Publications by authors named "Ludovic Lhermitte"

53Publications

Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype.

Leukemia 2020 Jun 17. Epub 2020 Jun 17.

Service d'Hématologie Adultes, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, 149-161 rue de Sèvres, 75015, Paris, France.

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http://dx.doi.org/10.1038/s41375-020-0900-3DOI Listing
June 2020

CBFβ-SMMHC Affects Genome-wide Polycomb Repressive Complex 1 Activity in Acute Myeloid Leukemia.

Cell Rep 2020 01;30(2):299-307.e3

Université Paris Descartes Sorbonne Cité, Institut Necker Enfants Malades (INEM), Institut National de Recherche Médicale (INSERM) U1151, Paris, France; Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland; National Children's Research Centre, Children's Health Ireland at Crumlin, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.12.026DOI Listing
January 2020

How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?

Authors:
Francine Garnache-Ottou Chrystelle Vidal Sabeha Biichlé Florian Renosi Eve Poret Maïder Pagadoy Maxime Desmarets Anne Roggy Estelle Seilles Lou Soret Françoise Schillinger Sandrine Puyraimond Tony Petrella Claude Preudhomme Christophe Roumier Elisabeth A MacIntyre Véronique Harrivel Yohan Desbrosses Bérengère Gruson Franck Geneviève Sylvain Thepot Yuriy Drebit Thibaut Leguay François-Xavier Gros Nicolas Lechevalier Pascale Saussoy Véronique Salaun Edouard Cornet Zehaira Benseddik Richard Veyrat-Masson Orianne Wagner-Ballon Célia Salanoubat Marc Maynadié Julien Guy Denis Caillot Marie-Christine Jacob Jean-Yves Cahn Rémy Gressin Johann Rose Bruno Quesnel Estelle Guerin Franck Trimoreau Jean Feuillard Marie-Pierre Gourin Adriana Plesa Lucile Baseggio Isabelle Arnoux Norbert Vey Didier Blaise Romaric Lacroix Christine Arnoulet Blandine Benet Véronique Dorvaux Caroline Bret Bernard Drenou Agathe Debliquis Véronique Latger-Cannard Caroline Bonmati Marie-Christine Bene Pierre Peterlin Michel Ticchioni Pierre-Simon Rohrlich Anne Arnaud Stefan Wickenhauser Valérie Bardet Sabine Brechignac Benjamin Papoular Victoria Raggueneau Jacques Vargaftig Rémi Letestu Daniel Lusina Thorsten Braun Vincent Foissaud Jérôme Tamburini Hind Bennani Nicolas Freynet Catherine Cordonnier Magali Le Garff-Tavernier Nathalie Jacques Karim Maloum Damien Roos-Weil Didier Bouscary Vahid Asnafi Ludovic Lhermitte Felipe Suarez Etienne Lengline Frédéric Féger Giorgia Battipaglia Mohamad Mohty Sabrina Bouyer Ouda Ghoual Elodie Dindinaud Caroline Basle Mathieu Puyade Carinne Lafon Thierry Fest Mikael Roussel Xavier Cahu Elsa Bera Sylvie Daliphard Fabrice Jardin Lydia Campos Françoise Solly Denis Guyotat Anne-Cécile Galoisy Alice Eischen Caroline Mayeur-Rousse Blandine Guffroy Christian Recher Marie Loosveld Alice Garnier Vincent Barlogis Maria Alessandra Rosenthal Sophie Brun Nathalie Contentin Sébastien Maury Mary Callanan Christine Lefebvre Natacha Maillard Patricia Okamba Christophe Ferrand Olivier Adotevi Philippe Saas Fanny Angelot-Delettre Delphine Binda Eric Deconinck

Blood Adv 2019 12;3(24):4238-4251

University of Bourgogne Franche-Comté, INSERM, Établissement Français du Sang Bourgogne/Franche-Comté, Unite Mixte de Recherche (UMR) 1098, RIGHT (Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et Génique), Besançon, France.

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http://dx.doi.org/10.1182/bloodadvances.2019000647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929390PMC
December 2019

[Biological diagnosis of mature B cell malignancies].

