Ludmila Kazdová

Ludmila Kazdová

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Ludmila Kazdová

Ludmila Kazdová

Publications by authors named "Ludmila Kazdová"

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The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach.

J Diabetes Res 2019 6;2019:8712979. Epub 2019 Dec 6.

Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.

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http://dx.doi.org/10.1155/2019/8712979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925916PMC
December 2019

Fenofibrate Decreases Hepatic P-Glycoprotein in a Rat Model of Hereditary Hypertriglyceridemia.

Front Pharmacol 2019 7;10:56. Epub 2019 Feb 7.

Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czechia.

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http://dx.doi.org/10.3389/fphar.2019.00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373460PMC
February 2019

Single-Gene Congenic Strain Reveals the Effect of on Dexamethasone-Induced Insulin Resistance.

Front Endocrinol (Lausanne) 2018 20;9:185. Epub 2018 Apr 20.

The First Faculty of Medicine, Institute of Biology and Medical Genetics, Charles University, The General Teaching Hospital, Prague, Czechia.

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http://journal.frontiersin.org/article/10.3389/fendo.2018.00
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http://dx.doi.org/10.3389/fendo.2018.00185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919955PMC
April 2018

Systems genetic analysis of brown adipose tissue function.

Physiol Genomics 2018 01 10;50(1):52-66. Epub 2017 Nov 10.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus , Aurora, Colorado.

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http://dx.doi.org/10.1152/physiolgenomics.00091.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866413PMC
January 2018

Downregulation of Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat.

Hypertension 2017 06 10;69(6):1084-1091. Epub 2017 Apr 10.

From the Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic (F.L., O.Š., V.K., M.P.); Institute of Physiology (V.L., V.Z., P.M., J.Š., M.Š., M.P.) and Institute of Molecular Genetics (H.S.), Czech Academy of Sciences, Prague, Czech Republic; Institute for Experimental Medicine, Prague, Czech Republic (J.T., V.Š., L.K.); Department of Genetics, Cell Biology, and Development and Center for Genome Engineering, University of Minnesota, Minneapolis (C.G.S., D.F.V.); Max-Delbrück-Center for Molecular Medicine in the Hemholtz Society, Berlin, Germany (Z.I.); and Department of Molecular Medicine "Sapienza" University of Rome, Italy (M.M.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08798DOI Listing
June 2017

The Effect of Meal Frequency on the Fatty Acid Composition of Serum Phospholipids in Patients with Type 2 Diabetes.

J Am Coll Nutr 2016 May-Jun;35(4):317-25. Epub 2015 Dec 23.

a Institute for Clinical and Experimental Medicine , Prague , CZECH REPUBLIC.

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http://dx.doi.org/10.1080/07315724.2015.1046197DOI Listing
February 2017

Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat.

Lipids Health Dis 2016 Nov 21;15(1):199. Epub 2016 Nov 21.

Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Albertov 4, 128 00, Prague 2, Czech Republic.

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http://dx.doi.org/10.1186/s12944-016-0376-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117636PMC
November 2016

Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model.

PLoS One 2016 31;11(3):e0152708. Epub 2016 Mar 31.

Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and the General Teaching Hospital, Prague, Czech Republic.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152708PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816345PMC
August 2016

Improvement bioavailability of silymarin ameliorates severe dyslipidemia associated with metabolic syndrome.

Xenobiotica 2015 16;45(9):751-6. Epub 2015 Jul 16.

a Department of Pharmacology, Faculty of Medicine and Dentistry , Palacky University Olomouc , Olomouc , Czech Republic .

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http://dx.doi.org/10.3109/00498254.2015.1010633DOI Listing
June 2016

Conjugated linoleic acid reduces visceral and ectopic lipid accumulation and insulin resistance in chronic severe hypertriacylglycerolemia.

Nutrition 2015 Jul-Aug;31(7-8):1045-51. Epub 2015 Apr 20.

Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.nut.2015.03.011DOI Listing
May 2016

Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome.

Hypertension 2016 Feb 14;67(2):335-41. Epub 2015 Dec 14.

