Lucia Altucci

Lucia Altucci

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Lucia Altucci

Publications by authors named "Lucia Altucci"

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DOT1L: a key target in normal chromatin remodeling and in mixed-lineage leukemia treatment.

Epigenetics 2019 Dec 2. Epub 2019 Dec 2.

Dipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli" Napoli, Vico L. De Crecchio 7, 80138 Napoli, IT.

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http://dx.doi.org/10.1080/15592294.2019.1699991DOI Listing
December 2019

Monoacylglycerides from the Diatom Induce Selective Cell Death in Cancer Cells.

Mar Drugs 2019 Nov 1;17(11). Epub 2019 Nov 1.

Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.

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http://dx.doi.org/10.3390/md17110625DOI Listing
November 2019

HDAC2-dependent miRNA signature in acute myeloid leukemia.

FEBS Lett 2019 Sep 19;593(18):2574-2584. Epub 2019 Jul 19.

Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.1002/1873-3468.13521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790563PMC
September 2019

Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy.

Cancers (Basel) 2019 Sep 29;11(10). Epub 2019 Sep 29.

Department of Precision Medicine, University of Campania "L. Vanvitelli", via L. De Crecchio, 7, 80138 Naples, Italy.

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http://dx.doi.org/10.3390/cancers11101465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826381PMC
September 2019

Histone Deacetylase Inhibitors Impair Vasculogenic Mimicry from Glioblastoma Cells.

Cancers (Basel) 2019 May 29;11(6). Epub 2019 May 29.

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.

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http://dx.doi.org/10.3390/cancers11060747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627137PMC
May 2019

Cardioprotective effect of a moderate and prolonged exercise training involves sirtuin pathway.

Life Sci 2019 Apr 5;222:140-147. Epub 2019 Mar 5.

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli", 80138, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2019.03.001DOI Listing
April 2019

BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition.

Cell Death Dis 2019 Apr 18;10(5):338. Epub 2019 Apr 18.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. De Crecchio 7, 80138, Napoli, Italy.

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http://dx.doi.org/10.1038/s41419-019-1570-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472371PMC
April 2019

Hypoxia-Regulated miRNAs in Human Mesenchymal Stem Cells: Exploring the Regulatory Effects in Ischemic Disorders.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

Department of Precision Medicine, Università degli Studi della Campania L. Vanvitelli, Via L. De Crecchio, 7, 80138 Naples, Italy.

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http://dx.doi.org/10.3390/ijms20061340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471025PMC
March 2019

on anti-FGFR to fight cancer resistance.

EMBO Mol Med 2019 02;11(2)

Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.

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http://dx.doi.org/10.15252/emmm.201810116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365924PMC
February 2019

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

Eur J Med Chem 2019 Jan 3;162:290-320. Epub 2018 Nov 3.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, via Aldo Moro 2, I-53100, Siena, Italy; Istituto Toscano Tumori, University of Siena, via Aldo Moro 2, I-53100, Siena, Italy; Department of Pharmacy, University of Napoli Federico II, DoE Department of Excellence 2018-2022, Via D. Montesano 49, 80131, Napoli, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183095
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http://dx.doi.org/10.1016/j.ejmech.2018.11.004DOI Listing
January 2019

Dual Tumor Suppressor and Tumor Promoter Action of Sirtuins in Determining Malignant Phenotype.

Front Pharmacol 2019 30;10:38. Epub 2019 Jan 30.

Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.

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http://dx.doi.org/10.3389/fphar.2019.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363704PMC
January 2019

Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1-Dichloromethylinden-1-ol Analogues.

ChemMedChem 2018 09 21;13(18):1949-1956. Epub 2018 Aug 21.

Departamento de Química Orgánica, Facultade de Química, CINBIO and IBIV, Universidade de Vigo, Campus As Lagoas-Marcosende, 36310, Vigo, Spain.

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http://dx.doi.org/10.1002/cmdc.201800377DOI Listing
September 2018

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.

Eur J Med Chem 2018 Sep 31;157:127-138. Epub 2018 Jul 31.

European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2018.07.069DOI Listing
September 2018

3-Chloro-'-(2-hydroxybenzylidene) benzohydrazide: An LSD1-Selective Inhibitor and Iron-Chelating Agent for Anticancer Therapy.

Front Pharmacol 2018 7;9:1006. Epub 2018 Sep 7.

Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.

