Publications by authors named "Ludovic Vallier"

125Publications

Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn's Disease.

Dev Cell 2020 Dec 7;55(6):771-783.e5. Epub 2020 Dec 7.

Wellcome Trust, MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0SZ, UK; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals Trust, Cambridge CB2 0QQ, UK. Electronic address:

View Article and Find Full Text PDF
December 2020

GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells.

Stem Cell Res Ther 2020 09 18;11(1):406. Epub 2020 Sep 18.

Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre; Department of Surgery, University of Cambridge, Cambridge, CB2 0AW, UK.

View Article and Find Full Text PDF
September 2020

A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.

Stem Cell Reports 2020 10 3;15(4):827-835. Epub 2020 Sep 3.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

View Article and Find Full Text PDF
October 2020

Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation.

Cell Stem Cell 2020 Sep 13;27(3):470-481.e6. Epub 2020 Aug 13.

Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Surgery, University of Cambridge, Cambridge, UK. Electronic address:

View Article and Find Full Text PDF
September 2020

A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei.

Stem Cell Reports 2020 06 21;14(6):1123-1134. Epub 2020 May 21.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK; Molecular Infection Medicine Sweden and Molecular Biology Department, Umeå University, 90187 Umeå, Sweden. Electronic address:

View Article and Find Full Text PDF
June 2020

Cell cycle regulators control mesoderm specification in human pluripotent stem cells.

J Biol Chem 2019 11 12;294(47):17903-17914. Epub 2019 Sep 12.

Wellcome-Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge CB2 0SZ, United Kingdom

View Article and Find Full Text PDF
November 2019

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells.

iScience 2019 Jun 27;16:192-205. Epub 2019 May 27.

Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Department of Biochemistry and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore. Electronic address:

View Article and Find Full Text PDF
June 2019

Tissue-Engineering the Intestine: The Trials before the Trials.

Cell Stem Cell 2019 06;24(6):855-859

Specialist Neonatal and Paediatric Surgery Unit, Great Ormond Street Hospital, London, UK; Stem Cells & Regenerative Medicine Section, NIHR Biomedical Research Center, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:

View Article and Find Full Text PDF
June 2019

Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue.

Nat Protoc 2019 06 20;14(6):1884-1925. Epub 2019 May 20.

Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge, UK.

View Article and Find Full Text PDF
June 2019

Use of Biliary Organoids in Cholestasis Research.

Methods Mol Biol 2019 ;1981:373-382

Wellcome Trust and MRC Cambridge Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK.

View Article and Find Full Text PDF
August 2019

Conditional Gene Knockout in Human Cells with Inducible CRISPR/Cas9.

Methods Mol Biol 2019 ;1961:185-209

Wellcome Trust-MRC Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.

View Article and Find Full Text PDF
July 2019

A proteomic time course through the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.

Sci Rep 2019 03 1;9(1):3270. Epub 2019 Mar 1.

Department of Pharmacology, Faculty of Health Sciences, School of Medicine, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa.

View Article and Find Full Text PDF
March 2019