Presse Med 2019 Jul - Aug;48(7-8 Pt 1):816-824. Epub 2019 Aug 19.

Laboratoire d'onco-hématologie, hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.lpm.2019.07.021DOI Listing
September 2019

Clinical and biological features of PTPN2-deleted adult and pediatric T-cell acute lymphoblastic leukemia.

Blood Adv 2019 07;3(13):1981-1988

Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades, Institut National de Recherche Médicale U1151, Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Paris, France.

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https://ashpublications.org/bloodadvances/article/3/13/1981/
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http://dx.doi.org/10.1182/bloodadvances.2018028993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616254PMC
July 2019

Omalizumab Therapy for Mast Cell-Mediator Symptoms in Patients with ISM, CM, MMAS, and MCAS.

J Allergy Clin Immunol Pract 2019 Sep - Oct;7(7):2387-2395.e3. Epub 2019 Apr 5.

Imagine Institute, INSERM U1163 and CNRS ERL 8654, Paris Descartes University, Sorbonne Paris Cité, Paris, France; Department of Hematology, Necker Children's Hospital, APHP, Paris, France; French Reference Center for Mastocytosis (CEREMAST), Necker Children's Hospital, APHP, Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S22132198193032
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http://dx.doi.org/10.1016/j.jaip.2019.03.039DOI Listing
October 2020

A Single-Tube, EuroClonality-Inspired, TRG Clonality Multiplex PCR Aids Management of Patients with Enteropathic Diseases, including from Formaldehyde-Fixed, Paraffin-Embedded Tissues.

J Mol Diagn 2019 01 28;21(1):111-122. Epub 2018 Sep 28.

Hematology Laboratory, Necker-Enfants Malades Hosptial and Paris Descartes, Sorbonne Paris Cité University, Paris, France; Hematology Laboratory, Hôpital Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris, Paris, France; INSERM UMR1151 and Institut Necker-Enfants Malades, Paris, France; Centre national Expert des Lymphomes Associés à la maladie Coeliaque, Hôpital Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2018.08.006DOI Listing
January 2019

A "foamy" mastocytosis case.

Blood 2018 02;131(5):586

Université Paris Descartes-Sorbonne Paris Cité.

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http://dx.doi.org/10.1182/blood-2017-08-803726DOI Listing
February 2018

Early Response-Based Therapy Stratification Improves Survival in Adult Early Thymic Precursor Acute Lymphoblastic Leukemia: A Group for Research on Adult Acute Lymphoblastic Leukemia Study.

J Clin Oncol 2017 Aug 12;35(23):2683-2691. Epub 2017 Jun 12.

Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amélie Trinquand, Elizabeth Macintyre, and Vahid Asnafi, Hôpital Necker-Enfants Malades; Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amélie Trinquand, Elizabeth Macintyre, and Vahid Asnafi, Institut National de la santé et de la recherche médicale (INSERM) U1151; Hervé Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore Spicuglia, Aix-Marseille University, Marseille; Véronique Lheritier, Centre Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stéphane Leprêtre, Centre Henri Becquerel and Université de Rouen Normandie, Rouen; Françoise Huguet, CHU de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos Graux, Godinne University Hospital, Yvoir, Belgium.

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http://dx.doi.org/10.1200/JCO.2016.71.8585DOI Listing
August 2017

Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placebo-controlled, phase 3 study.

Lancet 2017 02 7;389(10069):612-620. Epub 2017 Jan 7.

Department of Hematology, Université Paris Descartes, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France; Institut Imagine INSERM U1163 and CNRS ERL8654, Université Paris Descartes, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France; AB Science, Paris, France. Electronic address:

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://dx.doi.org/10.1016/S0140-6736(16)31403-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985971PMC
February 2017

Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia.

Cancer Discov 2016 09 28;6(9):972-85. Epub 2016 Jun 28.

Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0675DOI Listing
September 2016

An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.

Haematologica 2016 06 4;101(6):732-40. Epub 2016 Mar 4.

Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut National de Recherche Médicale (INSERM) U1151, and Laboratory of OncoHematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker EnfantsMalades, Paris

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http://dx.doi.org/10.3324/haematol.2015.141218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013941PMC
June 2016

Targeting IRAK1 in T-cell acute lymphoblastic leukemia.