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http://dx.doi.org/10.3389/fphar.2018.01006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137965PMC
September 2018

Forskolin Sensitizes Human Acute Myeloid Leukemia Cells to H3K27me2/3 Demethylases GSKJ4 Inhibitor via Protein Kinase A.

Front Pharmacol 2018 20;9:792. Epub 2018 Jul 20.

Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.3389/fphar.2018.00792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063003PMC
July 2018

Cancer epigenetics: Moving forward.

PLoS Genet 2018 06 7;14(6):e1007362. Epub 2018 Jun 7.

Dipartimento di Medicina di Precisione, Università degli Studi della Campania "L. Vanvitelli," Napoli, Italy.

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http://dx.doi.org/10.1371/journal.pgen.1007362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991666PMC
June 2018

The HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia.

Oncogene 2018 05 22;37(19):2559-2572. Epub 2018 Feb 22.

Department of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli", Vico L. De Crecchio 7, 80138, Napoli, Italy.

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http://dx.doi.org/10.1038/s41388-018-0143-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945585PMC
May 2018

HDAC inhibitors as epigenetic regulators for cancer immunotherapy.

Int J Biochem Cell Biol 2018 05 10;98:65-74. Epub 2018 Mar 10.

Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2018.03.004DOI Listing
May 2018

Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells.

Sci Rep 2018 04 11;8(1):5842. Epub 2018 Apr 11.

Department of Biochemistry, Biophysics and General Pathology, Università degli Studi della Campania L. Vanvitelli, Via L. De Crecchio, 7, 80138, Naples, Italy.

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http://dx.doi.org/10.1038/s41598-018-24221-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895792PMC
April 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death.

ChemMedChem 2018 02 18;13(3):227-230. Epub 2018 Jan 18.

Department for Life Quality Studies, Alma Mater Studiorum - University of Bologna, Corso d'Augusto 237, 47921, Rimini, Italy.

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http://dx.doi.org/10.1002/cmdc.201700601DOI Listing
February 2018

MicroRNA Expression Profiling Using Agilent One-Color Microarray.

Methods Mol Biol 2017 ;1509:169-183

Institute of Genetics and Biophysics, CNR, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/978-1-4939-6524-3_16DOI Listing
January 2018

Bisphenol A induces cell cycle arrest in primary and prostate cancer cells through EGFR/ERK/p53 signaling pathway activation.

Oncotarget 2017 12 18;8(70):115620-115631. Epub 2017 Dec 18.

Department of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.18632/oncotarget.23360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777798PMC
December 2017

Breast Cancer Vaccines: New Insights.

Front Endocrinol (Lausanne) 2017 13;8:270. Epub 2017 Oct 13.

Dipartimento di Biochimica Biofisica e Patologia generale, Università degli Studi della Campania 'L. Vanvitelli' Naples, Naples, Italy.

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http://dx.doi.org/10.3389/fendo.2017.00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645504PMC
October 2017

Time-resolved analysis of DNA-protein interactions in living cells by UV laser pulses.

Sci Rep 2017 09 15;7(1):11725. Epub 2017 Sep 15.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Università degli Studi della Campania "L. Vanvitelli", Vico L. De Crecchio 7, 80138, Napoli, IT, Italy.

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http://dx.doi.org/10.1038/s41598-017-12010-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601431PMC
September 2017

Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.

ChemMedChem 2017 08 12;12(16):1359-1368. Epub 2017 Apr 12.

Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" Università di Roma, P.le Aldo Moro 5, 00185, Roma, Italy.

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http://dx.doi.org/10.1002/cmdc.201700040DOI Listing
August 2017

A key HDAC6 dependency of ARID1A-mutated ovarian cancer.

Authors:
Lucia Altucci

Nat Cell Biol 2017 Jul;19(8):889-890

Dipartimento di Biochimica, Biofisica e Patologia generale, Università degli Studi della Campania 'Luigi Vanvitelli', Vico L. De Crecchio 7, 80138 Napoli, Italy.

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http://dx.doi.org/10.1038/ncb3588DOI Listing
July 2017

Identification and characterization of PKF118-310 as a KDM4A inhibitor.

Epigenetics 2017 03 21;12(3):198-205. Epub 2016 Oct 21.

a Dipartimento di Biochimica , Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli , Napoli , Italy.

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http://dx.doi.org/10.1080/15592294.2016.1249089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406213PMC
March 2017

Epigenetic drugs: from chemistry via biology to medicine and back.

Clin Epigenetics 2016 23;8:56. Epub 2016 May 23.

