Ludger A Wessjohann

Ludger A Wessjohann

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Ludger A Wessjohann

Publications by authors named "Ludger A Wessjohann"

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Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma.

Eur J Med Chem 2019 Oct 28;179:515-526. Epub 2019 Jun 28.

Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Halle (Saale), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.06.075DOI Listing
October 2019

Synthetic Tubulysin Derivative, Tubugi-1, Against Invasive Melanoma Cells: The Cell Death Triangle.

Anticancer Res 2019 Oct;39(10):5403-5415

Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Belgrade, Serbia

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13734DOI Listing
October 2019

Metabolites profiling of Ziziphus leaf taxa via UHPLC/PDA/ESI-MS in relation to their biological activities.

Food Chem 2019 Sep 25;293:233-246. Epub 2019 Apr 25.

Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr el Aini St., P.B. 11562, Cairo, Egypt; Department of Chemistry, American University in Cairo, New Cairo, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2019.04.097DOI Listing
September 2019

Nor-guanacastepene pigments from the Chilean mushroom Cortinarius pyromyxa.

Phytochemistry 2019 Sep 21;165:112048. Epub 2019 Jun 21.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120, Halle (Saale), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2019.05.021DOI Listing
September 2019

Stabilization of Cyclic β-Hairpins by Ugi-Reaction-Derived -Alkylated Peptides: The Quest for Functionalized β-Turns.

Org Lett 2019 Sep 4;21(18):7307-7310. Epub 2019 Sep 4.

Department of Bioorganic Chemistry , Leibniz Institute of Plant Biochemistry , Weinberg 3 , 06120 Halle/Saale , Germany.

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http://dx.doi.org/10.1021/acs.orglett.9b02592DOI Listing
September 2019

Sensory Metabolite Profiling in a Date Pit Based Coffee Substitute and in Response to Roasting as Analyzed via Mass Spectrometry Based Metabolomics.

Molecules 2019 Sep 17;24(18). Epub 2019 Sep 17.

Leibniz Institute of Plant Biochemistry, Dept. Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.3390/molecules24183377DOI Listing
September 2019

Apoptosis Caused by Triterpenes and Phytosterols and Antioxidant Activity of an Enriched Flavonoid Extract from Passiflora mucronata.

Anticancer Agents Med Chem 2018 ;18(10):1405-1416

Laboratorio de Produtos Naturais e Ensaios Biologicos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Departamento de Produtos Naturais e Alimentos, CCS, Rio de Janeiro, RJ, Brazil.

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http://dx.doi.org/10.2174/1871520618666180315090949DOI Listing
August 2019

Multicomponent synthesis of α-acylamino and α-acyloxy amide derivatives of desmycosin and their activity against gram-negative bacteria.

Bioorg Med Chem 2019 Aug 1;27(15):3237-3247. Epub 2019 Jun 1.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Saale, Germany; Institute of Organic Chemistry, Faculty of Natural Sciences II, Martin-Luther-University Halle-Wittenberg, Kurt-Mothes-Strasse 2, 06120 Halle, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.05.046DOI Listing
August 2019

The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model.

Food Chem Toxicol 2019 Jul 26;129:257-268. Epub 2019 Apr 26.

Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2019.04.046DOI Listing
July 2019

The synthetic tubulysin derivative, tubugi-1, improves the innate immune response by macrophage polarization in addition to its direct cytotoxic effects in a murine melanoma model.

Exp Cell Res 2019 Jul 28;380(2):159-170. Epub 2019 Apr 28.

Institute for Biological Research "Siniša Stanković", University of Belgrade, Bulevar despota Stefana 142, Belgrade, 11060, Serbia. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2019.04.028DOI Listing
July 2019

Variation in Ceratonia siliqua pod metabolome in context of its different geographical origin, ripening stage and roasting process.

Food Chem 2019 Jun 14;283:675-687. Epub 2019 Jan 14.

Leibniz Institute of Plant Biochemistry, Dept. Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1016/j.foodchem.2018.12.118DOI Listing
June 2019

The unusual fragmentation of long-chain feruloyl esters under negative ion electrospray conditions.

J Mass Spectrom 2019 Jun;54(6):549-556

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120, Halle/Saale, Germany.

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http://dx.doi.org/10.1002/jms.4357DOI Listing
June 2019

Comparative metabolome-based classification of Senna drugs: a prospect for phyto-equivalency of its different commercial products.

