Lucilla Luzi

IEO, European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Via Santa Sofia 9, 20142 Milan, Italy. Electronic address:

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January 2019

Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology.

Authors:

Stefano Amatori Giuseppe Persico Claudio Paolicelli Roman Hillje Nora Sahnane Francesco Corini Daniela Furlan Lucilla Luzi Saverio Minucci Marco Giorgio Pier Giuseppe Pelicci Mirco Fanelli

Clin Epigenetics 2018 11 16;10(1):143. Epub 2018 Nov 16.

Department of Biomolecular Sciences, Molecular Pathology Laboratory "PaoLa", University of Urbino "Carlo Bo", Via Arco d'Augusto 2, 61032, Fano, PU, Italy.

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November 2018

PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry.

Authors:

Angela Palmigiano Francesco Santaniello Aurora Cerutti Dmitry Penkov Divya Purushothaman Ekta Makhija Lucilla Luzi Fabrizio d'Adda di Fagagna Pier Giuseppe Pelicci Viveswara Shivashankar Gaetano Ivan Dellino Francesco Blasi

Sci Rep 2018 02 16;8(1):3198. Epub 2018 Feb 16.

IFOM (Foundation FIRC Institute of Molecular Oncology), via Adamello 16, 20139, Milan, Italy.

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February 2018

A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data.

Authors:

Giorgio E M Melloni Luca Mazzarella Loris Bernard Margherita Bodini Anna Russo Lucilla Luzi Pier Giuseppe Pelicci Laura Riva

Breast Cancer Res 2017 05 31;19(1):63. Epub 2017 May 31.

Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, Milan, Italy.

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May 2017

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

Cancer Discov 2016 06 13;6(6):650-63. Epub 2016 May 13.

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

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June 2016

The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations.

Blood 2015 Jan 12;125(4):600-5. Epub 2014 Dec 12.

Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Milan, Italy;

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January 2015

The genomic and epigenomic landscapes of AML.

Authors:

Luca Mazzarella Laura Riva Lucilla Luzi Chiara Ronchini Pier Giuseppe Pelicci

Semin Hematol 2014 Oct 26;51(4):259-72. Epub 2014 Aug 26.

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy. Electronic address:

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October 2014

Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy.

Authors:

Michelle B Hookham Helen C O'Donovan Rachel H Church Annie Mercier-Zuber Lucilla Luzi Simon P Curran Rosemarie M Carew Alejandra Droguett Sergio Mezzano Markus Schubert Morris F White John K Crean Derek P Brazil

FEBS J 2013 Jul 29;280(14):3232-43. Epub 2013 May 29.

Centre for Vision and Vascular Science, Queen's University Belfast, UK.

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July 2013

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging.

Authors:

Valentina Gambino Giulia De Michele Oriella Venezia Pierluigi Migliaccio Valentina Dall'Olio Loris Bernard Simone Paolo Minardi Maria Agnese Della Fazia Daniela Bartoli Giuseppe Servillo Myriam Alcalay Lucilla Luzi Marco Giorgio Heidi Scrable Pier Giuseppe Pelicci Enrica Migliaccio

Aging Cell 2013 Jun 27;12(3):435-45. Epub 2013 Mar 27.

European Institute of Oncology, Via Ripamonti 435, Milan, 20141, Italy.

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June 2013

Genome-wide mapping of human DNA-replication origins: levels of transcription at ORC1 sites regulate origin selection and replication timing.

Authors:

Gaetano Ivan Dellino Davide Cittaro Rossana Piccioni Lucilla Luzi Stefania Banfi Simona Segalla Matteo Cesaroni Ramiro Mendoza-Maldonado Mauro Giacca Pier Giuseppe Pelicci

Genome Res 2013 Jan 27;23(1):1-11. Epub 2012 Nov 27.

Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.

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January 2013

Genomics of acute myeloid leukemia: the next generation.

Authors:

Laura Riva Lucilla Luzi Pier Giuseppe Pelicci

Front Oncol 2012 1;2:40. Epub 2012 May 1.

Department of Experimental Oncology, European Institute of Oncology Milan, Italy.

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August 2012

Transcription factor binding sites are genetic determinants of retroviral integration in the human genome.

Authors:

Barbara Felice Claudia Cattoglio Davide Cittaro Anna Testa Annarita Miccio Giuliana Ferrari Lucilla Luzi Alessandra Recchia Fulvio Mavilio

PLoS One 2009 24;4(2):e4571. Epub 2009 Feb 24.

IFOM, FIRC Institute of Molecular Oncology Foundation, Milan, Italy.

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April 2009

Melanoma: targeting signaling pathways and RaLP.

Authors:

Luigi Pasini Margherita Y Turco Lucilla Luzi Ewa Aladowicz Ernesta Fagiani Luisa Lanfrancone

Expert Opin Ther Targets 2009 Jan;13(1):93-104

IFOM-IEO Campus, European Institute of Oncology, Department of Experimental Oncology, Via Adamello, 16 20139 Milan, Italy.

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January 2009

AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets.

Authors:

Alessandro Gardini Matteo Cesaroni Lucilla Luzi Akiko J Okumura Joseph R Biggs Simone P Minardi Elisa Venturini Dong-Er Zhang Pier Giuseppe Pelicci Myriam Alcalay

PLoS Genet 2008 Nov 28;4(11):e1000275. Epub 2008 Nov 28.

Department of Experimental Oncology, IEO-European Institute of Oncology, Milan, Italy.