University Medical Center Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.1186/s13148-016-0222-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876560PMC
December 2016

Sirtuin functions and modulation: from chemistry to the clinic.

Clin Epigenetics 2016 25;8:61. Epub 2016 May 25.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, 80138 Napoli, Italy.

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http://dx.doi.org/10.1186/s13148-016-0224-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879741PMC
December 2016

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs.

Cell Rep 2016 11;17(8):2087-2100

Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, the Netherlands; Dipartimento di Patologia Generale, Seconda Università degli Studi di Napoli, Vico Luigi de Crecchio 7, 80138 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.082DOI Listing
November 2016

Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems.

Cell Rep 2016 11;17(8):2101-2111

CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, Barcelona 08028, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889099PMC
November 2016

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies.

Future Med Chem 2016 09 24;8(13):1573-87. Epub 2016 Aug 24.

European Research Centre for Drug Discovery & Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.4155/fmc-2016-0068DOI Listing
September 2016

MicroRNA-34a regulates doxorubicin-induced cardiotoxicity in rat.

Oncotarget 2016 Sep;7(38):62312-62326

Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy.

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http://dx.doi.org/10.18632/oncotarget.11468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308729PMC
September 2016

ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias.

Epigenetics 2015 27;10(1):6-18. Epub 2015 Jan 27.

a Dipartimento di Biochimica, Biofisica e Patologia Generale ; Seconda Università di Napoli ; Napoli , Italy.

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http://dx.doi.org/10.4161/15592294.2014.988035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622697PMC
June 2016

Genetic mutations in epigenetic modifiers as therapeutic targets in acute myeloid leukemia.

Expert Opin Ther Targets 2015 30;19(9):1187-202. Epub 2015 May 30.

Department of Biochemistry, Biophysics and General Pathology, Second University of Naples , Via L. De Crecchio 7, 80138 Naples , Italy.

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http://dx.doi.org/10.1517/14728222.2015.1051728DOI Listing
April 2016

Secretome profiling of cytokines and growth factors reveals that neuro-glial differentiation is associated with the down-regulation of Chemokine Ligand 2 (MCP-1/CCL2) in amniotic fluid derived-mesenchymal progenitor cells.

Proteomics 2016 Feb 18;16(4):674-88. Epub 2016 Jan 18.

Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Caserta, Italy.

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http://dx.doi.org/10.1002/pmic.201500223DOI Listing
February 2016

D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts.

Biochim Biophys Acta 2016 01 28;1862(1):93-104. Epub 2015 Oct 28.

Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.10.021DOI Listing
January 2016

Epigenetic-based therapy: From single- to multi-target approaches.

Int J Biochem Cell Biol 2015 Dec 19;69:121-31. Epub 2015 Oct 19.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università di Napoli, Vico L. De Crecchio 7, 80138 Napoli, Italy; Istituto di Genetica e Biofisica, Adriano Buzzati Traverso, CNR-IGB, Via P. Castellino 111, 80131 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2015.10.016DOI Listing
December 2015

Glycation of Wild-Type Apomyoglobin Induces Formation of Highly Cytotoxic Oligomeric Species.

J Cell Physiol 2015 Nov;230(11):2807-20

Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.

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http://dx.doi.org/10.1002/jcp.25011DOI Listing
November 2015

Targeting Histone Deacetylases in Diseases: Where Are We?

Antioxid Redox Signal 2015 Jul 6;23(1):99-126. Epub 2014 Mar 6.

1 Department of Biochemistry, Biophysics, and General Pathology, Seconda Università degli Studi di Napoli , Napoli, Italy .

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http://dx.doi.org/10.1089/ars.2013.5776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492558PMC
July 2015

Corrigendum to "SIRT1 inhibition affects angiogenic properties of human MSCs".

Biomed Res Int 2015 25;2015:132086. Epub 2015 Mar 25.

Department of Biochemistry, Biophysics and General Pathology, Second University of Napoli, Via L. De Crecchio 7, 80138 Napoli, Italy.

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http://dx.doi.org/10.1155/2015/132086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389819PMC
July 2015

SIRT1 inhibition affects angiogenic properties of human MSCs.

Biomed Res Int 2014 27;2014:783459. Epub 2014 Aug 27.

Department of Biochemistry, Biophysics and General Pathology, Second University of Napoli, Via L. De Crecchio 7, 80138 Napoli, Italy ; Istituto Nazionale Tumori, Struttura Complessa Oncologia Medica Melanoma Immunoterapia Oncologica e Terapia Innovativa, Via Mariano Semmola, 80131 Napoli, Italy.

