Lucie Carrier

Lucie Carrier

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Lucie Carrier

Publications by authors named "Lucie Carrier"

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Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3.

Clin Genet 2019 Sep 30. Epub 2019 Sep 30.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.

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http://dx.doi.org/10.1111/cge.13645DOI Listing
September 2019

Biallelic mutation in MYH7 and MYBPC3 leads to severe cardiomyopathy with left ventricular noncompaction phenotype.

Hum Mutat 2019 Aug 24;40(8):1101-1114. Epub 2019 Apr 24.

Comprehensive Heart Failure Center (CHFC) and Department of Medicine I, University and University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/humu.23757DOI Listing
August 2019

Myoarchitectural disarray of hypertrophic cardiomyopathy begins pre-birth.

J Anat 2019 Jul 26. Epub 2019 Jul 26.

Institute of Cardiovascular Science, University College London, London, UK.

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http://dx.doi.org/10.1111/joa.13058DOI Listing
July 2019

Gene therapy strategies in the treatment of hypertrophic cardiomyopathy.

Pflugers Arch 2019 May 3;471(5):807-815. Epub 2018 Jul 3.

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00424-018-2173-5DOI Listing
May 2019

Cardiomyopathy phenotypes in human-induced pluripotent stem cell-derived cardiomyocytes-a systematic review.

Pflugers Arch 2019 May 15;471(5):755-768. Epub 2018 Oct 15.

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00424-018-2214-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475632PMC
May 2019

Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue.

Front Physiol 2019 28;10:239. Epub 2019 Mar 28.

Institute of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.3389/fphys.2019.00239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447666PMC
March 2019

Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.

J Mol Cell Cardiol 2019 02 4;127:31-43. Epub 2018 Dec 4.

Department of Clinical Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg, Kiel, Lübeck, Germany; Institute of Pharmacy, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828183072
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http://dx.doi.org/10.1016/j.yjmcc.2018.12.001DOI Listing
February 2019

Making Sense of Inhibiting Nonsense in Hypertrophic Cardiomyopathy.

Authors:
Lucie Carrier

Circulation 2019 Feb;139(6):812-814

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg, Germany. German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037936DOI Listing
February 2019

Autophagy in cardiomyopathies.

Biochim Biophys Acta Mol Cell Res 2019 Feb 6. Epub 2019 Feb 6.

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2019.01.013DOI Listing
February 2019

S100A4 as a Target of the E3-Ligase Asb2β and Its Effect on Engineered Heart Tissue.

Front Physiol 2018 19;9:1292. Epub 2018 Sep 19.

Cardiovascular Research Center, Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.3389/fphys.2018.01292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157440PMC
September 2018

Activation of Autophagy Ameliorates Cardiomyopathy in -Targeted Knockin Mice.

Circ Heart Fail 2017 Oct;10(10)

From the Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Germany (S.R.S., A.T.L.Z., B.G., S.R.-D., M.P., E.K., S.S., L.C.); DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany (S.R.S., A.T.L.Z., B.G., S.R.-D., M.P., E.K., S.S., L.C.); Department of Pediatrics, The Heart Institute, The Cincinnati Children's Hospital Medical Center, OH (S.R.S., H.O., Q.M., J.R.); Radcliffe Department of Medicine, University of Oxford, United Kingdom (C.R.); Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands (J.v.d.V.); and ICIN-Netherlands Heart Institute, Utrecht (J.v.d.V.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679453PMC
October 2017

Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model.

Front Physiol 2017 2;8:558. Epub 2017 Aug 2.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-EppendorfHamburg, Germany.

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http://dx.doi.org/10.3389/fphys.2017.00558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539082PMC
August 2017

Diltiazem prevents stress-induced contractile deficits in cardiomyocytes, but does not reverse the cardiomyopathy phenotype in Mybpc3-knock-in mice.

