Luigi Frati

Luigi Frati

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Luigi Frati

Luigi Frati

Publications by authors named "Luigi Frati"

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ST2/IL-33 signaling in cardiac fibrosis.

Int J Biochem Cell Biol 2019 11 24;116:105619. Epub 2019 Sep 24.

Department of Biomedical Sciences for Health, University of Milan, Milan, Italy; U.O.C. SMEL-1 of Clinical Pathology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13572725193019
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http://dx.doi.org/10.1016/j.biocel.2019.105619DOI Listing
November 2019

Aspirin-Dependent Effects on Purinergic P2Y1 Receptor Expression.

Thromb Haemost 2019 May 13;119(5):726-734. Epub 2019 Feb 13.

Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678707
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http://dx.doi.org/10.1055/s-0039-1678707DOI Listing
May 2019

MiR-21 role in aspirin-dependent PPARα and multidrug resistance protein 4 upregulation.

Res Pract Thromb Haemost 2018 Jul 17;2(3):596-606. Epub 2018 May 17.

Department of Experimental Medicine Sapienza-University of Rome Rome Italy.

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http://dx.doi.org/10.1002/rth2.12104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046603PMC
July 2018

Implementing the Risk of Ovarian Malignancy Algorithm Adding Obesity as a Predictive Factor.

Anticancer Res 2016 12;36(12):6425-6429

Department of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.21873/anticanres.11240DOI Listing
December 2016

Enhanced platelet MRP4 expression and correlation with platelet function in patients under chronic aspirin treatment.

Thromb Haemost 2016 Nov 29;116(6):1100-1110. Epub 2016 Sep 29.

Fabio M. Pulcinelli, MD, Department of Experimental Medicine, "Sapienza" University of Rome, Viale Regina Elena 324, 00161, Rome, Italy, Tel.: +39 06 49973002, Fax: +39 06 4452955, E-mail:

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http://dx.doi.org/10.1160/TH16-04-0316DOI Listing
November 2016

Protein induced by vitamin K absence or antagonist-II (PIVKA-II) specifically increased in Italian hepatocellular carcinoma patients.

Scand J Gastroenterol 2016 Oct 26;51(10):1257-62. Epub 2016 May 26.

a Department of Molecular Medicine , "Sapienza" University of Rome , Roma , Italy ;

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http://dx.doi.org/10.1080/00365521.2016.1183705DOI Listing
October 2016

Nonsteroidal anti-inflammatory drugs in-vitro and in-vivo treatment and Multidrug Resistance Protein 4 expression in human platelets.

Vascul Pharmacol 2016 Jan 2;76:11-7. Epub 2015 Jul 2.

Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, Roma 00161, Italy.

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http://dx.doi.org/10.1016/j.vph.2015.06.016DOI Listing
January 2016

Triple-negative breast cancer: new perspectives for targeted therapies.

Onco Targets Ther 2015 16;8:177-93. Epub 2015 Jan 16.

Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Oncology Unit, Istituto Chirurgico Ortopedico Traumatologico, Latina, Italy.

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http://dx.doi.org/10.2147/OTT.S67673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303459PMC
February 2015

Hepatitis C virus present in the sera of infected patients interferes with the autophagic process of monocytes impairing their in-vitro differentiation into dendritic cells.

Biochim Biophys Acta 2014 Jul 12;1843(7):1348-55. Epub 2014 Apr 12.

Department of Experimental Medicine, Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza University, 00161 Rome Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01674889140012
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http://dx.doi.org/10.1016/j.bbamcr.2014.04.003DOI Listing
July 2014

May increased CA125 in borderline ovarian tumor be indicative of a poor prognosis? A case report.

Tumour Biol 2014 Jul 17;35(7):6969-71. Epub 2014 Apr 17.

Department of Molecular Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy,

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http://dx.doi.org/10.1007/s13277-014-1898-9DOI Listing
July 2014

Is CA72-4 a useful biomarker in differential diagnosis between ovarian endometrioma and epithelial ovarian cancer?

