Ludwig Kappos

Ludwig Kappos

UNVERIFIED PROFILE

Are you Ludwig Kappos?   Register this Author

Register author
Ludwig Kappos

Ludwig Kappos

Publications by authors named "Ludwig Kappos"

Are you Ludwig Kappos?   Register this Author

100Publications

2732Reads

30Profile Views

Onset of clinical and MRI efficacy of ocrelizumab in relapsing multiple sclerosis.

Neurology 2019 Nov 4;93(19):e1778-e1786. Epub 2019 Sep 4.

From the Department of Radiology and Nuclear Medicine (F.B.), VU University Medical Centre, Amsterdam, the Netherlands; UCL Institutes of Healthcare Engineering and Neurology (F.B.), London, UK; Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering (L.K.), University Hospital Basel, University of Basel, Switzerland; Department of Neurology (J.S.W.), McGovern Medical School, UTHealth, Houston, TX; Department of Radiology (D.K.B.L.), University of British Columbia, Vancouver, Canada; Department of Neurology and Center for Neuroinflammation and Experimental Therapeutics (A.B.-O.), University of Pennsylvania, Philadelphia; Department of Neurology, Medical Faculty (H.-P.H.), Heinrich-Heine University Düsseldorf, Germany; F. Hoffmann-La Roche Ltd. (S.B., A.S., J.N., H.K.), Basel, Switzerland; Genentech, Inc. (J.H., L.J.), South San Francisco; and Department of Neurology (S.L.H.), University of California, San Francisco. During completion of the work related to this article, S. Belachew was an employee of F. Hoffmann-La Roche Ltd.; his current affiliation is Biogen, Cambridge, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000008189DOI Listing
November 2019

Accurate, rapid and reliable, fully automated MRI brainstem segmentation for application in multiple sclerosis and neurodegenerative diseases.

Hum Brain Mapp 2019 10 17;40(14):4091-4104. Epub 2019 Jun 17.

Neurology Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.24687DOI Listing
October 2019

A case of progressive multifocal leukoencephalopathy under dimethyl fumarate treatment without severe lymphopenia or immunosenescence.

Mult Scler 2019 Oct 18;25(12):1682-1685. Epub 2019 Jun 18.

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458519852100DOI Listing
October 2019

PML with dimethyl fumarate-No convincing case against natalizumab.

Mult Scler 2019 Oct 22;25(12):1687-1688. Epub 2019 Aug 22.

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458519872894DOI Listing
October 2019

Hepatitis E virus infections in patients with MS on oral disease-modifying treatment.

Neurol Neuroimmunol Neuroinflamm 2019 Sep 11;6(5). Epub 2019 Jul 11.

From the Departments of Medicine, University Hospital Basel, Neurologic Clinic and Policlinic, Clinical Research and Biomedicine, University of Basel, Petersgraben, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXI.0000000000000594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705628PMC
September 2019

Extended treatment with fingolimod for relapsing multiple sclerosis: the 14-year LONGTERMS study results.

Ther Adv Neurol Disord 2019 25;12:1756286419878324. Epub 2019 Sep 25.

Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1756286419878324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763939PMC
September 2019

Long-term outcomes with teriflunomide in patients with clinically isolated syndrome: Results of the TOPIC extension study.

Mult Scler Relat Disord 2019 Aug 24;33:131-138. Epub 2019 May 24.

McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msard.2019.05.014DOI Listing
August 2019

Short timescale modulation of cortical and cerebellar activity in the early phase of motor sequence learning: an fMRI study.

Brain Imaging Behav 2019 Jul 27. Epub 2019 Jul 27.

Department of Neurology, DKD Helios Klinik Wiesbaden, Wiesbaden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11682-019-00167-8DOI Listing
July 2019

Preferential spinal cord volume loss in primary progressive multiple sclerosis.

Mult Scler 2019 06 21;25(7):947-957. Epub 2018 May 21.

Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458518775006DOI Listing
June 2019

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

JAMA Neurol 2019 Jun 17. Epub 2019 Jun 17.

UCL Institute of Neurology, Queen Square, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2019.1534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580449PMC
June 2019

Blood neurofilament light as a potential endpoint in Phase 2 studies in MS.

Ann Clin Transl Neurol 2019 Jun 28;6(6):1081-1089. Epub 2019 May 28.

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering University Hospital Basel, University of Basel Basel Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562031PMC
June 2019

Ocrelizumab efficacy in subgroups of patients with relapsing multiple sclerosis.

J Neurol 2019 May 28;266(5):1182-1193. Epub 2019 Feb 28.

Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00415-019-09248-6
Publisher Site
http://dx.doi.org/10.1007/s00415-019-09248-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469695PMC
May 2019

Damage of the lateral geniculate nucleus in MS: Assessing the missing node of the visual pathway.

Neurology 2019 May 10;92(19):e2240-e2249. Epub 2019 Apr 10.

From the Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedical Engineering (A. Papadopoulou, L.G., A. Pfister, C.T., M.H., L.K., T.S., S.M.), and Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering (A. Papadopoulou, L.G., A.A., C.T., S.M.), University Hospital Basel and University of Basel, Switzerland; NeuroCure Clinical Research Center (NCRC) (A. Papadopoulou, A.U.B.), and Experimental and Clinical Research Center (A. Papadopoulou, A.U.B.), Max Delbrück Center for Molecular Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; Medical Image Analysis Center (MIAC) (L.G., A.A., C.T., S.M.), Basel, Switzerland; Imeka Solutions (F.M.), Sherbrooke, Canada; Department of Neurology (A.U.B.), University of California Irvine; Cerebral Imaging Centre (M.M.C.), Douglas Mental Health University Institute; Departments of Psychiatry and Biomedical Engineering (M.M.C.), McGill University, Montreal; University of Sherbrooke (M.D.), Canada; and Department of Neurology (T.S.), DKD Helios Klinik Wiesbaden, Germany. The present address for L.G. is F. Hoffmann-La Roche, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537126PMC
May 2019

Electronic Neurostatus-EDSS increases the quality of expanded disability status scale assessments: Experience from two phase 3 clinical trials.

Mult Scler 2019 May 7:1352458519845108. Epub 2019 May 7.

Neurology, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458519845108DOI Listing
May 2019

Effect of HLA-DRB1 alleles and genetic variants on the development of neutralizing antibodies to interferon beta in the BEYOND and BENEFIT trials.

Mult Scler 2019 04 9;25(4):565-573. Epub 2018 Mar 9.

Department of Neurology, Klinikum rechts der Isar, Technische Universität München, München, Germany/German Competence Network Multiple Sclerosis (KKNMS), München, Germany/Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458518763089DOI Listing
April 2019

Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis.

Mult Scler 2019 04 15;25(5):678-686. Epub 2018 Mar 15.

Department of Neurology and Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458518765666DOI Listing
April 2019

Clinical associations of T2-weighted lesion load and lesion location in small vessel disease: Insights from a large prospective cohort study.

Neuroimage 2019 04 24;189:727-733. Epub 2019 Jan 24.

Department of Neurology, University Hospital of Basel, Petersgraben 4, 4031, Basel, Switzerland; Department of Neurology, DKD Helios Klinik Wiesbaden, Aukammallee 33, 65191, Wiesbaden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2019.01.052DOI Listing
April 2019

Effect of dimethyl fumarate on lymphocytes in RRMS: Implications for clinical practice.

Neurology 2019 Apr 27;92(15):e1724-e1738. Epub 2019 Mar 27.

