Lucio G Costa

Lucio G Costa

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Lucio G Costa

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Prenatal and early life diesel exhaust exposure disrupts cortical lamina organization: Evidence for a reelin-related pathogenic pathway induced by interleukin-6.

Brain Behav Immun 2019 May 19;78:105-115. Epub 2019 Jan 19.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Center on Human Development and Disability, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557404PMC
May 2019

Acute exposure to diesel exhaust impairs adult neurogenesis in mice: prominence in males and protective effect of pioglitazone.

Arch Toxicol 2018 05 10;92(5):1815-1829. Epub 2018 Mar 10.

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt, Suite No. 100, Seattle, WA, 98105, USA.

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http://link.springer.com/10.1007/s00204-018-2180-5
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http://dx.doi.org/10.1007/s00204-018-2180-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538829PMC
May 2018

Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice.

Part Fibre Toxicol 2018 04 20;15(1):18. Epub 2018 Apr 20.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1186/s12989-018-0254-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910592PMC
April 2018

Organophosphorus Compounds at 80: Some Old and New Issues.

Authors:
Lucio G Costa

Toxicol Sci 2018 03;162(1):24-35

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105.

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https://academic.oup.com/toxsci/article/162/1/24/4706006
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http://dx.doi.org/10.1093/toxsci/kfx266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693380PMC
March 2018

Paraoxonase-1 and Early-Life Environmental Exposures.

Ann Glob Health 2016 Jan-Feb;82(1):100-10

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA. Electronic address:

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http://dx.doi.org/10.1016/j.aogh.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916371PMC
January 2018

Metals and Paraoxonases.

Adv Neurobiol 2017 ;18:85-111

Department of Medicine (Division of Medical Genetics), University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA, 98105, USA.

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http://link.springer.com/10.1007/978-3-319-60189-2_5
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http://dx.doi.org/10.1007/978-3-319-60189-2_5DOI Listing
December 2017

Neurobehavioral assessment of mice following repeated oral exposures to domoic acid during prenatal development.

Neurotoxicol Teratol 2017 Nov 13;64:8-19. Epub 2017 Sep 13.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, United States; Institute for Risk Analysis and Risk Communication, University of Washington, Seattle, WA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ntt.2017.09.002DOI Listing
November 2017

Co-Culture of Neurons and Microglia.

Curr Protoc Toxicol 2017 Nov 8;74:11.24.1-11.24.17. Epub 2017 Nov 8.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1002/cptx.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774987PMC
November 2017

Overview of Neurotoxicology.

Authors:
Lucio G Costa

Curr Protoc Toxicol 2017 Nov 8;74:11.1.1-11.1.11. Epub 2017 Nov 8.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1002/cptx.36DOI Listing
November 2017

Developmental Neurotoxicity of Traffic-Related Air Pollution: Focus on Autism.

Curr Environ Health Rep 2017 06;4(2):156-165

Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt, Suite No. 100, Seattle, WA, 98105, USA.

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http://dx.doi.org/10.1007/s40572-017-0135-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952375PMC
June 2017

Behavioral Phenotyping for Autism Spectrum Disorders in Mice.

Curr Protoc Toxicol 2017 May 2;72:11.22.1-11.22.21. Epub 2017 May 2.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.

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http://doi.wiley.com/10.1002/cptx.19
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http://dx.doi.org/10.1002/cptx.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494990PMC
May 2017

Neurotoxicity of traffic-related air pollution.

Neurotoxicology 2017 03 21;59:133-139. Epub 2015 Nov 21.

Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.neuro.2015.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875879PMC
March 2017

Neural mechanisms of functional impairment across the lifespan: The 15th Biennial Meeting of the International Neurotoxicology Association and 39th Annual Meeting of the Neurobehavioral Teratology Society.

Neurotoxicology 2017 03;59:131-132

Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL-3508, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.neuro.2017.03.003DOI Listing
March 2017

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More.

Oxid Med Cell Longev 2016 24;2016:2986796. Epub 2016 Jan 24.

