Publications by authors named "Luigi Bennardo"

71 Publications

Neck Rejuvenation With a New Infrared Emission.

Dermatol Pract Concept 2022 May 1;12(2):e2022044. Epub 2022 Apr 1.

Department of Health Sciences, Unit of Dermatology, Magna Graecia University, Catanzaro, Italy.

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http://dx.doi.org/10.5826/dpc.1202a44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116521PMC
May 2022

Combination of Specific Vascular Lasers and Vascular Intense Pulsed Light Improves Facial Telangiectasias and Redness.

Medicina (Kaunas) 2022 May 11;58(5). Epub 2022 May 11.

Department of Systems Medicine, Tor Vergata University, 00100 Rome, Italy.

Facial telangiectasias are dilated blood vessels that can represent a cosmetic issue for patients. They may be associated with other conditions, such as rosacea. Laser and light treatments are nowadays becoming a cornerstone in the management of these lesions. In total, 68 patients seeking medical treatment for facial telangiectasias were enrolled from 1 March 2019 to 1 March 2020 at the Dermatological Unit of Magna Graecia University (Catanzaro, Italy). A protocol consisting of a 1064 Nd:YAG laser for darker blue telangiectasias and 532 nm Nd:YAG for red lesions followed by intense pulsed light with an optimized spectrum for vascular lesion 3 weeks after the first procedure was proposed. A three-month follow-up visit assessed patient's satisfaction using a visual analog scale (VAS). Two dermatologists measured clinical results using a 4-point scale, comparing pictures before treatment and at follow-up. A total of 68 patients (32 males and 36 females) completed the study, performing all requested treatments. No severe side effects were reported. Patient satisfaction was very high (8.15 ± 1.05 out of a 10-point VAS scale), as well as dermatologists' clinical evaluations (2.19 ± 0.74 out of 3). The combination of vascular lasers and Vascular Intense Pulsed Light acting specifically on small blood vessels may help to improve the aesthetic outcome, reducing side effects. A prospective study with a larger number of participants will be necessary to confirm this study's findings.
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http://dx.doi.org/10.3390/medicina58050651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147706PMC
May 2022

Post-Stroke Asymmetric Prurigo Nodularis Responding to Dupilumab Treatment: A Case Report.

Brain Sci 2022 May 5;12(5). Epub 2022 May 5.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Prurigo nodularis (PN) is a dermatological condition characterized by nodular hyperkeratotic lesions mainly on the legs and arms. Asymmetrical PN is a rare dermatological condition often associated with paralysis and stroke. In this paper, we present the case of a 77-year-old woman who developed post-ictal PN which responded to dupilumab, an anti-interleukin-4/13 drug approved for the management of AD, with an extreme reduction in itch sensation. Dupilumab and other therapies reducing Th2 inflammation may, in the future, become an alternative treatment for post-ictal pruritus/PN nonresponding to traditional therapies. Of course, larger studies will be necessary to confirm our case's findings.
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http://dx.doi.org/10.3390/brainsci12050605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139789PMC
May 2022

A New Protocol to Treat Abdominal Subcutaneous Fat Combining Microwaves and Flat magnetic stimulation.

Bioengineering (Basel) 2022 Apr 21;9(5). Epub 2022 Apr 21.

Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00100 Rome, Italy.

Background: A healthy lifestyle is not always able to improve the abdomen's appearance, especially in those patients who have undergone sudden weight changes.

Objective: We aimed at evaluating the efficacy of combined microwaves and flat magnetic stimulation (FMS) to treat abdominal localized adiposity and laxity.

Methods: Twenty-five patients were subjected to two treatment sessions per month on the abdominal area with microwaves. FMS was also performed twice per week, with a minimum of two days between each session for two months. The technology uses three types of different protocols: massage, muscle definition (shaping), and muscular strengthening. Measurements, including body mass index (BMI) and waist, and abdominal ultrasound were performed at baseline and three months after the last treatment session. Blood examinations were performed, and a 5-Likert scale questionnaire was used to assess patient satisfaction.

Results: At follow-up, three months after the last treatment, the mean waist circumference (WC) was significantly reduced, and skin laxity improved in all patients ( < 0.001). A significant improvement in abdominal muscle tissue thickness was also shown in all abdominal areas, and the thickness of the adipose tissue evaluated by ultrasound was reduced.

