Publications by authors named "Lucia Altucci"

100Publications

Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs).

Bioorg Chem 2020 Nov 6:104462. Epub 2020 Nov 6.

Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, via G. Campi 103, 41125 Modena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2020.104462DOI Listing
November 2020

Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation.

Eur J Med Chem 2020 Nov 7:112998. Epub 2020 Nov 7.

Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2020.112998DOI Listing
November 2020

Preclinical and Clinical Epigenetic-Based Reconsideration of Beckwith-Wiedemann Syndrome.

Front Genet 2020 15;11:563718. Epub 2020 Sep 15.

Department of Precision Medicine, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.3389/fgene.2020.563718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522569PMC
September 2020

Extracellular Vesicle-Based Nucleic Acid Delivery: Current Cancer Therapeutic Strategies.

Pharmaceutics 2020 Oct 16;12(10). Epub 2020 Oct 16.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio 7, 80138 Naples, Italy.

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http://dx.doi.org/10.3390/pharmaceutics12100980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589909PMC
October 2020

Recent insights into : biological function and involvement in pathogenesis.

Epigenetics 2020 Oct 4:1-13. Epub 2020 Oct 4.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli" , Naples, Italy.

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http://dx.doi.org/10.1080/15592294.2020.1827723DOI Listing
October 2020

A global network for network medicine.

NPJ Syst Biol Appl 2020 08 31;6(1):29. Epub 2020 Aug 31.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41540-020-00143-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459285PMC
August 2020

SIRT1 Activation by Natural Phytochemicals: An Overview.

Front Pharmacol 2020 7;11:1225. Epub 2020 Aug 7.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.3389/fphar.2020.01225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426493PMC
August 2020

Editorial: Sirtuinome Rewiring to Hijack Cancer Cell Behavior and Hamper Resistance to Anticancer Intervention.

Front Oncol 2020 22;10:1242. Epub 2020 Jul 22.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.3389/fonc.2020.01242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387680PMC
July 2020

The Ubiquitin Proteasome System in Hematological Malignancies: New Insight into Its Functional Role and Therapeutic Options.

Cancers (Basel) 2020 Jul 14;12(7). Epub 2020 Jul 14.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. De Crecchio 7, 80138 Naples, Italy.

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http://dx.doi.org/10.3390/cancers12071898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409207PMC
July 2020

A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin.

Front Chem 2020 25;8:312. Epub 2020 May 25.

Departamento de Química Orgánica, Facultade de Química and Centro de Investigacións Biomédicas (CINBIO), Universidade de Vigo, Vigo, Spain.

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http://dx.doi.org/10.3389/fchem.2020.00312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261929PMC
May 2020

Design of Dual Inhibitors of Histone Deacetylase 6 and Heat Shock Protein 90.

ACS Omega 2020 May 11;5(20):11473-11480. Epub 2020 May 11.

Department of Life Sciences, University of Modena and Reggio Emilia. Via G. Campi 103, 41125 Modena, Italy.

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http://dx.doi.org/10.1021/acsomega.0c00559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254527PMC
May 2020

The Cannabinoid Receptor CB1 Stabilizes Sperm Chromatin Condensation Status During Epididymal Transit by Promoting Disulphide Bond Formation.

Int J Mol Sci 2020 Apr 28;21(9). Epub 2020 Apr 28.

Department of Experimental Medicine, Sez. Bottazzi, Università degli Studi della Campania "L. Vanvitelli", Via Costantinopoli 16, 80138 Napoli, Italy.

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http://dx.doi.org/10.3390/ijms21093117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247701PMC
April 2020

The Network Medicine Imperative and the Need for an International Network Medicine Consortium.

Am J Med 2020 09 19;133(9):e451-e454. Epub 2020 Apr 19.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.03.034DOI Listing
September 2020

Fetal-Perinatal Exposure to Bisphenol-A Affects Quality of Spermatozoa in Adulthood Mouse.