Metabolomics 2019 May 13;15(5):80. Epub 2019 May 13.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany.

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http://dx.doi.org/10.1007/s11306-019-1538-xDOI Listing
May 2019

Influence of Pickling Process on and Metabolome as Determined Mass Spectrometry-Based Metabolomics.

Molecules 2019 Mar 7;24(5). Epub 2019 Mar 7.

Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.3390/molecules24050928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429351PMC
March 2019

Introducing the Petasis Reaction for Late-Stage Multicomponent Diversification, Labeling, and Stapling of Peptides.

Angew Chem Int Ed Engl 2019 Feb 25;58(9):2700-2704. Epub 2019 Jan 25.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle/Saale, Germany.

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http://doi.wiley.com/10.1002/anie.201812620
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http://dx.doi.org/10.1002/anie.201812620DOI Listing
February 2019

Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH₂ Core and Evaluation of Their Anticancer Activity.

Pharmaceutics 2019 Feb 1;11(2). Epub 2019 Feb 1.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany.

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http://dx.doi.org/10.3390/pharmaceutics11020059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409784PMC
February 2019

A Peptide Backbone Stapling Strategy Enabled by the Multicomponent Incorporation of Amide N-Substituents.

Chemistry 2019 Jan 13;25(3):769-774. Epub 2018 Dec 13.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle/Saale, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.2018053
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http://dx.doi.org/10.1002/chem.201805318DOI Listing
January 2019

A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge.

Bioconjug Chem 2019 01 7;30(1):253-259. Epub 2019 Jan 7.

Department of Bioorganic Chemistry , Leibniz Institute of Plant Biochemistry , Weinberg 3 , D-06120 , Halle (Saale) , Germany.

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http://pubs.acs.org/doi/10.1021/acs.bioconjchem.8b00906
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http://dx.doi.org/10.1021/acs.bioconjchem.8b00906DOI Listing
January 2019

Synthesis of a tubugi-1-toxin conjugate by a modulizable disulfide linker system with a neuropeptide Y analogue showing selectivity for hY1R-overexpressing tumor cells.

Beilstein J Org Chem 2019 10;15:96-105. Epub 2019 Jan 10.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.3762/bjoc.15.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334802PMC
January 2019

Salicylic acid and its derivatives elicit the production of diterpenes and sterols in corals and their algal symbionts: a metabolomics approach to elicitor SAR.

Metabolomics 2018 09 17;14(10):127. Epub 2018 Sep 17.

Dept. Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany.

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http://dx.doi.org/10.1007/s11306-018-1416-yDOI Listing
September 2018

Droplet-Assisted Microfluidic Fabrication and Characterization of Multifunctional Polysaccharide Microgels Formed by Multicomponent Reactions.

Polymers (Basel) 2018 Sep 21;10(10). Epub 2018 Sep 21.

Institute of Physical Chemistry and Polymer Physics, Leibniz-Institut für Polymerforschung Dresden e.V., D-01069 Dresden, Germany.

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http://dx.doi.org/10.3390/polym10101055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403549PMC
September 2018

Comparative analysis of Hibiscus sabdariffa (roselle) hot and cold extracts in respect to their potential for α-glucosidase inhibition.

Food Chem 2018 Jun 3;250:236-244. Epub 2018 Jan 3.

Pharmacognosy Department, College of Pharmacy, Cairo University, 11562 Cairo, Egypt; Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, Egypt. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03088146183002
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http://dx.doi.org/10.1016/j.foodchem.2018.01.020DOI Listing
June 2018

Comparative Metabolomics Approach Detects Stress-Specific Responses during Coral Bleaching in Soft Corals.

J Proteome Res 2018 06 27;17(6):2060-2071. Epub 2018 Apr 27.

Department of Bioorganic Chemistry , Leibniz Institute of Plant Biochemistry , Weinberg 3 , D-06120 Halle (Saale) , Germany.

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http://dx.doi.org/10.1021/acs.jproteome.7b00929DOI Listing
June 2018

Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15.

Nanomaterials (Basel) 2018 May 12;8(5). Epub 2018 May 12.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.3390/nano8050322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977336PMC
May 2018

Gas Chromatography/Mass Spectrometry-Based Metabolite Profiling of Nutrients and Antinutrients in Eight Lens and Lupinus Seeds (Fabaceae).