Conclusions: This study proves that the combination of microwaves and FMS treatment is secure and efficient for treating abdominal subcutaneous fat and skin laxity.
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http://dx.doi.org/10.3390/bioengineering9050182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137650PMC
April 2022

A 24-weeks real-world experience of dupilumab in adolescents with moderate-to-severe atopic dermatitis.

Dermatol Ther 2022 Aug 22;35(8):e15588. Epub 2022 May 22.

Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.

Dupilumab is a monoclonal antibody approved for the treatment of moderate-to-severe atopic dermatitis (AD) in patients aged ≥12 years. Large, double-blind, randomized, placebo-controlled trials showed its efficacy and safety in adolescents. However, real-life data are few. The aim of this monocentric retrospective observational study (December 2020-November 2021) was to assess the effectiveness and safety of dupilumab in AD adolescents treated for at least 24 weeks. For each patient demographic features, clinical data and adverse events (AEs) were collected. Eczema Area and Severity Index (EASI), Numerical Rating Scale (NRS) for pruritus (P-NRS) and for sleep disturbances (S-NRS), and Children Dermatology Life Quality Index (cDLQI) were assessed at baseline, week (W)4, W16, and W24. Twenty-seven patients (18 males; 15.23 ± 3.54 years) were enrolled. Dupilumab was administered subcutaneously at dosage of 600 mg induction dose, followed by 300 mg every 2 weeks in 14 (51.85%) patients with a weight ≥60 kg, while 13 (48.15%) patients with a weight <60 kg were treated with dupilumab 200 mg every 2 weeks after a loading dose of 400 mg. The mean EASI score at baseline was 26.96 ± 4.93 and significantly reduced to 3.74 ± 3.47 at W16 (<0.001), and to 3.4 ± 5.04 at W24 (p < 0.001). P-NRS (9.14 ± 0.94 at baseline vs. 2.33 ± 4.93 at W16 [p < 0.001], and 1.45 ± 2.35 at W24 [p < 0.001]), S-NRS (7.88 ± 1.64 at baseline vs. 0.92 ± 1.35 at W16 [p < 0.001], and 1.66 ± 2.84 at W24 [p < 0.0001]) and cDLQI (26.62 ± 4.45 vs. 2.18 ± 3.51 at baseline vs. 2.18 ± 3.51 at W16 [p < 0.001], and 3.4 ± 5.02 at W24 [p < 0.001]) showed a statistically significative improvement as well. Injection-site reaction (5/27; 18.52%), conjunctivitis (2/27; 7.41%), and asthenia (2/27; 7.41%) were the main AEs collected. This study seems to confirm the efficacy and safety of dupilumab in adolescents with moderate-to-severe AD also in real-life setting.
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http://dx.doi.org/10.1111/dth.15588DOI Listing
August 2022

Clinical Evaluation on the Performance and Safety of a Non-Ablative Fractional 1340 nm Laser for the Treatment of Stretch Marks in Adolescents and Young Adults: A Case Series.

Bioengineering (Basel) 2022 Mar 25;9(4). Epub 2022 Mar 25.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

A large part of the world's population suffers from Striae distensae (SD) or stretch marks, which create physical and psychological discomfort in people. We evaluate the SD clinical improvement by using a non-ablative fractional Nd:YAP 1340 nm laser. The research was performed on 25 patients of both sexes, with a mean age of 31 ± 13.09 years. Each patient underwent from a minimum of 3 to a maximum of 4 treatments, with an Nd:YAP (1340 nm) medical device, every four weeks, with 3- and 6-month follow-up, in these areas: back, abdomen, breast, flanks, lower limbs, buttocks, and thighs. Manchester Scar Scale assessed stretch marks improvement. Side effects, patient pain, and SD overall appearance improvement were also recorded for all patients. Digital photographs measured the aesthetic results. Treatment was well-tolerated (pain score 1.08 ± 0.76) by all patients. There were no long-term side effects, and 88% of patients revealed an SD excellent improvement showing good aesthetic results achieved by the treatment. The total mean pretreatment Manchester Scar Scale score decreased from 13.80 (±1.58) to 10.36 (±1.70) after 3 months ( < 0.01) and to 8.36 (±1.07) after 6 months ( < 0.01). An Nd:YAP (1340 nm) laser seems to be a safe and effective treatment, showing a higher security profile with no side effects.
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http://dx.doi.org/10.3390/bioengineering9040139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027695PMC
March 2022

Non-epidermolytic palmoplantar keratoderma treated with blue LED light.

