Lucia Chávez-Gutiérrez

Lucia Chávez-Gutiérrez

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Lucia Chávez-Gutiérrez

Lucia Chávez-Gutiérrez

Publications by authors named "Lucia Chávez-Gutiérrez"

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27Publications

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Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease.

Biol Psychiatry 2018 02 10;83(4):320-327. Epub 2017 Aug 10.

KU Leuven Department for Neurosciences, Leuven, Belgium; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.biopsych.2017.08.001DOI Listing
February 2018

Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds.

Neurobiol Dis 2017 Aug 28;104:97-103. Epub 2017 Apr 28.

Normandie Univ, UNIROUEN, Inserm U1245, Rouen University Hospital, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, F 76000 Rouen, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.04.020DOI Listing
August 2017

Identification and characterization of Nanobodies targeting the EphA4 receptor.

J Biol Chem 2017 07 19;292(27):11452-11465. Epub 2017 May 19.

From the KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), 3000 Leuven, Belgium,

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http://dx.doi.org/10.1074/jbc.M116.774141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500810PMC
July 2017

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Cell 2017 Jul;170(3):443-456.e14

KU Leuven-VIB Center for Brain & Disease Research, VIB, 3000 Leuven, Belgium; Department of Neurosciences, Leuven Institute for Neuroscience and Disease, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.004DOI Listing
July 2017

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Lancet Neurol 2016 Dec 21;15(13):1326-1335. Epub 2016 Oct 21.

Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(16)30193-4DOI Listing
December 2016

Probing γ-secretase-substrate interactions at the single amino acid residue level.

EMBO J 2016 08 1;35(15):1597-9. Epub 2016 Jul 1.

VIB Center for the Biology of Disease, VIB-Leuven, Leuven, Belgium Center for Human Genetics, Universitaire Ziekenhuizen and LIND, KU Leuven, Leuven, Belgium Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.15252/embj.201694978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969572PMC
August 2016

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Neuron 2016 04;90(2):410-6

VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics, and Leuven Institute for Neurodegenerative Diseases (LIND), University of Leuven (KU Leuven), 3000 Leuven, Belgium; Institute of Neurology, University College London, London, WC1N 3BG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.03.010DOI Listing
April 2016

Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.

J Exp Med 2015 Nov 19;212(12):2003-13. Epub 2015 Oct 19.

VIB Center for the Biology of Disease, University of Leuven (KU Leuven), 3000 Leuven, Belgium Center for Human Genetics (CME) and Leuven Research Institute for Neuroscience and Disease (LIND), University of Leuven (KU Leuven), 3000 Leuven, Belgium

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http://dx.doi.org/10.1084/jem.20150892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647268PMC
November 2015

Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond.

Annu Rev Pharmacol Toxicol 2015 1;55:419-37. Epub 2014 Oct 1.

VIB Center for the Biology of Disease, Vlaams Instituut voor Biotechnologie, BE-3000 Leuven, Belgium.

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http://dx.doi.org/10.1146/annurev-pharmtox-010814-124309DOI Listing
September 2015

Signature amyloid β profiles are produced by different γ-secretase complexes.

J Biol Chem 2014 Feb 13;289(7):4346-55. Epub 2013 Dec 13.

From the Center for the Biology of Disease, Flemish Institute for Biology (VIB), 3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M113.530907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924297PMC
February 2014

Dissecting γ-secretase function.

J Neurochem 2013 Apr;125(1):1-3

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http://dx.doi.org/10.1111/jnc.12077DOI Listing
April 2013

Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.

J Biol Chem 2011 Apr 4;286(14):12271-82. Epub 2011 Feb 4.

Laboratory for the Research of Neurodegenerative Diseases, Center for Human Genetics, KULeuven, Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M110.216978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069430PMC
April 2011

Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.

J Biol Chem 2011 Mar 5;286(10):8677-87. Epub 2011 Jan 5.

Department of Molecular and Developmental Genetics, VIB, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M110.194860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048749PMC
March 2011

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.

J Biol Chem 2008 Jul 23;283(29):20096-105. Epub 2008 May 23.

Center for Human Genetics, KULeuven, and Department for Molecular and Developmental Genetics, VIB4, Herestraat 49, Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M803040200DOI Listing
July 2008

Stage-specific modulation of neprilysin and aminopeptidase N in the limbic system during kindling progression.

J Mol Neurosci 2007 17;33(3):252-61. Epub 2007 Apr 17.

Div. Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñíz, México D.F., México.

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http://dx.doi.org/10.1007/s12031-007-0020-9DOI Listing
February 2008

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

J Biol Chem 2006 Sep 14;281(37):27633-42. Epub 2006 Jul 14.

Neuronal Cell Biology and Gene Transfer Laboratory, Center for Human Genetics, VIB4 and K. U. Leuven, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M604997200DOI Listing
September 2006

Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family.

J Biol Chem 2006 Jul 12;281(27):18581-90. Epub 2006 Apr 12.

Departamento de Genética del Desarrollo y Fisiología Molecular, Universidad Nacional Autónoma de México, 62271 Cuernavaca, Morelos, México.

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http://dx.doi.org/10.1074/jbc.M601392200DOI Listing
July 2006

3,3',5'-triiodo-L-thyronine reduces efficiency of mRNA knockdown by antisense oligodeoxynucleotides: a study with pyroglutamyl aminopeptidase II in adenohypophysis.

Oligonucleotides 2004 ;14(3):176-90

Departamento de Genetica del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Mor., México.

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http://dx.doi.org/10.1089/oli.2004.14.176DOI Listing
August 2005

A truncated isoform of pyroglutamyl aminopeptidase II produced by exon extension has dominant-negative activity.

J Neurochem 2005 Feb;92(4):807-17

Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02916.xDOI Listing
February 2005