From Biogen (D.M., C.M., E.B., J.H., S.L., A.M., C.A.v.H., L.Y.), Cambridge, MA; NeuroRx Research (D.L.A.), Montreal; Montreal Neurological Institute (D.L.A.), McGill University, Montreal, Canada; Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology (A.B.-O.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (L.K.), University Hospital Basel, Switzerland; University of New Mexico Health Sciences Center (J.T.P.), Albuquerque; Department of Neurology, Multiple Sclerosis Division (D.R.), Morsani College of Medicine, University of South Florida, Tampa; Mellen Center for Multiple Sclerosis, Neurological Institute (R.J.F.), Cleveland Clinic, OH; Envision Pharma Group (J.C.), Sydney, Australia; and Envision Pharma Group (K.S.), Southport, CT.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511089PMC
April 2019

Central Slab versus Whole Brain to Measure Brain Atrophy in Multiple Sclerosis.

Eur Neurol 2018 3;80(3-4):207-214. Epub 2019 Jan 3.

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland,

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/495798
Publisher Site
http://dx.doi.org/10.1159/000495798DOI Listing
March 2019

Blood neurofilament light chain as a biomarker of MS disease activity and treatment response.

Neurology 2019 03 8;92(10):e1007-e1015. Epub 2019 Feb 8.

From the Neurologic Clinic and Policlinic (J.K., C.B., L.K.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Novartis Pharma AG (H.K., D.A.H., F.D., D.T., D.L.), Basel, Switzerland; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; and DATAMAP GmbH (R.M.), Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442011PMC
March 2019

Design and construction of an innovative brain phantom prototype for MRI.

Magn Reson Med 2019 02 17;81(2):1165-1171. Epub 2018 Sep 17.

Department of Biomedical Engineering, University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mrm.27464DOI Listing
February 2019

Measuring and Validating the Levels of Brain-Derived Neurotrophic Factor in Human Serum.

eNeuro 2018 Mar-Apr;5(2). Epub 2018 Mar 22.

School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/ENEURO.0419-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898630PMC
January 2019

Unraveling treatment response in multiple sclerosis: A clinical and MRI challenge.

Neurology 2019 01 26;92(4):180-192. Epub 2018 Dec 26.

From the Department of Neurosciences (C.G., L.P.), San Camillo-Forlanini Hospital, Rome, Italy; Centre d'Esclerosi Multiple de Catalunya (Cemcat), Department of Neurology/Neuroimmunology (M.T., J.R., J.S.-G., X.M.), and Magnetic Resonance Unit, Department of Radiology (A.R.), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Biostatistics Unit (M.P.S.), Department of Health Sciences, University of Genoa; Neuroimaging Research Unit (M.F., M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Nuffield Department of Clinical Neurosciences (J.P.), West Wing, John Radcliffe Hospital, Oxford; Institutes of Neurology & Healthcare Engineering (O.C., F.B.), University College London (O.C.), UK; Amsterdam Neuroscience and Department of Radiology and Nuclear Medicine (F.B., H.V.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (J.L.F.), Rigshospitalet Glostrup and University of Copenhagen, Denmark; Neuroradiological Academic Unit (T.A.Y.), Institute of Neurology, London, UK; Department of Neurology (C.E.), Medical University of Graz, Austria; Neurologic Clinic and Policlinic, Department of Medicine (L.K.), Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, University of Basel, Switzerland; Department of Neurology and Psychiatry (C.P.), Sapienza University, Rome; and Neurology and Neurometabolic Unit, Department of Neurological and Behavioral Sciences (N.D.S.), University of Siena, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345120PMC
January 2019

Slowly expanding/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions.

Mult Scler 2018 Dec 19:1352458518814117. Epub 2018 Dec 19.

NeuroRx Research, Montreal, QC, Canada/Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458518814117DOI Listing
December 2018

Neurofilaments as biomarkers in neurological disorders.

Nat Rev Neurol 2018 10;14(10):577-589

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41582-018-0058-z
Publisher Site
http://dx.doi.org/10.1038/s41582-018-0058-zDOI Listing
October 2018

Clinical Correlations of Brain Lesion Location in Multiple Sclerosis: Voxel-Based Analysis of a Large Clinical Trial Dataset.

