Publications by authors named "Ludmil Alexandrov"

99Publications

Bioinformatic Methods to Identify Mutational Signatures in Cancer.

Methods Mol Biol 2021 ;2185:447-473

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.

View Article and Find Full Text PDF
January 2021

Generating realistic null hypothesis of cancer mutational landscapes using SigProfilerSimulator.

BMC Bioinformatics 2020 Oct 7;21(1):438. Epub 2020 Oct 7.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.

View Article and Find Full Text PDF
October 2020

Strength of immune selection in tumors varies with sex and age.

Nat Commun 2020 08 17;11(1):4128. Epub 2020 Aug 17.

Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA, 92093, USA.

View Article and Find Full Text PDF
August 2020

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice.

Nat Commun 2020 01 20;11(1):394. Epub 2020 Jan 20.

UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94158, USA.

View Article and Find Full Text PDF
January 2020

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events.

BMC Genomics 2019 Aug 30;20(1):685. Epub 2019 Aug 30.

Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.

View Article and Find Full Text PDF
August 2019

Somatic evolution and global expansion of an ancient transmissible cancer lineage.

Science 2019 08;365(6452)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

View Article and Find Full Text PDF
August 2019

Insights into BRCA Cancer Predisposition from Integrated Germline and Somatic Analyses in 7632 Cancers.

JNCI Cancer Spectr 2019 Jun 19;3(2):pkz028. Epub 2019 Apr 19.

Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.

View Article and Find Full Text PDF
June 2019