Publications by authors named "Ludmilla Fitri Untari"

2 Publications

  • Page 1 of 1

Anti-cancer Evaluation of Depsides Isolated from Indonesian Folious Lichens: , and .

Biomolecules 2020 10 8;10(10). Epub 2020 Oct 8.

School of Chemistry & Molecular Bioscience and Molecular Horizons, University of Wollongong, and Illawarra Health & Medical Research Institute, Wollongong, NSW 2522, Australia.

Cancer is a serious health burden on global societies. The discovery and development of new anti-cancer therapies remains a challenging objective. Although it has been shown that lichen secondary metabolites may be potent sources for new anti-cancer agents, the Indonesian- grown folious lichens, and have not yet been explored. In this study exhaustive preparative high-performance liquid chromatography was employed to isolate the lichen constituents with spectroscopic and spectrometric protocols identifying nine depsides -, including the new methyl 4-formyl-2,3-dihydroxy-6-methylbenzoate . The cytotoxicity of the depsides towards cancer cells was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated lowest toxicity of the depsides towards human A549 lung cancer cells. Importantly, the di-depsides (, and ) showed greatest toxicity, indicating that these structures are biologically more active than the mono-depsides against the HepG2 liver cancer, A549 lung cancer and HL-60 leukemia cell lines.
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October 2020

Anthelmintic and antimicrobial activities of three new depsides and ten known depsides and phenols from Indonesian lichen: Ach.

Nat Prod Res 2021 Dec 6;35(23):5001-5010. Epub 2020 May 6.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle/Saale, Germany.

An extensive phytochemical study of a foliose lichen from Indonesia, , resulted in the successful isolation of 13 phenol and depside derivatives (-) including the previously unreported depsides 3'-hydroxyl-5'-pentylphenyl 2,4-dihydroxyl-6-methylbenzoate (), 3'-hydroxyl-5'-propylphenyl 2,4-dihydroxyl-6-methylbenzoate () and 3'-hydroxyl-5'-methylphenyl 2-hydroxyl-4-methoxyl-6-propylbenzoate (). The anti-infective activity of isolated compounds was evaluated against the gram-negative bacterium and the nematode . 2,4-Dihydroxyl-6-pentylbenzoate () and lecanoric acid () induced growth inhibition of with inhibition values of 49% and 100% at a concentration of 100 µM, respectively. The antibacterial activity might be due to their free carboxyl group. A phenolic group at C4 also contributed to the antimicrobial activity of the depsides as shown for compounds and , which caused 89% and 96% growth inhibition at 100 µM, respectively. Lecanoric acid () in addition possesses significant anthelmintic effects causing 80% mortality of at 100 µg/mL.
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December 2021