J Agric Food Chem 2018 Apr 10;66(16):4267-4280. Epub 2018 Apr 10.

Department of Bioorganic Chemistry , Leibniz Institute of Plant Biochemistry , Weinberg 3 , D-06120 Halle , Germany.

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http://dx.doi.org/10.1021/acs.jafc.8b00369DOI Listing
April 2018

Loss of epithelium-specific GPx2 results in aberrant cell fate decisions during intestinal differentiation.

Oncotarget 2018 Jan 23;9(1):539-552. Epub 2017 Nov 23.

Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 06112 Halle (Saale), Germany.

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http://dx.doi.org/10.18632/oncotarget.22640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787487PMC
January 2018

Effect of Oxylipins, Terpenoid Precursors and Wounding on Soft Corals' Secondary Metabolism as Analyzed via UPLC/MS and Chemometrics.

Molecules 2017 Dec 10;22(12). Epub 2017 Dec 10.

Leibniz Centre for Tropical Marine Research, Fahrenheit Str.6, D-28359 Bremen, Germany.

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http://dx.doi.org/10.3390/molecules22122195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149794PMC
December 2017

Peptide Macrocyclization Assisted by Traceless Turn Inducers Derived from Ugi Peptide Ligation with Cleavable and Resin-Linked Amines.

Org Lett 2017 08 13;19(15):4022-4025. Epub 2017 Jul 13.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry , Weinberg 3, 06120 Halle/Saale, Germany.

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http://dx.doi.org/10.1021/acs.orglett.7b01761DOI Listing
August 2017

Cytotoxic Effects of Sarcophyton sp. Soft Corals-Is There a Correlation to Their NMR Fingerprints?

Mar Drugs 2017 Jul 4;15(7). Epub 2017 Jul 4.

Department Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D06120 Halle (Saale), Germany.

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http://dx.doi.org/10.3390/md15070211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532653PMC
July 2017

Altered protein expression pattern in colon tissue of mice upon supplementation with distinct selenium compounds.

Proteomics 2017 Jun;17(11)

Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Halle, (Saale), Germany.

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http://dx.doi.org/10.1002/pmic.201600486DOI Listing
June 2017

Metabolomics reveals biotic and abiotic elicitor effects on the soft coral Sarcophyton ehrenbergi terpenoid content.

Sci Rep 2017 04 5;7(1):648. Epub 2017 Apr 5.

Leibniz Institute of Plant Biochemistry, Dept. Bioorganic Chemistry, Weinberg 3, D-06120, Halle (Saale), Germany.

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http://dx.doi.org/10.1038/s41598-017-00527-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428729PMC
April 2017

Rats' urinary metabolomes reveal the potential roles of functional foods and exercise in obesity management.

Food Funct 2017 Mar;8(3):985-996

Therapeutic Chemistry Department, National Research Center, Cairo, Egypt.

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http://dx.doi.org/10.1039/c6fo01753cDOI Listing
March 2017

One-Pot Assembly of Amino Acid Bridged Hybrid Macromulticyclic Cages through Multiple Multicomponent Macrocyclizations.

Angew Chem Int Ed Engl 2017 03 17;56(13):3501-3505. Epub 2017 Feb 17.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle/Saale, Germany.

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http://dx.doi.org/10.1002/anie.201610801DOI Listing
March 2017

Methionine and seleno-methionine type peptide and peptoid building blocks synthesized by five-component five-center reactions.

Chem Commun (Camb) 2017 Mar;53(26):3777-3780

Leibniz-Institute of Plant Biochemistry, Bioorganic Chemistry, Weinberg 3, 06120, Halle (Saale), Germany.

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http://dx.doi.org/10.1039/c7cc00399dDOI Listing
March 2017

No Silver Bullet - Canonical Poly(ADP-Ribose) Polymerases (PARPs) Are No Universal Factors of Abiotic and Biotic Stress Resistance of .

Front Plant Sci 2017 6;8:59. Epub 2017 Feb 6.

Plant Nutrition Laboratory, Institute of Agricultural and Nutritional Sciences, Faculty of Natural Sciences III, Martin Luther University Halle-WittenbergHalle (Saale), Germany; Agrochemisches Institut Piesteritz e.V.Lutherstadt Wittenberg, Germany.

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http://dx.doi.org/10.3389/fpls.2017.00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292411PMC
February 2017

Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice.

