Lucy S K Walker

Lucy S K Walker

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Lucy S K Walker

Lucy S K Walker

Publications by authors named "Lucy S K Walker"

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T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship.

Front Immunol 2018 27;9:1941. Epub 2018 Aug 27.

Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, United Kingdom.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01941
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http://dx.doi.org/10.3389/fimmu.2018.01941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119692PMC
September 2019

Tipping the balance: inhibitory checkpoints in intestinal homeostasis.

Mucosal Immunol 2019 01 29;12(1):21-35. Epub 2018 Nov 29.

Laboratory of Pediatrics, Division Gastroenterology and Nutrition, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41385-018-0113-5DOI Listing
January 2019

Characterization of CTLA4 Trafficking and Implications for Its Function.

Biophys J 2018 10 23;115(7):1330-1343. Epub 2018 Aug 23.

Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany; Centre for Individualised Infection Medicine, Hannover, Germany; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063495183097
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http://dx.doi.org/10.1016/j.bpj.2018.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170599PMC
October 2018

Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells.

J Exp Med 2018 04 16;215(4):1227-1243. Epub 2018 Mar 16.

Institute of Immunology and Immunotherapy, Medical School/IBR, University of Birmingham, Birmingham, England, UK

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http://dx.doi.org/10.1084/jem.20160832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881458PMC
April 2018

Study of an extended family with CTLA-4 deficiency suggests a CD28/CTLA-4 independent mechanism responsible for differences in disease manifestations and severity.

Clin Immunol 2018 03 3;188:94-102. Epub 2018 Jan 3.

Seccion de Infectología e Inmunopatología, Unidad de Pediatria, Hospital Virgen del Rocío, Sevilla, Instituto de Biomedicina de Sevilla (IBiS), Spain.

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http://dx.doi.org/10.1016/j.clim.2018.01.001DOI Listing
March 2018

MAIT cells in type 1 diabetes: a good friend turned bad.

Nat Immunol 2017 11;18(12):1283-1285

Institute of Immunity & Transplantation, University College London Division of Infection & Immunity, Royal Free Campus, London, UK.

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http://dx.doi.org/10.1038/ni.3869DOI Listing
November 2017

Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes.

Diabetologia 2017 07 17;60(7):1294-1303. Epub 2017 Feb 17.

Diabetes and Metabolism, Level 2 Learning and Research, University of Bristol, Southmead Hospital, Bristol, BS10 5NB, UK.

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http://dx.doi.org/10.1007/s00125-017-4221-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487689PMC
July 2017

PD-1 and CTLA4: Two checkpoints, one pathway?

Authors:
Lucy S K Walker

Sci Immunol 2017 May;2(11)

Institute of Immunity & Transplantation, University College London Division of Infection & Immunity, Royal Free Campus, London, UK NW3 2PF.

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http://dx.doi.org/10.1126/sciimmunol.aan3864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436606PMC
May 2017

EFIS Lecture: Understanding the CTLA-4 checkpoint in the maintenance of immune homeostasis.

Authors:
Lucy S K Walker

Immunol Lett 2017 04 16;184:43-50. Epub 2017 Feb 16.

Institute of Immunity & Transplantation, University College London Division of Infection & Immunity, Royal Free Campus, London, NW3 2PF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2017.02.007DOI Listing
April 2017

Follicular T Helper Cells: A New Marker of Type 1 Diabetes Risk?

Diabetes 2017 02;66(2):258-260

Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, U.K.

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http://dx.doi.org/10.2337/dbi16-0062DOI Listing
February 2017

Regulatory T Cells in Autoimmune Diabetes: Mechanisms of Action and Translational Potential.

Prog Mol Biol Transl Sci 2015 9;136:245-77. Epub 2015 Sep 9.

Institute of Immunity & Transplantation, Division of Infection & Immunity, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/bs.pmbts.2015.08.004DOI Listing
November 2016

Contemplating autoimmunity in the Aegean islands.

Nat Immunol 2016 Mar;17(3):218-20

Institute of Experimental Immunology, Inflammation Research Unit, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/ni.3367DOI Listing
March 2016

CTLA-4 and Autoimmunity: New Twists in the Tale.

Authors:
Lucy S K Walker

Trends Immunol 2015 Dec 28;36(12):760-762. Epub 2015 Nov 28.

