Publications by authors named "Luisa Minghetti"

80Publications

A few ethical issues in translational research for medicinal products discovery and development.

Ann Ist Super Sanita 2020 Oct-Dec;56(4):487-491

President, Istituto Superiore di Sanità, Rome, Italy.

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December 2020

An analysis of the strategic plan development processes of major public organisations funding health research in nine high-income countries worldwide.

Health Res Policy Syst 2020 Sep 18;18(1):106. Epub 2020 Sep 18.

Research Coordination and Support Service, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.

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September 2020

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin.

Nutrients 2020 Aug 19;12(9). Epub 2020 Aug 19.

Center for Gender-Specific Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.

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August 2020

EATRIS, the European Research Infrastructure for Translational Medicine and A_IATRIS, its Italian node.

Int J Biol Markers 2020 Feb;35(1_suppl):3-4

Research Coordination and Support Service, Istituto Superiore di Sanità, Rome, Italy.

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February 2020

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis.

Neurotherapeutics 2016 10;13(4):918-927

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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October 2016

Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism.

J Neuroinflammation 2016 06 14;13(1):149. Epub 2016 Jun 14.

Section of Experimental Neurology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Rome, Italy.

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June 2016

Glycogen synthase kinase 3 is part of the molecular machinery regulating the adaptive response to LPS stimulation in microglial cells.

Brain Behav Immun 2016 07 22;55:225-235. Epub 2015 Nov 22.

Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

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July 2016

The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses.

J Neurochem 2015 Oct 3;135(1):147-56. Epub 2015 Aug 3.

Experimental Neurology Unit, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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October 2015

Microglia in development and disease.

Clin Dev Immunol 2013 27;2013:736459. Epub 2013 Aug 27.

Department of Zoology and Immunobiology Lab, Panihati Mahavidyalaya, West Bengal State University, Sodepur, Kolkata 700110, India.

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February 2014

The stimulation of adenosine A2A receptors ameliorates the pathological phenotype of fibroblasts from Niemann-Pick type C patients.

J Neurosci 2013 Sep;33(39):15388-93

Department of Cell Biology and Neuroscience, and Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, 00161 Rome, Italy.

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September 2013

Microglial polarization and plasticity: evidence from organotypic hippocampal slice cultures.

Glia 2013 Oct 5;61(10):1698-711. Epub 2013 Aug 5.

Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, 00185 Rome, Italy.

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October 2013

Early-life sex-dependent vulnerability to oxidative stress: the natural twining model.

J Matern Fetal Neonatal Med 2013 Feb 19;26(3):259-62. Epub 2012 Oct 19.

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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February 2013

hMTH1 expression protects mitochondria from Huntington's disease-like impairment.

Neurobiol Dis 2013 Jan 10;49:148-58. Epub 2012 Sep 10.

Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address:

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January 2013

Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation, and differentiation.

Dev Neurobiol 2012 May;72(5):713-28

Department of Biology and Biotechnologies Charles Darwin, Center of Neurobiology Research Daniel Bovet, La Sapienza University of Rome, Rome, Italy.

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May 2012

Oxidative stress in twin neonates is influenced by birth weight and weight discordance.

Clin Biochem 2011 Jun 22;44(8-9):654-8. Epub 2011 Feb 22.

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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June 2011

TGF-β and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression.

J Neurochem 2010 Oct 30;115(2):450-9. Epub 2010 Aug 30.

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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October 2010

Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions.

Pharmaceuticals (Basel) 2010 Jun 14;3(6):1949-1965. Epub 2010 Jun 14.

Experimental Neurology Section, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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June 2010

Pro-gliogenic effect of IL-1alpha in the differentiation of embryonic neural precursor cells in vitro.

J Neurochem 2010 May 4;113(4):1060-72. Epub 2010 Mar 4.

Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy.

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May 2010

Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice.

Exp Gerontol 2010 May 18;45(5):343-50. Epub 2010 Jan 18.

Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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May 2010

Striatal 6-OHDA lesion in mice: Investigating early neurochemical changes underlying Parkinson's disease.

Behav Brain Res 2010 Mar 13;208(1):137-43. Epub 2009 Nov 13.

Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, 00161 Rome, Italy.

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March 2010

Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells.

J Neuropathol Exp Neurol 2009 Jul;68(7):797-808

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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July 2009

Non steroidal anti-inflammatory drugs and neurogenesis in the adult mammalian brain.

Curr Pharm Des 2008 ;14(14):1435-42

Department of Cell Biology and Neurosciences, Section of Degenerative and Inflammatory Neurological Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.