Biochim Biophys Acta Gen Subj 2017 Jan 24;1861(1 Pt A):3323-3334. Epub 2016 Aug 24.

Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 06112 Halle (Saale), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2016.08.015DOI Listing
January 2017

Early responses of mature Arabidopsis thaliana plants to reduced water potential in the agar-based polyethylene glycol infusion drought model.

J Plant Physiol 2017 Jan 10;208:70-83. Epub 2016 Nov 10.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Germany.

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http://dx.doi.org/10.1016/j.jplph.2016.09.013DOI Listing
January 2017

Expeditious Entry to Functionalized Pseudo-peptidic Organoselenide Redox Modulators via Sequential Ugi/SN Methodology.

Anticancer Agents Med Chem 2016 ;16(5):621-32

Organic Chemistry Division, Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhorya Street, 35516 Mansoura, Egypt.

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December 2016

Modulation of MHC class I surface expression in B16F10 melanoma cells by methylseleninic acid.

Oncoimmunology 2017 21;6(6):e1259049. Epub 2016 Dec 21.

Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

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http://dx.doi.org/10.1080/2162402X.2016.1259049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486188PMC
December 2016

Natural Products from Microalgae with Potential against Alzheimer's Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors.

Mar Drugs 2016 Nov 2;14(11). Epub 2016 Nov 2.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120 Halle (Saale), Germany.

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http://dx.doi.org/10.3390/md14110203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128746PMC
November 2016

Combinatorial synthesis, in silico, molecular and biochemical studies of tetrazole-derived organic selenides with increased selectivity against hepatocellular carcinoma.

Eur J Med Chem 2016 Oct 6;122:55-71. Epub 2016 Jun 6.

Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.06.005DOI Listing
October 2016

Applications of Convertible Isonitriles in the Ligation and Macrocyclization of Multicomponent Reaction-Derived Peptides and Depsipeptides.

J Org Chem 2016 08 14;81(15):6535-45. Epub 2016 Jul 14.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry , Weinberg 3, 06120, Halle/Saale, Germany.

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http://dx.doi.org/10.1021/acs.joc.6b01150DOI Listing
August 2016

Solution- and Solid-Phase Macrocyclization of Peptides by the Ugi-Smiles Multicomponent Reaction: Synthesis of N-Aryl-Bridged Cyclic Lipopeptides.

Org Lett 2016 08 9;18(16):4096-9. Epub 2016 Aug 9.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry , Weinberg 3, 06120 Halle/Saale, Germany.

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http://dx.doi.org/10.1021/acs.orglett.6b02001DOI Listing
August 2016

Comparative metabolite profiling and fingerprinting of genus Passiflora leaves using a multiplex approach of UPLC-MS and NMR analyzed by chemometric tools.

Anal Bioanal Chem 2016 May 16;408(12):3125-43. Epub 2016 Feb 16.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany.

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http://dx.doi.org/10.1007/s00216-016-9376-4DOI Listing
May 2016

Prenylated phenyl polyketides and acylphloroglucinols from Hypericum peplidifolium.

Phytochemistry 2016 Apr 12;124:108-13. Epub 2016 Feb 12.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2016.02.003DOI Listing
April 2016

Soft Corals Biodiversity in the Egyptian Red Sea: A Comparative MS and NMR Metabolomics Approach of Wild and Aquarium Grown Species.

J Proteome Res 2016 Apr 8;15(4):1274-87. Epub 2016 Mar 8.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry , Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1021/acs.jproteome.6b00002DOI Listing
April 2016

Tricyclic Acylphloroglucinols from Hypericum lanceolatum and Regioselective Synthesis of Selancins A and B.

J Nat Prod 2016 Apr 7;79(4):743-53. Epub 2016 Mar 7.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry , Weinberg 3, 06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1021/acs.jnatprod.5b00673DOI Listing
April 2016

Versatile antitumor potential of isoxanthohumol: Enhancement of paclitaxel activity in vivo.

Pharmacol Res 2016 Mar 16;105:62-73. Epub 2016 Jan 16.

Institute for Biological Research "Siniša Stanković", University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.01.011DOI Listing
March 2016

Ericoside, a new antibacterial biflavonoid from Erica mannii (Ericaceae).

Fitoterapia 2016 Mar 21;109:206-11. Epub 2016 Jan 21.

Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2015.12.022DOI Listing
March 2016

Metabolite profiling in 18 Saudi date palm fruit cultivars and their antioxidant potential via UPLC-qTOF-MS and multivariate data analyses.

Food Funct 2016 Feb;7(2):1077-86

Leibniz Institute of Plant Biochemistry, Dept. Bioorganic Chemistry, Weinberg 3, D 06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1039/c5fo01570gDOI Listing
February 2016

Redox proteomics: Methods for the identification and enrichment of redox-modified proteins and their applications.

Proteomics 2016 Jan 17;16(2):197-213. Epub 2015 Dec 17.

Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany.

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http://dx.doi.org/10.1002/pmic.201500268DOI Listing
January 2016

A fluorescence-based bioassay for antibacterials and its application in screening natural product extracts.

J Antibiot (Tokyo) 2015 Dec 8;68(12):734-40. Epub 2015 Jul 8.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.

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http://www.nature.com/articles/ja201571
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http://dx.doi.org/10.1038/ja.2015.71DOI Listing
December 2015

Unraveling the active hypoglycemic agent trigonelline in Balanites aegyptiaca date fruit using metabolite fingerprinting by NMR.

J Pharm Biomed Anal 2015 Nov 4;115:383-7. Epub 2015 Aug 4.

Leibniz Institute of Plant Biochemistry, Dept. Bioorganic Chemistry, Weinberg 3, 06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1016/j.jpba.2015.08.003DOI Listing
November 2015

Phytochemical, antioxidant and antidiabetic evaluation of eight Bauhinia L. species from Egypt using UHPLC-PDA-qTOF-MS and chemometrics.

Phytochemistry 2015 Nov 24;119:41-50. Epub 2015 Sep 24.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1016/j.phytochem.2015.09.004DOI Listing
November 2015

Isolation and anticancer, anthelminthic, and antiviral (HIV) activity of acylphloroglucinols, and regioselective synthesis of empetrifranzinans from Hypericum roeperianum.

Bioorg Med Chem 2015 Oct 28;23(19):6327-34. Epub 2015 Aug 28.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.08.028DOI Listing
October 2015

Hydrogen peroxide - production, fate and role in redox signaling of tumor cells.

Cell Commun Signal 2015 Sep 14;13:39. Epub 2015 Sep 14.

Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Magdeburger Str. 2, 06112, Halle/Saale, Germany.

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http://dx.doi.org/10.1186/s12964-015-0118-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570748PMC
September 2015

Macrocyclization of Peptide Side Chains by the Ugi Reaction: Achieving Peptide Folding and Exocyclic N-Functionalization in One Shot.

J Org Chem 2015 Jul 17;80(13):6697-707. Epub 2015 Jun 17.

†Center for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400, La Habana, Cuba.

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http://dx.doi.org/10.1021/acs.joc.5b00858DOI Listing
July 2015

Organoselenocyanates and symmetrical diselenides redox modulators: Design, synthesis and biological evaluation.

Eur J Med Chem 2015 Jun 4;97:190-201. Epub 2015 May 4.

Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.05.002DOI Listing
June 2015

Integrated comparative metabolite profiling via MS and NMR techniques for Senna drug quality control analysis.

Anal Bioanal Chem 2015 Mar 11;407(7):1937-49. Epub 2015 Jan 11.

Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr el Aini st., P.B. 11562, Cairo, Egypt,

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http://dx.doi.org/10.1007/s00216-014-8432-1DOI Listing
March 2015

Synthesis of antibacterial 1,3-diyne-linked peptoids from an Ugi-4CR/Glaser coupling approach.

Beilstein J Org Chem 2015 7;11:25-30. Epub 2015 Jan 7.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle/Saale, Germany.

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http://dx.doi.org/10.3762/bjoc.11.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311588PMC
February 2015

Profiling the chemical content of Ficus lyrata extracts via UPLC-PDA-qTOF-MS and chemometrics.

Nat Prod Res 2014 17;28(19):1549-56. Epub 2014 Jun 17.

a Pharmacognosy Department , Faculty of Pharmacy, Cairo University , Kasr El-Aini 11562 , Egypt.

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http://dx.doi.org/10.1080/14786419.2014.926353DOI Listing
January 2015

Bidirectional macrocyclization of peptides by double multicomponent reactions.