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http://www.hindawi.com/journals/bmri/2014/783459/
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http://dx.doi.org/10.1155/2014/783459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163475PMC
June 2015

Analysis of chromatin-nuclear receptor interactions by laser-chromatin immunoprecipitation.

Methods Mol Biol 2014 ;1204:25-34

Dipartimento di Biochimica, Biofisica e Patologia Generale-II Università di Napoli, Via L. De Crecchio, 7, 80138, Naples, Italy.

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http://link.springer.com/10.1007/978-1-4939-1346-6_3
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-1346-6_3DOI Listing
May 2015

HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape.

Oncotarget 2015 Jan;6(2):886-901

Department of Biochemistry, Biophysics and General Pathology, Seconda Università degli Studi di Napoli, vico L. De Crecchio, Naples, IT.Institute of Genetics and Biophysics, IGB 'Adriano Buzzati-Traverso', Via P. Castellino, Naples, IT.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359263PMC
http://dx.doi.org/10.18632/oncotarget.2816DOI Listing
January 2015

Natural compounds in epigenetics: a current view.

Food Chem Toxicol 2014 Nov 17;73:71-83. Epub 2014 Aug 17.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Universita' di Napoli, Via L. De Crecchio 7, 80138 Napoli, Italy; Istituto di Genetica e Biofisica, Adriano Buzzati-Traverso, IGB, Via P. Castellino 111, 80131 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2014.08.005DOI Listing
November 2014

Epigenetic drugs against cancer: an evolving landscape.

Arch Toxicol 2014 Sep 2;88(9):1651-68. Epub 2014 Aug 2.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, 80138, Naples, Italy.

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http://dx.doi.org/10.1007/s00204-014-1315-6DOI Listing
September 2014

1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.

J Med Chem 2014 Jul 8;57(14):6259-65. Epub 2014 Jul 8.

Department of Drug Chemistry and Technologies, Sapienza University of Rome , P. le A. Moro 5, 00185 Rome Italy.

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http://pubs.acs.org/doi/10.1021/jm500303u
Publisher Site
http://dx.doi.org/10.1021/jm500303uDOI Listing
July 2014

Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies.

Eur J Med Chem 2014 Jun 15;80:569-78. Epub 2014 Apr 15.

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy; Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.04.042DOI Listing
June 2014

Identification of NuRSERY, a new functional HDAC complex composed by HDAC5, GATA1, EKLF and pERK present in human erythroid cells.

Int J Biochem Cell Biol 2014 May 1;50:112-22. Epub 2014 Mar 1.

Hematology/Oncology, Mount Sinai School of Medicine, One Gustave L. Levy, New York, NY, USA; Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita', Viale Regina Elena 299, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003889PMC
May 2014

Functions, aberrations, and advances for chromatin modulation in cancer.

Cancer Treat Res 2014 ;159:227-39

Dipartimento di Biochimica, Biofisica e Patologia generale, Seconda Università di Napoli, Vico L. De Crecchio 7, 80138, Naples, Italy.

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http://dx.doi.org/10.1007/978-3-642-38007-5_13DOI Listing
April 2014

Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392.

Cancer Res 2014 Apr 24;74(8):2328-39. Epub 2014 Feb 24.

Authors' Affiliations: Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli; Istituto di Genetica e Biofisica, IGB, Adriano Buzzati Traverso, Naples; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy; NCMLS, Radboud University, Nijmegen, the Netherlands; Inserm, CRCM, U1068, TrGET & ISCB, University of Marseille; and Laboratoire U944 and UMR 7212, University Paris-Diderot, Paris, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2568DOI Listing
April 2014

Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications.

Stem Cell Res 2014 Mar 28;12(2):323-37. Epub 2013 Nov 28.

Department of Biophysics, Biochemistry and General Pathology, Seconda Università di Napoli, 80138 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2013.11.008DOI Listing
March 2014

Nuclear size as estrogen-responsive chromatin quality parameter of mouse spermatozoa.

Gen Comp Endocrinol 2013 Nov 21;193:201-9. Epub 2013 Aug 21.

Dipartimento di Medicina Sperimentale, Sez. Bottazzi, Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00166480130033
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http://dx.doi.org/10.1016/j.ygcen.2013.07.018DOI Listing
November 2013

The class I-specific HDAC inhibitor MS-275 modulates the differentiation potential of mouse embryonic stem cells.

