Lucas D Ward

Lucas D Ward

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Lucas D Ward

Lucas D Ward

Publications by authors named "Lucas D Ward"

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27Publications

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Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence.

Toxicol Sci 2019 02;167(2):593-603

Comparative Biology and Safety Sciences, Amgen Inc, Cambridge, Massachusetts 02142.

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http://dx.doi.org/10.1093/toxsci/kfy265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358245PMC
February 2019

Comment on "Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors".

Drug Saf 2018 11;41(11):1097-1099

Department of Comparative Biology and Safety Sciences, Amgen, Inc, 360 Binney St, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1007/s40264-018-0702-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182455PMC
November 2018

Modernizing Human Cancer Risk Assessment of Therapeutics.

Trends Pharmacol Sci 2018 03 11;39(3):232-247. Epub 2017 Dec 11.

ToxRox Consulting, McLean, VA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01656147173022
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http://dx.doi.org/10.1016/j.tips.2017.11.005DOI Listing
March 2018

HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease.

Nucleic Acids Res 2016 Jan 10;44(D1):D877-81. Epub 2015 Dec 10.

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA The Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA

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http://dx.doi.org/10.1093/nar/gkv1340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702929PMC
January 2016

Integrative analysis of 111 reference human epigenomes.

Nature 2015 Feb;518(7539):317-30

1] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, Massachusetts 02139, USA. [2] The Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature14248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530010PMC
February 2015

Characterizing a collective and dynamic component of chromatin immunoprecipitation enrichment profiles in yeast.

BMC Genomics 2014 Jun 19;15:494. Epub 2014 Jun 19.

Department of Biological Sciences, Columbia University, 1212 Amsterdam Ave, New York, NY 10027, USA.

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http://dx.doi.org/10.1186/1471-2164-15-494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124144PMC
June 2014

Response to comment on "Evidence of abundant purifying selection in humans for recently acquired regulatory functions".

Science 2013 May;340(6133):682

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1233366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131756PMC
May 2013

Interpreting noncoding genetic variation in complex traits and human disease.

Nat Biotechnol 2012 Nov 8;30(11):1095-106. Epub 2012 Nov 8.

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703467PMC
November 2012

Evidence of abundant purifying selection in humans for recently acquired regulatory functions.

Science 2012 Sep 5;337(6102):1675-8. Epub 2012 Sep 5.

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1225057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104271PMC
September 2012

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants.

Nucleic Acids Res 2012 Jan 7;40(Database issue):D930-4. Epub 2011 Nov 7.

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology and The Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1093/nar/gkr917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245002PMC
January 2012

A high-resolution map of human evolutionary constraint using 29 mammals.

Nature 2011 Oct 12;478(7370):476-82. Epub 2011 Oct 12.

Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature10530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207357PMC
October 2011

Predicting functional transcription factor binding through alignment-free and affinity-based analysis of orthologous promoter sequences.

Bioinformatics 2008 Jul;24(13):i165-71

Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

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http://dx.doi.org/10.1093/bioinformatics/btn154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718632PMC
July 2008

Dissecting complex transcriptional responses using pathway-level scores based on prior information.

BMC Bioinformatics 2007 Sep 27;8 Suppl 6:S6. Epub 2007 Sep 27.

Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, MC 2441, New York, NY 10027, USA.

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http://dx.doi.org/10.1186/1471-2105-8-S6-S6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995543PMC
September 2007

Predictive modeling of genome-wide mRNA expression: from modules to molecules.

Annu Rev Biophys Biomol Struct 2007 ;36:329-47

Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

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http://dx.doi.org/10.1146/annurev.biophys.36.040306.132725DOI Listing
August 2007

Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster.

Proc Natl Acad Sci U S A 2006 Aug 31;103(32):12027-32. Epub 2006 Jul 31.

Department of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1073/pnas.0605003103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567692PMC
August 2006