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July 2008

Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.

PPAR Res 2008 ;2008:864140

Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.

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July 2011

PPAR-gamma, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches.

PPAR Res 2008 ;2008:295784

Departmento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, 00161 Rome, Italy.

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July 2011

Altered expression of cyclooxygenase-2, presenilins and oxygen radical scavenging enzymes in a rat model of global perinatal asphyxia.

Exp Neurol 2008 Jan 25;209(1):192-8. Epub 2007 Oct 25.

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Roma, Italy.

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January 2008

Plasma levels of 15-F(2t)-isoprostane in newborn infants are affected by mode of delivery.

Clin Biochem 2007 Dec 21;40(18):1420-2. Epub 2007 Sep 21.

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena, 299-00161 Rome, Italy.

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December 2007

Cyclooxygenase-2, prostaglandin E2, and microglial activation in prion diseases.

Int Rev Neurobiol 2007 ;82:265-75

Department of Cell Biology and Neurosciences, Degenerative and Inflammatory Neurological Diseases Unit, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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September 2007

Role of COX-2 in inflammatory and degenerative brain diseases.

Authors:
Luisa Minghetti

Subcell Biochem 2007 ;42:127-41

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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August 2007

Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.

Exp Gerontol 2007 Jan-Feb;42(1-2):37-45. Epub 2006 Jun 30.

Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, I-00161 Rome, Italy.

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October 2007

Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons.

Neurobiol Dis 2006 Jul 13;23(1):23-35. Epub 2006 Mar 13.

Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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July 2006

Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer's disease.

J Neuroinflammation 2006 Mar 3;3. Epub 2006 Mar 3.

Department of Cell Biology and Neurosciences, Section of Degenerative and Inflammatory Neurological Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.

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March 2006

PPAR-gamma agonists as regulators of microglial activation and brain inflammation.

Curr Pharm Des 2006 ;12(1):93-109

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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February 2006

Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases.

Neurobiol Dis 2006 Apr 22;22(1):25-32. Epub 2005 Nov 22.

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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April 2006

Isoprostanes as biomarkers and mediators of oxidative injury in infant and adult central nervous system diseases.

Curr Neurovasc Res 2004 Oct;1(4):341-54

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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October 2004

Role of inflammation in neurodegenerative diseases.

Authors:
Luisa Minghetti

Curr Opin Neurol 2005 Jun;18(3):315-21

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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June 2005

Microglial activation in chronic neurodegenerative diseases: roles of apoptotic neurons and chronic stimulation.

Brain Res Brain Res Rev 2005 Apr 18;48(2):251-6. Epub 2005 Jan 18.

Department of Cell Biology and Neurosciences, Istituto Superiore Di Sanità, Italy.

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April 2005

Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures.

J Neuroinflammation 2005 Jan 25;2(1). Epub 2005 Jan 25.

Department of Cell Biology and Neurosciences, Section of Degenerative and Inflammatory Neurological Diseases, Istituto Superiore di Sanità, Rome, Italy.

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January 2005

Adenosine A2A receptor antagonism and neuroprotection: mechanisms, lights, and shadows.

Crit Rev Neurobiol 2004 ;16(1-2):99-106

Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Roma, Italy.

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January 2005

Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases.

Authors:
Luisa Minghetti

J Neuropathol Exp Neurol 2004 Sep;63(9):901-10

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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September 2004

Cerebrospinal fluid isoprostanes are not related to inflammatory activity in relapsing-remitting multiple sclerosis.

J Neurol Sci 2004 Sep;224(1-2):23-7

Department of Cell Biology and Neuroscience, Instituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.

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September 2004

Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats.

Exp Neurol 2004 Sep;189(1):162-72

Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, 00161 Rome, Italy.

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September 2004

Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions.

Neurochem Res 2004 May;29(5):965-78

Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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May 2004

Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction.

Mol Neurobiol 2004 Apr;29(2):197-212

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Italy.

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April 2004

Increased brain levels of F2-isoprostane are an early marker of behavioral sequels in a rat model of global perinatal asphyxia.

Pediatr Res 2004 Jan 15;55(1):85-92. Epub 2003 Oct 15.

Section of Comparative Psychology, Laboratorio di Fisiopatologia, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161 Roma, Italy.

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January 2004

Opposite regulation of prostaglandin E2 synthesis by transforming growth factor-beta1 and interleukin 10 in activated microglial cultures.

J Neuroimmunol 1998 Feb;82(1):31-39

Neurobiology Section, Laboratory of Pathophysiology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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February 1998