Org Biomol Chem 2015 Jan;13(2):438-46

Center for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400, La Habana, Cuba.

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http://dx.doi.org/10.1039/c4ob01915fDOI Listing
January 2015

Screening of synthetic and natural product databases: Identification of novel androgens and antiandrogens.

Eur J Med Chem 2015 Jan 13;90:267-79. Epub 2014 Nov 13.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle/Saale, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.11.026DOI Listing
January 2015

Unequivocal glycyrrhizin isomer determination and comparative in vitro bioactivities of root extracts in four Glycyrrhiza species.

J Adv Res 2015 Jan 14;6(1):99-104. Epub 2014 May 14.

Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1016/j.jare.2014.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293670PMC
January 2015

Developmental changes in leaf phenolics composition from three artichoke cvs. (Cynara scolymus) as determined via UHPLC-MS and chemometrics.

Phytochemistry 2014 Dec 20;108:67-76. Epub 2014 Nov 20.

Leibniz Institute of Plant Biochemistry, Dept. Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1016/j.phytochem.2014.09.004DOI Listing
December 2014

A multicomponent conjugation strategy to unique N-steroidal peptides: first evidence of the steroidal nucleus as a β-turn inducer in acyclic peptides.

Chemistry 2014 Oct 11;20(41):13150-61. Epub 2014 Sep 11.

Center for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400, La Habana (Cuba).

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http://dx.doi.org/10.1002/chem.201403773DOI Listing
October 2014

Metabolomic fingerprints of 21 date palm fruit varieties from Egypt using UPLC/PDA/ESI-qTOF-MS and GC-MS analyzed by chemometrics.

Food Res Int 2014 Oct 20;64:218-226. Epub 2014 Jun 20.

Leibniz Institute of Plant Biochemistry, Dept. Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.foodres.2014.06.021DOI Listing
October 2014

Rare biscoumarin derivatives and flavonoids from Hypericum riparium.

Phytochemistry 2014 Sep 11;105:171-7. Epub 2014 Jun 11.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2014.05.008DOI Listing
September 2014

Palladium-catalyzed direct arylation of selenophene.

J Org Chem 2014 Jul 16;79(13):5987-92. Epub 2014 Jun 16.

Instituto de Química, Departamento de Química Orgânica, Universidade Federal do Rio Grande do Sul , UFRGS, 91501-970 Porto Alegre-RS, Brazil.

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http://dx.doi.org/10.1021/jo500094tDOI Listing
July 2014

Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids.

Beilstein J Org Chem 2014 5;10:1017-22. Epub 2014 May 5.

Laboratório de Química Metodológica e Orgânica Sintética, Instituto de Química, Universidade de Brasília, CP 4478, 70910-970 Brasília-DF, Brazil.

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http://dx.doi.org/10.3762/bjoc.10.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077530PMC
July 2014

Metabolomics driven analysis of six Nigella species seeds via UPLC-qTOF-MS and GC-MS coupled to chemometrics.

Food Chem 2014 May 16;151:333-42. Epub 2013 Nov 16.

Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1016/j.foodchem.2013.11.032DOI Listing
May 2014

Phytochemical, phylogenetic, and anti-inflammatory evaluation of 43 Urtica accessions (stinging nettle) based on UPLC-Q-TOF-MS metabolomic profiles.

Phytochemistry 2013 Dec 26;96:170-83. Epub 2013 Oct 26.

Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr el Aini st., P.B. 11562, Cairo, Egypt; Leibniz Institute of Plant Biochemistry, Dept. Bioorganic Chemistry, Weinberg 3, D-06120Halle (Saale), Germany.

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http://dx.doi.org/10.1016/j.phytochem.2013.09.016DOI Listing
December 2013

Metabolomics driven analysis of artichoke leaf and its commercial products via UHPLC-q-TOF-MS and chemometrics.

Phytochemistry 2013 Nov 29;95:177-87. Epub 2013 Jul 29.

Pharmacognosy Department, College of Pharmacy, Cairo University, Cairo, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2013.07.003DOI Listing
November 2013

Total synthesis of epothilone D: the nerol/macroaldolization approach.

J Org Chem 2013 Nov 22;78(21):10588-95. Epub 2013 Oct 22.

Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry , Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1021/jo401355rDOI Listing
November 2013

Cytotoxic effect of commercial Humulus lupulus L. (hop) preparations - In comparison to its metabolomic fingerprint.