From the Department of Model Diseases, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic (M.P., V.Z., V.L., P.M., J.Š., M.Š.); Institute of Inherited Metabolic Disorders, 1st Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic (V.K., J.K., J.Š.); Center of Experimental Medicine, Department of Metabolism and Diabetes, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (V.Š., J.T., L.K.); and Department of Laboratory Medicine, University of California, San Francisco (T.K., J.W., T.W.K.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06158DOI Listing
February 2016

Genomic determinants of triglyceride and cholesterol distribution into lipoprotein fractions in the rat.

PLoS One 2014 8;9(10):e109983. Epub 2014 Oct 8.

Institute of Biology and Medical Genetics, the First Faculty of Medicine, Charles University and the General Teaching Hospital, Prague, Czech Republic; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109983PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190321PMC
October 2015

Relationship of Circulating Fatty Acid Profile to Metabolic Disorders Associated with Insulin Resistance.

Authors:
Ludmila Kazdova

EBioMedicine 2015 Oct 15;2(10):1308-9. Epub 2015 Oct 15.

Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.ebiom.2015.09.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634871PMC
October 2015

Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation.

Am J Physiol Gastrointest Liver Physiol 2015 Jul 4;309(2):G100-11. Epub 2015 Jun 4.

Center for Experimental Medicine, Department of Metabolism and Diabetes, Charles University, Prague, Czech Republic;

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http://dx.doi.org/10.1152/ajpgi.00329.2014DOI Listing
July 2015

Autophagy inhibition in early but not in later stages prevents 3T3-L1 differentiation: Effect on mitochondrial remodeling.

Differentiation 2014 Jun 18;87(5):220-9. Epub 2014 Jul 18.

Center of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.diff.2014.06.002DOI Listing
June 2014

Tissue-specific peroxisome proliferator activated receptor gamma expression and metabolic effects of telmisartan.

Am J Hypertens 2013 Jun 20;26(6):829-35. Epub 2013 Feb 20.

Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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http://dx.doi.org/10.1093/ajh/hpt019DOI Listing
June 2013

Comparison of gene expression of epicardial and visceral adipocytes with regard to the differentiation stage.

Neuro Endocrinol Lett 2012 ;33 Suppl 2:93-7

Department of Metabolism and Diabetes, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

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April 2013

The opposite effects of high-sucrose and high-fat diet on Fatty Acid oxidation and very low density lipoprotein secretion in rat model of metabolic syndrome.

J Nutr Metab 2012 17;2012:757205. Epub 2012 Oct 17.

Department of Metabolism and Diabetes, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 4, 14021 Prague, Czech Republic.

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http://www.hindawi.com/journals/jnme/2012/757205/
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http://dx.doi.org/10.1155/2012/757205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483727PMC
November 2012

Availability of energetic substrates and exercise performance in heart failure with or without diabetes.

Eur J Heart Fail 2012 Jul 12;14(7):754-63. Epub 2012 Jun 12.

Department of Cardiology, Institute of Clinical and Experimental Medicine-IKEM, Prague 4, 140 28, Czech Republic.

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http://dx.doi.org/10.1093/eurjhf/hfs080DOI Listing
July 2012

Kupffer cells ameliorate hepatic insulin resistance induced by high-fat diet rich in monounsaturated fatty acids: the evidence for the involvement of alternatively activated macrophages.

Nutr Metab (Lond) 2012 Mar 22;9:22. Epub 2012 Mar 22.

Department of Metabolism and Diabetes, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic.

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http://dx.doi.org/10.1186/1743-7075-9-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348013PMC
March 2012

Epinephrine-dependent control of glucose metabolism in white adipose tissue: the role of α- and β-adrenergic signalling.

Exp Biol Med (Maywood) 2012 Feb 2;237(2):211-8. Epub 2012 Feb 2.

Department of Metabolism and Diabetes, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 4, Czech Republic.

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http://journals.sagepub.com/doi/10.1258/ebm.2011.011189
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http://dx.doi.org/10.1258/ebm.2011.011189DOI Listing
February 2012

Role of FAT/CD36 in novel PKC isoform activation in heart of spontaneously hypertensive rats.

Mol Cell Biochem 2011 Nov 31;357(1-2):163-9. Epub 2011 May 31.

Department of Cell Biology, Charles University, Vinicna 7, 12843 Prague, Czech Republic.

