Luigi Lay

Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Saldini 50, 20133 Milano, Italy. Electronic address:

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November 2018

The Conformation of the Mannopyranosyl Phosphate Repeating Unit of the Capsular Polysaccharide of Serogroup A and Its Carba-Mimetic.

Authors:

Ilaria Calloni Luca Unione Gonzalo Jiménez-Osés Francisco Corzana Linda Del Bino Alessio Corrado Olimpia Pitirollo Cinzia Colombo Luigi Lay Roberto Adamo Jesús Jiménez-Barbero

European J Org Chem 2018 Sep 17;2018(33):4548-4555. Epub 2018 Aug 17.

Chemical Glycobiology Lab CIC bioGUNE Bizkaia Technology Park, Building 800 48160 Derio Spain.

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September 2018

Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development.

Authors:

Cinzia Colombo Olimpia Pitirollo Luigi Lay

Molecules 2018 Jul 13;23(7). Epub 2018 Jul 13.

Dipartimento di Chimica, Universita' degli Studi di Milano, via Golgi 19, 20133 Milano, Italy.

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July 2018

Impact of ConcanavalinA affinity in the intracellular fate of Protein Corona on Glucosamine Au nanoparticles.

Authors:

Desirè Di Silvio Alessandro Silvestri Luigi Lay Laura Polito Sergio E Moya

Sci Rep 2018 06 13;8(1):9046. Epub 2018 Jun 13.

Soft Matter Nanotechnology Group, CIC biomaGUNE, Paseo Miramon, 182, 20014, San Sebastian, Spain.

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June 2018

Combined Chemical Synthesis and Tailored Enzymatic Elongation Provide Fully Synthetic and Conjugation-Ready Neisseria meningitidis Serogroup X Vaccine Antigens.

Authors:

Davide Oldrini Timm Fiebig Maria Rosaria Romano Daniela Proietti Monika Berger Marta Tontini Riccardo De Ricco Laura Santini Laura Morelli Luigi Lay Rita Gerardy-Schahn Francesco Berti Roberto Adamo

ACS Chem Biol 2018 04 1;13(4):984-994. Epub 2018 Mar 1.

GSK , Via Fiorentina 1 , 53100 Siena , Italy.

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April 2018

Fluidic Manufacture of Star-Shaped Gold Nanoparticles.

Authors:

Alessandro Silvestri Luigi Lay Rinaldo Psaro Laura Polito Claudio Evangelisti

Chemistry 2017 Jul 3;23(41):9732-9735. Epub 2017 Jul 3.

Nanotechnology Lab., National Council of the Research, CNR-ISTM, Via G. Fantoli 16/15, 20138, Milan, Italy.

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July 2017

Preparation and immunogenicity of gold glyco-nanoparticles as antipneumococcal vaccine model.

Authors:

Maria Vetro Dodi Safari Silvia Fallarini Korrie Salsabila Martina Lahmann Soledad Penadés Luigi Lay Marco Marradi Federica Compostella

Nanomedicine (Lond) 2017 Jan 23;12(1):13-23. Epub 2016 Nov 23.

Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Saldini 50, 20133 Milano, Italy.

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January 2017

A Synthetic Disaccharide Analogue from Neisseria meningitidis A Capsular Polysaccharide Stimulates Immune Cell Responses and Induces Immunoglobulin G (IgG) Production in Mice When Protein-Conjugated.

Authors:

Silvia Fallarini Benedetta Buzzi Sara Giovarruscio Laura Polito Giulia Brogioni Marta Tontini Francesco Berti Roberto Adamo Luigi Lay Grazia Lombardi

ACS Infect Dis 2015 Oct 17;1(10):487-96. Epub 2015 Aug 17.

Department of Pharmaceutical Sciences, University of "Piemonte Orientale, A. Avogadro" , Largo Donegani 2, 28100 Novara, Italy.

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October 2015

Synthesis of di- and tri-saccharide fragments of Salmonella typhi Vi capsular polysaccharide and their zwitterionic analogues.

Authors:

Matteo Fusari Silvia Fallarini Grazia Lombardi Luigi Lay

Bioorg Med Chem 2015 Dec 30;23(23):7439-47. Epub 2015 Oct 30.

Department of Chemistry and CRC Materiali Polimerici (LaMPo), University of Milan, Via Golgi 19, 20133 Milan, Italy. Electronic address:

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December 2015

Synthesis and immunological evaluation of protein conjugates of Neisseria meningitidis X capsular polysaccharide fragments.

