Ludovic Lacroix

Ludovic Lacroix

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Ludovic Lacroix

Ludovic Lacroix

Publications by authors named "Ludovic Lacroix"

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Image-guided tumour biopsies in a prospective molecular triage study (MOSCATO-01): What are the real risks?

Eur J Cancer 2018 11 14;103:108-119. Epub 2018 Sep 14.

Department of Interventional Radiology, Gustave Roussy, Villejuif, France; Faculté de Médecine, Kremlin-Bicêtre, Université Paris Sud, France; Laboratory of Translational Research in Immunology - LRTI, INSERM U1015, Gustave Roussy, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.08.003DOI Listing
November 2018

Does smoking alter the mutation profile of human papillomavirus-driven head and neck cancers?

Eur J Cancer 2018 05 20;94:61-69. Epub 2018 Mar 20.

Department of Head and Neck Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, F-94805, France.

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http://dx.doi.org/10.1016/j.ejca.2018.02.013DOI Listing
May 2018

Human epidermal receptor family inhibitors in patients with ERBB3 mutated cancers: Entering the back door.

Eur J Cancer 2018 03 3;92:1-10. Epub 2018 Feb 3.

Drug Development Department, Gustave Roussy, Department of Medical Oncology, Faculté de Medicine Paris-Sud XI, Kremlin-Bicêtre, France; Gustave Roussy Department of Medical Oncology, Faculté de Medicine Paris-Sud XI, Kremlin-Bicêtre, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.12.020DOI Listing
March 2018

LKB1/STK11 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value.

Lung Cancer 2017 10 7;112:62-68. Epub 2017 Aug 7.

Medical Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France; University Paris-Sud Kremlin Bicetre/Chatenay-Malabry, Le Kremlin-Bicêtre, France. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.08.002DOI Listing
October 2017

Radiation exposure and thyroid cancer: a review.

Arch Endocrinol Metab 2017 Mar-Apr;61(2):180-187. Epub 2017 Feb 16.

Institut Gustave Roussy, Université Paris-Sud, Villejuif, France.

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http://dx.doi.org/10.1590/2359-3997000000257DOI Listing
September 2017

RECIST response and variation of circulating tumour cells in phase 1 trials: A prospective multicentric study.

Eur J Cancer 2017 09 22;83:185-193. Epub 2017 Jul 22.

Drug Development Department (DITEP), Gustave Roussy, 94805, Villejuif, France; Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Orsay, 91405, France.

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http://dx.doi.org/10.1016/j.ejca.2017.05.016DOI Listing
September 2017

EGFR and KRAS molecular genotyping for pulmonary carcinomas: Feasibility of a simple and rapid technique implementable in any department of pathology.

Pathol Res Pract 2017 Jul 30;213(7):793-798. Epub 2017 Mar 30.

Department of Medical Oncology, Gustave Roussy University Hospital, 114 rue Edouard Vaillant, 94805, Villejuif, France; Department of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, 133 Avenue de la Résistance, 92350, Le Plessis Robinson, France.

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http://dx.doi.org/10.1016/j.prp.2017.03.011DOI Listing
July 2017

The cost of molecular-guided therapy in oncology: a prospective cost study alongside the MOSCATO trial.

Genet Med 2017 06 1;19(6):683-690. Epub 2016 Dec 1.

Gustave Roussy, Service de Biostatistique et d'Epidémiologie, Villejuif, France.

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http://dx.doi.org/10.1038/gim.2016.174DOI Listing
June 2017

Concordance between HER-2 status determined by qPCR in Fine Needle Aspiration Cytology (FNAC) samples compared with IHC and FISH in Core Needle Biopsy (CNB) or surgical specimens in breast cancer patients.

Mol Oncol 2016 11 5;10(9):1430-1436. Epub 2016 Aug 5.

Departement de Biologie et Pathologie Médicales, Gustave Roussy Cancer Campus, Villejuif, France; Laboratoire de Recherche Translationnelle et Centre de Ressources Biologiques, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy Cancer Campus, France. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2016.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423214PMC
November 2016

Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma.

J Neuropathol Exp Neurol 2016 Oct 18;75(10):971-980. Epub 2016 Aug 18.