J Adv Res 2013 Jul 4;4(4):417-21. Epub 2012 Sep 4.

Leibniz Institute of Plant Biochemistry, Dept. of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1016/j.jare.2012.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293872PMC
July 2013

A multiple multicomponent approach to chimeric peptide-peptoid podands.

Chemistry 2013 May 19;19(20):6417-28. Epub 2013 Mar 19.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle/Saale, Germany.

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http://dx.doi.org/10.1002/chem.201201591DOI Listing
May 2013

Alkylating enzymes.

Curr Opin Chem Biol 2013 Apr 18;17(2):229-35. Epub 2013 Mar 18.

Leibniz-Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle, Germany.

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http://dx.doi.org/10.1016/j.cbpa.2013.02.016DOI Listing
April 2013

Direct synthesis of sensitive selenocysteine peptides by the Ugi reaction.

Org Biomol Chem 2012 Dec 31;10(47):9330-3. Epub 2012 Oct 31.

Leibniz-Institut für Pflanzenbiochemie, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1039/c2ob26552dDOI Listing
December 2012

The multicomponent approach to N-methyl peptides: total synthesis of antibacterial (-)-viridic acid and analogues.

Beilstein J Org Chem 2012 28;8:2085-90. Epub 2012 Nov 28.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany, Tel: +49 345 5582 1301, Address for correspondence).

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http://dx.doi.org/10.3762/bjoc.8.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511043PMC
December 2012

Volatiles profiling in medicinal licorice roots using steam distillation and solid-phase microextraction (SPME) coupled to chemometrics.

J Food Sci 2012 Nov 5;77(11):C1179-84. Epub 2012 Nov 5.

Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.1111/j.1750-3841.2012.02927.xDOI Listing
November 2012

Characterization of Constituents and Anthelmintic Properties of Hagenia abyssinica.

Sci Pharm 2012 Apr-Jun;80(2):433-46. Epub 2012 Mar 2.

Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

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http://dx.doi.org/10.3797/scipharm.1109-04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383206PMC
October 2012

Carbohydrate-steroid conjugation by Ugi reaction: one-pot synthesis of triple sugar/pseudo-peptide/spirostane hybrids.

Carbohydr Res 2012 Oct 11;359:102-10. Epub 2012 May 11.

Center for Natural Products Study, Faculty of Chemistry, University of Havana, La Habana, Cuba.

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http://dx.doi.org/10.1016/j.carres.2012.05.003DOI Listing
October 2012

Synthesis of (-)-julocrotine and a diversity oriented Ugi-approach to analogues and probes.

Beilstein J Org Chem 2011 7;7:1504-7. Epub 2011 Nov 7.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.

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http://dx.doi.org/10.3762/bjoc.7.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252850PMC
August 2012

Traceless tosylhydrazone-based triazole formation: a metal-free alternative to strain-promoted azide-alkyne cycloaddition.

Angew Chem Int Ed Engl 2012 May 18;51(22):5343-6. Epub 2012 Apr 18.

Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, Halle, Germany.

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http://dx.doi.org/10.1002/anie.201108850DOI Listing
May 2012

Comparative metabolite profiling and fingerprinting of medicinal licorice roots using a multiplex approach of GC-MS, LC-MS and 1D NMR techniques.

Phytochemistry 2012 Apr 13;76:60-72. Epub 2012 Feb 13.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.

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http://dx.doi.org/10.1016/j.phytochem.2011.12.010DOI Listing
April 2012

Metabolome classification of commercial Hypericum perforatum (St. John's Wort) preparations via UPLC-qTOF-MS and chemometrics.

Planta Med 2012 Mar 23;78(5):488-96. Epub 2012 Jan 23.

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle-Saale, Germany.

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http://dx.doi.org/10.1055/s-0031-1298170DOI Listing
March 2012

Fast and efficient MCR-based synthesis of clickable rhodamine tags for protein profiling.

Org Biomol Chem 2012 Feb 1;10(5):958-65. Epub 2011 Dec 1.

Leibniz-Institute of Plant Biochemistry, Dept. of Bioorganic Chemistry, Weinberg 3, 06120, Halle, Germany.

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http://xlink.rsc.org/?DOI=C1OB06581E
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http://dx.doi.org/10.1039/c1ob06581eDOI Listing
February 2012