Dis Markers 2013 22;35(5):331-5. Epub 2013 Sep 22.

Department of Molecular Medicine, "Sapienza" University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161 Rome, Italy.

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http://www.hindawi.com/journals/dm/2013/984641/
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http://dx.doi.org/10.1155/2013/984641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793285PMC
June 2014

Effect of Serenoa repens (Permixon®) on the expression of inflammation-related genes: analysis in primary cell cultures of human prostate carcinoma.

J Inflamm (Lond) 2013 14;10:11. Epub 2013 Mar 14.

Department of Urology, Sapienza University of Rome, Rome, Italy ; Prostate Unit - Department Urology, University Sapienza, Viale Policlinico 155, 00161, Rome, Italy.

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http://dx.doi.org/10.1186/1476-9255-10-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653817PMC
May 2014

Serum HE4 levels combined with CE CT imaging improve the management of monitoring women affected by epithelial ovarian cancer.

Oncol Rep 2013 Nov 21;30(5):2481-7. Epub 2013 Aug 21.

Department of Radiological, Oncological and Anatomopathological Sciences, 'Sapienza' University, Umberto I Hospital, I-00161 Rome, Italy.

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http://dx.doi.org/10.3892/or.2013.2682DOI Listing
November 2013

Circulating tumor cells in high-risk nonmetastatic colorectal cancer.

Tumour Biol 2013 Oct 29;34(5):2507-9. Epub 2013 Mar 29.

Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 000161, Rome, Italy,

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http://dx.doi.org/10.1007/s13277-013-0752-9DOI Listing
October 2013

Evaluation of a CLEIA automated assay system for the detection of a panel of tumor markers.

Tumour Biol 2013 Oct 18;34(5):3093-100. Epub 2013 Jun 18.

Laboratory of Tumor Markers, Department of Molecular Medicine, University "Sapienza", Viale Regina Elena 324, 00161, Rome, Italy.

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http://dx.doi.org/10.1007/s13277-013-0877-xDOI Listing
October 2013

The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1.

Mol Carcinog 2013 Jul 2;52(7):526-34. Epub 2012 Mar 2.

Department of Experimental Medicine, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1002/mc.21887DOI Listing
July 2013

The use of HE4, CA125 and CA72-4 biomarkers for differential diagnosis between ovarian endometrioma and epithelial ovarian cancer.

J Ovarian Res 2013 Jul 1;6(1):44. Epub 2013 Jul 1.

Department of Gynaecology, Obstetrics and Urology, "Sapienza" University of Rome, Policlinico Umberto I, Viale del Policlinico 155, Rome 00161, Italy.

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http://dx.doi.org/10.1186/1757-2215-6-44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701500PMC
July 2013

Oxidative stress posttranslationally regulates the expression of Ha-Ras and Ki-Ras in cultured astrocytes.

Oxid Med Cell Longev 2012 31;2012:792705. Epub 2012 Oct 31.

Department of Human Sciences, Society, and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.

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http://dx.doi.org/10.1155/2012/792705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504475PMC
April 2013

Breast cancer risk after exposure to fertility drugs.

Expert Rev Anticancer Ther 2013 Feb;13(2):149-57

Department of Medical-Surgical Sciences and Biotechnologies, University of Rome Sapienza Corso della Repubblica, 04100, Latina, Italy.

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http://dx.doi.org/10.1586/era.12.181DOI Listing
February 2013

HE4 combined with MDCT imaging is a good marker in the evaluation of disease extension in advanced epithelial ovarian carcinoma.

Tumour Biol 2012 Oct 20;33(5):1291-8. Epub 2012 Mar 20.

Department of Molecular Medicine, Sapienza University, Viale Regina Elena 324, 00161, Rome, Italy.

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http://link.springer.com/10.1007/s13277-012-0376-5
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http://dx.doi.org/10.1007/s13277-012-0376-5DOI Listing
October 2012

Role of HE4, CA72.4, and CA125 in monitoring ovarian cancer.