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http://link.springer.com/content/pdf/10.1007/s11010-011-0886
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http://link.springer.com/10.1007/s11010-011-0886-2
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http://dx.doi.org/10.1007/s11010-011-0886-2DOI Listing
November 2011

The increased activity of liver lysosomal lipase in nonalcoholic Fatty liver disease contributes to the development of hepatic insulin resistance.

Biochem Res Int 2012 23;2012:135723. Epub 2011 Aug 23.

Department of Metabolism and Diabetes, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021 Prague 4, Czech Republic.

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http://dx.doi.org/10.1155/2012/135723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163129PMC
November 2011

Lipolytic effects of B-type natriuretic peptide 1-32 in adipose tissue of heart failure patients compared with healthy controls.

J Am Coll Cardiol 2011 Sep;58(11):1119-25

Department of Cardiology, Institute of Clinical and Experimental Medicine, IKEM, Videnska 1958/9, Prague, Czech Republic.

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https://linkinghub.elsevier.com/retrieve/pii/S07351097110228
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http://dx.doi.org/10.1016/j.jacc.2011.05.042DOI Listing
September 2011

Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats.

Mol Cell Biochem 2011 Aug 5;354(1-2):83-96. Epub 2011 Apr 5.

Department of Cardiology and Center for Cardiovascular Research, Institute for Clinical and Experimental Medicine-IKEM, Videnska 1958/9, Prague 4, 140 21, Czech Republic.

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http://dx.doi.org/10.1007/s11010-011-0808-3DOI Listing
August 2011

Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain.

Biochem Biophys Res Commun 2010 Jan 16;391(3):1348-51. Epub 2009 Dec 16.

Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.bbrc.2009.12.050DOI Listing
January 2010

Pharmacogenetic model of retinoic acid-induced dyslipidemia and insulin resistance.

Pharmacogenomics 2009 Dec;10(12):1915-27

Institute of Biology and Medical Genetics, the First Faculty of Medicine, Charles University, General Teaching Hospital, Prague, Czech Republic.

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http://dx.doi.org/10.2217/pgs.09.113DOI Listing
December 2009

Renal activity of Akt kinase in obese Zucker rats.

Exp Biol Med (Maywood) 2008 Oct 18;233(10):1231-41. Epub 2008 Jul 18.

Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

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http://dx.doi.org/10.3181/0801-RM-29DOI Listing
October 2008

Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity.

Biochemistry 2008 May 2;47(21):5858-68. Epub 2008 May 2.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Praha 6, Czech Republic.

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http://dx.doi.org/10.1021/bi702086wDOI Listing
May 2008

Pharmacogenomics of metabolic effects of rosiglitazone.

Pharmacogenomics 2008 Feb;9(2):141-55

Centre Hospitalier de l'Université de Montréal, Centre de Recherche, Technôpole Angus, 2901 Rachel East, Office 314, Montréal, Québec H1W 4A4, Canada.

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http://dx.doi.org/10.2217/14622416.9.2.141DOI Listing
February 2008

Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat.

Hypertension 2008 Jan 10;51(1):148-53. Epub 2007 Dec 10.

Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.100743DOI Listing
January 2008

The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat.

Plant Foods Hum Nutr 2007 Jun;62(2):59-63

Institute of Pharmacology, Medical Faculty, Palacký University, Hnevotínská 3, 775 15, Olomouc, Czech Republic.

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http://dx.doi.org/10.1007/s11130-007-0042-zDOI Listing
June 2007

Sucrose feeding during pregnancy and lactation elicits distinct metabolic response in offspring of an inbred genetic model of metabolic syndrome.

Am J Physiol Endocrinol Metab 2007 May 9;292(5):E1318-24. Epub 2007 Jan 9.

Institute of Biology and Medical Genetics of the First Faculty of Medicine of Charles University and the General Teaching Hospital,Prague, Czech Republic.

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http://www.physiology.org/doi/10.1152/ajpendo.00526.2006
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http://dx.doi.org/10.1152/ajpendo.00526.2006DOI Listing
May 2007

Novel double-congenic strain reveals effects of spontaneously hypertensive rat chromosome 2 on specific lipoprotein subfractions and adiposity.

Physiol Genomics 2006 Oct 5;27(1):95-102. Epub 2006 Jul 5.