Authors:

Laura Morelli Damiano Cancogni Marta Tontini Alberto Nilo Sara Filippini Paolo Costantino Maria Rosaria Romano Francesco Berti Roberto Adamo Luigi Lay

Beilstein J Org Chem 2014 13;10:2367-76. Epub 2014 Oct 13.

Dipartimento di Chimica and ISTM-CNR, Universita degli Studi di Milano, via Golgi 19, I-20133 Milano, Italy.

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November 2014

Immunoactivity of protein conjugates of carba analogues from Neisseria meningitidis a capsular polysaccharide.

Authors:

Qi Gao Marta Tontini Giulia Brogioni Alberto Nilo Sara Filippini Carole Harfouche Laura Polito Maria R Romano Paolo Costantino Francesco Berti Roberto Adamo Luigi Lay

ACS Chem Biol 2013 Nov 19;8(11):2561-7. Epub 2013 Sep 19.

Dipartimento di Chimica and ISTM-CNR, Università degli Studi di Milano , via Golgi 19, I-20133 Milano, Italy.

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November 2013

Synthesis of a structural analogue of the repeating unit from Streptococcus pneumoniae 19F capsular polysaccharide based on the cross-metathesis-selenocyclization reaction sequence.

Authors:

Paolo Ronchi Catalina Scarponi Matteo Salvi Silvia Fallarini Laura Polito Enrico Caneva Luana Bagnoli Luigi Lay

J Org Chem 2013 Jun 24;78(11):5172-83. Epub 2013 May 24.

Dipartimento di Chimica and ISTM-CNR, Università degli Studi di Milano, via Golgi 19, I-20133 Milano, Italy.

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June 2013

Factors affecting T cell responses induced by fully synthetic glyco-gold-nanoparticles.

Authors:

Silvia Fallarini Tiziana Paoletti Carolina Orsi Battaglini Paolo Ronchi Luigi Lay Renato Bonomi Satadru Jha Fabrizio Mancin Paolo Scrimin Grazia Lombardi

Nanoscale 2013 Jan 23;5(1):390-400. Epub 2012 Nov 23.

Department of Pharmaceutical Sciences, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy.

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January 2013

Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit using novel L-FucNAc and D-FucNAc synthons and immunochemical evaluation.

Authors:

Elisa Danieli Daniela Proietti Giulia Brogioni Maria R Romano Emilia Cappelletti Marta Tontini Francesco Berti Luigi Lay Paolo Costantino Roberto Adamo

Bioorg Med Chem 2012 Nov 31;20(21):6403-15. Epub 2012 Aug 31.

Research Center, Novartis Vaccine and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy.

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November 2012

Synthesis and preliminary biological evaluation of carba analogues from Neisseria meningitidis A capsular polysaccharide.

Authors:

Qi Gao Cristina Zaccaria Marta Tontini Laura Poletti Paolo Costantino Luigi Lay

Org Biomol Chem 2012 Sep;10(33):6673-81

Dipartimento di Chimica and ISTM-CNR, Università degli Studi di Milano, Italy.

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September 2012

Phosphorylation of the synthetic hexasaccharide repeating unit is essential for the induction of antibodies to Clostridium difficile PSII cell wall polysaccharide.

Authors:

Roberto Adamo Maria R Romano Francesco Berti Rosanna Leuzzi Marta Tontini Elisa Danieli Emilia Cappelletti Osman S Cakici Erwin Swennen Vittoria Pinto Barbara Brogioni Daniela Proietti Cesira L Galeotti Luigi Lay Mario A Monteiro Maria Scarselli Paolo Costantino

ACS Chem Biol 2012 Aug 7;7(8):1420-8. Epub 2012 Jun 7.

Research Center, Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy.

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August 2012

Novel carbohydrate-based bifunctional organocatalysts for nucleophilic addition to nitroolefins and imines.

Authors:

Alessandra Puglisi Maurizio Benaglia Laura Raimondi Luigi Lay Laura Poletti

Org Biomol Chem 2011 May 23;9(9):3295-302. Epub 2011 Mar 23.

Dipartimento di Chimica Organica e Industriale, CISI, Universitá degli Studi di Milano, via Golgi 19, I-20133, Milano, Italy.

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May 2011

First synthesis of C. difficile PS-II cell wall polysaccharide repeating unit.