Tumour Biol 2012 Oct 13;33(5):1335-9. Epub 2012 Apr 13.

CNR-IBPM, Consiglio Nazionale delle Ricerche, Viale Regina Elena 324, 00161, Roma, Italy.

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http://dx.doi.org/10.1007/s13277-012-0381-8DOI Listing
October 2012

Syk-dependent regulation of Hrs phosphorylation and ubiquitination upon FcεRI engagement: impact on Hrs membrane/cytosol localization.

Eur J Immunol 2012 Oct 25;42(10):2744-53. Epub 2012 Jul 25.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1002/eji.201142278DOI Listing
October 2012

Chemotherapy and target therapy in the management of adult high- grade gliomas.

Curr Cancer Drug Targets 2012 Oct;12(8):1016-31

Department of Medical-Surgical Science and Biotechnology, University of Rome Sapienza, Polo Pontino, Latina, Italy.

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http://dx.doi.org/10.2174/156800912803251207DOI Listing
October 2012

Activation of dendritic cells by tumor cell death.

Oncoimmunology 2012 Oct;1(7):1218-1219

Department of Experimental Medicine; Istituto Pasteur-Fondazione Cenci Bolognetti; Sapienza University; Rome, Italy.

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http://dx.doi.org/10.4161/onci.20428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494652PMC
October 2012

HHV-8 reduces dendritic cell migration through down-regulation of cell-surface CCR6 and CCR7 and cytoskeleton reorganization.

Virol J 2012 May 14;9:92. Epub 2012 May 14.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Experimental Medicine, La Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy.

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http://dx.doi.org/10.1186/1743-422X-9-92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442995PMC
May 2012

PIP2-dependent regulation of Munc13-4 endocytic recycling: impact on the cytolytic secretory pathway.

Blood 2012 Mar 23;119(10):2252-62. Epub 2012 Jan 23.

Department of Experimental Medicine, Istituto Pasteur–Fondazione Cenci-Bolognetti, Fondazione Eleonora Lorillard Spencer Cenci, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1182/blood-2010-12-324160DOI Listing
March 2012

Circulating tumor cells: highlight on practical implications.

Mol Diagn Ther 2012 Feb;16(1):7-11

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1007/bf03256424DOI Listing
February 2012

Circulating tumor cells and "suspicious objects" evaluated through CellSearch® in metastatic renal cell carcinoma.

Anticancer Res 2011 Dec;31(12):4219-21

Dipartimento Medicina Molecolare, Sapienza Università di Roma, Viale Regina Elena 324, 00161 Rome, Italy.

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December 2011

Clinical Significance of MicroRNA Expression Profiles and Polymorphisms in Lung Cancer Development and Management.

Patholog Res Int 2011 27;2011:780652. Epub 2011 Jul 27.

Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324-00161 Rome, Italy.

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http://dx.doi.org/10.4061/2011/780652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146996PMC
November 2011

Circulating tumor cells count and characterization in a male breast cancer patient.

Cancer Biol Ther 2011 Sep 1;12(5):379-82. Epub 2011 Sep 1.

Department of Molecular Medicine,apienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.4161/cbt.12.5.16304DOI Listing
September 2011

Current role and safety profile of aromatase inhibitors in early breast cancer.

Expert Rev Anticancer Ther 2011 Aug;11(8):1253-63

Dipartimento di Scienze Ginecologico-Ostetriche e Scienze Urologiche-Università di Roma Sapienza, Rome, Italy.

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http://dx.doi.org/10.1586/era.11.96DOI Listing
August 2011

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

Mol Cancer Res 2011 Jan 20;9(1):67-77. Epub 2010 Dec 20.

Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena, 324, 00161, Rome, Italy.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0227DOI Listing
January 2011

HE4 in the differential diagnosis of a pelvic mass: a case report.

