Luis Diambra, Luis A. Diambra - Centro Regional de Estudios Genómicos/ UNLP

Luis Diambra, Luis A. Diambra

Centro Regional de Estudios Genómicos/ UNLP

La Plata | Argentina

Main Specialties: Biochemical Genetics, Biotechnology

Additional Specialties: Systems Biology

ORCID logohttps://orcid.org/0000-0001-8052-4880


Top Author

Luis Diambra, Luis A. Diambra - Centro Regional de Estudios Genómicos/ UNLP

Luis Diambra, Luis A. Diambra

Introduction

I am group leader of the System Biology Lab at CREG since 2006: Here, my work focused on developing Bioinformatics tools to analysis and modeling biological data. These applications ranging from sequence analysis, genome assembly, to reverse engineering gene networks. On the modeling side, I focused on several aspect of the physiology such as: circadian rhythms, intracellular calcium signaling, and gene expression stochastic models. I also worked on biological pattern formation from regulatory networks. The mathematical tools behind these research are: Numerical methods for differential equations, Information Theory, Statistical mechanics and Dynamical systems. Many of these tools have been acquired from previous experience on other research areas. Additionally, I want to mention that I am reviewer of some international journals such as: Physical Review, Physica A, Chaos, Plos One and Frontiers.

Primary Affiliation: Centro Regional de Estudios Genómicos/ UNLP - La Plata , Argentina

Specialties:

Additional Specialties:


View Luis Diambra, Luis A. Diambra’s Resume / CV

Education

Mar 1993 - Dec 1996
Universidad Nacional de la Plata
PhD
Departamento de Fisica

Experience

Jul 2006 - Jul 2006
Consejo Nacional de Investigaciones Cientificas y Tecnicas
Investigador Indep

Publications

36Publications

895Reads

504Profile Views

552PubMed Central Citations

Gene target discovery with network analysis in Toxoplasma gondii.

Sci Rep 2019 Jan 24;9(1):646. Epub 2019 Jan 24.

CREG, CONICET-Universidad Nacional de La Plata, La Plata, CP 1900, Argentina.

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http://www.nature.com/articles/s41598-018-36671-y
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http://dx.doi.org/10.1038/s41598-018-36671-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345969PMC
January 2019
101 Reads
5.078 Impact Factor

Phylogenomics of tomato chloroplasts using assembly and alignment-free method.

Mitochondrial DNA A DNA Mapp Seq Anal 2018 10 16;29(7):1128-1138. Epub 2018 Jan 16.

a Facultad de Ciencias Exactas-UNLP , CREG , La Plata , Argentina.

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http://dx.doi.org/10.1080/24701394.2017.1419214DOI Listing
October 2018
6 Reads

Commentary: Systems Biology Approach to Model the Life Cycle of .

Front Cell Infect Microbiol 2017 18;7. Epub 2017 Jan 18.

Laboratorio de Biología de Sistemas, Centro Regional de Estudios Genómicos, Facultad de Ciencias Exactas, Universidad Nacional de La PlataLa Plata, Argentina; Consejo Nacional de Investigaciones Científicas y TécnicasArgentina.

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http://dx.doi.org/10.3389/fcimb.2017.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241278PMC
March 2018
12 Reads
1 Citation
2.620 Impact Factor

Modeling the flux of metabolites in the juvenile hormone biosynthesis pathway using generalized additive models and ordinary differential equations.

PLoS One 2017 3;12(2):e0171516. Epub 2017 Feb 3.

Department of Biological Sciences, Florida International University, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171516PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291429PMC
August 2017
10 Reads
3.234 Impact Factor

Bicodon bias can determine the role of synonymous SNPs in human diseases.

BMC Genomics 2017 03 13;18(1):227. Epub 2017 Mar 13.

Centro Regional de Estudio Génomicos, Universidad Nacional de La Plata, Boulevard 120, La Plata, Argentina.