Institute of Biology and Medical Genetics of the First Faculty of Medicine of Charles University and the General Teaching Hospital, Prague, Czech Republic.

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http://www.physiology.org/doi/10.1152/physiolgenomics.00039.
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http://dx.doi.org/10.1152/physiolgenomics.00039.2006DOI Listing
October 2006

Telmisartan but not valsartan increases caloric expenditure and protects against weight gain and hepatic steatosis.

Hypertension 2006 May 27;47(5):1003-9. Epub 2006 Mar 27.

Department of Laboratory Medicine, University of California, San Francisco, CA 94107, USA.

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http://dx.doi.org/10.1161/01.HYP.0000215181.60228.f7DOI Listing
May 2006

Roles of nitric oxide and oxidative stress in the regulation of blood pressure and renal function in prehypertensive Ren-2 transgenic rats.

Kidney Blood Press Res 2005 23;28(2):117-26. Epub 2005 Mar 23.

Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

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http://dx.doi.org/10.1159/000084649DOI Listing
July 2005

Renal cyclooxygenase-2 in obese Zucker (fatty) rats.

Kidney Int 2005 Jun;67(6):2151-8

Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

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http://linkinghub.elsevier.com/retrieve/pii/S008525381550704
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http://dx.doi.org/10.1111/j.1523-1755.2005.00320.xDOI Listing
June 2005

A new transgenic rat model of hepatic steatosis and the metabolic syndrome.

Hypertension 2005 May 4;45(5):1004-11. Epub 2005 Apr 4.

Department of Laboratory Medicine, University of California, San Francisco, USA.

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http://dx.doi.org/10.1161/01.HYP.0000161995.64192.2bDOI Listing
May 2005

Dynamic genetic architecture of metabolic syndrome attributes in the rat.

Physiol Genomics 2005 Apr 22;21(2):243-52. Epub 2005 Feb 22.

Centre de Recherche, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.

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http://dx.doi.org/10.1152/physiolgenomics.00230.2004DOI Listing
April 2005

Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats.

Pharmacol Res 2004 Aug;50(2):123-30

Institute of Pharmacology, Medical Faculty, Palacký University, Hnevotínská 3, 775 15 Olomouc, Czech Republic.

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http://dx.doi.org/10.1016/j.phrs.2003.12.013DOI Listing
August 2004

Effects of ACE inhibition and AT1-receptor blockade on haemodynamic responses to L-arginine in Type 1 diabetes.

J Renin Angiotensin Aldosterone Syst 2004 Mar;5(1):33-8

Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

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http://dx.doi.org/10.3317/jraas.2004.006DOI Listing
March 2004

Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat.

J Biol Chem 2003 Nov 27;278(46):45209-15. Epub 2003 Aug 27.

Institute of Physiology, Czech Academy of Sciences and the Center for Integrated Genomics, Prague 14220, Czech Republic.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M304869200
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http://dx.doi.org/10.1074/jbc.M304869200DOI Listing
November 2003

Captopril enhanced insulin-stimulated glycogen synthesis in skeletal muscle but not fatty acid synthesis in adipose tissue of hereditary hypertriglyceridemic rats.

Metabolism 2003 Nov;52(11):1406-12

Department of Metabolic Research, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

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http://dx.doi.org/10.1016/s0026-0495(03)00319-6DOI Listing
November 2003

Rosiglitazone fails to improve hypertriglyceridemia and glucose tolerance in CD36-deficient BN.SHR4 congenic rat strain.

Physiol Genomics 2003 Jan 15;12(2):73-8. Epub 2003 Jan 15.

Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.

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http://physiolgenomics.physiology.org/content/physiolgenomic
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http://physiolgenomics.physiology.org/lookup/doi/10.1152/phy
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http://dx.doi.org/10.1152/physiolgenomics.00113.2002DOI Listing
January 2003

Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone.

J Biol Chem 2002 Dec 15;277(50):48501-7. Epub 2002 Oct 15.

Department of Laboratory Medicine, University of California, San Francisco, 94143, USA.

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http://dx.doi.org/10.1074/jbc.M206655200DOI Listing
December 2002

Relationship between insulin resistance and muscle triglyceride content in nonobese and obese experimental models of insulin resistance syndrome.

Ann N Y Acad Sci 2002 Jun;967:440-5

Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

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June 2002