Int J Endocrinol 2020 20;2020:2750501. Epub 2020 Mar 20.

Department of Experimental Medicine, Sez. Bottazzi, Università degli Studi della Campania "L. Vanvitelli", Via Costantinopoli 16, 80138 Napoli, Italy.

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http://dx.doi.org/10.1155/2020/2750501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109585PMC
March 2020

Blocks Proliferation in Chronic Myelogenous Leukemia via the BCR-ABL/STAT5 Pathway.

Cells 2020 02 6;9(2). Epub 2020 Feb 6.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

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http://dx.doi.org/10.3390/cells9020379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072565PMC
February 2020

DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment.

Epigenetics 2020 05 28;15(5):439-453. Epub 2019 Dec 28.

Dipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli" Napoli, Napoli, Italy.

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http://dx.doi.org/10.1080/15592294.2019.1699991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188393PMC
May 2020

Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy.

Cancers (Basel) 2019 Sep 29;11(10). Epub 2019 Sep 29.

Department of Precision Medicine, University of Campania "L. Vanvitelli", via L. De Crecchio, 7, 80138 Naples, Italy.

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http://dx.doi.org/10.3390/cancers11101465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826381PMC
September 2019

HDAC2-dependent miRNA signature in acute myeloid leukemia.

FEBS Lett 2019 09 19;593(18):2574-2584. Epub 2019 Jul 19.

Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.1002/1873-3468.13521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790563PMC
September 2019

Histone Deacetylase Inhibitors Impair Vasculogenic Mimicry from Glioblastoma Cells.

Cancers (Basel) 2019 May 29;11(6). Epub 2019 May 29.

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.

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http://dx.doi.org/10.3390/cancers11060747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627137PMC
May 2019

BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition.

Cell Death Dis 2019 04 18;10(5):338. Epub 2019 Apr 18.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. De Crecchio 7, 80138, Napoli, Italy.

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http://dx.doi.org/10.1038/s41419-019-1570-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472371PMC
April 2019

Hypoxia-Regulated miRNAs in Human Mesenchymal Stem Cells: Exploring the Regulatory Effects in Ischemic Disorders.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

Department of Precision Medicine, Università degli Studi della Campania L. Vanvitelli, Via L. De Crecchio, 7, 80138 Naples, Italy.

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http://dx.doi.org/10.3390/ijms20061340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471025PMC
March 2019

Cardioprotective effect of a moderate and prolonged exercise training involves sirtuin pathway.

Life Sci 2019 Apr 5;222:140-147. Epub 2019 Mar 5.

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli", 80138, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2019.03.001DOI Listing
April 2019

Dual Tumor Suppressor and Tumor Promoter Action of Sirtuins in Determining Malignant Phenotype.

Front Pharmacol 2019 30;10:38. Epub 2019 Jan 30.

Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.

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http://dx.doi.org/10.3389/fphar.2019.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363704PMC
January 2019

on anti-FGFR to fight cancer resistance.

EMBO Mol Med 2019 02;11(2)

Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.

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http://dx.doi.org/10.15252/emmm.201810116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365924PMC
February 2019

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

Eur J Med Chem 2019 Jan 3;162:290-320. Epub 2018 Nov 3.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, via Aldo Moro 2, I-53100, Siena, Italy; Istituto Toscano Tumori, University of Siena, via Aldo Moro 2, I-53100, Siena, Italy; Department of Pharmacy, University of Napoli Federico II, DoE Department of Excellence 2018-2022, Via D. Montesano 49, 80131, Napoli, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183095
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http://dx.doi.org/10.1016/j.ejmech.2018.11.004DOI Listing
January 2019

3-Chloro-'-(2-hydroxybenzylidene) benzohydrazide: An LSD1-Selective Inhibitor and Iron-Chelating Agent for Anticancer Therapy.