Int J Mol Sci 2011 Jan 18;12(1):627-32. Epub 2011 Jan 18.

Department of Molecular Medicine, Sapienza University, Rome 00161, Italy; E-Mails: (S.C.); (L.F.); (C.M.).

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http://dx.doi.org/10.3390/ijms12010627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039970PMC
January 2011

Ovarian function, reproduction and strategies for fertility preservation after breast cancer.

Crit Rev Oncol Hematol 2010 Oct 24;76(1):1-12. Epub 2010 Feb 24.

Department of Obstetrics and Gynecology, University of Rome "Sapienza", Italy.

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http://dx.doi.org/10.1016/j.critrevonc.2009.12.005DOI Listing
October 2010

Current approach in the treatment of hepatocellular carcinoma.

World J Gastrointest Oncol 2010 Sep;2(9):348-59

Luigi Rossi, Federica Zoratto, Anselmo Papa, Marina Minozzi, Luigi Frati, Silverio Tomao, Department of Experimental Medicine, University of Rome "Sapienza", Viale Regina Elena 324, 00161 Rome, Italy.

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http://dx.doi.org/10.4251/wjgo.v2.i9.348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999141PMC
September 2010

CX3CR1/CX3CL1 axis negatively controls glioma cell invasion and is modulated by transforming growth factor-β1.

Neuro Oncol 2010 Jul 8;12(7):701-10. Epub 2010 Feb 8.

Department of Experimental Medicine, La Sapienza University, Viale Regina Elena, 324, 00161 Rome, Italy.

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http://dx.doi.org/10.1093/neuonc/nop076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940654PMC
July 2010

HE4: a new potential early biomarker for the recurrence of ovarian cancer.

Tumour Biol 2010 Apr 23;31(2):113-9. Epub 2010 Jan 23.

Department of Oncology, University "Sapienza", Viale Regina Elena 324, 00161, Rome, Italy,

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http://dx.doi.org/10.1007/s13277-009-0015-yDOI Listing
April 2010

Emerging role of pemetrexed in ovarian cancer.

Expert Rev Anticancer Ther 2009 Dec;9(12):1727-35

Dipartimento di Ginecologia, Perinatologia ed Ostetricia, Università di Roma Sapienza, Viale Regina Elena 324,00161, Rome, Italy.

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http://www.tandfonline.com/doi/full/10.1586/era.09.141
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http://dx.doi.org/10.1586/era.09.141DOI Listing
December 2009

The challenge of reform: 10 years of curricula change in Italian medical schools.

Med Teach 2009 Dec;31(12):1047-55

First and Second Faculty of Medicine, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.3109/01421590903178506DOI Listing
December 2009

Epstein-Barr virus infection leads to partial phenotypic reversion of terminally differentiated malignant B cells.

Cancer Lett 2009 Nov 28;284(2):165-74. Epub 2009 May 28.

Istituto Pasteur-Fondazione Cenci-Bolognetti, Department of Experimental Medicine and Pathology, University of Rome La Sapienza Viale Regina Elena 324, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.canlet.2009.04.025DOI Listing
November 2009

Hair regeneration from transected follicles in duplicative surgery: rate of success and cell populations involved.

Dermatol Surg 2009 Jul 28;35(7):1119-25. Epub 2009 Apr 28.

Department of Skin-Venereal Disease and Reconstructive and Plastic Surgery, Sapienza University of Rome, Rome, Italy.

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http://Insights.ovid.com/crossref?an=00042728-200907000-0001
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http://dx.doi.org/10.1111/j.1524-4725.2009.01197.xDOI Listing
July 2009

Chemotherapy and immunotherapy in metastatic colorectal cancer.

N Engl J Med 2009 May;360(20):2134-5; author reply 2135-6

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May 2009

Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells.

J Pineal Res 2009 Mar 29;46(2):172-80. Epub 2008 Oct 29.

Surgery Department "Pietro Valdoni", Rome, Italy.

