Luciano Adorini

Luciano Adorini

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Luciano Adorini

Publications by authors named "Luciano Adorini"

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Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development.

J Hepatol 2019 Aug 13. Epub 2019 Aug 13.

Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, MI, Italy; Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 20090 Pieve Emanuele, MI, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.08.005DOI Listing
August 2019

Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.

Mol Metab 2018 03 11;9:131-140. Epub 2018 Jan 11.

Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870099PMC
March 2018

Beneficial effects of bile acid receptor agonists in pulmonary disease models.

Expert Opin Investig Drugs 2017 Nov 3;26(11):1215-1228. Epub 2017 Oct 3.

a Department of Biomedical, Experimental and Clinical Sciences , University of Florence , Florence , Italy.

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http://dx.doi.org/10.1080/13543784.2017.1385760DOI Listing
November 2017

Megatrends in bile acid receptor research.

Hepatol Commun 2017 10 24;1(8):831-835. Epub 2017 Aug 24.

Icahn School of Medicine at Mount Sinai New York NY.

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http://dx.doi.org/10.1002/hep4.1085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678912PMC
October 2017

Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human β-defensin-1 and -2 secretion by colonic epithelial cells.

FASEB J 2017 09 9;31(9):3848-3857. Epub 2017 May 9.

Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland;

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http://dx.doi.org/10.1096/fj.201601365RDOI Listing
September 2017

A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice.

J Biol Chem 2017 07 8;292(29):12018-12024. Epub 2017 Jun 8.

From the Division of Renal Diseases and Hypertension, Department of Medicine, Denver Veterans Affairs Medical Center and University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 and

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http://dx.doi.org/10.1074/jbc.C117.794982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519354PMC
July 2017

Anti-fibrotic effects of chronic treatment with the selective FXR agonist obeticholic acid in the bleomycin-induced rat model of pulmonary fibrosis.

J Steroid Biochem Mol Biol 2017 04 20;168:26-37. Epub 2017 Jan 20.

Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy; I.N.B.B. (Istituto Nazionale Biostrutture e Biosistemi), Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2017.01.010DOI Listing
April 2017

Cardiopulmonary protective effects of the selective FXR agonist obeticholic acid in the rat model of monocrotaline-induced pulmonary hypertension.

J Steroid Biochem Mol Biol 2017 01 15;165(Pt B):277-292. Epub 2016 Jul 15.

Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy; I.N.B.B. (Istituto Nazionale Biostrutture e Biosistemi), Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.07.004DOI Listing
January 2017

G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes.

J Am Soc Nephrol 2016 05 30;27(5):1362-78. Epub 2015 Sep 30.

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado;

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http://dx.doi.org/10.1681/ASN.2014121271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849814PMC
May 2016

Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat.

J Pharmacol Exp Ther 2014 Jul 1;350(1):56-68. Epub 2014 May 1.

Dipartimento di Chimica "G. Ciamician" Alma Mater Studiorum-University of Bologna, Italy (A.R., C:C:, S.S.); Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Italy (R.P., A.G.); Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum-University of Bologna, Italy (F.N., M.M.); TES Pharma S.r.l., Corciano, Italy (R.P., D.P., F.D.F., C.C.); Intercept Pharmaceuticals, Inc., New York, New York; and Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum-University of Bologna, Bologna, Italy (R.A.).

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http://dx.doi.org/10.1124/jpet.114.214650DOI Listing
July 2014

Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis.

Hepatology 2014 May 1;59(5):1761-1771. Epub 2014 Apr 1.

Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.

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http://dx.doi.org/10.1002/hep.26714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938573PMC
May 2014

Metabolic syndrome induces inflammation and impairs gonadotropin-releasing hormone neurons in the preoptic area of the hypothalamus in rabbits.

Mol Cell Endocrinol 2014 Jan 21;382(1):107-119. Epub 2013 Sep 21.

Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy; CIRMAR (Centro Interuniversitario di Ricerca sulle basi molecolari della Malattie della Riproduzione), 20122 Milan, Italy; I.N.B.B. - Istituto Nazionale Biostrutture e Biosistemi, 00136 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2013.09.017DOI Listing
January 2014

FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS.

J Endocrinol 2013 6;218(2):215-31. Epub 2013 Jul 6.

Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy.

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http://dx.doi.org/10.1530/JOE-13-0109DOI Listing
September 2013

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis.

Drug Discov Today 2012 Sep 29;17(17-18):988-97. Epub 2012 May 29.

Intercept Pharmaceuticals, 18 Desbrosses Street, New York, NY 10013, USA.

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http://dx.doi.org/10.1016/j.drudis.2012.05.012DOI Listing
September 2012

Antiinflammatory effect of androgen receptor activation in human benign prostatic hyperplasia cells.

J Endocrinol 2012 Jul 4;214(1):31-43. Epub 2012 May 4.

Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy.