Photodermatol Photoimmunol Photomed 2022 Apr 1. Epub 2022 Apr 1.

Department of Health Sciences, University of Magna Graecia, Catanzaro, Italy.

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http://dx.doi.org/10.1111/phpp.12791DOI Listing
April 2022

Colchicine in Managing Skin Conditions: A Systematic Review.

Pharmaceutics 2022 Jan 27;14(2). Epub 2022 Jan 27.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

(1) Background: Colchicine is a natural alkaloid with anti-inflammatory properties used to treat various disorders, including some skin diseases. This paper aims to incorporate all the available studies proposing colchicine as a treatment alternative in the management of cutaneous conditions. (2) Methods: In this systematic review, the available articles present in various databases (PubMed, Scopus-Embase, and Web of Science), proposing colchicine as a treatment for cutaneous pathological conditions, have been selected. Exclusion criteria included a non-English language and non-human studies. (3) Results: Ninety-six studies were included. Most of them were case reports and case series studies describing colchicine as single therapy, or in combination with other drugs. Hidradenitis suppurativa, pyoderma gangrenosum, erythema nodosum, erythema induratum, storage diseases, perforating dermatosis, bullous diseases, psoriasis, vasculitis, acne, urticaria, stomatitis, actinic keratosis, and pustular dermatosis were the main diseases discussed in literature. Although the therapeutic outcomes were variable, most of the studies reported, on average, good clinical results (4) Conclusions: Colchicine could be, as a single therapy or in combination with other drugs, a possible treatment to manage several skin diseases.
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http://dx.doi.org/10.3390/pharmaceutics14020294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878049PMC
January 2022

Erythema Migrans-like COVID Vaccine Arm: A Literature Review.

J Clin Med 2022 Feb 1;11(3). Epub 2022 Feb 1.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

COVID Vaccine Arm (CVA) is an adverse drug reaction from mRNA vaccine for SARS-CoV-2. CVA is characterized by erythema and edema on the vaccination site (usually deltoid area) that appears from 5 to 10 days after vaccination and is sometimes associated with itching or pain. The exact etiology of CVA is still unclear, but delayed hypersensitivity against an excipient seems to play an essential role in the pathogenesis of the disease. This work performs a systematic literature review on CVA using three different databases containing articles published until 10 November 2021. The literature review includes eight papers reporting single cases or case series of CVA. Moreover, it also addresses, other cutaneous reactions following COVID 19 vaccinations as well as possible differential diagnosis. CVA migrans-like erythema is characterized by a ring-shaped rash in the injection area, which appears some days after the injection and disappears in about 10 days. This reaction may appear more rapidly in subsequent doses.
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http://dx.doi.org/10.3390/jcm11030797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836892PMC
February 2022

Microwave Therapy for Cellulite: An Effective Non-Invasive Treatment.

J Clin Med 2022 Jan 20;11(3). Epub 2022 Jan 20.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Background: Cellulite represents a common cosmetic problem that affects nearly all women. This study aimed to evaluate microwave therapy's effectiveness for cellulite treatment.

Methods: In this study, 26 women showing severe or moderate cellulite underwent four sessions of microwave therapy on the buttocks and posterior thighs. The following assessments were performed at baseline and the three-month follow-up after the last treatment: the Cellulite Severity Scale (CSS), Nürnberger-Müller classification scale, photographic evaluation, and buttocks/posterior thighs circumference measurements. A Likert scale questionnaire was used to assess patient satisfaction at the 3-month follow-up.

Results: The treatment positively affected the cellulite severity as confirmed by the Cellulite Severity Scale (CSS) and Nürnberger-Müller classification scale results. CSS showed a significant amelioration in cellulite severity between the initial assessment and the 3-month follow-up for the buttocks and posterior thighs, with total average scores that ranged from 10.7 ± 3.1 to 4.5 ± 1.8 ( < 0.01). The treatment also resulted in a remarkable improvement in comfort/satisfaction and a buttocks and posterior thighs circumference reduction. No serious adverse events were observed.

Conclusions: Microwave therapy has proven to be a safe treatment for improving cellulite appearance and reducing body circumferences.
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http://dx.doi.org/10.3390/jcm11030515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836637PMC
January 2022

Fractional Micro-ablative CO2 Laser as Therapy in Penile Lichen Sclerosus.

