Ludmil B Alexandrov

Ludmil B Alexandrov

UNVERIFIED PROFILE

Are you Ludmil B Alexandrov?   Register this Author

Register author
Ludmil B Alexandrov

Ludmil B Alexandrov

Publications by authors named "Ludmil B Alexandrov"

Are you Ludmil B Alexandrov?   Register this Author

82Publications

4683Reads

48Profile Views

Somatic evolution and global expansion of an ancient transmissible cancer lineage.

Science 2019 08;365(6452)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aau9923DOI Listing
August 2019

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events.

BMC Genomics 2019 Aug 30;20(1):685. Epub 2019 Aug 30.

Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-019-6041-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717374PMC
August 2019

Insights into BRCA Cancer Predisposition from Integrated Germline and Somatic Analyses in 7632 Cancers.

JNCI Cancer Spectr 2019 Jun 19;3(2):pkz028. Epub 2019 Apr 19.

Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jncics/pkz028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649772PMC
June 2019

Stem cell replication, somatic mutations and role of randomness in the development of cancer.

Eur J Epidemiol 2019 May 8;34(5):439-445. Epub 2019 Jan 8.

CESP (Inserm U1018), Facultés de Médicine Université Paris-Sud, UVSQ, Université Paris-Saclay, Gustave Roussy, 94805, Villejuif, France.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10654-018-0477-6
Publisher Site
http://dx.doi.org/10.1007/s10654-018-0477-6DOI Listing
May 2019

Nonnegative/Binary matrix factorization with a D-Wave quantum annealer.

PLoS One 2018 10;13(12):e0206653. Epub 2018 Dec 10.

Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206653PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287781PMC
April 2019

Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.

Cancer Cell 2019 Mar;35(3):441-456.e8

Research Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK; Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428691PMC
March 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41586-019-0883-2
Publisher Site
http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41588-018-0086-z
Publisher Site
http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Evaluating the role of coherent delocalized phonon-like modes in DNA cyclization.

Sci Rep 2017 08 29;7(1):9731. Epub 2017 Aug 29.

Theoretical Division, Los Alamos National Laboratory, Los Alamos, 87545, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-09537-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575098PMC
August 2017

Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas.

J Pathol 2017 05 29;242(1):10-15. Epub 2017 Mar 29.

INSERM UMR-S1147, Personalized Medicine, Pharmacogenomics, Therapeutic Optimization, Université Paris Descartes, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.4880DOI Listing
May 2017

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature17676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

Understanding mutagenesis through delineation of mutational signatures in human cancer.

Carcinogenesis 2016 06 4;37(6):531-40. Epub 2016 May 4.

Theoretical Biology and Biophysics (T-6) and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA and University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87102, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgw055DOI Listing
June 2016

The role of structural parameters in DNA cyclization.

BMC Bioinformatics 2016 Feb 4;17:68. Epub 2016 Feb 4.

Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12859-016-0897-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743258PMC
February 2016

Clock-like mutational processes in human somatic cells.

Nat Genet 2015 Dec 9;47(12):1402-7. Epub 2015 Nov 9.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783858PMC
December 2015

Understanding the origins of human cancer.

Science 2015 Dec;350(6265):1175

Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aad7363DOI Listing
December 2015

The genome as a record of environmental exposure.

Mutagenesis 2015 Nov 6;30(6):763-70. Epub 2015 Oct 6.

Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/mutage/gev073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637815PMC
November 2015

A mutational signature in gastric cancer suggests therapeutic strategies.

Nat Commun 2015 Oct 29;6:8683. Epub 2015 Oct 29.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms9683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918743PMC
October 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

View Article

Download full-text PDF

Source
https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
Web Search
http://www.nature.com/doifinder/10.1038/ng.3221
Publisher Site
http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3202DOI Listing
March 2015

C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency.

Genome Res 2014 Oct 16;24(10):1624-36. Epub 2014 Jul 16.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom; Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.175547.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199376PMC
October 2014

Fast randomization of large genomic datasets while preserving alteration counts.

Bioinformatics 2014 Sep;30(17):i617-23

Fondazione Bruno Kessler, I-38100 Povo (Trento), Italy, European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge CB10 1SD, UK, Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK and Universitat Pompeu Fabra, Barcelona 08003, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btu474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147926PMC
September 2014

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes.

Curr Opin Genet Dev 2014 Feb 29;24:52-60. Epub 2013 Dec 29.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gde.2013.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990474PMC
February 2014

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

Deciphering signatures of mutational processes operative in human cancer.

Cell Rep 2013 Jan 10;3(1):246-59. Epub 2013 Jan 10.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2012.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588146PMC
January 2013

Mammalian stem cells reprogramming in response to terahertz radiation.

PLoS One 2010 Dec 31;5(12):e15806. Epub 2010 Dec 31.

Department of Medicine, Endocrinology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015806PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013123PMC
December 2010

DNA dynamics play a role as a basal transcription factor in the positioning and regulation of gene transcription initiation.

Nucleic Acids Res 2010 Apr 17;38(6):1790-5. Epub 2009 Dec 17.

Los Alamos National Laboratory, Theoretical Division and Center for Nonlinear Studies, Los Alamos, NM, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkp1084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847213PMC
April 2010

Computer modeling describes gravity-related adaptation in cell cultures.

PLoS One 2009 Dec 16;4(12):e8332. Epub 2009 Dec 16.

Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008332PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790613PMC
December 2009

A nonlinear dynamic model of DNA with a sequence-dependent stacking term.

Nucleic Acids Res 2009 Apr 5;37(7):2405-10. Epub 2009 Mar 5.

Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkp016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673413PMC
April 2009