Publications by authors named "Ludovic Vallier"

125Publications

Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn's Disease.

Authors:
Rasa Elmentaite Alexander D B Ross Kenny Roberts Kylie R James Daniel Ortmann Tomás Gomes Komal Nayak Liz Tuck Sophie Pritchard Omer Ali Bayraktar Robert Heuschkel Ludovic Vallier Sarah A Teichmann Matthias Zilbauer

Dev Cell 2020 Dec 7;55(6):771-783.e5. Epub 2020 Dec 7.

Wellcome Trust, MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0SZ, UK; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals Trust, Cambridge CB2 0QQ, UK. Electronic address:

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December 2020

GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells.

Authors:
Loriana Vitillo Catherine Durance Zoe Hewitt Harry Moore Austin Smith Ludovic Vallier

Stem Cell Res Ther 2020 09 18;11(1):406. Epub 2020 Sep 18.

Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre; Department of Surgery, University of Cambridge, Cambridge, CB2 0AW, UK.

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September 2020

A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.

Authors:
Cara B Eldridge Finian J Allen Alastair Crisp Rodrigo A Grandy Ludovic Vallier Julian E Sale

Stem Cell Reports 2020 10 3;15(4):827-835. Epub 2020 Sep 3.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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October 2020

Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation.

Authors:
Daniel Ortmann Stephanie Brown Anne Czechanski Selcan Aydin Daniele Muraro Yuanhua Huang Rute A Tomaz Anna Osnato Giovanni Canu Brandon T Wesley Daniel A Skelly Oliver Stegle Ted Choi Gary A Churchill Christopher L Baker Peter J Rugg-Gunn Steven C Munger Laura G Reinholdt Ludovic Vallier

Cell Stem Cell 2020 Sep 13;27(3):470-481.e6. Epub 2020 Aug 13.

Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Surgery, University of Cambridge, Cambridge, UK. Electronic address:

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September 2020

Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation.

Authors:
Giovanni Canu Emmanouil Athanasiadis Rodrigo A Grandy Jose Garcia-Bernardo Paulina M Strzelecka Ludovic Vallier Daniel Ortmann Ana Cvejic

Genome Biol 2020 07 1;21(1):157. Epub 2020 Jul 1.

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.

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July 2020

A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei.

Authors:
Jaishree Tripathi Charis-Patricia Segeritz Gareth Griffiths Wendy Bushell Ludovic Vallier William C Skarnes Maria M Mota Oliver Billker

Stem Cell Reports 2020 06 21;14(6):1123-1134. Epub 2020 May 21.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK; Molecular Infection Medicine Sweden and Molecular Biology Department, Umeå University, 90187 Umeå, Sweden. Electronic address:

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June 2020

Publisher Correction: Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression.

Authors:
Anna S E Cuomo Daniel D Seaton Davis J McCarthy Iker Martinez Marc Jan Bonder Jose Garcia-Bernardo Shradha Amatya Pedro Madrigal Abigail Isaacson Florian Buettner Andrew Knights Kedar Nath Natarajan Ludovic Vallier John C Marioni Mariya Chhatriwala Oliver Stegle

Nat Commun 2020 Mar 23;11(1):1572. Epub 2020 Mar 23.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridge, UK.

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March 2020

Regional differences in human biliary tissues and corresponding in vitro derived organoids.

Authors:
Casey A Rimland Samantha G Tilson Carola M Morell Rute A Tomaz Wei-Yu Lu Simone E Adams Nikitas Georgakopoulos Francisco Otaizo-Carrasquero Timothy G Myers John R Ferdinand Richard L Gieseck Fotios Sampaziotis Olivia C Tysoe Brandon Wesley Daniele Muraro Gabriel C Oniscu Nicholas Rf Hannan Stuart J Forbes Kourosh Saeb-Parsy Thomas A Wynn Ludovic Vallier

Hepatology 2020 Mar 29. Epub 2020 Mar 29.

Wellcome-Medical Research Council , Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.

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March 2020

Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.

Authors:
Anthony P Coll Michael Chen Pranali Taskar Debra Rimmington Satish Patel John A Tadross Irene Cimino Ming Yang Paul Welsh Samuel Virtue Deborah A Goldspink Emily L Miedzybrodzka Adam R Konopka Raul Ruiz Esponda Jeffrey T-J Huang Y C Loraine Tung Sergio Rodriguez-Cuenca Rute A Tomaz Heather P Harding Audrey Melvin Giles S H Yeo David Preiss Antonio Vidal-Puig Ludovic Vallier K Sreekumaran Nair Nicholas J Wareham David Ron Fiona M Gribble Frank Reimann Naveed Sattar David B Savage Bernard B Allan Stephen O'Rahilly

Nature 2020 Feb;578(7796):E24

MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

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February 2020

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression.