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http://dx.doi.org/10.1186/s12864-017-3609-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347174PMC
March 2017
109 Reads
1 Citation
3.990 Impact Factor

Promoters Architecture-Based Mechanism for Noise-Induced Oscillations in a Single-Gene Circuit.

PLoS One 2016 9;11(3):e0151086. Epub 2016 Mar 9.

Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, La Plata, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151086PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784906PMC
August 2016
8 Reads
1 Citation
3.234 Impact Factor

Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi.

PLoS One 2016 11;11(1):e0146947. Epub 2016 Jan 11.

Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, La Plata, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146947PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709001PMC
July 2016
163 Reads
2 Citations
3.234 Impact Factor

Cooperative binding: a multiple personality.

J Math Biol 2016 06 29;72(7):1747-74. Epub 2015 Aug 29.

Felix Bernstein Institute for Mathematical Statistics in the Biosciences, Georg-August University Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00285-015-0922-zDOI Listing
June 2016
8 Reads
2 Citations
1.850 Impact Factor

Allatotropin modulates myostimulatory and cardioacceleratory activities in Rhodnius prolixus (Stal).

PLoS One 2015 21;10(4):e0124131. Epub 2015 Apr 21.

Cátedra Histología y Embriología Animal (FCNyM-UNLP), La Plata, Argentina; Centro Regional de Estudios Genómicos (CREG-UNLP), La Plata, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124131PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405368PMC
April 2016
8 Reads
1 Citation
3.234 Impact Factor

Abortive and propagating intracellular calcium waves: analysis from a hybrid model.

PLoS One 2015 20;10(1):e0115187. Epub 2015 Jan 20.

Centro Regional de Estudios Genómicos (CREG), Universidad Nacional de La Plata; Blvd 120 N 1461 (1900) La Plata, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115187PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300085PMC
September 2015
150 Reads
2 Citations
3.234 Impact Factor

Genomic and functional characterization of a methoprene-tolerant gene in the kissing-bug Rhodnius prolixus.

Gen Comp Endocrinol 2015 May 8;216:1-8. Epub 2015 May 8.

Cátedra de Histología y Embriología Animal, (Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata), La Plata, Argentina; Centro Regional de Estudios Genómicos (CREG), (Facultad de Ciencias Exactas, Universidad Nacional de La Plata), La Plata, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.ygcen.2015.04.018DOI Listing
May 2015
12 Reads
2 Citations
2.470 Impact Factor

Noise minimisation in gene expression switches.

PLoS One 2013 23;8(12):e84020. Epub 2013 Dec 23.

Laboratorio de Biología de Sistemas, Centro Regional de Estudios Genómicos, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084020PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871557PMC
March 2015
7 Reads
3.234 Impact Factor

Cooperativity to increase Turing pattern space for synthetic biology.

ACS Synth Biol 2015 Feb 22;4(2):177-86. Epub 2014 Aug 22.

Centro Regional de Estudios Geńomicos, Universidad Nacional de La Plata , Blvd. 120 No. 1461, 1900 La Plata, Argentine.

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http://dx.doi.org/10.1021/sb500233uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384830PMC
February 2015
7 Reads
6 Citations
3.951 Impact Factor

Allatotropin: an ancestral myotropic neuropeptide involved in feeding.

PLoS One 2013 15;8(10):e77520. Epub 2013 Oct 15.

Cátedra Histología y Embriología Animal, Facultad de Ciencias Naturales y Museo; Universidad Nacional de la Plata (FCNyM -UNLP), La Plata, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077520PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797082PMC
June 2014
9 Reads
5 Citations
3.234 Impact Factor

Genetically encoded sender-receiver system in 3D mammalian cell culture.

ACS Synth Biol 2014 May 20;3(5):264-72. Epub 2013 Dec 20.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG) , Dr. Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1021/sb400053bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046804PMC
May 2014
7 Reads
12 Citations
3.951 Impact Factor

First comparative transcriptomic analysis of wild adult male and female Lutzomyia longipalpis, vector of visceral leishmaniasis.

PLoS One 2013 12;8(3):e58645. Epub 2013 Mar 12.