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November 2008

CARPET: a web-based package for the analysis of ChIP-chip and expression tiling data.

Authors:

Matteo Cesaroni Davide Cittaro Alessandro Brozzi Pier Giuseppe Pelicci Lucilla Luzi

Bioinformatics 2008 Dec 21;24(24):2918-20. Epub 2008 Oct 21.

Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy.

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December 2008

RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.

Authors:

Ernesta Fagiani Giuseppina Giardina Lucilla Luzi Matteo Cesaroni Micaela Quarto Maria Capra Giovanni Germano Maria Bono Manuela Capillo PierGiuseppe Pelicci Luisa Lanfrancone

Cancer Res 2007 Apr;67(7):3064-73

Department of Experimental Oncology, European Institute of Oncology, Universita' degli Studi di Milano, Milan, Italy.

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April 2007

Myc-binding-site recognition in the human genome is determined by chromatin context.

Authors:

Ernesto Guccione Francesca Martinato Giacomo Finocchiaro Lucilla Luzi Laura Tizzoni Valentina Dall' Olio Giuseppe Zardo Clara Nervi Loris Bernard Bruno Amati

Nat Cell Biol 2006 Jul 11;8(7):764-70. Epub 2006 Jun 11.

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Milan 20139, Italy.

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July 2006

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia.

Blood 2006 Sep 23;108(6):1999-2005. Epub 2006 May 23.

Institute of Hematology, Policlinico Monteluce, 06122 Perugia, Italy.

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September 2006

Complex Loci in human and mouse genomes.

PLoS Genet 2006 Apr 28;2(4):e47. Epub 2006 Apr 28.

Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, Bergen, Norway.

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April 2006

Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.

Authors:

Emanuela Colombo Paola Martinelli Raffaella Zamponi Danielle C Shing Paola Bonetti Lucilla Luzi Sara Volorio Loris Bernard Giancarlo Pruneri Myriam Alcalay Pier Giuseppe Pelicci

Cancer Res 2006 Mar;66(6):3044-50

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

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March 2006

Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis.

Authors:

Marco Giorgio Enrica Migliaccio Francesca Orsini Demis Paolucci Maurizio Moroni Cristina Contursi Giovanni Pelliccia Lucilla Luzi Saverio Minucci Massimo Marcaccio Paolo Pinton Rosario Rizzuto Paolo Bernardi Francesco Paolucci Pier Giuseppe Pelicci

Cell 2005 Jul;122(2):221-33

Experimental Oncology Department, European Institute of Oncology, Milan, Italy.

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July 2005

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance.

Authors:

Myriam Alcalay Enrico Tiacci Roberta Bergomas Barbara Bigerna Elisa Venturini Simone P Minardi Natalia Meani Daniela Diverio Loris Bernard Laura Tizzoni Sara Volorio Lucilla Luzi Emanuela Colombo Francesco Lo Coco Cristina Mecucci Brunangelo Falini Pier Giuseppe Pelicci

Blood 2005 Aug 14;106(3):899-902. Epub 2005 Apr 14.

IFOM-IEO Campus, Via Adamello 16, 20139, Milan, Italy.

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August 2005

DG-CST (Disease Gene Conserved Sequence Tags), a database of human-mouse conserved elements associated to disease genes.

Authors:

Angelo Boccia Mauro Petrillo Diego di Bernardo Alessandro Guffanti Flavio Mignone Stefano Confalonieri Lucilla Luzi Graziano Pesole Giovanni Paolella Andrea Ballabio Sandro Banfi

Nucleic Acids Res 2005 Jan;33(Database issue):D505-10

CEINGE Biotecnologie Avanzate, Naples, Italy.

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January 2005

Automated DNA chip annotation tables at IFOM: the importance of synchronisation and cross-referencing of sequence databases.

Authors:

Alessandro Guffanti Giacomo Finocchiaro James F Reid Lucilla Luzi Myriam Alcalay Stefano Confalonieri Lelio Lassandro Heiko Muller

Appl Bioinformatics 2003 ;2(4):245-9

FIRC Institute of Molecular Oncology, Milan, Italy.

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June 2004

Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair.

Authors:

Myriam Alcalay Natalia Meani Vania Gelmetti Anna Fantozzi Marta Fagioli Annette Orleth Daniela Riganelli Carla Sebastiani Enrico Cappelli Cristina Casciari Maria Teresa Sciurpi Angela Rosa Mariano Simone Paolo Minardi Lucilla Luzi Heiko Muller Pier Paolo Di Fiore Guido Frosina Pier Giuseppe Pelicci

J Clin Invest 2003 Dec;112(11):1751-61

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

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December 2003

The PML gene is not involved in the regulation of MHC class I expression in human cell lines.

Authors:

Silvia Bruno Fabio Ghiotto Franco Fais Marta Fagioli Lucilla Luzi Pier Giuseppe Pelicci Carlo Enrico Grossi Ermanno Ciccone

Blood 2003 May 27;101(9):3514-9. Epub 2002 Dec 27.

Department of Experimental Medicine, Section of Human Anatomy, Genoa University, Genoa, Italy.

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May 2003

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter.

Authors:

Andrea Ventura Lucilla Luzi Sonia Pacini Cosima T Baldari Pier Giuseppe Pelicci

J Biol Chem 2002 Jun 10;277(25):22370-6. Epub 2002 Apr 10.

Department of Experimental Oncology, European Institute of Oncology, Milan 20141, Italy.

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June 2002

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