J Lasers Med Sci 2021 18;12:e61. Epub 2021 Oct 18.

Department of Health Sciences, Unit of Dermatology, - Magna Graecia University, Catanzaro, Italy.

Topical steroids remain the first-line therapy to treat lichen sclerosus (LS), but circumcision may be curative in most cases. Positive results have been obtained by using a fractional micro-ablative CO2 laser to treat genital LS. This study aims to assess the safety and efficacy of the fractional micro-ablative CO2 laser in the treatment of penile LS. Five treatments with the fractional CO2 laser were performed on one 69-year-old man affected by penile LS. A significant improvement in symptomatology was noted after the first treatment session. Complete clinical remission was achieved 14 weeks after the last treatment. The fractional micro-ablative CO2 laser may represent a practical therapeutic approach in penile LS.
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http://dx.doi.org/10.34172/jlms.2021.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837861PMC
October 2021

Pulsed dye laser prior to CO laser ablation to treat multiple cutaneous neurofibromas in von Recklinghausen's disease: A case report.

Dermatol Ther 2022 04 10;35(4):e15355. Epub 2022 Feb 10.

Department of Health Sciences, University of Magna Graecia, Catanzaro, Italy.

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http://dx.doi.org/10.1111/dth.15355DOI Listing
April 2022

Sequential Use of CO Laser Prior to Nd:YAG and Dye Laser in the Management of Non-Facial Warts: A Retrospective Study.

Medicina (Kaunas) 2022 Jan 12;58(1). Epub 2022 Jan 12.

Department of Systems Medicine, Tor Vergata University, 00173 Rome, Italy.

: Warts are benign lesions of viral etiology characterized by a hyperkeratotic appearance tending to spread across the skin surface. Various treatments have been proposed to manage this condition, such as acids, imiquimod, photodynamic therapy, cryotherapy, and various lasers. In this paper, we describe a combination protocol using CO laser prior to Nd:YAG laser for lesions interesting the palmoplantar areas or dye laser for lesions on other skin surfaces in the management of non-facial warts resistant to traditional therapies. In total, 34 patients with 103 warts suffering from wart infection resistant to traditional therapies treated from 1 January 2019 to 1 June 2020 were retrospectively enrolled at the Dermatological Unit of Magna Graecia University (Catanzaro, Italy). Two dermatologists measured clinical results, classifying lesions with complete resolution, partial resolution, or non-responding. Patients at four months follow-up were asked to evaluate their degree of satisfaction with a visual analog scale (VAS). Almost all patients reported the complete resolution of lesions, with no patient reporting scarring. Five patients reported hypopigmentation in the treated areas. The mean satisfaction level was high. Only three patients experienced a relapse of the condition. Using a vascular laser following a CO superficial ablation of warts may help reduce the risk of scarring and decrease the incidence of relapses for lesions resistant to traditional therapies. Therefore, more extensive studies will be necessary to confirm the obtained results.
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http://dx.doi.org/10.3390/medicina58010115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780825PMC
January 2022

Erbium Laser for Skin Surgery: A Single-Center Twenty-Five Years' Experience.

Medicines (Basel) 2021 Nov 24;8(12). Epub 2021 Nov 24.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

 (1) Introduction: The Erbium laser is a very versatile laser system used in dermatology. Its ability to be almost selectively absorbed by water makes it a perfect device for managing various cutaneous skin conditions. (2) Methods: In this paper, we report our twenty-five years' experience with the Erbium laser. More than three thousand patients were treated for common skin disorders such as flat warts, seborrheic keratosis, xanthelasmas, and scars. (3) Results: A complete response was observed in 89.6%, without significant side effects. Local anesthesia was used in only a tiny percentage of patients. (4) Conclusions: This study confirms that the Erbium laser is a valuable and flexible procedure for laser surgery with excellent safety and short healing times.
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http://dx.doi.org/10.3390/medicines8120074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705569PMC
November 2021

Combined CO and dye laser technique in the treatment of outcomes due to flap necrosis after surgery for basal cell carcinoma on the nose.

Lasers Surg Med 2022 04 27;54(4):523-529. Epub 2021 Nov 27.

Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Background And Objective: Basal cell carcinoma (BCC) is the most frequent cutaneous cancer worldwide, and the nasal area is the most commonly affected region. Skin flaps are usually performed to achieve radical results, but various adverse events often occur. The necrosis of the skin flap is one of the most frequently observed, resulting in scars and anti-aesthetic outcomes. Ablative and non-ablative lasers have been proposed to improve scars resulting from surgical failure and skin flap necrosis.

Study Design/materials And Methods: This study aims to evaluate a new laser protocol combining ablative CO -laser with flashlamp pulsed dye laser for the treatment of nasal scars resulting from the necrosis of flap that occurred after surgery. Twelve patients were enrolled in the study, and a total of five laser sessions were planned, spaced from 14 days to 1 month apart.

Results: Seven out of 12 patients underwent all the five laser sessions planned, while 5/12 patients achieved optimal cosmetic results within the fourth session. Eighty percent of the patients reported good/optimal cosmetic results, and no significant side effects were observed during the study.

Conclusion: Combining fractionated CO laser with flashlamp pulsed dye laser represents a new effective modality for treating skin flap necrosis after BBC removal, representing a valid alternative to other surgical procedures.
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http://dx.doi.org/10.1002/lsm.23502DOI Listing
April 2022

Skin Manifestations after Ionizing Radiation Exposure: A Systematic Review.

Bioengineering (Basel) 2021 Oct 22;8(11). Epub 2021 Oct 22.

Department of Health Science, Magna Graecia University, 88100 Catanzaro, Italy.

Morphological and functional skin alterations secondary to the action of ionizing radiation are well documented. In addition to its application in the medical field, ionizing radiation represents a public health problem for diagnostic and therapeutic purposes due to the potential risk of exposure to unexpected events, such as nuclear accidents or malicious acts. With regard to the use of ionizing radiations in the medical field, today, they constitute a fundamental therapeutic method for various neoplastic pathologies. Therefore, the onset of adverse skin events induced by radiation represents a widespread and not negligible problem, affecting 95% of patients undergoing radiotherapy. A systematic literature search was performed from July 2021 up to August 2021 using PubMed, Embase, and Cochrane databases. Articles were screened by title, abstract and full text as needed. A manual search among the references of the included papers was also performed. This systematic review describes the various skin reactions that can arise following exposure to ionizing radiation and which significantly impact the quality of life, especially in cancer patients.
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http://dx.doi.org/10.3390/bioengineering8110153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614920PMC
October 2021

Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study.

Clin Pract 2021 Sep 23;11(4):708-714. Epub 2021 Sep 23.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

(1) Benign hyperpigmentations are a common problem in cosmetic dermatology. Melasma, solar lentigo, and other acquired hyperpigmentations represent an aesthetic issue for an increasing number of patients. The gold standard in managing this condition is currently 1064/532 nanometers (nm) Q-Switched lasers. This study reports our experience on the use of a Q-switched laser with a nanosecond pulse to treat these conditions. (2) Methods: A total of 96 patients asking for benign hyperpigmentation removal were consecutively enrolled at the Magna Graecia University of Catanzaro and Tor Vergata University of Rome. Treating parameters were the following: 1064 nm with a pulse duration of 6 nanoseconds (ns) for dermic lesions and 532 nm with 6 ns for epidermal ones. Up to five treatments with a minimum interval between laser treatments of thirty days were performed. A follow-up visit three months after the last session assessed patient satisfaction with a Visual Analogue Scale (VAS). Two blinded dermatologists assessed the cosmetic result using a five-point scale comparing pictures before treatment and at follow-up. (3) Results: 96 patients were included; 47 participants were women (49.0%) and 49 men (51.0%). The mean reported age was 50.0 ± 17.3 years. All patients reached a good to complete hyperpigmentation removal at the dermatological evaluation with a mean VAS score of 8.91 ± 1.07. (4) Conclusions: Q Switched 1064/532 nm laser may be considered the gold standard treatment for benign hyperpigmentations. Our results confirm the literature findings on the effectiveness of these devices.
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http://dx.doi.org/10.3390/clinpract11040086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544362PMC
September 2021

A giant epidermal nevus of the face treated with a CO and dye laser combination: a case report and literature review.

J Cosmet Laser Ther 2021 May 20;23(3-4):59-64. Epub 2021 Oct 20.

Department of Health Sciences, University of Magna Graecia, Catanzaro, Italy.