Front Pharmacol 2018 7;9:1006. Epub 2018 Sep 7.

Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.

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http://dx.doi.org/10.3389/fphar.2018.01006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137965PMC
September 2018

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.

Eur J Med Chem 2018 Sep 31;157:127-138. Epub 2018 Jul 31.

European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2018.07.069DOI Listing
September 2018

Forskolin Sensitizes Human Acute Myeloid Leukemia Cells to H3K27me2/3 Demethylases GSKJ4 Inhibitor via Protein Kinase A.

Front Pharmacol 2018 20;9:792. Epub 2018 Jul 20.

Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.3389/fphar.2018.00792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063003PMC
July 2018

Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1-Dichloromethylinden-1-ol Analogues.

ChemMedChem 2018 09 21;13(18):1949-1956. Epub 2018 Aug 21.

Departamento de Química Orgánica, Facultade de Química, CINBIO and IBIV, Universidade de Vigo, Campus As Lagoas-Marcosende, 36310, Vigo, Spain.

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http://dx.doi.org/10.1002/cmdc.201800377DOI Listing
September 2018

Cancer epigenetics: Moving forward.

PLoS Genet 2018 06 7;14(6):e1007362. Epub 2018 Jun 7.

Dipartimento di Medicina di Precisione, Università degli Studi della Campania "L. Vanvitelli," Napoli, Italy.

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http://dx.doi.org/10.1371/journal.pgen.1007362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991666PMC
June 2018

Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells.

Sci Rep 2018 04 11;8(1):5842. Epub 2018 Apr 11.

Department of Biochemistry, Biophysics and General Pathology, Università degli Studi della Campania L. Vanvitelli, Via L. De Crecchio, 7, 80138, Naples, Italy.

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http://dx.doi.org/10.1038/s41598-018-24221-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895792PMC
April 2018

HDAC inhibitors as epigenetic regulators for cancer immunotherapy.

Int J Biochem Cell Biol 2018 05 10;98:65-74. Epub 2018 Mar 10.

Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Vico L. De Crecchio 7, 80138, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2018.03.004DOI Listing
May 2018

The HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia.

Oncogene 2018 05 22;37(19):2559-2572. Epub 2018 Feb 22.

Department of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli", Vico L. De Crecchio 7, 80138, Napoli, Italy.

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http://dx.doi.org/10.1038/s41388-018-0143-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945585PMC
May 2018

Bisphenol A induces cell cycle arrest in primary and prostate cancer cells through EGFR/ERK/p53 signaling pathway activation.

Oncotarget 2017 12 18;8(70):115620-115631. Epub 2017 Dec 18.

Department of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.18632/oncotarget.23360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777798PMC
December 2017

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death.

ChemMedChem 2018 02 18;13(3):227-230. Epub 2018 Jan 18.

Department for Life Quality Studies, Alma Mater Studiorum - University of Bologna, Corso d'Augusto 237, 47921, Rimini, Italy.

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http://dx.doi.org/10.1002/cmdc.201700601DOI Listing
February 2018

Breast Cancer Vaccines: New Insights.

Front Endocrinol (Lausanne) 2017 13;8:270. Epub 2017 Oct 13.

Dipartimento di Biochimica Biofisica e Patologia generale, Università degli Studi della Campania 'L. Vanvitelli' Naples, Naples, Italy.

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http://dx.doi.org/10.3389/fendo.2017.00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645504PMC
October 2017

Time-resolved analysis of DNA-protein interactions in living cells by UV laser pulses.

Sci Rep 2017 09 15;7(1):11725. Epub 2017 Sep 15.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Università degli Studi della Campania "L. Vanvitelli", Vico L. De Crecchio 7, 80138, Napoli, IT, Italy.

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http://dx.doi.org/10.1038/s41598-017-12010-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601431PMC
September 2017

A key HDAC6 dependency of ARID1A-mutated ovarian cancer.

