Lucia R Languino

Lucia R Languino

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Lucia R Languino

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Prostate cancer sheds the αvβ3 integrin in vivo through exosomes.

Matrix Biol 2019 04 8;77:41-57. Epub 2018 Aug 8.

Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA 19107, USA; Departments of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541230PMC
April 2019

Activated Extracellular Vesicles as New Therapeutic Targets?

Trends Cell Biol 2019 04 27;29(4):276-278. Epub 2019 Feb 27.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.tcb.2019.02.003DOI Listing
April 2019

Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth.

iScience 2019 Apr 27;14:199-209. Epub 2019 Mar 27.

Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, USA; Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia PA 19107, USA; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461598PMC
April 2019

αβ Integrin Mediates Radioresistance of Prostate Cancer Cells through Regulation of Survivin.

Mol Cancer Res 2019 02 28;17(2):398-408. Epub 2018 Sep 28.

Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359981PMC
February 2019

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.

Matrix Biol 2018 09 9;70:20-35. Epub 2018 Mar 9.

Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081240PMC
September 2018

Evaluation of drug combination effect using a Bliss independence dose-response surface model.

Stat Biopharm Res 2018 13;10(2):112-122. Epub 2018 Feb 13.

Immunology, Microenvironment & Metastasis, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104.

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http://dx.doi.org/10.1080/19466315.2018.1437071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415926PMC
February 2018

c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.

J Cell Biochem 2017 01 12;118(1):66-73. Epub 2016 Jul 12.

Prostate Cancer Discovery and Development Program, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcb.25611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552241PMC
January 2017

Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype.

Mol Cancer Res 2016 11 20;14(11):1136-1146. Epub 2016 Jul 20.

Prostate Cancer Discovery and Development Program, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107121PMC
November 2016

A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice.

Oncotarget 2016 Oct;7(43):70462-70474

Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT 05405, USA.

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http://dx.doi.org/10.18632/oncotarget.11992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342565PMC
October 2016

αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor.

Cancer Res 2016 09 22;76(17):5163-74. Epub 2016 Jul 22.

Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania. Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012867PMC
September 2016

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.

Cancer Cell 2016 08;30(2):257-272

Prostate Cancer Discovery and Development Program, Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131882PMC
August 2016

Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma.

Am J Transl Res 2016 15;8(5):2432-7. Epub 2016 May 15.

Department of Dermatology & Cutaneous Biology, Thomas Jefferson UniversityPhiladelphia, USA; Squamous Cell Carcinoma Tumor Ecology and Microenvironment (STEM) Research Group, Thomas Jefferson UniversityPhiladelphia, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891457PMC
June 2016

Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression.

PLoS One 2015 24;10(6):e0130060. Epub 2015 Jun 24.

Division of Pathology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Organ Transplant, University of Milan, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130060PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479381PMC
April 2016

Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism.

Sci Rep 2015 Oct 30;5:15981. Epub 2015 Oct 30.

Prostate Cancer Discovery and Development Program, Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104.

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http://dx.doi.org/10.1038/srep15981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626838PMC
October 2015

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1.

J Cell Biochem 2015 Sep;116(9):2098-108

Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine Burlington, Vermont, USA.

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http://dx.doi.org/10.1002/jcb.25167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515199PMC
September 2015

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion.

Sci Signal 2015 Aug 11;8(389):ra80. Epub 2015 Aug 11.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA 19104, USA. Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aab1
Publisher Site
http://dx.doi.org/10.1126/scisignal.aab1624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539531PMC
August 2015

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.

Proc Natl Acad Sci U S A 2015 Jul 29;112(28):8638-43. Epub 2015 Jun 29.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA 19104; Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1500722112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507184PMC
July 2015

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

J Natl Cancer Inst 2015 Mar 3;107(3). Epub 2015 Feb 3.

Prostate Cancer Discovery and Development Program (JCG, MT, YCC, SL, MCC, JHS, LRL, DCA), Tumor Microenvironment and Metastasis Program (JCG, MT, YCC, SL, MCC, JHS, DCA), Center for Systems and Computational Biology (AVK), and Center for Chemical Biology and Translational Medicine (DCS), The Wistar Institute, Philadelphia, PA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY (MDS); Istituto Nazionale Genetica Molecolare "Romeo and Enrica Invernizzi," Milan, Italy (VV); Division of Pathology (VV, AF, SB), Division of Neurosurgery (PR), and Division of Surgery (MG), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Metabolon, Inc. Durham, NC (RDM); Department of Pathophysiology and Organ Transplant, University of Milan, Milan, Italy (SB); Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA (LRL).