Department of Neuroscience, University of Parma Medical School, 43100 Parma, Italy.

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http://dx.doi.org/10.1155/2016/2986796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745323PMC
December 2016

Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain.

Toxicology 2016 Dec 16;374:1-9. Epub 2016 Nov 16.

Dept. of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Dept. of Neuroscience, University of Parma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154914PMC
December 2016

Developmental expression of paraoxonase 2.

Chem Biol Interact 2016 Nov 7;259(Pt B):168-174. Epub 2016 Apr 7.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, United States; Dept. of Neuroscience, University of Parma, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055469PMC
http://dx.doi.org/10.1016/j.cbi.2016.04.001DOI Listing
November 2016

Paraoxonases-1, -2 and -3: What are their functions?

Chem Biol Interact 2016 Nov 26;259(Pt B):51-62. Epub 2016 May 26.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Neuroscience, University of Parma, Parma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391248PMC
November 2016

Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms.

Neurotoxicology 2016 09 16;56:204-214. Epub 2016 Aug 16.

Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Department of Neuroscience, University of Parma, Italy. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048600PMC
http://dx.doi.org/10.1016/j.neuro.2016.08.006DOI Listing
September 2016

The neurotoxicity of organochlorine and pyrethroid pesticides.

Authors:
Lucio G Costa

Handb Clin Neurol 2015 ;131:135-48

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA and Department of Neuroscience, University of Parma, Parma, Italy. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-62627-1.00009-3DOI Listing
August 2016

The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice.

Neurotoxicology 2015 May 19;48:68-76. Epub 2015 Mar 19.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.neuro.2015.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442709PMC
May 2015

Prenatal Ethanol Exposure Up-Regulates the Cholesterol Transporters ATP-Binding Cassette A1 and G1 and Reduces Cholesterol Levels in the Developing Rat Brain.

Alcohol Alcohol 2014 Nov 31;49(6):626-34. Epub 2014 Jul 31.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA Jesse Brown VA Medical Center, Chicago, IL, USA

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http://dx.doi.org/10.1093/alcalc/agu049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834908PMC
November 2014

A mechanistic view of polybrominated diphenyl ether (PBDE) developmental neurotoxicity.

Toxicol Lett 2014 Oct 20;230(2):282-94. Epub 2013 Nov 20.

Department of Neuroscience, University of Parma, Parma, Italy.

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http://dx.doi.org/10.1016/j.toxlet.2013.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028440PMC
October 2014

Neurotoxicants are in the air: convergence of human, animal, and in vitro studies on the effects of air pollution on the brain.

Biomed Res Int 2014 12;2014:736385. Epub 2014 Jan 12.

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt, Suite No. 100, Seattle, WA 98105, USA.

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http://downloads.hindawi.com/journals/bmri/2014/736385.pdf
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http://www.hindawi.com/journals/bmri/2014/736385/
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http://dx.doi.org/10.1155/2014/736385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912642PMC
September 2014

Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection.

Neurotoxicology 2014 Jul 4;43:3-9. Epub 2013 Sep 4.

Division of Medical Genetics and Department of Genome Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.neuro.2013.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942372PMC
July 2014

Synaptic structure quantification in cultured neurons.

Curr Protoc Toxicol 2014 May 27;60:12.22.1-32. Epub 2014 May 27.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1002/0471140856.tx1222s60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318557PMC
May 2014

Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione.

Toxicology 2014 Apr 19;318:59-68. Epub 2014 Feb 19.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Neuroscience, University of Parma, Parma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2014.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999384PMC
April 2014

Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons.

Toxicol Appl Pharmacol 2014 Feb 14;274(3):372-82. Epub 2013 Dec 14.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Neuroscience, University of Parma, Parma, Italy.

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http://dx.doi.org/10.1016/j.taap.2013.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916905PMC
February 2014

Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin: a mechanism of neuroprotection?

Neurochem Res 2013 Sep 7;38(9):1809-18. Epub 2013 Jun 7.