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http://dx.doi.org/10.1530/JOE-12-0142DOI Listing
July 2012

Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists.

Bioorg Med Chem 2012 Jun 20;20(11):3429-45. Epub 2012 Apr 20.

Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo, I-06123 Perugia, Italy.

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http://dx.doi.org/10.1016/j.bmc.2012.04.021DOI Listing
June 2012

Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators.

ACS Med Chem Lett 2012 Apr 6;3(4):273-7. Epub 2012 Feb 6.

Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia , Via del Liceo 1, 06123 Perugia, Italy.

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http://dx.doi.org/10.1021/ml200256dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025660PMC
April 2012

Testosterone protects from metabolic syndrome-associated prostate inflammation: an experimental study in rabbit.

J Endocrinol 2012 Jan 18;212(1):71-84. Epub 2011 Oct 18.

Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy.

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http://dx.doi.org/10.1530/JOE-11-0289DOI Listing
January 2012

Farnesoid X receptor activation improves erectile dysfunction in models of metabolic syndrome and diabetes.

Biochim Biophys Acta 2011 Aug 5;1812(8):859-66. Epub 2010 Nov 5.

Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1016/j.bbadis.2010.10.013DOI Listing
August 2011

Vitamin D endocrine system and the immune response in rheumatic diseases.

Vitam Horm 2011 ;86:327-51

Research Laboratories and Academic Unit of Clinical Rheumatology, Postgraduate Academic School of Rheumatology, University of Genova, Genova, Italy.

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http://dx.doi.org/10.1016/B978-0-12-386960-9.00014-9DOI Listing
July 2011

Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine.

Bioorg Med Chem 2011 Apr 10;19(8):2650-8. Epub 2011 Mar 10.

Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.bmc.2011.03.004DOI Listing
April 2011

Farnesoid X receptor activation improves erectile function in animal models of metabolic syndrome and diabetes.

J Sex Med 2011 Jan 18;8(1):57-77. Epub 2010 Oct 18.

Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1111/j.1743-6109.2010.02073.xDOI Listing
January 2011

The Italian Society of Immunology: past, present and future.

Eur J Immunol 2010 Oct;40(10):2664-6

Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1002/eji.201090055DOI Listing
October 2010

Comparison between VDR analogs and current immunosuppressive drugs in relation to CXCL10 secretion by human renal tubular cells.

Transpl Int 2010 Sep 18;23(9):914-23. Epub 2010 Mar 18.

Excellence Center for Research, Transfer and High Education (DENOthe), University of Florence, Florence, Italy.

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http://doi.wiley.com/10.1111/j.1432-2277.2010.01078.x
Publisher Site
http://dx.doi.org/10.1111/j.1432-2277.2010.01078.xDOI Listing
September 2010

Vitamin D receptor agonists target static, dynamic, and inflammatory components of benign prostatic hyperplasia.

Ann N Y Acad Sci 2010 Apr;1193:146-52

Intercept Pharmaceuticals, Corciano (Perugia), Italy.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05299.xDOI Listing
April 2010

The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria.

Am J Physiol Renal Physiol 2009 Dec 23;297(6):F1587-96. Epub 2009 Sep 23.

Department of Medicine, University of Colorado Denver, and Veterans Affairs Medical Center, Aurora, Colorado, USA.

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http://www.physiology.org/doi/10.1152/ajprenal.00404.2009
Publisher Site
http://dx.doi.org/10.1152/ajprenal.00404.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801344PMC
December 2009

Prostate autoimmunity: from experimental models to clinical counterparts.

Expert Rev Clin Immunol 2009 Sep;5(5):577-86

Intercept Pharmaceuticals, 06073 Corciano (Perugia), Italy.

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http://dx.doi.org/10.1586/eci.09.37DOI Listing
September 2009

Vitamin D receptor polymorphisms in primary biliary cirrhosis: a functional connection?

Authors:
Luciano Adorini

J Hepatol 2009 Jun 27;50(6):1071-3. Epub 2009 Mar 27.

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http://dx.doi.org/10.1016/j.jhep.2009.03.005DOI Listing
June 2009

Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists.

Hum Immunol 2009 May;70(5):345-52

Intercept Pharmaceuticals, Perugia, Italy.

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http://dx.doi.org/10.1016/j.humimm.2009.01.016DOI Listing
May 2009

Induction of tolerogenic dendritic cells by vitamin D receptor agonists.

Handb Exp Pharmacol 2009 (188):251-73

Intercept Pharma, Via Togliatti 22 bis, 06073 Corciano (Perugia), Italy.

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http://dx.doi.org/10.1007/978-3-540-71029-5_12DOI Listing
February 2009

Control of autoimmune diseases by the vitamin D endocrine system.

Nat Clin Pract Rheumatol 2008 Aug 1;4(8):404-12. Epub 2008 Jul 1.

Intercept Pharmaceuticals, Corciano (Perugia), Italy.