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http://dx.doi.org/10.1093/jnci/dju502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565533PMC
March 2015

The αvβ6 integrin is transferred intercellularly via exosomes.

J Biol Chem 2015 Feb 7;290(8):4545-51. Epub 2015 Jan 7.

From the Prostate Cancer Discovery and Development Program, Department of Cancer Biology, Sidney Kimmel Cancer Center, and

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http://dx.doi.org/10.1074/jbc.C114.617662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335196PMC
February 2015

Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks.

Cell Rep 2014 Aug 31;8(3):671-7. Epub 2014 Jul 31.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA 19104, USA; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.06.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127146PMC
August 2014

IGF-IR promotes prostate cancer growth by stabilizing α5β1 integrin protein levels.

PLoS One 2013 9;8(10):e76513. Epub 2013 Oct 9.

Department of Cancer Biology, Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076513PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793919PMC
June 2014

Integrin αvβ6 promotes an osteolytic program in cancer cells by upregulating MMP2.

Cancer Res 2014 Mar 2;74(5):1598-608. Epub 2014 Jan 2.

Authors' Affiliations: Prostate Cancer Discovery and Development Program; Departments of Cancer Biology and Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Cell Biology, Radiation Oncology, Pathology, and Orthopedics, University of Massachusetts Medical School, Worcester; Biogen Idec, Inc., Cambridge, Massachusetts; and Department of Biochemistry, The University of Vermont, Burlington, Vermont.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967411PMC
March 2014

Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions.

Cancer Res 2013 May 27;73(10):3155-67. Epub 2013 Mar 27.

Prostate Cancer Discovery and Development Program, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-3266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655712PMC
May 2013

Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis.

J Cell Physiol 2012 Nov;227(11):3670-7

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1002/jcp.24074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369113PMC
November 2012

Molecular targets for radiation oncology in prostate cancer.

Front Oncol 2011 13;1:17. Epub 2011 Jul 13.

Department of Radiation Oncology, University of Massachusetts Medical School Worcester, MA, USA.

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http://dx.doi.org/10.3389/fonc.2011.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355820PMC
August 2012

PSA regulates androgen receptor expression in prostate cancer cells.

Prostate 2012 May 28;72(7):769-76. Epub 2011 Sep 28.

Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1002/pros.21482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404455PMC
May 2012

TRAP-1, the mitochondrial Hsp90.

Biochim Biophys Acta 2012 Mar 22;1823(3):767-73. Epub 2011 Aug 22.

Prostate Cancer Discovery and Development Program, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2011.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263322PMC
March 2012

Insulin-like growth factor 1 stimulation of androgen receptor activity requires β(1A) integrins.

J Cell Physiol 2012 Feb;227(2):751-8

Department of Cancer Biology, Prostate Cancer Discovery and Development Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/jcp.22784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195902PMC
February 2012

Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1.

J Cell Physiol 2010 Jul;224(1):210-7

Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1002/jcp.22116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885855PMC
July 2010

Protein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer.

Cancer Res 2010 Mar 16;70(5):2095-104. Epub 2010 Feb 16.

Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197700PMC
March 2010

Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.

Am J Pathol 2010 Jan 30;176(1):393-401. Epub 2009 Nov 30.

Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797899PMC
January 2010

IAP regulation of metastasis.

Cancer Cell 2010 Jan;17(1):53-64

Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.11.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818597PMC
January 2010

The launch of the american journal of translational research.

Am J Transl Res 2009 Sep 1;1(1). Epub 2009 Sep 1.

University of California at Irvine Irvine, CA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776285PMC
September 2009

Prostate cancer regulatory networks.

J Cell Biochem 2009 Aug;107(5):845-52

Department of Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA.

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http://dx.doi.org/10.1002/jcb.22162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896787PMC
August 2009

Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1.

Cancer Res 2009 Jul 23;69(13):5374-82. Epub 2009 Jun 23.

Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-09-0186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779723PMC
July 2009

Endogenous tumor suppression mediated by PTEN involves survivin gene silencing.

Cancer Res 2009 Jun 26;69(12):4954-8. Epub 2009 May 26.

Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718425PMC
June 2009

Integrin signaling aberrations in prostate cancer.

Am J Transl Res 2009 Apr 20;1(3):211-20. Epub 2009 Apr 20.

Department of Cancer Biology, Prostate Cancer Discovery and Development Program, Cancer Center, University of Massachusetts Medical School Worcester, MA 01605, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757165PMC
April 2009

Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation.

Prostate 2008 Dec;68(16):1734-42

Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1002/pros.20838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748789PMC
December 2008

Integrins in prostate cancer progression.

Endocr Relat Cancer 2008 Sep 4;15(3):657-64. Epub 2008 Jun 4.

Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1677/ERC-08-0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668544PMC
September 2008

Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention.

Expert Rev Anticancer Ther 2008 Jun;8(6):967-74

Department of Radiation Oncology, University of Massachusetts Medical School, 55 Lake Avenue North Worcester, MA 01605, USA.

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http://dx.doi.org/10.1586/14737140.8.6.967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764989PMC
June 2008

The integrin-growth factor receptor duet.

J Cell Physiol 2007 Dec;213(3):649-53

Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1002/jcp.21278DOI Listing
December 2007

"D" approach to prevent metastasis.

Cancer Biol Ther 2007 Jan;6(1):110-1

Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.4161/cbt.6.1.3786DOI Listing
January 2007

Androgen action series.

J Cell Biochem 2006 Oct;99(2):331-2

Department of Cancer Biology and Cell Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1002/jcb.21062DOI Listing
October 2006

Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment.

Cancer Res 2006 Jan;66(1):331-42

Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2588DOI Listing
January 2006

The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion.

Mol Cell Biol 2005 Oct;25(19):8581-91

Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

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http://dx.doi.org/10.1128/MCB.25.19.8581-8591.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265732PMC
October 2005

beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts.

Cancer Res 2005 Aug;65(15):6692-700

Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4315DOI Listing
August 2005

High dose fractionated ionizing radiation inhibits prostate cancer cell adhesion and beta(1) integrin expression.

Prostate 2005 Jun;64(1):83-91

Department of Radiation Oncology, University of Massachusetts Memorial Health Care Hospitals, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1002/pros.20227DOI Listing
June 2005

Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins.

J Cell Biol 2004 Aug;166(3):407-18

Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation St., Worcester 01605, USA.

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http://dx.doi.org/10.1083/jcb.200403003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172270PMC
August 2004

Integrin signaling in cancer.

Cancer Treat Res 2004 ;119:15-31

Department of Cancer Biology, University of Massachusetts Medical School, Boston, USA.

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http://dx.doi.org/10.1007/1-4020-7847-1_2DOI Listing
June 2004

Advances in prostate cancer research. Part III.

Authors:
Lucia R Languino

J Cell Biochem 2004 Mar;91(4):647-8

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http://dx.doi.org/10.1002/jcb.20054DOI Listing
March 2004

Advances in prostate cancer research. Part II.

Authors:
Lucia R Languino

J Cell Biochem 2004 Feb;91(3):431-2

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http://dx.doi.org/10.1002/jcb.20020DOI Listing
February 2004

Regulation of beta1C and beta1A integrin expression in prostate carcinoma cells.

J Biol Chem 2004 Jan 29;279(3):1692-702. Epub 2003 Oct 29.

Institute of Biomembranes and Bioenergetics, National Research Council (C.N.R.), Via Amendola 165/A, 70126 Bari, Italy.

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January 2004

Advances in prostate cancer research.

Authors:
Lucia R Languino

J Cell Biochem 2004 Jan;91(1):1-2

Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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http://dx.doi.org/10.1002/jcb.10792DOI Listing
January 2004

Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway.

J Biol Chem 2003 Dec 30;278(50):50402-11. Epub 2003 Sep 30.

Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1074/jbc.M307627200DOI Listing
December 2003

Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration.

J Cell Biol 2003 May;161(4):817-26

Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1083/jcb.200212172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199360PMC
May 2003