Authors:
Anna S E Cuomo Daniel D Seaton Davis J McCarthy Iker Martinez Marc Jan Bonder Jose Garcia-Bernardo Shradha Amatya Pedro Madrigal Abigail Isaacson Florian Buettner Andrew Knights Kedar Nath Natarajan Ludovic Vallier John C Marioni Mariya Chhatriwala Oliver Stegle

Nat Commun 2020 02 10;11(1):810. Epub 2020 Feb 10.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, CB10 1SD Hinxton, Cambridge, UK.

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February 2020

GDF15 mediates the effects of metformin on body weight and energy balance.

Authors:
Anthony P Coll Michael Chen Pranali Taskar Debra Rimmington Satish Patel John A Tadross Irene Cimino Ming Yang Paul Welsh Samuel Virtue Deborah A Goldspink Emily L Miedzybrodzka Adam R Konopka Raul Ruiz Esponda Jeffrey T-J Huang Y C Loraine Tung Sergio Rodriguez-Cuenca Rute A Tomaz Heather P Harding Audrey Melvin Giles S H Yeo David Preiss Antonio Vidal-Puig Ludovic Vallier K Sreekumaran Nair Nicholas J Wareham David Ron Fiona M Gribble Frank Reimann Naveed Sattar David B Savage Bernard B Allan Stephen O'Rahilly

Nature 2020 02 25;578(7795):444-448. Epub 2019 Dec 25.

MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

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February 2020

Cell cycle regulators control mesoderm specification in human pluripotent stem cells.

Authors:
Loukia Yiangou Rodrigo A Grandy Anna Osnato Daniel Ortmann Sanjay Sinha Ludovic Vallier

J Biol Chem 2019 11 12;294(47):17903-17914. Epub 2019 Sep 12.

Wellcome-Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge CB2 0SZ, United Kingdom

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November 2019

Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells.

Authors:
Angélique Fourrier Frédéric Delbos Séverine Menoret Camille Collet Linh Trinh Thi Thuy Anne Myara François Petit Laia Tolosa Sophie Laplanche María José Gómez-Lechón Philippe Labrune Ignacio Anegon Ludovic Vallier Delphine Garnier Tuan Huy Nguyen

Xenotransplantation 2020 01 25;27(1):e12544. Epub 2019 Jul 25.

INSERM, UMRS 1064-Center for Research in Transplantation and Immunology, Nantes, France.

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January 2020

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells.

Authors:
Natasha Hui Jin Ng Joanita Binte Jasmen Chang Siang Lim Hwee Hui Lau Vidhya Gomathi Krishnan Juned Kadiwala Rohit N Kulkarni Helge Ræder Ludovic Vallier Shawn Hoon Adrian Kee Keong Teo

iScience 2019 Jun 27;16:192-205. Epub 2019 May 27.

Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Department of Biochemistry and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore. Electronic address:

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June 2019

Tissue-Engineering the Intestine: The Trials before the Trials.

Authors:
Hans Clevers Ryan K Conder Vivian S W Li Matthias P Lutolf Ludovic Vallier Sarah Chan Tracy C Grikscheit Kim B Jensen Paolo De Coppi

Cell Stem Cell 2019 06;24(6):855-859

Specialist Neonatal and Paediatric Surgery Unit, Great Ormond Street Hospital, London, UK; Stem Cells & Regenerative Medicine Section, NIHR Biomedical Research Center, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:

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June 2019

Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue.

Authors:
Olivia C Tysoe Alexander W Justin Teresa Brevini Si Emma Chen Krishnaa T Mahbubani Anna K Frank Hajer Zedira Espen Melum Kourosh Saeb-Parsy Athina E Markaki Ludovic Vallier Fotios Sampaziotis

Nat Protoc 2019 06 20;14(6):1884-1925. Epub 2019 May 20.

Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge, UK.

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June 2019

Use of Biliary Organoids in Cholestasis Research.

Authors:
Fotios Sampaziotis Olivia Tysoe Teresa Brevini Ludovic Vallier

Methods Mol Biol 2019 ;1981:373-382

Wellcome Trust and MRC Cambridge Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK.

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August 2019

Conditional Gene Knockout in Human Cells with Inducible CRISPR/Cas9.

Authors:
Kirsten E Snijders James D Cooper Ludovic Vallier Alessandro Bertero

Methods Mol Biol 2019 ;1961:185-209

Wellcome Trust-MRC Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.

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July 2019

A proteomic time course through the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.

Authors:
Tracey Hurrell Charis-Patricia Segeritz Ludovic Vallier Kathryn S Lilley Allan D Cromarty

Sci Rep 2019 03 1;9(1):3270. Epub 2019 Mar 1.

Department of Pharmacology, Faculty of Health Sciences, School of Medicine, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa.

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March 2019

Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity.

Authors:
Stephanie M Linker Lara Urban Stephen J Clark Mariya Chhatriwala Shradha Amatya Davis J McCarthy Ingo Ebersberger Ludovic Vallier Wolf Reik Oliver Stegle Marc Jan Bonder

Genome Biol 2019 02 11;20(1):30. Epub 2019 Feb 11.

European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK.

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February 2019