Biol Open 2013 22;2(10):1070-7. Epub 2013 Aug 22.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli , Vico L. De Crecchio 7, 80138 Napoli , Italy ; Department of Molecular Biology, Faculties of Science and Medicine, Radboud University, Nijmegen Center for Molecular Life Sciences , 6500 HB Nijmegen , The Netherlands.

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http://dx.doi.org/10.1242/bio.20135587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798190PMC
October 2013

Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells.

Cell Stem Cell 2013 Sep 11;13(3):360-9. Epub 2013 Jul 11.

Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences NCMLS, Radboud University, 6525GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.stem.2013.06.002DOI Listing
September 2013

Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells.

J Clin Endocrinol Metab 2013 Jun 29;98(6):E1031-40. Epub 2013 Mar 29.

Istituto di Endocrinologia ed Oncologia Sperimentale-Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II and European School of Molecular Medicine, Naples 80131, Italy.

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http://dx.doi.org/10.1210/jc.2012-4092DOI Listing
June 2013

Antioxidant, antimicrobial and anti-proliferative activities of Solanum tuberosum L. var. Vitelotte.

Food Chem Toxicol 2013 May 11;55:304-12. Epub 2013 Jan 11.

Department of General Pathology, Second University of Naples, Vico L. de Crecchio 7, 80138 Napoli, Italy.

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http://dx.doi.org/10.1016/j.fct.2012.12.048DOI Listing
May 2013

Altered folate receptor 2 expression in uraemic patients on haemodialysis: implications for folate resistance.

Nephrol Dial Transplant 2013 May 24;28(5):1214-24. Epub 2013 Feb 24.

First Division of Nephrology, Department of Cardio-thoracic and Respiratory Sciences, Second University of Naples, School of Medicine, Naples, Italy.

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http://dx.doi.org/10.1093/ndt/gfs510DOI Listing
May 2013

tert-Butylcarbamate-containing histone deacetylase inhibitors: apoptosis induction, cytodifferentiation, and antiproliferative activities in cancer cells.

ChemMedChem 2013 May 25;8(5):800-11. Epub 2013 Mar 25.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le A. Moro 5, 00185 Roma, Italy.

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http://dx.doi.org/10.1002/cmdc.201300005DOI Listing
May 2013

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

Blood 2013 Apr 25;121(17):3459-68. Epub 2013 Feb 25.

Department of Experimental Oncology at the IFOM-IEO Campus, European Institute of Oncology, via Adamello 16, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2012-10-461988DOI Listing
April 2013

Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line.

Bioorg Med Chem Lett 2013 Mar 30;23(6):1631-5. Epub 2013 Jan 30.

Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain.

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http://dx.doi.org/10.1016/j.bmcl.2013.01.085DOI Listing
March 2013

miRNA-mediated deregulation in leukemia.

Front Genet 2012 15;3:252. Epub 2012 Nov 15.

Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche Naples, Italy ; Department of General Pathology, Second University of Naples Naples, Italy.

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http://dx.doi.org/10.3389/fgene.2012.00252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555518PMC
February 2013

Histone deacetylase inhibitors: a patent review (2009 - 2011).

Expert Opin Ther Pat 2013 Jan 25;23(1):1-17. Epub 2012 Oct 25.

Seconda Università degli Studi di Napoli, Dipartimento di Patologia Generale, Italy.

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http://dx.doi.org/10.1517/13543776.2013.736493DOI Listing
January 2013

A DNA methyltransferase modulator inspired by peyssonenyne natural product structures.

ChemMedChem 2012 Dec 9;7(12):2101-12. Epub 2012 Oct 9.

Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain.

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http://dx.doi.org/10.1002/cmdc.201200366DOI Listing
December 2012

Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues.

Epigenetics 2012 Dec 18;7(12):1355-67. Epub 2012 Oct 18.

Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.4161/epi.22562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528691PMC
December 2012

Trials with 'epigenetic' drugs: an update.

Mol Oncol 2012 Dec 6;6(6):657-82. Epub 2012 Oct 6.

Dipartimento di Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. de Crecchio 7, Napoli 80138, Italy.

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http://dx.doi.org/10.1016/j.molonc.2012.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528349PMC
December 2012

Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies.

ChemMedChem 2012 Nov;7(11):1905-8

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le A. Moro 5, 00185 Roma (Italy).

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http://doi.wiley.com/10.1002/cmdc.201200318
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http://dx.doi.org/10.1002/cmdc.201200318DOI Listing
November 2012