Brain Topogr 2018 09 29;31(5):886-894. Epub 2018 May 29.

Medical Image Analysis Center (MIAC) AG, Marktgasse 8, 4051, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10548-018-0652-9DOI Listing
September 2018

A comparison of brain magnetic resonance imaging lesions in multiple sclerosis by race with reference to disability progression.

J Neuroinflammation 2018 Sep 5;15(1):255. Epub 2018 Sep 5.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12974-018-1295-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125988PMC
September 2018

Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis.

Brain 2018 08;141(8):2382-2391

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awy154DOI Listing
August 2018

Predictors of relapse and disability progression in MS patients who discontinue disease-modifying therapy.

J Neurol Sci 2018 08 2;391:72-76. Epub 2018 Jun 2.

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology, Alfred Hospital, Melbourne, VIC, Australia; Box Hill Hospital, Melbourne, VIC, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2018.06.001DOI Listing
August 2018

Reference videos reduce variability of motor dysfunction assessments in multiple sclerosis.

Mult Scler J Exp Transl Clin 2018 Jul-Sep;4(3):2055217318792399. Epub 2018 Aug 9.

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital of Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2055217318792399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088490PMC
August 2018

Spinal cord volume loss: A marker of disease progression in multiple sclerosis.

Neurology 2018 07 27;91(4):e349-e358. Epub 2018 Jun 27.

From the Department of Neurology (C.T., S.M., L.G., Y.N., M.A., T.S., L.K., K.P.), Division of Diagnostic and Interventional Neuroradiology, Department of Radiology (M.A., C.S.), and Division of Radiological Physics, Department of Radiology (O.B.), University Hospital Basel, University of Basel; Medical Image Analysis Center (MIAC AG) (C.T., S.M., L.G., M.A., J.W.), Basel; Department of Biomedical Engineering (S.P., P.C.), University of Basel, Switzerland; and Department of Neurology (T.S.), DKD HELIOS Klinik Wiesbaden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000005853DOI Listing
July 2018

Comparative analysis of natalizumab versus fingolimod as second-line treatment in relapsing-remitting multiple sclerosis.

Mult Scler 2018 05 24;24(6):777-785. Epub 2018 Apr 24.

Neurologic Clinic and Policlinic, Department of Neurology, University Hospital Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458518768433DOI Listing
May 2018

Fingolimod effect on gray matter, thalamus, and white matter in patients with multiple sclerosis.

Neurology 2018 04 14;90(15):e1324-e1332. Epub 2018 Mar 14.

From the Medical Image Analysis Centre (L.G., E.-W.R., N.M.-L., T.S.), University Hospital Basel; Neurologic Clinic and Policlinic (L.G., L.K., T.S.), Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital and University of Basel; Novartis Pharma AG (D.A.H., D.T.), Basel, Switzerland; Novartis Healthcare Pvt Ltd (A.T.), Hyderabad, India; and Department of Neurology (T.S.), DKD HELIOS Klinik Wiesbaden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000005292DOI Listing
April 2018

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis.

Mult Scler 2018 02 20;24(2):96-120. Epub 2018 Jan 20.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458517751049DOI Listing
February 2018

Dimethyl fumarate influences innate and adaptive immunity in multiple sclerosis.

J Autoimmun 2018 01 27;86:39-50. Epub 2017 Sep 27.

Laboratory of Clinical Neuroimmunology, Neurologic Clinic and Policlinic, Departments of Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2017.09.009DOI Listing
January 2018

PML risk and natalizumab: the elephant in the room.

Lancet Neurol 2017 11 29;16(11):864-865. Epub 2017 Sep 29.

