophysiological and neurochemical study on GIRK2 mutant mice.

Int J Neuropsychopharmacol 2013 Jun 8;16(5):1093-104. Epub 2012 Oct 8.

Department of Pharmacology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1017/S1461145712000971DOI Listing
June 2013

Endocannabinoid modulation of dopaminergic motor circuits.

Front Pharmacol 2012 12;3:110. Epub 2012 Jun 12.

Faculty of Medicine and Dentistry, Department of Pharmacology, University of the Basque Country Leioa, Spain.

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http://dx.doi.org/10.3389/fphar.2012.00110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372848PMC
October 2012

The locus coeruleus is directly implicated in L-DOPA-induced dyskinesia in parkinsonian rats: an electrophysiological and behavioural study.

PLoS One 2011 9;6(9):e24679. Epub 2011 Sep 9.

Department of Pharmacology, Faculty of Medicine and Dentistry, University of the Basque Country, Vizcaya, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024679PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170382PMC
February 2012

Locus coeruleus and dorsal raphe neuron activity and response to acute antidepressant administration in a rat model of Parkinson's disease.

Int J Neuropsychopharmacol 2011 Mar 29;14(2):187-200. Epub 2010 Apr 29.

Department of Pharmacology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1017/S146114571000043XDOI Listing
March 2011

Nigrostriatal denervation changes the effect of cannabinoids on subthalamic neuronal activity in rats.

Psychopharmacology (Berl) 2011 Mar 20;214(2):379-89. Epub 2010 Oct 20.

Department of Pharmacology, Faculty of Medicine, University of the Basque Country, 48940, Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1007/s00213-010-2043-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045509PMC
March 2011

Regulation of subthalamic neuron activity by endocannabinoids.

Synapse 2010 Sep;64(9):682-98

Department of Pharmacology, Faculty of Medicine, University of the Basque Country, E-48940 Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1002/syn.20778DOI Listing
September 2010

Two opposite effects of Delta(9)-tetrahydrocannabinol on subthalamic nucleus neuron activity: involvement of GABAergic and glutamatergic neurotransmission.

Synapse 2010 Jan;64(1):20-9

Faculty of Medicine, Department of Pharmacology, University of the Basque Country, E-48940, Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1002/syn.20701DOI Listing
January 2010

Excitatory regulation of noradrenergic neurons by L-arginine/nitric oxide pathway in the rat locus coeruleus in vivo.

Naunyn Schmiedebergs Arch Pharmacol 2007 Jul 1;375(5):337-47. Epub 2007 May 1.

Department of Pharmacology, Faculty of Medicine, University of the Basque Country (UPV/EHU), Sarriena Auzoa z/g, E-48940, Leioa, Bizkaia, Spain.

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http://link.springer.com/10.1007/s00210-007-0163-9
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http://dx.doi.org/10.1007/s00210-007-0163-9DOI Listing
July 2007

In vivo effect of tramadol on locus coeruleus neurons is mediated by alpha2-adrenoceptors and modulated by serotonin.

Neuropharmacology 2006 Jul 30;51(1):146-53. Epub 2006 May 30.

Pharmacology and Neuroscience Research Group, Department of Neuroscience (Pharmacology and Psychiatry), School of Medicine, University of Cádiz, Plaza Falla 9, E-11003 Cádiz, Spain.

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http://dx.doi.org/10.1016/j.neuropharm.2006.03.013DOI Listing
July 2006

Acute and long-term administration of citalopram desensitizes alpha2-adrenoceptors in the rat vas deferens.

J Pharm Pharmacol 2006 Mar;58(3):367-73

Departamento de Farmacología, Universidad del País Vasco, E-48940 Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1211/jpp.58.3.0011DOI Listing
March 2006

alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons.

Eur J Pharmacol 2005 Jul;517(1-2):51-8

Departamento de Farmacología, Universidad del País Vasco, E-48940 Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1016/j.ejphar.2005.05.033DOI Listing
July 2005

Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice.

Neuropsychopharmacology 2004 Jun;29(6):1122-33

Laboratori de Neurofarmacologia, Facultat de Ciènces de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1038/sj.npp.1300416DOI Listing
June 2004

Comparative study of the effects of desipramine and reboxetine on locus coeruleus neurons in rat brain slices.

Neuropharmacology 2004 May;46(6):815-23

Department of Pharmacology, Faculty of Medicine, University of the Basque Country, E-48940 Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1016/j.neuropharm.2003.11.033DOI Listing
May 2004

Agmatine-morphine interaction on nociception in mice.

Ann N Y Acad Sci 2003 Dec;1009:133-6

Department of Pharmacology, Faculty of Medicine, University of the Basque Country, Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1196/annals.1304.013DOI Listing
December 2003

Short-term effects of 3,4-methylenedioximethamphetamine on noradrenergic activity in locus coeruleus and hippocampus of the rat.

Neurosci Lett 2003 Feb;337(3):123-6

Department of Pharmacology, Faculty of Medicine and Odontology, University of the Basque Country, 48940-Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1016/s0304-3940(02)01252-1DOI Listing
February 2003

Effect of agmatine on locus coeruleus neuron activity: possible involvement of nitric oxide.

Br J Pharmacol 2002 Mar;135(5):1152-8

Departamento de Farmacología, Facultad de Medicina, Universidad del País Vasco, E-48940 Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1038/sj.bjp.0704556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573220PMC
March 2002