Epidermal nevi (EN) are cutaneous hamartomas present at birth, usually occurs in the trunk, the face, or the limbs, appearing as a patch of overgrowing skin. They may be small and localized, but they may interest extensive areas of the body. A 20 years old man came to our attention for an EN interesting all the face. The treatment protocol consisted of a session of CO laser in order to vaporize thicker areas, followed by a session of dye laser on the area to prevent scarring. This treatment was performed under local anesthesia and sedation in three surgical sessions spaced 3 months from each other. Two sessions of dye laser spaced apart 6 months were performed during follow-up to further improve the esthetic outcome. The patient was followed for 2 years with no recurrence. Although surgery is still considered the gold standard in EN management, it is not always feasible. This novel combination technique can obtain optimal cosmetic results with no relapse within the period of follow up. Although further trials on a more significant number of patients are required, the combination of CO and dye laser promises to become a valid therapeutic alternative when treating giant EN of the face.
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http://dx.doi.org/10.1080/14764172.2021.1990962DOI Listing
May 2021

CO laser in the management of eccrine hidrocystomas: a retrospective study.

Lasers Med Sci 2022 03 27;37(2):1365-1369. Epub 2021 Sep 27.

Department of Health Sciences, University of Magna Graecia, Viale Magna Graecia SNC, 87100, Catanzaro, Italy.

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http://dx.doi.org/10.1007/s10103-021-03424-9DOI Listing
March 2022

Management of laser treatments during the coronavirus disease 2019 pandemic: The Italian experience.

Clin Dermatol 2021 May-Jun;39(3):521-522. Epub 2021 Feb 16.

Dermatological Unit of "Magna Graecia" University, Catanzaro, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clindermatol.2021.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884231PMC
November 2021

Erythema Multiforme and COVID-19: What Do We Know?

Medicina (Kaunas) 2021 Aug 16;57(8). Epub 2021 Aug 16.

Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.

: Erythema multiforme (EM) is an acute cutaneous eruption often associated with infections and more rarely with drugs. This review aimed to evaluate the association between erythema multiforme and coronavirus disease 2019 (COVID-19). : A systematic search of PubMed/MEDLINE, Scimago Scopus, and ISI/Web of Science was performed. Original articles, case series, or case reports were evaluated and selected. : Fourteen articles were selected, describing a total of 70 patients. EM is a cutaneous eruption rarely occurring in COVID-19 and is, in most cases, associated with a hypersensitivity reaction to the virus. In these cases, EM seems to affect patients younger than 30 years or older than 55 years. Infrequently, some drugs used in the management of COVID-19 may induce EM, especially hydroxychloroquine. The three groups of patients seem to have different clinical characteristics and courses. : From these data, it is possible to preliminarily propose that EM or EM-like eruptions linked to COVID-19 might be divided into three types: the virus-related juvenile type (affecting patients <30-year-old), the virus-related older type (affecting patients >55 years), and the drug-induced type. The occurrence of a skin rash does not seem to be related to the severity and clinical course of COVID-19.
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http://dx.doi.org/10.3390/medicina57080828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401222PMC
August 2021

Safety of omalizumab treatment in patients with chronic spontaneous urticaria and COVID-19.

Dermatol Ther 2021 11 31;34(6):e15111. Epub 2021 Aug 31.

Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.

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http://dx.doi.org/10.1111/dth.15111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646731PMC
November 2021

Q-Switched 1064/532 nm Laser with Nanosecond Pulse in Tattoo Treatment: A Double-Center Retrospective Study.