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http://dx.doi.org/10.1111/j.1600-079X.2008.00645.xDOI Listing
March 2009

DNA instability in replicating Huntington's disease lymphoblasts.

BMC Med Genet 2009 Feb 11;10:11. Epub 2009 Feb 11.

Neurogenetics Unit, IRCCS Neuromed, Pozzilli, IS, Italy.

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http://dx.doi.org/10.1186/1471-2350-10-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645380PMC
February 2009

Suppression of dendritic cell differentiation through cytokines released by Primary Effusion Lymphoma cells.

Immunol Lett 2008 Oct 3;120(1-2):37-41. Epub 2008 Aug 3.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Experimental Medicine, La Sapienza University of Rome, 324 Viale Regina Elena, 00161 Rome, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S016524780800161
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http://dx.doi.org/10.1016/j.imlet.2008.06.011DOI Listing
October 2008

Molecular medicine: predicting and preventing Huntington's disease.

Neurol Sci 2008 Sep 20;29(4):205-7. Epub 2008 Sep 20.

Neurogenetics Unit IRCCS Neuromed and Centre for Rare Diseases, Località Camerelle, Pozzilli, Italy.

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http://dx.doi.org/10.1007/s10072-008-0969-3DOI Listing
September 2008

Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes.

J Neurochem 2008 Jul 12;106(2):551-9. Epub 2008 Apr 12.

Department of Experimental Medicine and Pathology, University of Rome 'La Sapienza', Rome, Italy.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05420.xDOI Listing
July 2008

PI5KI-dependent signals are critical regulators of the cytolytic secretory pathway.

Blood 2008 Apr 11;111(8):4165-72. Epub 2007 Dec 11.

Department of Experimental Medicine, Istituto Pasteur-Fondazione Cenci-Bolognetti, Rome, Italy.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-08-10
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http://dx.doi.org/10.1182/blood-2007-08-108886DOI Listing
April 2008

Different spectra of genomic deletions within the CCM genes between Italian and American CCM patient cohorts.

Neurogenetics 2008 Feb 1;9(1):25-31. Epub 2007 Dec 1.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1007/s10048-007-0109-xDOI Listing
February 2008

Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in T lymphocytes.

Mol Pharmacol 2007 Nov 2;72(5):1246-57. Epub 2007 Aug 2.

Department of Experimental Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, University La Sapienza, Viale Regina Elena 324, 00161, Rome, Italy.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.107.03
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http://dx.doi.org/10.1124/mol.107.038042DOI Listing
November 2007

Human herpesvirus 8 (HHV-8) inhibits monocyte differentiation into dendritic cells and impairs their immunostimulatory activity.

Immunol Lett 2007 Oct 21;113(1):40-6. Epub 2007 Aug 21.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Experimental Medicine University of Rome La Sapienza, Rome, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S016524780700161
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http://dx.doi.org/10.1016/j.imlet.2007.07.013DOI Listing
October 2007

AKT and MAPK signaling in KGF-treated and UVB-exposed human epidermal cells.

J Cell Physiol 2007 Sep;212(3):633-42

Department of Experimental Medicine, University Sapienza, Viale Regina Elena, Rome, Italy.

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http://dx.doi.org/10.1002/jcp.21056DOI Listing
September 2007

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

FASEB J 2007 Sep 26;21(11):2849-62. Epub 2007 Apr 26.

Department of Experimental Medicine and Pathology, University La Sapienza, Viale Regina Elena 324 00161, Rome, Italy.

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http://www.fasebj.org/doi/10.1096/fj.06-7925com
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http://dx.doi.org/10.1096/fj.06-7925comDOI Listing
September 2007

The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway.

J Immunol 2007 Aug;179(4):2089-96

Department of Experimental Medicine, Institute Pasteur-Fondazione Cenci Bolognetti, University La Sapienza, Rome, Italy.

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http://dx.doi.org/10.4049/jimmunol.179.4.2089DOI Listing
August 2007