J Physiol 2017 06 7;595(12):3987-3999. Epub 2017 Feb 7.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1113/JP273769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471503PMC
June 2017

Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes.

Mol Ther Nucleic Acids 2017 Jun 17;7:475-486. Epub 2017 May 17.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458066PMC
June 2017

Epigallocatechin-3-Gallate Accelerates Relaxation and Ca Transient Decay and Desensitizes Myofilaments in Healthy and -Targeted Knock-in Cardiomyopathic Mice.

Front Physiol 2016 5;7:607. Epub 2016 Dec 5.

Cardiovascular Research Center, Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-EppendorfHamburg, Germany; German Centre for Cardiovascular Research (DZHK)Hamburg, Germany.

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http://journal.frontiersin.org/article/10.3389/fphys.2016.00
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http://dx.doi.org/10.3389/fphys.2016.00607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136558PMC
December 2016

Serum Matrix Metalloproteinases as Quantitative Biomarkers for Myocardial Fibrosis and Sudden Cardiac Death Risk Stratification in Patients With Hypertrophic Cardiomyopathy.

J Card Fail 2016 Oct 24;22(10):845-50. Epub 2016 Mar 24.

Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2016.03.010DOI Listing
October 2016

Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue.

J Mol Cell Cardiol 2016 08 22;97:82-92. Epub 2016 Apr 22.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.03.003DOI Listing
August 2016

Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.

Cardiovasc Res 2016 May 29;110(2):200-14. Epub 2016 Jan 29.

Department of Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Netherlands ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.

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http://cardiovascres.oxfordjournals.org/content/cardiovascre
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http://cardiovascres.oxfordjournals.org/lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/cvr/cvw026DOI Listing
May 2016

S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.

FASEB J 2016 05 2;30(5):1849-64. Epub 2016 Feb 2.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Frankfurt, Germany;

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http://www.fasebj.org/content/early/2016/02/02/fj.201500048.
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http://www.fasebj.org/cgi/doi/10.1096/fj.201500048
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http://dx.doi.org/10.1096/fj.201500048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836368PMC
May 2016

Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.

Cardiovasc Res 2016 Jan 3;109(1):90-102. Epub 2015 Nov 3.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany

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http://cardiovascres.oxfordjournals.org/content/cardiovascre
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http://dx.doi.org/10.1093/cvr/cvv247DOI Listing
January 2016

Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology.

Gene 2015 Dec 8;573(2):188-97. Epub 2015 Sep 8.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.gene.2015.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660134PMC
December 2015

PLEKHM2 mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction.

Hum Mol Genet 2015 Dec 12;24(25):7227-40. Epub 2015 Oct 12.

Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel, National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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http://hmg.oxfordjournals.org/content/early/2015/10/27/hmg.d
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http://hmg.oxfordjournals.org/content/early/2015/10/11/hmg.d
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664165PMC
December 2015

The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.

J Mol Cell Cardiol 2015 Oct 3;87:214-24. Epub 2015 Sep 3.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.08.020DOI Listing
October 2015

I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model.

Int J Cardiol Heart Vasc 2015 Sep 29;8:87-94. Epub 2015 May 29.

Department of Pharmacology and Toxicology, University of Technology Dresden, Germany.

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http://dx.doi.org/10.1016/j.ijcha.2015.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497269PMC
September 2015

Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice.

Pflugers Arch 2015 Jun 11;467(6):1303-17. Epub 2014 Jul 11.

Department of Physiology, VU University Medical Center, Room B-156, Van der Boechorstraat 7, 1081 BT, Amsterdam, The Netherlands,

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http://dx.doi.org/10.1007/s00424-014-1570-7DOI Listing
June 2015

Animal and in silico models for the study of sarcomeric cardiomyopathies.

Cardiovasc Res 2015 Apr 18;105(4):439-48. Epub 2015 Jan 18.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvv006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375391PMC
April 2015

Research priorities in sarcomeric cardiomyopathies.