Oncotarget 2015 Aug;6(22):18956-65

Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut National de Recherche Médicale (INSERM) U1151 and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662467PMC
http://dx.doi.org/10.18632/oncotarget.4150DOI Listing
August 2015

Long-term efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis.

Blood 2015 Aug 22;126(8):1009-16; quiz 1050. Epub 2015 May 22.

Centre de Référence des Mastocytoses, Hôpital Necker Enfants Malades, Paris V, IFR Necker, Paris, France; Service d'Hématologie, Faculté de Médecine Paris V, Université Sorbonne Paris-Cité et Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France; Institut Imagine, Université Sorbonne Paris-Cité et Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France; and Laboratoire "Cellular and Molecular Basis of Hematological Disorders and Therapeutic Implications," INSERM U1163, CNRS ERL 8254, Paris, France.

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http://www.bloodjournal.org/content/early/2015/05/21/blood-2
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http://www.bloodjournal.org/content/bloodjournal/126/8/1009.
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-12-61
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http://dx.doi.org/10.1182/blood-2014-12-614743DOI Listing
August 2015

Isolated flushes without permanent, fixed or other skin lesions in patients with systemic mastocytosis: a case series of 9 patients.

Eur J Dermatol 2015 Apr;25(2):182-4

Centre de Référence des Mastocytoses, AP-HP Necker-Enfants Malades, 156 Rue de Vaugirard, 75743 Paris, France, CNRS UMR 8147, Hôpital Necker-Enfants malades, Paris, France, Service de Médecine interne, Hôpital Tenon, Paris, France.

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http://dx.doi.org/10.1684/ejd.2014.2484DOI Listing
April 2015

RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement.

J Exp Med 2014 Aug 18;211(9):1821-32. Epub 2014 Aug 18.

Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, 75015 Paris, France

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http://dx.doi.org/10.1084/jem.20132585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144731PMC
August 2014

Peripheral blood 8 colour flow cytometry monitoring of hairy cell leukaemia allows detection of high-risk patients.

Br J Haematol 2014 Jul 25;166(1):50-9. Epub 2014 Mar 25.

Laboratoire d'Hématologie and CNRS UMR8147, Hôpital Necker - Enfants Malades, Université Paris Descartes, 149 rue de Sèvres, 75743, Paris Cedex 15, France; INSERM UMR1098, Université de Franche-Comté, EFS-B/FC Plateforme de BioMonitoring, 1 Bd Fleming, 25000, Besançon, France.

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http://dx.doi.org/10.1111/bjh.12839DOI Listing
July 2014

ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases.

PLoS One 2014 21;9(1):e85362. Epub 2014 Jan 21.

Centre de Référence des Mastocytoses, Faculté de Médecine et AP-HP Necker-Enfants Malades, Paris, France ; CNRS UMR 8147 and Institut Imagine, AP-HP, Hôpital Necker-Enfants Malades, Paris, France ; Service d'Hématologie Adulte, Université Paris Descartes, Paris Sorbonne Cité, Faculté de Médecine et AP-HP Necker-Enfants Malades, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085362PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897447PMC
October 2014

Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.

J Clin Oncol 2013 Dec 28;31(34):4333-42. Epub 2013 Oct 28.

Amélie Trinquand, Raouf Ben Abdelali, Etienne Lengliné, Noémie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agnès Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR)-8147, and Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades; Jérôme Lambert, UMR-S-717, Hôpital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lengliné, and Hervé Dombret, University Paris 7, Hôpital Saint-Louis, AP-HP, and Institut Universitaire d'Hématologie, EA3518, Paris; Aline Tanguy-Schmidt and Norbert Ifrah, Pôle de Recherche et d'Enseignement Supérieur L'Université Nantes Angers Le Mans, Centre Hospitalier Universitaire Angers Service des Maladies du Sang et L'Institut National de la Santé et de la Recherche Médicale (INSERM) U892, Angers; Dominique Payet-Bornet and Bertrand Nadel, Center of Immunology of Marseille Luminy, Aix-Marseille University, INSERM U1104 and Centre National de la Recherche Scientifique (CNRS) UMR-7280, Marseille; Hossein Mossafa, Laboratoire Cerba, Cergy-Pontoise; Véronique Lhéritier and Xavier Thomas, Centre Hospitalier Lyon Sud, Lyon; Françoise Huguet, Hôpital Purpan, Toulouse; Thibaud Leguay, Centre Hospitalier du Haut Lévêque, Pessac; Jean-Yves Cahn, UMR-5525 CNRS-Université Joseph Fourier, Grenoble; Caroline Bonmati, Centre Hospitalier Régional Hôpital de Brabois, Vandoeuvre Les Nancy; Sebastien Maury, Hôpital Henry Mondor, Creteil, France; Yves Chalandon, University Hospital of Geneva, Geneva, Switzerland; and André Delannoy, Hopital de Jolimont, La Louviere, Belgium.