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1007/s11064-013-1085-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735620PMC
September 2013

Developmental neurotoxicity: some old and new issues.

ISRN Toxicol 2012 24;2012:814795. Epub 2012 Jun 24.

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA.

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http://dx.doi.org/10.5402/2012/814795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658697PMC
June 2013

Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity.

Toxicology 2013 May 31;307:115-22. Epub 2012 Jul 31.

Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X120028
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http://dx.doi.org/10.1016/j.tox.2012.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631PMC
May 2013

Protein adducts as biomarkers of exposure to organophosphorus compounds.

Toxicology 2013 May 20;307:46-54. Epub 2012 Dec 20.

Departments of Medicine (Division of Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.tox.2012.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747771PMC
May 2013

The birth and early years of INA, the International Neurotoxicology Association.

Authors:
Lucio G Costa

Neurotoxicology 2013 May 26;36:89-103. Epub 2013 Mar 26.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0161813X1300046
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http://dx.doi.org/10.1016/j.neuro.2013.03.006DOI Listing
May 2013

Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione.

Toxicol Sci 2013 Apr 12;132(2):399-408. Epub 2013 Jan 12.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA.

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https://academic.oup.com/toxsci/article/1671205/Low-Level
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http://dx.doi.org/10.1093/toxsci/kft002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693515PMC
April 2013

Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis.

Biochim Biophys Acta 2013 Feb 23;1831(2):263-75. Epub 2012 Sep 23.

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt way NE, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.bbalip.2012.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534809PMC
February 2013

Evaluation of DNA damage induced by 2 polybrominated diphenyl ether flame retardants (BDE-47 and BDE-209) in SK-N-MC cells.

Int J Toxicol 2012 Jul-Aug;31(4):372-9. Epub 2012 Jun 18.

Department of Human Anatomy, Pharmacology, and Forensic Sciences, University of Parma Medical School, Parma, Italy.

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http://dx.doi.org/10.1177/1091581812449663DOI Listing
December 2012

An interview with Lucio G. Costa and Michael Aschner, section editors for toxicology.

BMC Pharmacol Toxicol 2012 Nov 15;13:16. Epub 2012 Nov 15.

Department of Environmental and Occupational Health Sciences University of Washington, 4225 Roosevelt #100, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1186/2050-6511-13-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544138PMC
November 2012

Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon.

Neurotoxicol Teratol 2012 May-Jun;34(3):311-22. Epub 2012 Mar 7.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.ntt.2012.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367041PMC
October 2012

Morphological assessment of neurite outgrowth in hippocampal neuron-astrocyte co-cultures.

Curr Protoc Toxicol 2012 May;Chapter 11:Unit 11.16.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1002/0471140856.tx1116s52DOI Listing
May 2012

Ethanol impairs muscarinic receptor-induced neuritogenesis in rat hippocampal slices: Role of astrocytes and extracellular matrix proteins.

Biochem Pharmacol 2011 Dec 23;82(11):1792-9. Epub 2011 Aug 23.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.bcp.2011.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205233PMC
December 2011

Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?

Toxicol Appl Pharmacol 2011 Nov 23;256(3):369-78. Epub 2011 Feb 23.

Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.taap.2011.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155737PMC
November 2011

In vitro neurotoxicology: an introduction.

Methods Mol Biol 2011 ;758:1-9

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-61779-170-3_1DOI Listing
November 2011

Primary neurons in culture and neuronal cell lines for in vitro neurotoxicological studies.

Methods Mol Biol 2011 ;758:13-27

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-61779-170-3_2DOI Listing
November 2011

Measurements of cell death in neuronal and glial cells.

Methods Mol Biol 2011 ;758:171-8

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-61779-170-3_11DOI Listing
November 2011

Measurements of neuronal apoptosis.

Methods Mol Biol 2011 ;758:179-93

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-61779-170-3_12DOI Listing
November 2011

Assessment of glutathione homeostasis.