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http://dx.doi.org/10.1038/ncprheum0855DOI Listing
August 2008

Vitamin D receptor agonists as anti-inflammatory agents.

Expert Rev Clin Immunol 2007 Jul;3(4):477-89

BioXell, Via Olgettina 58, I-20132 Milano, Italy.

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http://dx.doi.org/10.1586/1744666X.3.4.477DOI Listing
July 2007

C-20 cyclopropyl vitamin D3 analogs.

Curr Top Med Chem 2006 ;6(12):1289-96

BioXell, Inc., Nutley, NJ 07110, USA.

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http://dx.doi.org/10.2174/156802606777864962DOI Listing
February 2007

Vitamin D receptor agonists, cancer and the immune system: an intricate relationship.

Curr Top Med Chem 2006 ;6(12):1297-301

BioXell, 20132 Milano, Italy.

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http://dx.doi.org/10.2174/156802606777864890DOI Listing
February 2007

The vitamin D receptor as a therapeutic target.

Expert Opin Ther Targets 2006 Oct;10(5):735-48

Institute of Biomedical Research, Wolfson Drive, University of Birmingham Medical School, Edgbaston, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1517/14728222.10.5.735 DOI Listing
October 2006

The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells.

J Cancer Res Clin Oncol 2006 Jun 17;132(6):408-16. Epub 2006 Feb 17.

Department of Clinical Physiopathology, Andrology Unit, Center of Research, Transfer and High Education DeNothe, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy.

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http://dx.doi.org/10.1007/s00432-006-0086-8DOI Listing
June 2006

Cutting edge: proangiogenic properties of alternatively activated dendritic cells.

J Immunol 2005 Sep;175(5):2788-92

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.4049/jimmunol.175.5.2788DOI Listing
September 2005

Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice.

J Immunol 2005 Aug;175(3):1991-9

Department of Molecular and Medical Pharmacology, University of California, School of Medicine, Los Angeles, CA 90095-1735, USA.

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http://dx.doi.org/10.4049/jimmunol.175.3.1991DOI Listing
August 2005

Prevention of chronic allograft rejection by Vitamin D receptor agonists.

Immunol Lett 2005 Aug;100(1):34-41

BioXell, Via Olgettina 58, I-20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.imlet.2005.06.017DOI Listing
August 2005

IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1alpha,25-dihydroxyvitamin D3.

J Leukoc Biol 2005 Jun 13;77(6):944-7. Epub 2005 Apr 13.

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1189/jlb.0205090DOI Listing
June 2005

Human bladder as a novel target for vitamin D receptor ligands.

J Clin Endocrinol Metab 2005 Feb 30;90(2):962-72. Epub 2004 Nov 30.

Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.

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http://dx.doi.org/10.1210/jc.2004-1496DOI Listing
February 2005

Intervention in autoimmunity: the potential of vitamin D receptor agonists.

Authors:
Luciano Adorini

Cell Immunol 2005 Feb;233(2):115-24

BioXell, Via Olgettina 58, I-20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.cellimm.2005.04.013DOI Listing
February 2005

Antigen-based immunointervention in human autoimmune diseases.

Authors:
Luciano Adorini

Trends Biotechnol 2004 Nov;22(11):547-9

BioXell, Via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.tibtech.2004.09.005DOI Listing
November 2004

Immunotherapeutic approaches in multiple sclerosis.

Authors:
Luciano Adorini

J Neurol Sci 2004 Aug;223(1):13-24

BioXell, Via Olgettina 58, I-20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.jns.2004.04.014DOI Listing
August 2004

Calcitriol derivatives with two different side chains at C-20. 24-hydroxy derivatives as metabolic products and molecular probes for VDR exploration.

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):35-8

Bioxell Inc., 340 Kingsland Street, Bldg. 76/13, Nutley, NJ 07110, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.047DOI Listing
May 2004

Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands.

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):437-41

BioXell, Via Olgettina 58, I-20132 Milano, Italy.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.013DOI Listing
May 2004

Pharmacological induction of tolerogenic dendritic cells and regulatory T cells.

Semin Immunol 2004 Apr;16(2):127-34

BioXell, Via Olgettina 58, Milano I-20132, Italy.

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http://dx.doi.org/10.1016/j.smim.2003.12.008DOI Listing
April 2004

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide.

J Clin Invest 2003 May;111(9):1365-71

Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

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http://dx.doi.org/10.1172/JCI17166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154446PMC
May 2003

Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting autoimmune diabetes.

Authors:
Luciano Adorini

Ann N Y Acad Sci 2003 Apr;987:258-61

BioXell, Via Olgettina 58, I-20132 Milano, Italy.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb06057.xDOI Listing
April 2003

Inflammation in multiple sclerosis: the good, the bad, and the complex.

Lancet Neurol 2002 Dec;1(8):499-509

Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

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December 2002