From the Department of Neurosurgery(MZ, ED, BD, JP), Department of Neuropathology, Sainte-Anne Hospital, Paris, France(MP, AT-E, FC, FA, PV), Department of Biochemistry, Paul Brousse Hospital, Paris, France(RS) Department of Pediatric Neurosurgery, Necker Enfants Malades Hospital, Paris, France(SP, CS-R, MZ), Paris Descartes University, Paris, France(MZ, MP, AT-E, SP, ED, BD, FC, FA, CS-R, MZ, J-FM, JP, PV), Department of Medical Biology and Pathology(LL), Department of Neurooncology, Gustave Roussy Institute, Villejuif, France(FD, SD, GL), Department of Neuroradiology, Sainte-Anne Hospital, Paris, France(J-FM) and Department of Pediatric Oncology, Gustave Roussy Institute, Villejuif, France(JG, CD).

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http://dx.doi.org/10.1093/jnen/nlw074DOI Listing
October 2016

Emerging circulating biomarkers in glioblastoma: promises and challenges.

Expert Rev Mol Diagn 2015 ;15(10):1311-23

c 3 AP-HP, Hôpital Universitaire la Pitié Salpêtrière, Service de Neurologie 2-Mazarin, F-75013, Paris, France.

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http://dx.doi.org/10.1586/14737159.2015.1087315DOI Listing
June 2016

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial.

Clin Cancer Res 2016 06 12;22(12):2960-8. Epub 2016 Jan 12.

Laboratoire de Recherche Translationnelle et Centre de RessourcesBiologiques, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy, Villejuif, France. INSERM U981, Gustave Roussy, Villejuif, France. Département de Biologie et Pathologie Médicales, Gustave Roussy, Villejuif, France. Faculté de Pharmacie, Université Paris Sud, Châtenay-Malabry, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2470DOI Listing
June 2016

A never-smoker lung adenocarcinoma patient with a MET exon 14 mutation (D1028N) and a rapid partial response after crizotinib.

Invest New Drugs 2016 06 18;34(3):397-8. Epub 2016 Feb 18.

Drug development Department (DITEP), Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif, France.

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http://link.springer.com/content/pdf/10.1007%2Fs10637-016-03
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http://link.springer.com/10.1007/s10637-016-0332-0
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http://dx.doi.org/10.1007/s10637-016-0332-0DOI Listing
June 2016

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC.

Oncoimmunology 2016 Apr 12;5(4):e1071008. Epub 2015 Aug 12.

Gustave Roussy Cancer Campus, Villejuif, France; Laboratoire d'Immunomonitoring en Oncologie, UMS 3655 CNRS / US 23 INSERM Gustave Roussy Cancer Campus, Villejuif, France; Centre d'Investigation Clinique en Biothérapies (CICBT) 1428, Villejuif, France; Laboratoire de Thérapie Cellulaire, Gustave Roussy Cancer Campus, Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2015.1071008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839329PMC
April 2016

Secondary Tumors Arising in Patients Undergoing BRAF Inhibitor Therapy Exhibit Increased BRAF-CRAF Heterodimerization.

Cancer Res 2016 Mar 29;76(6):1476-84. Epub 2016 Jan 29.

Département de médecine oncologique, Gustave Roussy, Villejuif, France. INSERM, U981, Villejuif, France. Faculté de Médecine, Université Paris-Sud, Le Kremlin Bicetre, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2900-TDOI Listing
March 2016

Acquired EGFR Mutation as the Potential Resistance Driver to Crizotinib in a MET-Mutated Tumor.

J Thorac Oncol 2016 Feb 18;11(2):e21-3. Epub 2015 Dec 18.

DITEP (Département d'Innovations Thérapeutiques et Essais Précoces), Gustave Roussy Cancer Campus, Villejuif, France; Faculté de médicine Paris-Sud XI, Kremlin-Bicêtre, France; U981 INSERM, Gustave Roussy Cancer Campus, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2015.08.001DOI Listing
February 2016

First Reported Case of Unexpected Response to an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in the I744M Uncommon EGFR Mutation.

Clin Lung Cancer 2015 Nov 24;16(6):e259-61. Epub 2015 Jun 24.

Gustave Roussy Cancer Campus, Drug Development Department and University Paris-Sud, Villejuif, France.

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https://linkinghub.elsevier.com/retrieve/pii/S15257304150016
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http://dx.doi.org/10.1016/j.cllc.2015.06.002DOI Listing
November 2015

¹⁸Fluorocholine PET/CT in parathyroid carcinoma: a new tool for disease staging?

Eur J Nucl Med Mol Imaging 2015 Nov 9;42(12):1941-2. Epub 2015 Aug 9.

Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif, France.

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http://dx.doi.org/10.1007/s00259-015-3130-6DOI Listing
November 2015

Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma.

Neuro Oncol 2015 Jul 21;17(7):953-64. Epub 2014 Dec 21.

CNRS UMR 8203 Vectorology and Anticancer Therapeutics, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (N.T., C.P., F.A., L.G.-R., G.C., L.L.-D., B.G., G.V., J.G.); Functional Genomics Unit, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (C.R.); Translational Research Laboratory and Biobank, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (L.L.); Inserm U981, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (L.L.); Department of Medical Biology and Pathology, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (L.L.); Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (B.G., J.G.); Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden (J.P., A.Ö.); Department of Neurosurgery, Necker-Sick Children Hospital, Paris Descartes University, Paris, France (S.P.).

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http://dx.doi.org/10.1093/neuonc/nou330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654348PMC
July 2015

HPV-related oropharyngeal squamous cell carcinomas: a comparison between three diagnostic approaches.

Am J Otolaryngol 2014 Jan-Feb;35(1):25-32. Epub 2013 Oct 7.

Department of Otolaryngology - Head and Neck Surgery, Institut Gustave Roussy, 114 rue Edouard Vaillant, Villejuif, France.

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http://dx.doi.org/10.1016/j.amjoto.2013.08.007DOI Listing
August 2014

Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas.

Pediatr Blood Cancer 2014 Jun 3;61(6):1101-3. Epub 2013 Dec 3.

Pediatric and Adolescent Oncology Department, Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1002/pbc.24891DOI Listing
June 2014

Vemurafenib cooperates with HPV to promote initiation of cutaneous tumors.

Cancer Res 2014 Apr 12;74(8):2238-45. Epub 2014 Feb 12.

Authors' Affiliations: Novartis Institutes for Biomedical Research, Emeryville; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California; Dermatology Unit and INSERM U 981; Department of Medical Biology and Pathology; Laboratory and Biobank; INSERM U 981, Institut Gustave Roussy, Villejuif Paris-Sud; and Unité de Génétique, Papillomavirus et Cancer Humain, Institut Pasteur, Paris, France.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-13-1065-TDOI Listing
April 2014

Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas.

Head Neck 2014 Feb 1;36(2):257-65. Epub 2013 Jun 1.

Department of Otolaryngology - Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1002/hed.23302DOI Listing
February 2014

Genomes in the clinic: the Gustave Roussy Cancer Center experience.

Curr Opin Genet Dev 2014 Feb 26;24:99-106. Epub 2014 Feb 26.

Gustave Roussy, Inserm U981, Villejuif F-94805, France; Gustave Roussy, Drug Development Department, Villejuif F-94805, France.

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http://dx.doi.org/10.1016/j.gde.2013.11.013DOI Listing
February 2014

Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array.

Thyroid 2014 Jan 24;24(1):43-51. Epub 2013 Dec 24.

1 Genetic Stability and Oncogenesis Research Unit, National Center for Scientific Research (CNRS UMR 8200), Gustave Roussy and University of Paris-Sud , Villejuif, France .

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http://dx.doi.org/10.1089/thy.2013.0514DOI Listing
January 2014

Small-cell carcinoma in the setting of pulmonary adenocarcinoma: new insights in the era of molecular pathology.

J Thorac Oncol 2013 Oct;8(10):1265-71

*Department of Pathology, Institut d'Oncologie Thoracique, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France; †Department of Medical Biology and Pathology; ‡Department of Oncology, Institut d'Oncologie Thoracique, Institut Gustave Roussy, Villejuif, France; and §Department of Thoracic and Vascular Surgery, Institut d'Oncologie Thoracique, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.

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http://dx.doi.org/10.1097/JTO.0b013e3182a407faDOI Listing
October 2013

Thymic carcinomas: clinicopathologic study of 37 cases from a single institution.

Virchows Arch 2013 Mar 15;462(3):307-13. Epub 2013 Jan 15.

Department of Pathology, Centre Chirurgical Marie Lannelongue, 133 avenue de la Résistance, Le Plessis Robinson, 92350 Paris, France.

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http://dx.doi.org/10.1007/s00428-013-1371-yDOI Listing
March 2013

Molecular guided therapy for advanced pancreatic cancer patients with PI3K activated mutation: vision or illusion?

Onco Targets Ther 2013 20;6:95-7. Epub 2013 Feb 20.