Authors:
Lucia Altucci

Nat Cell Biol 2017 Jul;19(8):889-890

Dipartimento di Biochimica, Biofisica e Patologia generale, Università degli Studi della Campania 'Luigi Vanvitelli', Vico L. De Crecchio 7, 80138 Napoli, Italy.

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http://dx.doi.org/10.1038/ncb3588DOI Listing
July 2017

Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.

ChemMedChem 2017 08 12;12(16):1359-1368. Epub 2017 Apr 12.

Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" Università di Roma, P.le Aldo Moro 5, 00185, Roma, Italy.

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http://dx.doi.org/10.1002/cmdc.201700040DOI Listing
August 2017

Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems.

Cell Rep 2016 11;17(8):2101-2111

CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, Barcelona 08028, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889099PMC
November 2016

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs.

Cell Rep 2016 11;17(8):2087-2100

Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, the Netherlands; Dipartimento di Patologia Generale, Seconda Università degli Studi di Napoli, Vico Luigi de Crecchio 7, 80138 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.082DOI Listing
November 2016

MicroRNA Expression Profiling Using Agilent One-Color Microarray.

Methods Mol Biol 2017 ;1509:169-183

Institute of Genetics and Biophysics, CNR, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/978-1-4939-6524-3_16DOI Listing
January 2018

Identification and characterization of PKF118-310 as a KDM4A inhibitor.

Epigenetics 2017 03 21;12(3):198-205. Epub 2016 Oct 21.

a Dipartimento di Biochimica , Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli , Napoli , Italy.

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http://dx.doi.org/10.1080/15592294.2016.1249089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406213PMC
March 2017

MicroRNA-34a regulates doxorubicin-induced cardiotoxicity in rat.

Oncotarget 2016 Sep;7(38):62312-62326

Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy.

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http://dx.doi.org/10.18632/oncotarget.11468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308729PMC
September 2016

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies.

Future Med Chem 2016 09 24;8(13):1573-87. Epub 2016 Aug 24.

European Research Centre for Drug Discovery & Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.4155/fmc-2016-0068DOI Listing
September 2016

Sirtuin functions and modulation: from chemistry to the clinic.

Clin Epigenetics 2016 25;8:61. Epub 2016 May 25.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, 80138 Napoli, Italy.

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http://dx.doi.org/10.1186/s13148-016-0224-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879741PMC
December 2016

Epigenetic drugs: from chemistry via biology to medicine and back.

Clin Epigenetics 2016 23;8:56. Epub 2016 May 23.

University Medical Center Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.1186/s13148-016-0222-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876560PMC
December 2016

Secretome profiling of cytokines and growth factors reveals that neuro-glial differentiation is associated with the down-regulation of Chemokine Ligand 2 (MCP-1/CCL2) in amniotic fluid derived-mesenchymal progenitor cells.

Proteomics 2016 Feb 18;16(4):674-88. Epub 2016 Jan 18.

Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Caserta, Italy.

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http://dx.doi.org/10.1002/pmic.201500223DOI Listing
February 2016

D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts.

Biochim Biophys Acta 2016 01 28;1862(1):93-104. Epub 2015 Oct 28.

Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.10.021DOI Listing
January 2016

Epigenetic-based therapy: From single- to multi-target approaches.

Int J Biochem Cell Biol 2015 Dec 19;69:121-31. Epub 2015 Oct 19.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università di Napoli, Vico L. De Crecchio 7, 80138 Napoli, Italy; Istituto di Genetica e Biofisica, Adriano Buzzati Traverso, CNR-IGB, Via P. Castellino 111, 80131 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2015.10.016DOI Listing
December 2015

Genetic mutations in epigenetic modifiers as therapeutic targets in acute myeloid leukemia.

Expert Opin Ther Targets 2015 30;19(9):1187-202. Epub 2015 May 30.

Department of Biochemistry, Biophysics and General Pathology, Second University of Naples , Via L. De Crecchio 7, 80138 Naples , Italy.