Cardiovasc Res 2015 Apr 28;105(4):449-56. Epub 2015 Jan 28.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvv019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375392PMC
April 2015

Targets for therapy in sarcomeric cardiomyopathies.

Cardiovasc Res 2015 Apr 29;105(4):457-70. Epub 2015 Jan 29.

Department of Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands ICIN-Netherlands Heart Institute, Utrecht, the Netherlands

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http://dx.doi.org/10.1093/cvr/cvv023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402369PMC
April 2015

Targeted Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities.

J Cardiovasc Dev Dis 2015;2(2):48-65. Epub 2015 Apr 21.

Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005 France; Paris Cardiovascular Research Center, INSERM U970, Paris 75016 France; Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris 75016 France.

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http://dx.doi.org/10.3390/jcdd2020048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725593PMC
April 2015

Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy.

Front Physiol 2014 16;5:484. Epub 2014 Dec 16.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf Hamburg, Germany ; German Centre for Cardiovascular Research (DZHK) Hamburg/Kiel/Lübeck, Germany.

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http://dx.doi.org/10.3389/fphys.2014.00484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267180PMC
January 2015

Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice.

Nat Commun 2014 Dec 2;5:5515. Epub 2014 Dec 2.

1] Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany [2] DZHK (German Centre for Cardiovascular Research), Partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.

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http://dx.doi.org/10.1038/ncomms6515DOI Listing
December 2014

AT1 blockade abolishes left ventricular hypertrophy in heterozygous cMyBP-C null mice: role of FHL1.

Fundam Clin Pharmacol 2014 Jun 18;28(3):249-56. Epub 2013 Apr 18.

Institut de Myologie, Inserm, U974, F-75013, Paris, France; Institut de Myologie, IFR14, Université Pierre et Marie Curie, UMR-S974, UM76, CNRS, UMR7215, F-75013, Paris, France.

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http://dx.doi.org/10.1111/fcp.12031DOI Listing
June 2014

Ubiquitin-proteasome system and hereditary cardiomyopathies.

J Mol Cell Cardiol 2014 Jun 28;71:25-31. Epub 2013 Dec 28.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany; Inserm, U974, Paris F-75013, France; Université Pierre et Marie Curie- Paris 6, UM 76, CNRS, UMR 7215, Institut de Myologie, IFR14, Paris F-75013, France. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2013.12.016DOI Listing
June 2014

Automated analysis of contractile force and Ca2+ transients in engineered heart tissue.

Am J Physiol Heart Circ Physiol 2014 May 28;306(9):H1353-63. Epub 2014 Feb 28.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistraße, Hamburg, Germany;

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http://dx.doi.org/10.1152/ajpheart.00705.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116534PMC
May 2014

MYBPC3 in hypertrophic cardiomyopathy: from mutation identification to RNA-based correction.

Pflugers Arch 2014 Feb 12;466(2):215-23. Epub 2013 Dec 12.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00424-013-1409-7DOI Listing
February 2014

Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice.

J Mol Cell Cardiol 2013 Oct 26;63:189-98. Epub 2013 Jul 26.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2013.07.011DOI Listing
October 2013

Repair of Mybpc3 mRNA by 5'-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy.

Mol Ther Nucleic Acids 2013 Jul 2;2:e102. Epub 2013 Jul 2.

1] Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany [2] DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.

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http://dx.doi.org/10.1038/mtna.2013.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731888PMC
July 2013

Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue.

Basic Res Cardiol 2013 May 10;108(3):349. Epub 2013 Apr 10.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00395-013-0349-xDOI Listing
May 2013

Genetics of hypertrophic and dilated cardiomyopathy.

Curr Pharm Biotechnol 2012 Oct;13(13):2467-76

Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.2174/138920112804583041DOI Listing
October 2012

Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315.

Am J Physiol Heart Circ Physiol 2012 Aug 25;303(3):H323-31. Epub 2012 May 25.

Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, the Netherlands.

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http://dx.doi.org/10.1152/ajpheart.00749.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734090PMC
August 2012

Aldosterone inhibits antifibrotic factors in mouse hypertensive heart.

Hypertension 2012 Jun 30;59(6):1179-87. Epub 2012 Apr 30.

Institut National de la Santé et de la Recherche Médicale U942 and Université Paris-Diderot, Paris, France.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.190512DOI Listing
June 2012

How do MYBPC3 mutations cause hypertrophic cardiomyopathy?

J Muscle Res Cell Motil 2012 May 5;33(1):75-80. Epub 2011 Nov 5.

NHLI, Imperial College London, London, UK.

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http://dx.doi.org/10.1007/s10974-011-9268-3DOI Listing
May 2012

Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice.

J Muscle Res Cell Motil 2012 May 11;33(1):5-15. Epub 2011 Nov 11.

Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1007/s10974-011-9273-6DOI Listing
May 2012

Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart.

Circ Res 2012 May 15;110(10):1303-10. Epub 2012 Mar 15.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.111.259630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559221PMC
May 2012

Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy.

Basic Res Cardiol 2012 Jan 22;107(1):235. Epub 2011 Dec 22.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00395-011-0235-3DOI Listing
January 2012

The ubiquitin-proteasome system in cardiomyopathies.

Curr Opin Cardiol 2011 May;26(3):190-5

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Hamburg, Germany.

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http://search.proquest.com/openview/c240e1a510830b117e8dc231
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http://www.springerlink.com/index/84242476r5007715.pdf
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/HCO.0b013e32834598feDOI Listing
May 2011

Cardiac myosin-binding protein C in hypertrophic cardiomyopathy: mechanisms and therapeutic opportunities.

J Mol Cell Cardiol 2011 Apr 1;50(4):613-20. Epub 2011 Feb 1.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2011.01.014DOI Listing
April 2011

Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium.

J Mol Cell Cardiol 2011 Mar 13;50(3):487-99. Epub 2010 Dec 13.

Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2010.12.002DOI Listing
March 2011

Too much of a good thing is bad: proteasome inhibition induces stressed hearts to fail.

Authors:
Lucie Carrier

Cardiovasc Res 2010 Dec 1;88(3):389-90. Epub 2010 Oct 1.

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http://dx.doi.org/10.1093/cvr/cvq315DOI Listing
December 2010

The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes.

Biochem Biophys Res Commun 2010 Nov 12;402(2):340-4. Epub 2010 Oct 12.

Department of Pharmacology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2010.10.030DOI Listing
November 2010

The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy.

Cardiovasc Res 2010 Jan 17;85(2):330-8. Epub 2009 Jul 17.

Institute of Experimental and Clinical Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.

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http://dx.doi.org/10.1093/cvr/cvp247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023315PMC
January 2010

Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.

Cardiovasc Res 2010 Jan 22;85(2):357-66. Epub 2009 Oct 22.

Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.

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http://dx.doi.org/10.1093/cvr/cvp348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023316PMC
January 2010

Nonsense-mediated mRNA decay and ubiquitin-proteasome system regulate cardiac myosin-binding protein C mutant levels in cardiomyopathic mice.

Circ Res 2009 Jul 9;105(3):239-48. Epub 2009 Jul 9.

Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.201251DOI Listing
July 2009

Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.

Circ Heart Fail 2009 May 25;2(3):233-42. Epub 2009 Mar 25.

Department of Biochemistry, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Thoraxcenter, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.108.806125DOI Listing
May 2009

The ubiquitin-proteasome system in cardiac dysfunction.

Biochim Biophys Acta 2008 Dec 25;1782(12):749-63. Epub 2008 Jun 25.

Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.bbadis.2008.06.009DOI Listing
December 2008

Ubiquitin-proteasome system impairment caused by a missense cardiac myosin-binding protein C mutation and associated with cardiac dysfunction in hypertrophic cardiomyopathy.