Life (Basel) 2021 Jul 16;11(7). Epub 2021 Jul 16.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Tattoo removal is a well-established procedure in dermatology. Lasers represent the gold standard in the management of this condition nowadays. In this study, we report our experience on the use of a Q-switched nanosecond source. A total of 52 patients were consecutively enrolled in performing tattoo removal at Magna Graecia University of Catanzaro and Tor Vergata University of Rome. Black and blue tattoos were treated with a 1064 nm laser, with a pulse duration of 6 ns and a fluence up to 10 J/cm, while colored tattoos were treated with sessions of 532 nm laser, with a pulse duration of 6 ns and a fluence up to 5 J/cm. Up to nine treatments with a minimum interval of 8 weeks between each session were performed. A six-month follow-up visit assessed patient satisfaction (Visual Analogue Scale). Overall clinical result was assessed with a clinical evaluation by two blinded dermatologists using a 5-point scale, comparing pictures before treatment and at follow up. A total of 52 patients were included and analyzed: 30 females (57.7%) and 22 males (42.3%). Mean age was 43.7 ± 12.7 years. According to Fitzpatrick's skin classification, 16 individuals (30.8%) were type II, 15 (28.8%) were type III, and 21 (40.4%) were type IV. Most of the treated tattoos were carried out by professionals. The mean number of sessions required to obtain a result was 4.6 ± 2.5, and the final tattoo removal rate was 60% or higher, with 51.9% of the patients reporting highest satisfaction scores Q-Switched 1064/532 nm laser may be considered today as the gold-standard treatment for tattoo removal. Our results confirm literature findings of the safety and effectiveness of these devices.
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http://dx.doi.org/10.3390/life11070699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304052PMC
July 2021

Histopathology and immunophenotyping of late onset cutaneous manifestations of COVID-19 in elderly patients: Three case reports.

World J Clin Cases 2021 Jul;9(20):5744-5751

Department of Medical and Surgical Sciences, Infectious and Tropical Disease Unit, Magna Graecia University, Catanzaro 88100, Italy.

Background: Several cutaneous manifestations such as urticarial rash, erythematous patches and chilblain-like lesions have been described in young adults with coronavirus disease 2019 (COVID-19) and are present in up to 20% patients, but few reports exist describing histopathological and immunophenotypic characteristics of dermatological lesions in older patients. Our aim was to characterize skin lesions in elderly patients during late stages of COVID-19 from clinical, histological and immunophenotypic perspectives.

Case Summary: Three patients, admitted for COVID-19, and who developed cutaneous manifestations underwent skin biopsies. Immunophenotypic analysis for CD20, CD3, CD4 and CD8 was performed on skin biopsies to assess immune cell infiltrates. CD1a was used as a marker of Langerhans cells, and CD31 as a marker of endothelial cells. In the three study patients, cutaneous manifestations were evident in the late-stage of COVID-19 (mean time from the first positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) swab to rash onset was 35 d). Skin biopsies showed a similar pattern of T lymphocyte infiltration in all patients. Indeed, a chronic dermatitis with perivascular lymphocytic infiltrate was observed with predominance of CD3+ T-cell (CD3+).

Conclusion: Our study confirms previous reports. Histological and immunophenotypic patterns in our patients confirm results described in the two previous reported experiences. This pattern is similar to what is found in some lympho-proliferative disorders. Therefore, since these findings are non-specific, SARS-CoV-2 infection should be suspected.
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http://dx.doi.org/10.12998/wjcc.v9.i20.5744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281404PMC
July 2021

Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?

Curr Oncol 2021 06 23;28(4):2317-2325. Epub 2021 Jun 23.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

: Squamous cell carcinoma (SCC) is one of the most common cancers involving skin and oral mucosa. Although this condition's gold-standard treatment is the surgical removal of the lesions, the physician must propose alternative treatments in some cases due to the patient's ineligibility for surgery. Among the available alternative therapies, local chemotherapy may represent an initial treatment in combination with radiotherapy or systemic chemotherapy due to the low frequency of side-effects and the lack of necessity for expensive devices. : In this paper, we review all available literature in various databases (PubMed, Scopus-Embase, Web of Science), proposing local chemotherapy as a treatment for cutaneous and oral SCC. Exclusion criteria included ocular lesions (where topical treatments are common), non-English language, and non-human studies. : We included 14 studies in this review. The majority were case reports and case series describing the treatment of non-resectable localized SCC with either imiquimod or 5-fluorouracil. We also analyzed small studies proposing combination treatments. Almost all studies reported an excellent clinical outcome, with a low risk of relapses in time. : Resection of the lesion remains the gold-standard treatment for SCC. When this approach is not feasible, local chemotherapy may represent a treatment alternative, and it may also be associated with radiotherapy or systemic chemotherapy.
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http://dx.doi.org/10.3390/curroncol28040213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293038PMC
June 2021

Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip.

Medicina (Kaunas) 2021 Jun 2;57(6). Epub 2021 Jun 2.

Department of Health Sciences, Magna Graecia University, Viale Europa, SNC, 88100 Catanzaro, Italy.