Authors:

Elisa Danieli Luigi Lay Daniela Proietti Francesco Berti Paolo Costantino Roberto Adamo

Org Lett 2011 Feb 29;13(3):378-81. Epub 2010 Dec 29.

Novartis Vaccines & Diagnostics, Vaccine Chemistry Department, Via Fiorentina 1, 53100 Siena, Italy.

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February 2011

Synthesis, molecular dynamics simulations, and biology of a carba-analogue of the trisaccharide repeating unit of Streptococcus pneumoniae 19F capsular polysaccharide.

Authors:

Laura Legnani Silvia Ronchi Silvia Fallarini Grazia Lombardi Federica Campo Luigi Panza Luigi Lay Laura Poletti Lucio Toma Fiamma Ronchetti Federica Compostella

Org Biomol Chem 2009 Nov 20;7(21):4428-36. Epub 2009 Aug 20.

Dipartimento di Chimica Organica, Università di Pavia, Via Taramelli 10, 27100, Pavia, Italy.

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November 2009

Modeling of synthetic phosphono and carba analogues of N-acetyl-alpha-D-mannosamine 1-phosphate, the repeating unit of the capsular polysaccharide from Neisseria meningitidis serovar A.

Authors:

Lucio Toma Laura Legnani Anna Rencurosi Laura Poletti Luigi Lay Giovanni Russo

Org Biomol Chem 2009 Sep 10;7(18):3734-40. Epub 2009 Jul 10.

Dipartimento di Chimica Organica, Università di Pavia, Via Taramelli 10, 27100, Pavia, Italy.

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September 2009

Exploiting the cross-metathesis reaction in the synthesis of pseudo-oligosaccharides.

Authors:

Paolo Ronchi Stefano Vignando Sara Guglieri Laura Polito Luigi Lay

Org Biomol Chem 2009 Jun 5;7(12):2635-44. Epub 2009 May 5.

Dipartimento di Chimica Organica e Industriale and Centro Interdisciplinare Studi Bio-molecolari e Applicazioni Industriali (CISI), Università degli Studi di Milano, Milano, Italy.

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June 2009

Expeditious synthesis of water-soluble, monolayer-protected gold nanoparticles of controlled size and monolayer composition.

Authors:

Flavio Manea Cristiano Bindoli Stefano Polizzi Luigi Lay Paolo Scrimin

Langmuir 2008 Apr 15;24(8):4120-4. Epub 2008 Mar 15.

Department of Chemical Sciences and ITM-CNR, University of Padova, Padova Section, 35131 Padua, Italy.

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April 2008

Synthesis and biological evaluation of phosphono analogues of capsular polysaccharide fragments from Neisseria meningitidis A.

Authors:

Maria I Torres-Sanchez Cristina Zaccaria Benedetta Buzzi Gianluca Miglio Grazia Lombardi Laura Polito Giovanni Russo Luigi Lay

Chemistry 2007 ;13(23):6623-35

Dipartimento di Chimica Organica e Industriale and Centro Interdisciplinare Studi Bio-molecolari e Applicazioni Industriali, Università degli Studi di Milano via Venezian 21, 20133 Milano, Italy.

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September 2007

Amphiphilic N-glycosyl-thiocarbamoyl cyclodextrins: synthesis, self-assembly, and fluorimetry of recognition by Lens culinaris lectin.

Authors:

Simone McNicholas Anna Rencurosi Luigi Lay Antonino Mazzaglia Luisa Sturiale Marta Perez Raphael Darcy

Biomacromolecules 2007 Jun 17;8(6):1851-7. Epub 2007 May 17.

Centre for Synthesis and Chemical Biology of the Conway Institute, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.

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June 2007

NMR evidence for the participation of triflated ionic liquids in glycosylation reaction mechanisms.

Authors:

Anna Rencurosi Luigi Lay Giovanni Russo Enrico Caneva Laura Poletti

Carbohydr Res 2006 May 10;341(7):903-8. Epub 2006 Mar 10.

CNR, Istituto di Scienze e Tecnologie Molecolari, via Golgi, 19, 20133 Milan, Italy.

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May 2006

Glycosylation with trichloroacetimidates in ionic liquids: influence of the reaction medium on the stereochemical outcome.

Authors:

Anna Rencurosi Luigi Lay Giovanni Russo Enrico Caneva Laura Poletti

J Org Chem 2005 Sep;70(19):7765-8

Istituto di Scienze e Tecnologie Molecolari, CNR, via Golgi, 19, 20133 Milan, Italy.

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September 2005

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