Methods Mol Biol 2011 ;758:205-14

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-61779-170-3_14DOI Listing
November 2011

Measurements of astrocyte proliferation.

Methods Mol Biol 2011 ;758:349-59

Department of Psychiatry, Jesse Brown VA Medical Center, University of Illinois at Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1007/978-1-61779-170-3_24DOI Listing
November 2011

Quantification of synaptic structure formation in cocultures of astrocytes and hippocampal neurons.

Methods Mol Biol 2011 ;758:361-90

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-61779-170-3_25DOI Listing
November 2011

Assessment of cholesterol homeostasis in astrocytes and neurons.

Methods Mol Biol 2011 ;758:403-14

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://link.springer.com/10.1007/978-1-61779-170-3_27
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http://dx.doi.org/10.1007/978-1-61779-170-3_27DOI Listing
November 2011

Retinoic acid isomers up-regulate ATP binding cassette A1 and G1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects.

J Pharmacol Exp Ther 2011 Sep 31;338(3):870-8. Epub 2011 May 31.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1124/jpet.111.182196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164352PMC
September 2011

Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression.

Toxicol Sci 2011 Sep 14;123(1):155-69. Epub 2011 Jun 14.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1093/toxsci/kfr157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164442PMC
September 2011

Behavioral Characterization of GCLM-Knockout Mice, a Model for Enhanced Susceptibility to Oxidative Stress.

J Toxicol 2011 27;2011:157687. Epub 2011 Apr 27.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1155/2011/157687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090610PMC
July 2011

Muscarinic receptor-activated signal transduction pathways involved in the neuritogenic effect of astrocytes in hippocampal neurons.

Eur J Pharmacol 2011 Jun 29;659(2-3):102-7. Epub 2011 Mar 29.

Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.ejphar.2011.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094474PMC
June 2011

Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites.

Mol Nutr Food Res 2011 May 14;55 Suppl 1:S35-43. Epub 2011 Jan 14.

Department of Agricultural and Food Sciences, University of Modena and Reggio Emilia, Via Amendola, Reggio Emilia, Italy.

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http://dx.doi.org/10.1002/mnfr.201000525DOI Listing
May 2011

Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on.

Biochem Pharmacol 2011 Feb 18;81(3):337-44. Epub 2010 Nov 18.

Dept. of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000629521000805
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http://dx.doi.org/10.1016/j.bcp.2010.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125PMC
February 2011

Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant?

Neurotoxicology 2011 Jan 21;32(1):9-24. Epub 2010 Dec 21.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.neuro.2010.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046405PMC
January 2011

Domoic acid as a developmental neurotoxin.

Neurotoxicology 2010 Sep 13;31(5):409-23. Epub 2010 May 13.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.neuro.2010.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934754PMC
September 2010

Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors.

Glia 2010 Sep;58(12):1395-406

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1002/glia.21015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925144PMC
September 2010

Long-term effects of developmental exposure to low doses of PCB 126 and methylmercury.

Toxicol Lett 2010 Aug 5;197(1):38-45. Epub 2010 May 5.

Department Physiology and Pharmacology, Sapienza University of Roma, 00185 Roma, Italy.

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http://dx.doi.org/10.1016/j.toxlet.2010.04.024DOI Listing
August 2010

Ethanol inhibits muscarinic receptor-induced axonal growth in rat hippocampal neurons.

Alcohol Clin Exp Res 2009 Nov 10;33(11):1945-55. Epub 2009 Aug 10.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2009.01032.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885893PMC
November 2009

Manganese inhibits the ability of astrocytes to promote neuronal differentiation.

Toxicol Appl Pharmacol 2009 Oct 12;240(2):226-35. Epub 2009 Jun 12.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.taap.2009.06.004DOI Listing
October 2009

The activation of M1 muscarinic receptor signaling induces neuronal differentiation in pyramidal hippocampal neurons.

J Pharmacol Exp Ther 2009 May 3;329(2):532-42. Epub 2009 Feb 3.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1124/jpet.108.150128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672861PMC
May 2009

Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds.