Background: Squamous cell carcinoma (SCC) is one of the most common neoplasms affecting the oral cavity and the face. Its more differentiated forms may be associated with human papilloma virus (HPV) infection.

Case Report: In this paper, we report the case of an 86-year-old patient with a well-differentiated SCC of the lower lip associated with HPV treated with surgery with a non-complete histological resolution. Imiquimod 5% cream was applied on the surgical scar once a day for two weeks and then once a week. Two years after SCC removal, no relapse has occurred.

Conclusions: Topical imiquimod may be a safe and effective treatment after surgery in SCC of the oral area to reduce the risk of relapses.
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http://dx.doi.org/10.3390/medicina57060563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227566PMC
June 2021

Histological Skin Changes After Treatment with 675 nm Laser.

Photobiomodul Photomed Laser Surg 2021 Sep 25;39(9):617-621. Epub 2021 May 25.

Unit of Dermatology, Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.

To evaluate the histological effects of a new 675-nm laser device on the skin. Innovative technologies based on physical principles have been proposed in recent years to improve the treatment of aging skin. Laser technology is currently being studied for its potential in skin care treatments. A new 675-nm laser device is being used for the treatment of hyperpigmentation, scars, and various types of wrinkles. A 42-year-old man underwent a 675-nm RedTouch laser session for the treatment of aging signs on the neck. Two 2.5-mm biopsies were taken from the treated area and the adjacent area untreated with the laser, 45 days after the procedure. Comparison of the immunohistochemistry findings and assessment of the collagen and elastin fibers were performed by a board-certified dermatopathologist. Skin biopsies revealed histological changes that comprised proliferation of new collagen fibers in the treated area, when compared to that in the untreated areas. Histological analysis suggests that the 675-nm laser has a potential role in stimulating collagen remodeling, with a significant increase in thin and new collagen fibers.
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http://dx.doi.org/10.1089/photob.2020.4927DOI Listing
September 2021

Blue light-emitting diodes in hair regrowth: the first prospective study.

Lasers Med Sci 2021 Oct 8;36(8):1719-1723. Epub 2021 Jun 8.

Department of Health Sciences, University of Magna Graecia, Catanzaro, Italy.

Different studies highlight photo-receptors' presence on the hair follicle that seems to be capable of eliciting hair growth. This study aims to demonstrate blue light's effectiveness on hair growth in patients affected by androgenetic alopecia. Twenty patients enrolled at Magna Graecia University Unit of Dermatology, affected by androgenetic alopecia, were treated with a blue LED light device at 417 ± 10 nm, fluence of 120 J/cm, and power intensity of 60 mW/cm ± 20%. The treatments were performed twice a week for ten consecutive weeks. Patients were evaluated before and 1 month after the end of therapy clinically using standardized global photographs and dermoscopically estimating hair density and hair shaft width. An increase in hair density and hair shaft width was recorded in 90% of patients after 10 weeks. Photographic improvement was noted in 80% of the patients. No serious adverse events have been reported. The only side effect consisted in a darkening of the hair, perhaps due to melanic stimulation due to blue light in 2 patients. Blue light therapy is a promising therapy for patients affected by androgenetic alopecia and other diseases characterized by hair loss. Further studies will be necessary to confirm the findings of this preliminary study.
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http://dx.doi.org/10.1007/s10103-021-03327-9DOI Listing
October 2021

Ixekizumab May Improve Renal Function in Psoriasis.

Healthcare (Basel) 2021 May 7;9(5). Epub 2021 May 7.

Unit of Dermatology, Department of Health Sciences, Magna Graecia University, Viale Europa SNC, 88100 Catanzaro, Italy.

Background: Psoriasis is a chronic dermatological condition characterized by lesions on extensor surfaces, hands, feet, and genital areas. Chronic renal failure is often associated with metabolic syndrome and inflammatory conditions, such as psoriasis.

Case Report: In this paper, we report a patient with stage-three chronic renal failure that improved his renal condition after treatment with ixekizumab, an anti-IL17A drug used in the treatment of various cutaneous and rheumatological conditions.

Conclusions: IL17A blockage may help to treat various autoimmune and inflammatory conditions, such as psoriasis, that may lead to renal impairment. Further investigation is necessary in order to prove the effectiveness of this drug in renal conditions.
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http://dx.doi.org/10.3390/healthcare9050543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148436PMC
May 2021
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