Neurology Clinic and Policlinic, Departments of Medicine, Biomedicine, Clinical Research, and Biomedical Engineering, University Hospital Basel, University of Basel, Basel 4031, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14744422173033
Publisher Site
http://dx.doi.org/10.1016/S1474-4422(17)30335-6DOI Listing
November 2017

Reversibility of the effects of natalizumab on peripheral immune cell dynamics in MS patients.

Neurology 2017 Oct 15;89(15):1584-1593. Epub 2017 Sep 15.

From Biogen (T.P., K.K.M., G.K., D.M., K.E., M.S., I.N., Y.C., Q.D., P.-R.H., D.A.), Cambridge, MA; Ashfield Healthcare Communications (A.A.), Middletown, CT; Hôpital Civil (J.D.S.), Strasbourg, France; Mellen Center for Multiple Sclerosis (R.F.), Cleveland Clinic, OH; St. Josef Hospital (R.G.), Ruhr University, Bochum, Germany; Piedmont HealthCare (D.J.), Mooresville, NC; Neurologic Clinic and Policlinic (L.K.), Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs MS Center and Pediatric MS Center of Excellence (B.W.-G.), Jacobs Neurological Institute, Buffalo, NY; Department of Neurology (H.-P.H.), Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany; and University of California San Francisco Multiple Sclerosis Center (B.A.C.C.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634662PMC
October 2017

Fluid biomarker and electrophysiological outcome measures for progressive MS trials.

Mult Scler 2017 Oct;23(12):1600-1613

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital of Basel, University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458517732844DOI Listing
October 2017

Teriflunomide slows BVL in relapsing MS: A reanalysis of the TEMSO MRI data set using SIENA.

Neurol Neuroimmunol Neuroinflamm 2017 Sep 9;4(5):e390. Epub 2017 Aug 9.

Medical Image Analysis Center (MIAC AG) (E.-W.R., L.G., N.M.-L., J.W.), Basel, Switzerland; DKD HELIOS Klinik (T.S.), Wiesbaden, Germany; Neurologic Clinic and Policlinic (T.S., L.G., L.K.), University Hospital Basel and University of Basel, Switzerland; Sanofi Genzyme (S.C., K.T.), Previously Sanofi Genzyme (M.A.P.), and WAVE Life Sciences (M.A.P.), Cambridge, MA; Fishawack Communications Ltd (J.E.D., F.M.W.), Abingdon, Oxfordshire, UK; and McGovern Medical School (J.S.W.), UTHealth, Houston, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXI.0000000000000390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550381PMC
September 2017

α4-integrin receptor desaturation and disease activity return after natalizumab cessation.

Neurol Neuroimmunol Neuroinflamm 2017 Sep 25;4(5):e388. Epub 2017 Aug 25.

Neurological Clinic and Policlinic (T.D.), Departments of Medicine and Biomedicine, University Hospital Basel; Novartis Pharma AG (J.M.K., M.S., D.T.), Basel; Neurological Clinic and Policlinic (L.K.), Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, Switzerland; Novartis Pharmaceuticals Corporation (Y.Z.), East Hanover, NJ; and Department of Neurology (H.W.), University of Münster, Germany; Novartis Healthcare Pvt. Ltd. (R.C.. A.T.), Hyderabad, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXI.0000000000000388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572051PMC
September 2017

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.

Ann Neurol 2017 Jun;81(6):857-870

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.24954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519945PMC
June 2017

Neurostatus e-Scoring improves consistency of Expanded Disability Status Scale assessments: A proof of concept study.

Mult Scler 2017 Apr 11;23(4):597-603. Epub 2016 Jul 11.

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458516657439DOI Listing
April 2017

Subcutaneous interferon β-1a in the treatment of clinically isolated syndromes: 3-year and 5-year results of the phase III dosing frequency-blind multicentre REFLEXION study.

J Neurol Neurosurg Psychiatry 2017 Apr 30;88(4):285-294. Epub 2016 Dec 30.

Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2016-314843DOI Listing
April 2017

Ocrelizumab in Primary Progressive and Relapsing Multiple Sclerosis.