Toxicol Appl Pharmacol 2009 Apr 9;236(2):142-53. Epub 2009 Feb 9.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.taap.2009.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717945PMC
April 2009

Mouse cerebellar astrocytes protect cerebellar granule neurons against toxicity of the polybrominated diphenyl ether (PBDE) mixture DE-71.

Neurotoxicology 2009 Mar 25;30(2):326-9. Epub 2008 Dec 25.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.neuro.2008.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185306PMC
March 2009

Shotgun proteomics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte cholinergic stimulation.

J Neurochem 2009 Feb 10;108(4):891-908. Epub 2008 Dec 10.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05836.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754805PMC
February 2009

Polybrominated diphenyl ether (PBDE) flame retardants: environmental contamination, human body burden and potential adverse health effects.

Acta Biomed 2008 Dec;79(3):172-83

Department of Human Anatomy, Pharmacology, and Forensic Science, University of Parma Medical School, Parma, Italy.

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December 2008

Modulation of neuritogenesis by astrocyte muscarinic receptors.

J Biol Chem 2008 Nov 28;283(46):31884-97. Epub 2008 Aug 28.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA.

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http://dx.doi.org/10.1074/jbc.M801316200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581542PMC
November 2008

Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels.

Toxicol Appl Pharmacol 2008 Oct 4;232(2):161-8. Epub 2008 Jul 4.

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.taap.2008.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634604PMC
October 2008

Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.

Crit Rev Toxicol 2008 ;38 Suppl 2:1-125

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1080/10408440802272158 DOI Listing
October 2008

Sonic hedgehog in Smith-Lemli-Opitz syndrome and tumor development.

J Pediatr Hematol Oncol 2008 Sep;30(9):641-2

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1097/MPH.0b013e318180bbb9DOI Listing
September 2008

Effects of postnatal ethanol exposure at different developmental phases on neurotrophic factors and phosphorylated proteins on signal transductions in rat brain.

Neurotoxicol Teratol 2008 May-Jun;30(3):228-36. Epub 2008 Jan 26.

Environmental Health Science Laboratory, Sumitomo Chemical Co. Ltd., 3-1-98 Kasugade-Naka, Osaka 554-8559, Japan.

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http://dx.doi.org/10.1016/j.ntt.2008.01.004DOI Listing
August 2008

Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III summary and research needs.

Neurotoxicology 2008 May 23;29(3):520-31. Epub 2008 Feb 23.

European Centre for the Validation of Alternative Methods (ECVAM), Institute of Health and Consumer Protection, European Commission Joint Research Centre, Ispra (VA), Italy.

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http://dx.doi.org/10.1016/j.neuro.2008.02.008DOI Listing
May 2008

Effects of postnatal ethanol exposure on neurotrophic factors and signal transduction pathways in rat brain.

J Appl Toxicol 2008 Apr;28(3):370-6

Environmental Health Science Laboratory, Sumitomo Chemical Co. Ltd., 3-1-98 Kasugade-Naka, Konohana-Ku, Osaka 554-8558, Japan.

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http://doi.wiley.com/10.1002/jat.1288
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http://dx.doi.org/10.1002/jat.1288DOI Listing
April 2008

Neurotoxicity of pesticides: a brief review.

Front Biosci 2008 Jan 1;13:1240-9. Epub 2008 Jan 1.

Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.2741/2758DOI Listing
January 2008

Neurobehavioral assessment of rats exposed to low doses of PCB126 and methyl mercury during development.

Environ Toxicol Pharmacol 2008 Jan 26;25(1):103-13. Epub 2007 Sep 26.

Department of Human Anatomy, Pharmacology and Forensic Sciences, University of Parma Medical School, Parma, Via Volturno 39, 43100 Parma, Italy.

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http://dx.doi.org/10.1016/j.etap.2007.09.006DOI Listing
January 2008

Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cells.

Toxicol Sci 2007 Dec 5;100(2):433-44. Epub 2007 Sep 5.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1093/toxsci/kfm236DOI Listing
December 2007

Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants.