Institute for Immunity & Transplantation, University College London Division of Infection & Immunity, Royal Free Campus, London, NW3 2PF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.it.2015.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681878PMC
December 2015

T-Regulatory Cells and Inflammatory and Inhibitory Cytokines in Malawian Children Residing in an Area of High and an Area of Low Malaria Transmission During Acute Uncomplicated Malaria and in Convalescence.

J Pediatric Infect Dis Soc 2015 Sep 7;4(3):232-41. Epub 2015 Jan 7.

Malawi-Liverpool Wellcome Trust Clinical Research Programme , College of Medicine , Blantyre ; Basic Medical Sciences Department , College of Medicine , Blantyre, Malawi.

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http://dx.doi.org/10.1093/jpids/piu140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554200PMC
September 2015

A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.

J Immunol 2015 Mar 28;194(5):2148-59. Epub 2015 Jan 28.

Division of Infection and Immunity, Department of Immunology, Institute of Immunity and Transplantation, University College London, Royal Free Hospital, London NW3 2PF, United Kingdom; and

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http://dx.doi.org/10.4049/jimmunol.1401876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522736PMC
March 2015

Confusing signals: recent progress in CTLA-4 biology.

Trends Immunol 2015 Feb 9;36(2):63-70. Epub 2015 Jan 9.

Institute for Immunity & Transplantation, University College London Division of Infection & Immunity, Royal Free Campus, London, NW3 2PF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.it.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323153PMC
February 2015

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.

Proc Natl Acad Sci U S A 2015 Jan 29;112(2):524-9. Epub 2014 Dec 29.

Institute of Immunity and Transplantation, University College London Division of Infection and Immunity, London, United Kingdom NW3 2PF; and

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http://dx.doi.org/10.1073/pnas.1414576112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299196PMC
January 2015

Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs.

Immunol Rev 2014 May;259(1):23-39

Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

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http://doi.wiley.com/10.1111/imr.12165
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http://dx.doi.org/10.1111/imr.12165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237543PMC
May 2014

IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells.

J Immunol 2014 Mar 27;192(5):2195-201. Epub 2014 Jan 27.

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1302082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932810PMC
March 2014

Treg and CTLA-4: two intertwining pathways to immune tolerance.

Authors:
Lucy S K Walker

J Autoimmun 2013 Sep 10;45:49-57. Epub 2013 Jul 10.

Institute of Immunity & Transplantation, University College London Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411130008
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http://dx.doi.org/10.1016/j.jaut.2013.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989116PMC
September 2013

CD28 costimulation: walking the immunological tightrope.

Eur J Immunol 2013 Jan;43(1):42-5

MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1002/eji.201243211DOI Listing
January 2013

Maintaining a competitive edge: new rules for peripheral T cell homeostasis.

Authors:
Lucy S K Walker

Immunity 2012 Oct;37(4):598-600

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, UK.

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http://dx.doi.org/10.1016/j.immuni.2012.10.005DOI Listing
October 2012

Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.

J Immunol 2012 Aug 29;189(3):1118-22. Epub 2012 Jun 29.

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1200972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442233PMC
August 2012

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.

Blood 2012 May 22;119(20):4656-64. Epub 2012 Mar 22.

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK.

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http://dx.doi.org/10.1182/blood-2011-10-388546DOI Listing
May 2012

Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model.

Diabetes Metab Res Rev 2011 Nov;27(8):946-50

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1002/dmrr.1277DOI Listing
November 2011

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.

Nat Rev Immunol 2011 11 25;11(12):852-63. Epub 2011 Nov 25.

MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK.

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http://dx.doi.org/10.1038/nri3108DOI Listing
November 2011

Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.

J Exp Med 2011 Aug 25;208(8):1579-84. Epub 2011 Jul 25.

MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham B15 2TT, England, UK.

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http://dx.doi.org/10.1084/jem.20101484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149223PMC
August 2011

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.

Science 2011 Apr 7;332(6029):600-3. Epub 2011 Apr 7.

Medical Research Council (MRC) Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1126/science.1202947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198051PMC
April 2011

B1 cells promote pancreas infiltration by autoreactive T cells.

J Immunol 2010 Sep 30;185(5):2800-7. Epub 2010 Jul 30.

Medical Research Council Center for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1000856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983558PMC
September 2010

Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.

J Immunol 2010 Mar 17;184(6):2886-98. Epub 2010 Feb 17.