J Mol Biol 2008 Dec 7;384(4):896-907. Epub 2008 Oct 7.

Division of Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science, Yonago, Japan.

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http://dx.doi.org/10.1016/j.jmb.2008.09.070DOI Listing
December 2008

Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes.

Circ Res 2007 Oct 6;101(9):928-38. Epub 2007 Sep 6.

Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.158774DOI Listing
October 2007

Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure.

J Mol Cell Cardiol 2007 Aug 13;43(2):223-9. Epub 2007 May 13.

Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, D-20246, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S002228280701025
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http://dx.doi.org/10.1016/j.yjmcc.2007.05.003DOI Listing
August 2007

Cardiac myosin-binding protein C in the heart.

Authors:
Lucie Carrier

Arch Mal Coeur Vaiss 2007 Mar;100(3):238-43

Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Centre Hamburg-Eppendorf, D-20246 Hamburg, Germany.

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March 2007

Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation.

Circulation 2006 Aug 7;114(7):670-80. Epub 2006 Aug 7.

Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Center Hamburg-Eppendorf, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.636845DOI Listing
August 2006

Length and protein kinase A modulations of myocytes in cardiac myosin binding protein C-deficient mice.

Cardiovasc Res 2006 Feb 27;69(2):370-80. Epub 2005 Dec 27.

INSERM U-637, CHU Arnaud de Villeneuve, F-34295 Montpellier, France.

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http://dx.doi.org/10.1016/j.cardiores.2005.11.009DOI Listing
February 2006

Diagnostic accuracy of a 2D left ventricle hypertrophy score for familial hypertrophic cardiomyopathy.

Eur Heart J 2005 Sep 28;26(18):1882-6. Epub 2005 Apr 28.

Service de Cardiologie, Hôpital Ambroise Paré, AP-HP, 9 Avenue Charles De Gaulle, Boulogne, France.

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http://dx.doi.org/10.1093/eurheartj/ehi276DOI Listing
September 2005

A minimal structural analogue of cyclic ADP-ribose: synthesis and calcium release activity in mammalian cells.

J Biol Chem 2005 Apr 15;280(16):15952-9. Epub 2005 Feb 15.

Institute of Biochemistry, Cellular Signal Transduction and Pharmacology, University Hospital Hamburg Eppendorf, Center of Experimental Medicine, Martinistrasse 52, 20246 Hamburg, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M414032200
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http://dx.doi.org/10.1074/jbc.M414032200DOI Listing
April 2005

Impairment of the ubiquitin-proteasome system by truncated cardiac myosin binding protein C mutants.

Cardiovasc Res 2005 Apr;66(1):33-44

Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-University Erlangen-Nuremberg, Germany.

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http://dx.doi.org/10.1016/j.cardiores.2005.01.004DOI Listing
April 2005

Expression of cardiac myosin-binding protein-C (cMyBP-C) in Drosophila as a model for the study of human cardiomyopathies.

Hum Mol Genet 2005 Jan 3;14(1):7-17. Epub 2004 Nov 3.

CNRS, UMR6545, LGPD-IBDM, Université de la Méditerranée, Marseille, France.

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http://dx.doi.org/10.1093/hmg/ddi002DOI Listing
January 2005

Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice.

Cardiovasc Res 2004 Aug;63(2):293-304

INSERM U582, Institut de Myologie, Bâtiment Babinski, GH Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/j.cardiores.2004.04.009DOI Listing
August 2004

Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties.

J Mol Cell Cardiol 2004 Mar;36(3):355-62

INSERM U582, Institut de Myologie, Bâtiment Babinski, Groupe Hospitalier Pitié-Salpêtrière, 47, Bld de l'Hôpital, 75651 Paris cedex 13, France.

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http://dx.doi.org/10.1016/j.yjmcc.2003.12.006DOI Listing
March 2004