Centro Regional de Estudios Genómicos, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595279PMC
September 2013
7 Reads
8 Citations
3.234 Impact Factor

Cooperative binding of transcription factors promotes bimodal gene expression response.

PLoS One 2012 12;7(9):e44812. Epub 2012 Sep 12.

Centro Regional de Estudios Genmicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044812PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440358PMC
March 2013
10 Reads
10 Citations
3.234 Impact Factor

Modeling the emergence of circadian rhythms in a clock neuron network.

PLoS One 2012 27;7(3):e33912. Epub 2012 Mar 27.

Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033912PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313962PMC
November 2012
8 Reads
1 Citation
3.234 Impact Factor

Time-course analysis of cyanobacterium transcriptome: detecting oscillatory genes.

PLoS One 2011 18;6(10):e26291. Epub 2011 Oct 18.

Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026291PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196541PMC
February 2012
6 Reads
1 Citation
3.234 Impact Factor

Metagenomic analysis of taxa associated with Lutzomyia longipalpis, vector of visceral leishmaniasis, using an unbiased high-throughput approach.

PLoS Negl Trop Dis 2011 Sep 6;5(9):e1304. Epub 2011 Sep 6.

Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina.

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http://dx.doi.org/10.1371/journal.pntd.0001304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167787PMC
September 2011
10 Reads
21 Citations

Genome sequence and analysis of the tuber crop potato.

Nature 2011 Jul 10;475(7355):189-95. Epub 2011 Jul 10.

BGI-Shenzhen, Chinese Ministry of Agricultural, Key Lab of Genomics, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China.

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http://dx.doi.org/10.1038/nature10158DOI Listing
July 2011
45 Reads
400 Citations
42.351 Impact Factor

Inositol (1,4,5)-trisphosphate receptor microarchitecture shapes Ca2+ puff kinetics.

Biophys J 2011 Feb;100(4):822-31

Laboratorio de Biología de Sistemas, Centro Regional de Estudios Genómicos, Florencio Varela, Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.bpj.2011.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037600PMC
February 2011
37 Reads
7 Citations
3.972 Impact Factor

Neuropeptide precursor gene discovery in the Chagas disease vector Rhodnius prolixus.

Insect Mol Biol 2011 Feb 19;20(1):29-44. Epub 2010 Oct 19.

Laboratorio de Genética y Genómica Funcional, Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, Buenos Aires, Argentina.

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http://dx.doi.org/10.1111/j.1365-2583.2010.01050.xDOI Listing
February 2011
7 Reads
11 Citations
2.590 Impact Factor

Localization and socialization: experimental insights into the functional architecture of IP3 receptors.

Chaos 2009 Sep;19(3):037103

Laboratorio de Biología de Sistemas, CREG-UNLP, Buenos Aires, Argentina.

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http://dx.doi.org/10.1063/1.3147425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771704PMC
September 2009
6 Reads
7 Citations
1.954 Impact Factor

Role of cooperative binding on noise expression.

Phys Rev E Stat Nonlin Soft Matter Phys 2009 Jul 22;80(1 Pt 1):011914. Epub 2009 Jul 22.

Laboratorio de Biología de Sistemas, CREG-UNLP, Av. Calchaqui Km 23.5, CP 1888, Florencio Varela, Argentina.

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http://dx.doi.org/10.1103/PhysRevE.80.011914DOI Listing
July 2009
8 Reads
5 Citations
2.290 Impact Factor

Pattern formation in a gene network model with boundary shape dependence.

Phys Rev E Stat Nonlin Soft Matter Phys 2006 Mar 20;73(3 Pt 1):031917. Epub 2006 Mar 20.

Institute of Physics at São Carlos, University of São Paulo, Caixa Postal 369, cep 13560-970, São Carlos, SP, Brazil.

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http://dx.doi.org/10.1103/PhysRevE.73.031917DOI Listing
March 2006
8 Reads
2 Citations
2.290 Impact Factor

Complex networks approach to gene expression driven phenotype imaging.