Neurotoxicology 2007 Nov 24;28(6):1047-67. Epub 2007 Aug 24.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, United States.

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http://dx.doi.org/10.1016/j.neuro.2007.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118052PMC
November 2007

Contaminants in fish: risk-benefit considerations.

Authors:
Lucio G Costa

Arh Hig Rada Toksikol 2007 Sep;58(3):367-74

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.2478/v10004-007-0025-3DOI Listing
September 2007

An in vitro approach to assess the toxicity of certain food contaminants: methylmercury and polychlorinated biphenyls.

Toxicology 2007 Jul 6;237(1-3):65-76. Epub 2007 May 6.

Department of Human Anatomy, Pharmacology and Forensic Sciences, University of Parma Medical School, Parma, Italy.

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http://dx.doi.org/10.1016/j.tox.2007.05.003DOI Listing
July 2007

Ethanol induces cholesterol efflux and up-regulates ATP-binding cassette cholesterol transporters in fetal astrocytes.

J Biol Chem 2007 Jun 3;282(26):18740-9. Epub 2007 May 3.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA.

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http://dx.doi.org/10.1074/jbc.M702398200DOI Listing
June 2007

Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency.

Toxicol Appl Pharmacol 2007 Mar 4;219(2-3):181-9. Epub 2006 Oct 4.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.taap.2006.09.016DOI Listing
March 2007

Current issues in organophosphate toxicology.

Authors:
Lucio G Costa

Clin Chim Acta 2006 Apr 6;366(1-2):1-13. Epub 2005 Dec 6.

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100 Seattle, WA 98105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000989810500627
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http://dx.doi.org/10.1016/j.cca.2005.10.008DOI Listing
April 2006

Paraoxonase (PON1): from toxicology to cardiovascular medicine.

Acta Biomed 2005 ;76 Suppl 2:50-7

Dept of Human Anatomy, Pharmacology and Forensic Science, University of Parma Medical School, Parma, Italy.

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March 2006

Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation.

Toxicology 2005 Nov 15;215(3):182-90. Epub 2005 Aug 15.

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way N.E. 100, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.tox.2005.07.004DOI Listing
November 2005

Paraoxonase 1 (PON1) status and risk of insecticide exposure.

J Biochem Mol Toxicol 2005 ;19(3):182-3

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195-7720, USA.

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http://dx.doi.org/10.1002/jbt.20079DOI Listing
October 2005

Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men.

Neurosci Lett 2005 Sep;385(2):158-62

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, #100, Seattle, WA 98105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S030439400500596
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http://dx.doi.org/10.1016/j.neulet.2005.05.035DOI Listing
September 2005

Dopamine transporter (SLC6A3) 5' region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson's disease.

Pharmacogenet Genomics 2005 Sep;15(9):659-68

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA.

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September 2005

Characterization of the in vitro transcriptional activity of polymorphic alleles of the human monoamine oxidase-B gene.

Neurosci Lett 2005 Jul 22-29;383(1-2):171-5. Epub 2005 Apr 19.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, 98105, USA.

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http://dx.doi.org/10.1016/j.neulet.2005.04.004DOI Listing
August 2005

Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism.

Pharmacogenet Genomics 2005 Aug;15(8):589-98

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195-7720, USA.

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August 2005

Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants.

Neurotoxicology 2005 Aug;26(4):651-9

Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Box 357720, Seattle, WA 98195-7720, USA.

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http://dx.doi.org/10.1016/j.neuro.2004.08.002DOI Listing
August 2005

Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioural profile: interference from the administration route.

Neurotoxicology 2005 Mar;26(2):183-92

Istituto Superiore di Sanità, Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.neuro.2004.11.005DOI Listing
March 2005

Modulation of paraoxonase (PON1) activity.

Biochem Pharmacol 2005 Feb;69(4):541-50

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520400619
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http://dx.doi.org/10.1016/j.bcp.2004.08.027DOI Listing
February 2005