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http://dx.doi.org/10.1517/14728222.2015.1051728DOI Listing
April 2016

Corrigendum to "SIRT1 inhibition affects angiogenic properties of human MSCs".

Biomed Res Int 2015 25;2015:132086. Epub 2015 Mar 25.

Department of Biochemistry, Biophysics and General Pathology, Second University of Napoli, Via L. De Crecchio 7, 80138 Napoli, Italy.

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http://dx.doi.org/10.1155/2015/132086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389819PMC
July 2015

Glycation of Wild-Type Apomyoglobin Induces Formation of Highly Cytotoxic Oligomeric Species.

J Cell Physiol 2015 Nov;230(11):2807-20

Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.

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http://dx.doi.org/10.1002/jcp.25011DOI Listing
November 2015

ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias.

Epigenetics 2015 27;10(1):6-18. Epub 2015 Jan 27.

a Dipartimento di Biochimica, Biofisica e Patologia Generale ; Seconda Università di Napoli ; Napoli , Italy.

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http://dx.doi.org/10.4161/15592294.2014.988035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622697PMC
June 2016

HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape.

Oncotarget 2015 Jan;6(2):886-901

Department of Biochemistry, Biophysics and General Pathology, Seconda Università degli Studi di Napoli, vico L. De Crecchio, Naples, IT.Institute of Genetics and Biophysics, IGB 'Adriano Buzzati-Traverso', Via P. Castellino, Naples, IT.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359263PMC
http://dx.doi.org/10.18632/oncotarget.2816DOI Listing
January 2015

SIRT1 inhibition affects angiogenic properties of human MSCs.

Biomed Res Int 2014 27;2014:783459. Epub 2014 Aug 27.

Department of Biochemistry, Biophysics and General Pathology, Second University of Napoli, Via L. De Crecchio 7, 80138 Napoli, Italy ; Istituto Nazionale Tumori, Struttura Complessa Oncologia Medica Melanoma Immunoterapia Oncologica e Terapia Innovativa, Via Mariano Semmola, 80131 Napoli, Italy.

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http://www.hindawi.com/journals/bmri/2014/783459/
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163475PMC
June 2015

Analysis of chromatin-nuclear receptor interactions by laser-chromatin immunoprecipitation.

Methods Mol Biol 2014 ;1204:25-34

Dipartimento di Biochimica, Biofisica e Patologia Generale-II Università di Napoli, Via L. De Crecchio, 7, 80138, Naples, Italy.

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http://link.springer.com/10.1007/978-1-4939-1346-6_3
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http://dx.doi.org/10.1007/978-1-4939-1346-6_3DOI Listing
May 2015

Natural compounds in epigenetics: a current view.

Food Chem Toxicol 2014 Nov 17;73:71-83. Epub 2014 Aug 17.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Universita' di Napoli, Via L. De Crecchio 7, 80138 Napoli, Italy; Istituto di Genetica e Biofisica, Adriano Buzzati-Traverso, IGB, Via P. Castellino 111, 80131 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2014.08.005DOI Listing
November 2014

Epigenetic drugs against cancer: an evolving landscape.

Arch Toxicol 2014 Sep 2;88(9):1651-68. Epub 2014 Aug 2.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, 80138, Naples, Italy.

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http://dx.doi.org/10.1007/s00204-014-1315-6DOI Listing
September 2014

1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.

J Med Chem 2014 Jul 8;57(14):6259-65. Epub 2014 Jul 8.

Department of Drug Chemistry and Technologies, Sapienza University of Rome , P. le A. Moro 5, 00185 Rome Italy.

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http://pubs.acs.org/doi/10.1021/jm500303u
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July 2014

Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies.

Eur J Med Chem 2014 Jun 15;80:569-78. Epub 2014 Apr 15.

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy; Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.04.042DOI Listing
June 2014