N Engl J Med 2017 04;376(17):1694

University Hospital Basel, Basel, Switzerland

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1702076DOI Listing
April 2017

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis.

N Engl J Med 2017 01 21;376(3):221-234. Epub 2016 Dec 21.

From the University of California, San Francisco (S.L.H.), and Genentech, South San Francisco (D.M., P.C., H.G.) - both in California; McGill University (A.B.-O., D.L.A.) and NeuroRx Research (D.L.A.), Montreal, and University of British Columbia, Vancouver, BC (A.T.) - both in Canada; University Vita-Salute San Raffaele, Milan (G.C.); Barts and the London School of Medicine and Dentistry, London (G.G.); Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf (H.-P.H.), and the Technical University of Munich and Munich Cluster for Systems Neurology, Munich (B.H.) - both in Germany; Icahn School of Medicine at Mount Sinai, New York (F.L.); Hospital Vall d'Hebron University, Barcelona (X.M.); University of Miami, Miami (K.W.R.); Medical University of Lodz and Center for Neurology, Lodz, Poland (K.S.); McGovern Medical School, University of Texas Health Science Center at Houston, Houston (J.S.W.); and F. Hoffmann-La Roche (G.K., P.F., S.B., N.M.) and University Hospital Basel, University of Basel (L.K.), Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1601277DOI Listing
January 2017

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis.

N Engl J Med 2017 01 21;376(3):209-220. Epub 2016 Dec 21.

From Hospital Vall d'Hebron University, Barcelona (X.M.); University of California, San Francisco, San Francisco (S.L.H.), and Genentech, South San Francisco (D.M., H.G., P.C.) - both in California; University Hospital Basel, University of Basel (L.K.), and F. Hoffmann-La Roche (A.S., P.F., S.B., N.M.), Basel, Switzerland; McGill University (D.L.A., A.B.-O.) and NeuroRx Research (D.L.A.), Montreal, and University of British Columbia, Vancouver (A.T.) - both in Canada; University Vita-Salute San Raffaele, Milan (G.C.); University Hospital of Strasbourg, Clinical Investigation Center (INSERM Unité 1434), Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France (J.S.); Barts and the London School of Medicine and Dentistry, London (G.G.); Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf (H.-P.H.), and Technical University of Munich and Munich Cluster for Systems Neurology, Munich (B.H.) - both in Germany; Icahn School of Medicine at Mount Sinai, New York (F.L.); University of Miami, Miami (K.W.R.); Medical University of Łódź, Łódź, Poland (K.S.); and McGovern Medical School, University of Texas Health Science Center at Houston, Houston (J.S.W.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1606468DOI Listing
January 2017

Mitochondrial cytopathy with common MELAS mutation presenting as multiple system atrophy mimic.

Neurol Genet 2016 Dec 17;2(6):e121. Epub 2016 Nov 17.

Neurologic Clinic and Policlinic (A.-K.P., P.F., L.K., M.S.), Departments of Medicine and Biomedicine; Division of Neuroradiology (J.L.), Department of Radiology; and Division of Neuropathology (J.H., S.F.), Department of Pathology, University Hospital Basel, University of Basel, Switzerland; Division of Human Genetics (A.S.), Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXG.0000000000000121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114693PMC
December 2016

Interdisciplinary Risk Management in the Treatment of Multiple Sclerosis.

Dtsch Arztebl Int 2016 Dec;113(51-52):879-886

Institute for Clinical Neuroimmunology, Biomedical Center and Hospital, Ludwig-Maximilians Universität München, Munich; Department of Neurology, Faculty of Medicine, Heinrich Heine University Düsseldorf; Department of Neurology, University Hospital Basel; Munich Cluster for Systems Neurology (SyNergy).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3238/arztebl.2016.0879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282476PMC
December 2016

The 11-year long-term follow-up study from the randomized BENEFIT CIS trial.