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http://dx.doi.org/10.1200/JCO.2012.48.5292DOI Listing
December 2013

[Utility of 8-colours multiparameter flow cytometry immunophenotyping of plasma cells for the management of monoclonal gammopathy].

Ann Biol Clin (Paris) 2013 May-Jun;71(3):313-23

Laboratoire d'hématologie, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris AP-HP, Paris, France.

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http://dx.doi.org/10.1684/abc.2013.0813DOI Listing
February 2014

Mast cell leukemia.

Blood 2013 Feb 14;121(8):1285-95. Epub 2012 Dec 14.

Centre de Référence des Mastocytoses, Faculté de Médecine et Assistance Publique-Hopitaux de Paris (AP-HP) Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1182/blood-2012-07-442400DOI Listing
February 2013

Relocalization of KIT D816V to cell surface after dasatinib treatment: potential clinical implications.

Clin Lymphoma Myeloma Leuk 2013 Feb 3;13(1):62-9. Epub 2012 Nov 3.

CNRS UMR 8113, Laboratoire de Biologie et Pharmacologie Appliquée, École Normale Supérieure de Cachan, Cachan, France.

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http://dx.doi.org/10.1016/j.clml.2012.08.004DOI Listing
February 2013

Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive.

Case Rep Hematol 2012 10;2012:517546. Epub 2012 Sep 10.

Service d'Hématologie, Centre Hospitalier Universitaire, Avenue Laennec, 80054 Amiens, France.

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http://dx.doi.org/10.1155/2012/517546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444844PMC
September 2012

Blood CD34-c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor.

Blood 2011 Nov 30;118(19):5246-9. Epub 2011 Aug 30.

Service d'Hématologie Adultes et Centre de Référence sur les Mastocytoses, Hôpital Necker-Enfants Malades, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris, France.

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http://dx.doi.org/10.1182/blood-2011-02-335950DOI Listing
November 2011

TGF-beta induces degradation of TAL1/SCL by the ubiquitin-proteasome pathway through AKT-mediated phosphorylation.

Blood 2009 Jun 30;113(26):6695-8. Epub 2009 Apr 30.

Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, Institut Fédératif de Recherche 128 Biosciences Lyon Gerland, Lyon, France.

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http://dx.doi.org/10.1182/blood-2008-07-166835DOI Listing
June 2009

Serum proteomic profiling of lung cancer in high-risk groups and determination of clinical outcomes.

J Thorac Oncol 2008 Aug;3(8):840-50

Department of Thoracic Oncology, CHU Montpellier, Hôpital Arnaud de Villeneuve, Montpellier, France.

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http://dx.doi.org/10.1097/JTO.0b013e31817e464aDOI Listing
August 2008

Comparison of supervised classification methods for protein profiling in cancer diagnosis.

Cancer Inform 2007 Jul 19;3:295-305. Epub 2007 Jul 19.

IURC, Department of Biostatistic, Epidemiology and Clinical Research, Montpellier, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675844PMC
July 2007

Clinical proteomics and mass spectrometry profiling for cancer detection.

Expert Rev Proteomics 2006 Jun;3(3):311-20

Hôpital Arnaud de Villeneuve, Laboratoire de Biologie Cellulaire- INSERM U540, 371 Avenue du Doyen Giraud, 34295 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1586/14789450.3.3.311DOI Listing
June 2006