SITEP (Service des Innovations Therapeutiques Précoces), Department of Medicine, Institut Gustave Roussy, Paris XI University, Villejuif, France.

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http://dx.doi.org/10.2147/OTT.S38520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581357PMC
March 2013

[Chromosomal rearrangements and fusion genes in carcinoma].

Bull Cancer 2011 Dec;98(12):1395-401

Institut Gustave-Roussy, département de médecine, Villejuif, France.

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http://dx.doi.org/10.1684/bdc.2011.1498DOI Listing
December 2011

Atypical teratoid rhabdoid tumor mimicking beta-catenin-positive nodular medulloblastoma.

Acta Neuropathol 2011 Mar 13;121(3):429-30. Epub 2011 Jan 13.

Department of Neuropathology, Sainte-Anne Hospital, 1 Rue Cabanis, Paris, France.

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http://dx.doi.org/10.1007/s00401-010-0796-5DOI Listing
March 2011

Implications of personalized medicine--perspective from a cancer center.

Nat Rev Clin Oncol 2011 03;8(3):177-83

Department of Medical Oncology and INSERM U981, Institut Gustave Roussy, 39 Rue Camilles Desmoulins, Villejuif 94805, France.

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http://www.nature.com/articles/nrclinonc.2010.222
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http://dx.doi.org/10.1038/nrclinonc.2010.222DOI Listing
March 2011

Aggressive inherited and sporadic medullary thyroid carcinomas display similar oncogenic pathways.

Endocr Relat Cancer 2009 Dec 12;16(4):1261-72. Epub 2009 Aug 12.

CNRS FRE 2939, Institut de Cancérologie Gustave-Roussy, Villejuif, France.

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http://dx.doi.org/10.1677/ERC-08-0289DOI Listing
December 2009

Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system.

Cancer Prev Res (Phila) 2009 Aug 28;2(8):702-11. Epub 2009 Jul 28.

Departments of Thoracic/Head and Neck MedicalOncology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382104PMC
August 2009

Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction.

Cancer Biol Ther 2009 May 17;8(9):801-7. Epub 2009 May 17.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.4161/cbt.8.9.8186DOI Listing
May 2009

Exonic expression profiling of breast cancer and benign lesions: a retrospective analysis.

Lancet Oncol 2009 Apr 25;10(4):381-90. Epub 2009 Feb 25.

Breast Cancer Unit, Department of Medical Oncology, Institut Gustave Roussy France, Villejuif, France.

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http://dx.doi.org/10.1016/S1470-2045(09)70024-5DOI Listing
April 2009

Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas.

J Clin Oncol 2009 Apr 16;27(11):1884-92. Epub 2009 Mar 16.

Department of Neurosurgery, Peter B Dirks, Christian Sainte-Rose, and Gilles Vassal Hôpital Necker Enfants Malades, Université Paris Descartes, France.

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http://dx.doi.org/10.1200/JCO.2007.15.4195DOI Listing
April 2009

Fine-needle aspiration for nucleic acid-ased molecular analyses in breast cancer.

Cancer 2009 Feb;117(1):32-9

Research Translational Laboratory, Histocytopathology Unit, Gustave Roussy Institute, 39 rue Camille Desmoulins, Villejuif, France.

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http://dx.doi.org/10.1002/cncy.20008DOI Listing
February 2009

EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts.

Int J Cancer 2008 Jul;123(1):209-16

Université Paris XI-IFR54, UPRES EA 3535 Pharmacology and New Treatment in Cancers, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1002/ijc.23488DOI Listing
July 2008

Gene expression profiling of non-small-cell lung cancer.

Expert Rev Mol Diagn 2008 Mar;8(2):167-78

Institut de Cancérologie Gustave Roussy, Translational Research Laboratory, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1586/14737159.8.2.167DOI Listing
March 2008

Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene.

J Natl Cancer Inst 2007 Nov 13;99(22):1668-82. Epub 2007 Nov 13.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://jnci.oxfordjournals.org/content/99/22/1668.full.pdf
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/djm208
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http://dx.doi.org/10.1093/jnci/djm208DOI Listing
November 2007

[Clinical and molecular predictors of response to EGFR tyrosine kinase inhibitors in non-small cell lung cancer].

Ann Pathol 2007 Oct;27(5):353-63

Institut Gustave Roussy, Département de biologie et pathologie médicales, 94805 Villejuif.

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http://dx.doi.org/10.1016/s0242-6498(07)78274-3DOI Listing
October 2007