Bioinformatics 2005 Oct 16;21(20):3846-51. Epub 2005 Aug 16.

Institute of Physics at São Carlos, University of São Paulo, Brazil.

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http://dx.doi.org/10.1093/bioinformatics/bti625DOI Listing
October 2005
7 Reads
2 Citations
4.981 Impact Factor

Modeling stochastic Ca2+ release from a cluster of IP3-sensitive receptors.

Authors:
L Diambra N Guisoni

Cell Calcium 2005 Apr;37(4):321-32

Instituto de Física de São Carlos, Universidade de São Paulo, Caixa Postal 369, Cep 13560-970, São Carlos SP, Brazil.

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http://dx.doi.org/10.1016/j.ceca.2004.12.001DOI Listing
April 2005
8 Reads
6 Citations
3.513 Impact Factor

Topographical maps as complex networks.

Phys Rev E Stat Nonlin Soft Matter Phys 2005 Feb 1;71(2 Pt 1):021901. Epub 2005 Feb 1.

Institute of Physics at São Carlos, University of São Paulo, São Carlos, SP, Caixa Postal 369, 13560-970, Brazil.

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https://link.aps.org/doi/10.1103/PhysRevE.71.021901
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http://dx.doi.org/10.1103/PhysRevE.71.021901DOI Listing
February 2005
8 Reads
2.290 Impact Factor

Infradian rhythmicity in sleep/wake ratio in developing infants.

Chronobiol Int 2004 Mar;21(2):217-27

GMDRB, Departamento de Fisiologia e Biofísica, Universidade de São Paulo, São Paulo, São Paulo, Brazil.

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March 2004
40 Reads
3.343 Impact Factor

Ciclograma: a tool for detection of rhythmicities in sleep/wake cycles.

Chronobiol Int 2002 Jul;19(4):793-803

GMDRB, Departamento de Fisiologia e Biofísica, ICB, Universidade de São Paulo, SP, Brazil.

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July 2002
8 Reads
1 Citation
3.343 Impact Factor

Chaos in two-loop negative feedback systems.

Phys Rev E Stat Nonlin Soft Matter Phys 2002 May 6;65(5 Pt 1):051905. Epub 2002 May 6.

Instituto do Coração, Universidade de São Paulo, Avenida Dr. Eneas de Carvalho Aguiar, 44, 05403-000 São Paulo, São Paulo, Brazil.

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https://link.aps.org/doi/10.1103/PhysRevE.65.051905
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http://dx.doi.org/10.1103/PhysRevE.65.051905DOI Listing
May 2002
8 Reads
2 Citations
2.290 Impact Factor

Information theory approach to learning of the perceptron rule.

Phys Rev E Stat Nonlin Soft Matter Phys 2001 Oct 20;64(4 Pt 2):046106. Epub 2001 Sep 20.

Departamento de Fisiologia e Biofísica, ICB Universidade de São Paulo, cep 05315-970, São Paulo, São Paulo,

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http://dx.doi.org/10.1103/PhysRevE.64.046106DOI Listing
October 2001
8 Reads
1 Citation
2.290 Impact Factor

Divergence measure between chaotic attractors.

Authors:
L Diambra

Phys Rev E Stat Nonlin Soft Matter Phys 2001 Sep 30;64(3 Pt 2):035202. Epub 2001 Aug 30.

Departamento de Fisiologia e Biofísica, Universidade de São Paulo, Avenue Professor Lineu Prestes 1524, ICB1 CEP 05508-900, São Paulo, SP Brazil.

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http://dx.doi.org/10.1103/PhysRevE.64.035202DOI Listing
September 2001
7 Reads
2.290 Impact Factor

Top co-authors

Mark Isalan
Mark Isalan

University of Cambridge

2
Vivek Raj Senthivel
Vivek Raj Senthivel

Centro Regional de Estudios Ge?omicos

2
Carla Layana
Carla Layana

Centro Regional de Estudios Genómicos

2