Centre for Liver Research, Institute of Biomedical Research, The University of Birmingham Medical School, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.0901216DOI Listing
March 2010

1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.

J Immunol 2009 Nov;183(9):5458-67

Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.0803217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810518PMC
November 2009

Regulatory T cells overturned: the effectors fight back.

Authors:
Lucy S K Walker

Immunology 2009 Apr;126(4):466-74

MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK.

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http://dx.doi.org/10.1111/j.1365-2567.2009.03053.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673359PMC
April 2009

Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.

J Immunol 2009 Jan;182(1):274-82

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.182.1.274DOI Listing
January 2009

Natural Treg in autoimmune diabetes: all present and correct?

Authors:
Lucy S K Walker

Expert Opin Biol Ther 2008 Nov;8(11):1691-703

University of Birmingham Medical School, Medical Research Council Centre for Immune Regulation, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1517/14712598.8.11.1691 DOI Listing
November 2008

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.

J Immunol 2008 Aug;181(3):1683-91

Division of Immunity and Infection, Medical Research Council Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758479PMC
http://dx.doi.org/10.4049/jimmunol.181.3.1683DOI Listing
August 2008

Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21.

J Immunol 2008 Apr;180(8):5393-401

Medical Research Council Center for Immune Regulation, University of Birmingham Medical School, Birmingham, UK.

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http://dx.doi.org/10.4049/jimmunol.180.8.5393DOI Listing
April 2008

Regulatory T cells: Folate receptor 4: a new handle on regulation and memory?

Authors:
Lucy S K Walker

Immunol Cell Biol 2007 Oct 21;85(7):506-7. Epub 2007 Aug 21.

Medical Research Council Center for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1038/sj.icb.7100115DOI Listing
October 2007

Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen.

Blood 2007 Feb 3;109(4):1602-10. Epub 2006 Oct 3.

Medical Research Council, Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, UK.

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http://dx.doi.org/10.1182/blood-2006-04-018465DOI Listing
February 2007

The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology.

Immunol Rev 2006 Aug;212:131-48

MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK.

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http://dx.doi.org/10.1111/j.0105-2896.2006.00419.xDOI Listing
August 2006

Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.

J Immunol 2006 Jul;177(1):593-603

Liver Research Laboratories, Medical Research Council for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK.

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http://dx.doi.org/10.4049/jimmunol.177.1.593DOI Listing
July 2006

CTLA4 gene polymorphism and autoimmunity.

Immunol Rev 2005 Apr;204:102-15

Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham B9 5SS, UK.

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http://dx.doi.org/10.1111/j.0105-2896.2005.00249.xDOI Listing
April 2005

CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion.

J Immunol 2004 Sep;173(5):2942-51

Medical Research Council Center for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.173.5.2942DOI Listing
September 2004

Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen.

J Exp Med 2004 Jun;199(12):1725-30

Department of Pathology, University of California, San Francisco, M590, 505 Parnassus Ave., San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1084/jem.20040124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212810PMC
June 2004

CD4+ CD25+ Treg: divide and rule?

Authors:
Lucy S K Walker

Immunology 2004 Feb;111(2):129-37

MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK.

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http://dx.doi.org/10.1111/j.0019-2805.2003.01788.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782405PMC
February 2004

Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo.

J Exp Med 2003 Jul;198(2):249-58

MRC Centre for Immune Regulation, University of Birmingham Medical School, Vincent Drive, Birmingham B15 2TT, United Kingdom.

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http://www.jem.org/lookup/doi/10.1084/jem.20030315
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http://dx.doi.org/10.1084/jem.20030315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194065PMC
July 2003

CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen.

J Immunol 2002 Dec;169(11):6202-9

Department of Pathology, University of California, San Francisco 94143, USA.

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http://dx.doi.org/10.4049/jimmunol.169.11.6202DOI Listing
December 2002

Functional tolerance is maintained despite proliferation of CD4 T cells after encounter with tissue-derived antigen.

Dev Immunol 2002 Sep;9(3):173-6

Department of Pathology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276103PMC
September 2002

The enemy within: keeping self-reactive T cells at bay in the periphery.

Nat Rev Immunol 2002 Jan;2(1):11-9

Department of Pathology, University of California San Francisco, 94143, USA.

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http://dx.doi.org/10.1038/nri701DOI Listing
January 2002