Neurology 2016 Sep 10;87(10):978-87. Epub 2016 Aug 10.

From Neurology (L.K.), Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, Switzerland; CHU-Hopital Pontchaillou (G.E.), Rennes, France; University of Ottawa (M.S.F.), and the Ottawa Hospital Research Institute, Ottawa, Canada; Hospital Universitari Vall d'Hebron (X.M.), Ps. Vall d'Hebron, Barcelona, Spain; Department of Neurology (H.-P.H., R.S.), Medical Faculty, Heinrich-Heine Universität, Düsseldorf; Technische Universität München (B.H.), Munich, Germany; Central Texas Neurology Consultants (E.J.F.), Round Rock, TX; VU University Medical Center (F.B.), Amsterdam, the Netherlands; Neuroimmunology and Multiple Sclerosis Research (S.S.), Department of Neurology, University Hospital Zurich and University of Zurich, Switzerland; Bayer Pharma AG (A.S., C.P., E.-M.W.), Berlin; Myelo Therapeutics GmbH (D.P.), Berlin; University Hospital of Bonn (C.P.), Germany; and Bayer HealthCare Pharmaceuticals (G.S.), Whippany, NJ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000003078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027814PMC
September 2016

Neurofilament light chain level is a weak risk factor for the development of MS.

Neurology 2016 Sep 12;87(11):1076-84. Epub 2016 Aug 12.

From Servei de Neurologia-Neuroimmunologia (G.A., C.E., H.E., J.S.-G., E.S., M.C., J.R., C.N., C.T., J.C., A.V.-J., I.G., M.J.A., X.M., M.T.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Barcelona; Universitat Autònoma de Barcelona (G.A., C.E., H.E., J.S.-G., E.S., M.C., J.R., C.N., C.T., J.C., A.V.-J., I.G., X.M., M.T.), Bellaterra; Departments of Neurology and Immunology (L.M.V., J.C.A.-C., C.P.), Multiple Sclerosis Unit, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Department of Neurology (J.K., L.K.), University Hospital Basel; Neurocentre of Southern Switzerland (G.D.), Ospedale Civico, Lugano, Switzerland; and Magnetic Resonance Unit (IDI) (D.P., C.A., A.R.), Hospital Universitari Vall d'Hebron, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000003085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027802PMC
September 2016

Assessing response to interferon-β in a multicenter dataset of patients with MS.

Neurology 2016 Jul 15;87(2):134-40. Epub 2016 Jun 15.

From the University of Genoa (M.P.S.); Hospital San Camillo Forlanini (C.G.) and Department of Neurology and Psychiatry (L.P., C.P.), Sapienza University, Rome; Department of Neurology (M.R., V.M., G.C.) and Neuroimaging Research Unit (M.A.R., M.F.), San Raffaele Scientific Institute, Milan, Italy; Hospital Universitario Vall d'Hebron (J.R., M. Tintorè, A.R., X.M.), Barcelona, Spain; University of Verona (M.C.); Department of Public Health, Clinical and Molecular Medicine (E.C.), and Department of Medical Sciences (M.G.M., E.C.), University of Cagliari, Italy; Department of Neurology (C.E., F.F.), Medical University of Graz, Austria; Dip. to di Scienze Mediche, Chirurgiche, Neurologiche, Metaboliche e dell'Invecchiamento (A.G., G.T.), Seconda Universita' di Napoli, MRI Research Center "SUN-FISM," Hermitage-Capodimonte Clinic, Naples, Italy; Neurology (L.K., T.S.), Departments of Medicine, Clinical Research, and Biomedical Engineering, University Hospital Basel, Switzerland; DKD Helios Klinik Wiesbaden (T.S.), Germany; University of Siena (M.L.S., N.D.S.); and Department of Medical Sciences, Neurosciences and Sense Organs (M. Trojano, C.T.), University of Bari, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000002830DOI Listing
July 2016